Stroke has become the second reason of death and the third reason of disability in the world, of which ischemic stroke accounts for more than 80% of cases. Nerve injury represents the primary reason of high mortality and disability as well as poor prognosis of ischemic stroke, and its mechanisms inv...

Recently, Professor Wei Fu’s team from the School of Pharmacy at Fudan University published a research paper titled “Discovery of Novel N-Sulfonamide-tetrahydroquinolines as Potent Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists for the Treatment of Psoriasis” in Jour...

Sun research group has recently developed an efficient total synthesis of marine alkaloid norzoanthamine. The related results have been published online in Journal of the American Chemical Society(JACS), entitled Concise Synthesis of Norzoanthamine Enabled by a Set of Photochemical Transformations.Z...

E1A binding protein (p300) and CREB binding protein (CBP), described as p300/CBP, are two highly homologous and multidomainhistone acetyltransferases. The bromodomain (BRD) and catalytic domain of p300/CBP synergistically regulate the level of the acetylated lysine of histone, which impacts related ...

Alzheimers disease (AD) is a progressive neurodegenerative disease. However, there is currently a lack of effective treatments to inhibit its progression, making it one of the most challenging brain diseases to treat clinically. Recent studies have shown that the phenotype and metabolic function of ...

Recently, a study on “design, synthesis and bioevaluation of novel NLRP3 inhibitor with IBD immunotherapy from the virtual screen” has been published in the Journal of Medicinal Chemistryby Professor Xianfeng Gus group from school of pharmacy，Fudan University. In this work, the research team used...

Traditional drug development faces challenges such as low success rates, high costs and lengthy development cycles, which necessitates the adoption of new technologies and models to change the status quo. The application of various omics technologies in patient cohort can reveal patient disease char...

Raman spectroscopy is widely used in chemical analysis, material sciences, and biomedical research due to its high specificity and fingerprint spectroscopy. Spontaneous Raman imaging of small molecules is often insensitive, with Raman scattering occurring in only 1 in 10 million incident photons. As...

Dr Wang’s group at School of Pharmacy, Fudan University, has recently developed a chemigenetic probe designed for monitoring NADPH dynamics in living cells. The research article was published in Journal of the American Chemical Societytitled Fluorogenic rhodamine-based chemigenetic biosensor for mo...

On June 19, 2024, the research team of Professor Xuemei Zhang, Department of Pharmacology, School of Pharmacy, Fudan University, published a paper in Autophagy (2024 IF: 14.6). The title of the research paper is “Activation of BK channels prevents diabetes-induced osteopenia by regulating mitochond...

Microtubules constitute a major component of the cellular cytoskeleton. Malignant tumor cells exhibit robust proliferation and highly active mitosis, making microtubules one of the most successful targets for anticancer therapy. Despite the availability of several marketed microtubule-targeting agen...

The intricate interplay between tumor cells, neighboring immune cells, and various immune cell types involves complex competitive-cooperative patterns rewired through metabolic and immune signals, which are essential for shaping the immunosuppressive tumor microenvironment (TME). This metabolic imba...

Histone acetylation is one of the epigenetic regulation within cells, which is important for gene transcription, DNA replication, and DNA damage repair. This chemical modification is dynamically modulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs). E1A associated protein p...

On February 19, 2024, Professor Li Qingquan's team published a research paper entitled "Methanine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal cancer" in Cell Metabolism. Pericytes are heterogeneous mural cells surrounding blood vessels that ar...

KRAS is one of the most prevalent oncogenic drivers of human malignancy including lung cancer. Approximately 25% of NSCLC harbor the mutated KRAS gene (KRASmut), among which KRASG12C is the most common type in lung adenocarcinoma (LUAD). Tissue factor (TF) activation can greatly promote the malignan...

Recently, Professor Jianxin Wangs group at the School of Pharmacy, Fudan University, published a paper in the esteemed pharmaceutical journal, theJournal of Controlled Release, in 364thissue of 2023. The paper was titled Ginsenoside Rg3 endows liposomes with prolonged blood circulation and reduced a...

Cancer metabolism plays multifaceted roles in the initiation and progression of tumors, and interventions in metabolism are considered fundamental approaches for cancer control. Within the vast metabolic networks of tumors, there exist numerous potential therapeutic targets, intricately interconnect...

In recent years, the immune regulatory function of retinoic acid receptor related orphan receptor RORγt in tumor microenvironment (TME) has attracted considerable attentions, and RORγt has become a highly promising drug target for cancer immunotherapy. Some studies have demonstrated that T helper ...

The DNA-encoded chemical library (DEL) has emerged as a powerful technology for rapidly synthesizing and selecting library members. DELs incorporating an electrophile warhead, known as covalent DELs, have been utilized for covalent drug discovery. However, the use of these covalent DELs has been lim...

The recognition of water molecules' significance in protein-ligand binding is well-established among researchers. Examining pivotal water molecules can provide insights into "anomalous" structure-activity relationships and offer guidance for the efficient design of lead compounds. Whi...