Apart from the blood-brain barrier (BBB), the efficacy of immunotherapy for glioblastoma (GBM) is also limited by intrinsic immune resistance represented by extremely low immunogenicity and adaptive immune resistance represented by an immunosuppressive microenvironment. This implies the need for the...

Neovascular retinal diseases, represented by wet age-related macular degeneration (wAMD), primarily affect critical ocular tissues such as the retina and choroid. The neovascularization at these sites is highly susceptible to leakage or rupture, leading to retinal edema or hemorrhage in the macular ...

In pancreatic ductal adenocarcinoma (PDAC), stromal cells and matrix proteins form a dense physical barrier that not only confines tumor cells but also severely restricts the penetration of therapeutic agents and CD8+ T lymphocytes. Concurrently, the hyperactivated TGF-β/SMAD signaling pathway furt...

Epigenetic dysregulation in tumors has been established as a pivotal driver of malignant progression, therapeutic resistance, and the formation of a pro-tumor immune microenvironment, mediated through its influence on gene expression and metabolic reprogramming. This uncontrolled metabolic pattern, ...

Microglia, as resident immune cells in the brain, play crucial roles in processes such as synaptic pruning, pathogen phagocytosis, neuronal excitability regulation, apoptotic cell clearance, and the formation of the immune microenvironment. To achieve their functional diversity, microglia exhibit mu...

Adoptive macrophage therapy has emerged as a promising strategy to combat solid tumors due to the phenotypic plasticity of macrophages, the tumor-penetrating capacity and the ability to modulate the tumor microenvironment. Currently, various genetic approaches have been developed to engineer macroph...

Covalent inhibitors have emerged as a promising therapeutic strategy due to their ability to form covalent bonds with target proteins. These inhibitors offer several advantages, including prolonged efficacy, precise targeting, and the potential to overcome drug resistance. However, the inherent reac...

Drimane-type merosesquiterpenoids (DMT) are a class of natural products with diverse structures and broad biological activity. Classical DMT synthesis relies on atom-inefficient plant-derived chiral pool building blocks, while alternative drimane-type building blocks such as drimenol and albicanol o...

A breakthrough study conducted by Professor Qizhi Zhangs group from the School of Pharmacy at Fudan University has unveiled a novel Nano-dredger technology that addresses axonal autophagic dysfunction—a key pathological feature of Alzheimers disease (AD). The research highlights how axonal autophago...

Recently, Professor Jianxin Wangs group at the School of Pharmacy, Fudan University, successfully developed an antigen self-presenting dendrosome nanovaccine. Through the synergistic co-delivery of antigens and STING agonists, this novel vaccine substantially enhances the efficacy of cancer immunoth...

In the context of the immune microenvironment characteristics of cold tumors, PROTACs has demonstrated unique advantages, including solving drug resistance problems and non-patent drug targets. However, there is still a lack of complete guidance reviews on targeted PROTAC drug delivery systems that ...

Recently, the Ker Yu’s research team from the School of Pharmacy, Fudan University, published an online research paper titled “Tissue factor promotes TREX1 protein stability to evade cGAS-STING innate immune response in pancreatic ductal adenocarcinoma” on the journal Oncogene, revealing for the ...

Stroke has become the second reason of death and the third reason of disability in the world, of which ischemic stroke accounts for more than 80% of cases. Nerve injury represents the primary reason of high mortality and disability as well as poor prognosis of ischemic stroke, and its mechanisms inv...

Recently, Professor Wei Fu’s team from the School of Pharmacy at Fudan University published a research paper titled “Discovery of Novel N-Sulfonamide-tetrahydroquinolines as Potent Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists for the Treatment of Psoriasis” in Jour...

Sun research group has recently developed an efficient total synthesis of marine alkaloid norzoanthamine. The related results have been published online in Journal of the American Chemical Society(JACS), entitled Concise Synthesis of Norzoanthamine Enabled by a Set of Photochemical Transformations.Z...

E1A binding protein (p300) and CREB binding protein (CBP), described as p300/CBP, are two highly homologous and multidomainhistone acetyltransferases. The bromodomain (BRD) and catalytic domain of p300/CBP synergistically regulate the level of the acetylated lysine of histone, which impacts related ...

Alzheimers disease (AD) is a progressive neurodegenerative disease. However, there is currently a lack of effective treatments to inhibit its progression, making it one of the most challenging brain diseases to treat clinically. Recent studies have shown that the phenotype and metabolic function of ...

Recently, a study on “design, synthesis and bioevaluation of novel NLRP3 inhibitor with IBD immunotherapy from the virtual screen” has been published in the Journal of Medicinal Chemistryby Professor Xianfeng Gus group from school of pharmacy，Fudan University. In this work, the research team used...

Traditional drug development faces challenges such as low success rates, high costs and lengthy development cycles, which necessitates the adoption of new technologies and models to change the status quo. The application of various omics technologies in patient cohort can reveal patient disease char...

Raman spectroscopy is widely used in chemical analysis, material sciences, and biomedical research due to its high specificity and fingerprint spectroscopy. Spontaneous Raman imaging of small molecules is often insensitive, with Raman scattering occurring in only 1 in 10 million incident photons. As...