In recent years, the rapid advancement of techniques such as super-resolution fluorescence imaging has provided unprecedented opportunities for the ultra-high spatiotemporal resolution visualization and biological functional research of target proteins. The high contrast labeling of target proteins ...

Maintenance of cellular oxygen homeostasis is essential for ensuring the normal life activities of cells. William Kaelin, Jr., Sir Peter Ratcliffe, and Gregg Semenza shared 2019 Nobel Prize in Physiology or Medicine for discovering how cells sense and adapt to oxygen availability. Hypoxia inducible ...

Recently, a cross-sectional study on prehospital delays among the stroke population in China, based on the Bigdata Observatory Platform for Stroke of China (BOSC), has been published online in The Lancet Regional Health -Western Pacific. This is the first study to report variations in prehospital de...

Recently, the research group led by Prof. Chen Jiang has reported a hydrogel nanoparticle drug delivery system, or namely nanogel, which is hopeful to address several problems facing the currently prevalent anti-epileptic drug therapies in epileptic treatment. The study was published online in ACS N...

The growing global population and increasing longevity have led to a surge in neurodegenerative diseases (NDs), contributing to higher rates of morbidity and mortality. Neurodegenerative diseases like Parkinson's disease (PD), Alzheimer's disease (AD), and Huntington's disease (HD) sh...

Recently, Prof. Wei Wu’s group at Fudan University School of Pharmacy published a research article titled “ ‘Hook&Loop’ multivalent interactions based on disk-shaped nanoparticles strengthen active targeting” in Vol. 354, Journal of Controlled Release.

Recently, the research group led by Prof. Chen Jiang has developed a versatile drug delivery system that can trigger transcytosis. The delivery system can efficiently deliver chemotherapy drugs to the deep tumor, regulate the microenvironment, and activate the anti-PDAC immune response. The study wa...

Ischemic stroke is a formidable disease with high morbidity, disability and fatality, which seriously threatens the life quality and health of patients. The clinically recommended treatment for ischemic stroke is intravenous thrombolysis or intra-arterial thrombectomy to timely restore the blood sup...

In recent years, the tumor immune regulatory function of adenosine A2A receptor (A2AR) has attracted much attention, and A2AR has been identified as an emerging potential target for cancer immunotherapy. In the tumor microenvironment (TME), hypoxia upregulates the expression of CD39 and CD73 through...

The recently emerged Omicron subvariants XBB and BQ.1.1 have presented striking immune evasion against most monoclonal neutralizing antibodies and convalescent plasma.Even three or four doses of parental messenger RNA (mRNA) vaccine cannot induce strong neutralization against XBB.The antibody evasio...

​Recently, the research group led by Prof. Chen Jiang has developed a bioinspired nanoerythrocyte, which could modulate the metabolic microenvironment of the brain lesion area and was applied for the whole process of acute ischemic stroke (AIS) treatment. The related article was published online in ...

​Drug delivery systems (DDSs) are important pharmaceutical solutions for optimizing the in vivo drug distribution, where DDSs triggered by local microenvironment represents the state-of-art of nanomedicine design. Currently, the hot topics are mainly concerning the long circulation, fine tumor targe...

Autophagy is a process of cellular scavenging that relies on lysosomes, whereby protein aggregates and damaged organelles are broken down. This process is evolutionarily conserved and serves to maintain cellular homeostasis, as well as promote cell survival in the face of stressors. Through the degr...

Recently, the research group of Professor Yan Li from the Department of Pharmaceutical Analysis, School of Pharmacy, Fudan University published a research article entitled “A Tractable Method for Rapid Quality Assessment of Therapeutic Antibodies in Harvested Cell Culture Fluid Based on FcγRIIIa I...

Lei Zuhai's research group at the School of Pharmacy has made progress in the field of fluorescence biosensing in the second near-infrared window (NIR-II). The research project constructed a NIR-II molecular platform, which can be conveniently developed for various activatable ratiometric NIR-II mol...

Recently, Professor Ying Chen’s Group (Department of Pharmaceutical Chemistry) and Associate Professor Hongrui Liu’s Group (Department of Pharmacology) published an article entitled “Novel Hybrids of 3-Substituted Coumarin and Phenylsulfonylfuroxan as Potent Antitumor Agents with Collateral Sensi...

Along with an increased global incidence, pancreatic cancer (PDAC) shows the worst prognosis, a 5-year survival rate of less than 5%. Despite ongoing research, PDAC has developed greater drug resistance due to its prominent feature of connective tissue proliferation in the mesenchyme, which raises i...

Lu Wang’s group in the School of Pharmacy, Fudan University, and Lin Yuan’s Group in Hunan University have developed a synergistic strategy to develop photostable and bright dyes with long Stokes shift for super-resolution microscopy. The study was published in the Nature Communications (https://w...

Interferon-alpha (IFN-α) has long been used in clinical practice. In 1986, IFN-α was first approved by the U.S. Food and Drug Administration (FDA) as a tumor immunotherapy drug to treat hairy cell leukemia. Till now, IFN-α has been widely approved across the world for treatment of a variety of ma...

Recently, Yonghui Wang’s group (School of Pharmacy, Fudan University) and Weiqiang Lu’s group (School of Life Science, ECNU) published an article entitled ‘Design, Synthesis, and Bioevaluation of 2-Aminopteridin-7(8H)-one Derivatives as Novel Potent Adenosine A2A Receptor Antagonists for Cancer I...