Zuhai Lei's group at the School of Pharmacy and Fan Zhang's group at the Department of Chemistry, Fudan University have made progress in the field of near-infrared II (NIR-II) in vivo fluorescence biosensing. The research project has developed a series of novel NIR-II fluorescent dyes, which can be ...

Beclin 1 is the scaffolding member of the Class III phosphatidylinositol-3-kinase (PI3KC3) complex and recruits two positive regulators Atg14L and UVRAG through its coiled-coil domain to upregulate PI3KC3 activity. Deficiency or dysfunction of Beclin 1 has been linked to human pathologies such as ca...

​Plant derived natural products have continued to play a significant role in the drug discovery and development process. The opportunity for identifying new chemical entities (NCEs) for emerging diseases depends on a diversity of drug-producing species. Plant diversity loss significantly exacerbated...

Trimethylamine-N-oxide (TMAO) has emerged as a promising new therapeutic target for the treatment of central nervous system diseases, atherosclerosis and other diseases. However, its origin in the brain is unclear. Gynostemma pentaphyllum (Thunb.) Makino can reduce the increase of TMAO level caused ...

Lu Wang’s group in the School of Pharmacy, Fudan University, and Kai Johnsson’s Group in Max Planck Institute for Medical Research have developed a new strategy for synthesizing fluorescent probes for super-resolution microscopy. The new strategy can transform the same rhodamine into either a high...

Wei Fu Group (School of Pharmacy, Fudan University) and Jinggen Liu Group (Shanghai Institute of Materia Medica, Chinese Academy of Sciences) has made progress in the study of novel selective μOR agonists as well as a structural basis for development of potential analgesic candidates. The discovery...

Liming Shao Group (School of Pharmacy, Fudan University) and Jinggen Liu Group (Shanghai Institute of Materia Medica, Chinese Academy of Sciences) has made progress in the study of novel κOR agonists and identification of compound SLL-1206 provides significant insights to the dissociation of analge...

Apoptosis is an essential process for eliminating aging or abnormal cells in the living system. Dysregulation of apoptosis is critical for various malignant tumor diseases and drug resistance in anti-tumor therapies. Bcl-2 family proteins are key regulators of the mitochondrial apoptotic pathway. St...

25% of colorectal cancer patients will experience peritoneal metastases (CCPM) due to its natural of serosa infiltration, with a 5-year survival rate less than 10% in clinic. CCPM, which is multiple and scattered, is the terminal stage of colorectal cancer, and the therapy is extremely difficult. CCPM ...

​Glioblastoma (GBM) is the most common primary malignant glioma. As a molecular marker, isocitrate dehydrogenase 1 (IDH1) plays a key role in predicting the prognosis of GBM. The vast majority (>90%) of GBM patients belong to the IDH1 wild type (IDH1WT) group, and their median survival (about 13 mon...

Glycogen synthase kinase 3β (GSK-3β) is a highly conserved serine/threonine kinase and named for its ability to phosphorylate and inactivate glycogen synthase. GSK-3β is critical in the regulation of transcription factors and signaling pathways that modulate gene transcription, cell growth, diffe...

Metastasis is the foremost cause of cancer-related death. Current clinical treatments, including tumor resection, chemotherapy and radiation therapy, can effectively remove the primary tumor but still fail to inhibit and might even induce tumor metastasis.Therefore, exploring an effective metastasis...

Recently, Professor Chen Jiang from School of Pharmacy, Fudan University, has developed a biomimetic dendrimer-peptide nanoconjugate, which had the function of regulating the pro-inflammatory microenvironment of brain lesions and was used for early multi-target treatment of Alzheimer’s disease (AD)...

The "New Trends in Virtual Screening" special issue edited by Professor Renxiao Wang from the Department of Medicinal Chemistry, School of Pharmacy, is just published in the Journal of Chemical Information and Modeling (American Chemical Society) as the September issue (https://pubs.acs .org/toc/jci...

Cardiovascular disease (CVD) is a leading cause of death and loss of productive life years worldwide1. Atherosclerosis (AS) is the underlying pathological cause for the development of CVDs and the main contributor to cardiovascular mortality2. The predominant cells present in atherosclerotic plaques...

A novel liposome-leukocytes combination delivery system was designed for ischemic stroke target therapy. The study was published on “Science Advances”, with Prof. Jianxin Wang and associate Prof. Jing Qin as co-responding authors.

Recently, Lu Zhou's lab from School of Pharmacy, Fudan University, has published a paper entitled "A novel allosteric inhibitor of phosphoglycerate mutase 1 suppresses growth and metastasis of non-small cell lung cancer" in Cell Metabolism (impact factor 22.415), collaborated with Ying Shen's group ...

Recently, Professor Wei Lu from School of Pharmacy, Fudan University, has designed a new theranostic preparation using “hitchhiking technique” for the intraoperative fluorescence image-guided cancer photodynamic and checkpoint blockade therapy. The work has been published entitled “High affinity ...

Vision has profound influence on the quality of life. Up to now, the number of visually impaired patients worldwide is about 1.3 billion, of which 36 million are blind. Chronic posterior ocular diseases are the causal factors for severe vision impairment and even blindness, including hereditary reti...

Recently, Professor Wei Lu from School of Pharmacy, Fudan University, has used biomimetic technology to prepare an adjuvant for cancer vaccine. The work has been published entitled “Bacterium-Mimicking Vector with Enhanced Adjuvanticity for Cancer Immunotherapy and Minimized Toxicity” in Advanced ...