Recently, a paper titled “A novel role of BK potassium channel activity in preventing the development of kidney fibrosis” was published on the internationally renowned academic journal “Kidney International”. The research was completed by Xuemei Zhang’s group (School of pharmacy, Fudan Universi...

Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype and is more likely to metastasize than other breast cancer subtypes. Metastasis accounts for over 90% of TNBC-caused mortality in women. The process of tumor metastasis is complex. The seed and soil theory is widely re...

Surgeons face challenges in intraoperatively defining margin of brain tumors due to its infiltrative nature. Extracellular acidosis caused by metabolic reprogramming of cancer cells is a reliable marker for tumor infiltrative regions. There is a spatiotemporal correlation between tissue acidity and ...

Inflammatory bowel disease (IBD) is a chronic, relapsing immune-mediated gastrointestinal disease with complex etiology. The incidence and prevalence of IBD have increased rapidly in developing countries over the past few years. High recurrence rate and severe complications have brought great challe...

Recently, Prof. Jianxin Wang's group has developed a dendritic cell (DC) bionanotropic nano-formulation that enables immunochemotherapy combination therapy and amplifies the tumor immune response effect with significant anti-tumor effects. The study has been published in the internationally renowned...

Inflammatory bowel disease (IBD) is a chronic, recurrent intestinal inflammatory disease of unknown pathogenesis, including ulcerative colitis (UC) and Crohn's disease (CD). The global incidence of IBD remains high, and China is the country with the highest incident rate of IBD (3.44 per 100,000 per...

Zuhai Lei's group at the School of Pharmacy and Fan Zhang's group at the Department of Chemistry, Fudan University have made progress in the field of near-infrared II (NIR-II) in vivo fluorescence biosensing. The research project has developed a series of novel NIR-II fluorescent dyes, which can be ...

Beclin 1 is the scaffolding member of the Class III phosphatidylinositol-3-kinase (PI3KC3) complex and recruits two positive regulators Atg14L and UVRAG through its coiled-coil domain to upregulate PI3KC3 activity. Deficiency or dysfunction of Beclin 1 has been linked to human pathologies such as ca...

​Plant derived natural products have continued to play a significant role in the drug discovery and development process. The opportunity for identifying new chemical entities (NCEs) for emerging diseases depends on a diversity of drug-producing species. Plant diversity loss significantly exacerbated...

Trimethylamine-N-oxide (TMAO) has emerged as a promising new therapeutic target for the treatment of central nervous system diseases, atherosclerosis and other diseases. However, its origin in the brain is unclear. Gynostemma pentaphyllum (Thunb.) Makino can reduce the increase of TMAO level caused ...

Lu Wang’s group in the School of Pharmacy, Fudan University, and Kai Johnsson’s Group in Max Planck Institute for Medical Research have developed a new strategy for synthesizing fluorescent probes for super-resolution microscopy. The new strategy can transform the same rhodamine into either a high...

Wei Fu Group (School of Pharmacy, Fudan University) and Jinggen Liu Group (Shanghai Institute of Materia Medica, Chinese Academy of Sciences) has made progress in the study of novel selective μOR agonists as well as a structural basis for development of potential analgesic candidates. The discovery...

Liming Shao Group (School of Pharmacy, Fudan University) and Jinggen Liu Group (Shanghai Institute of Materia Medica, Chinese Academy of Sciences) has made progress in the study of novel κOR agonists and identification of compound SLL-1206 provides significant insights to the dissociation of analge...

Apoptosis is an essential process for eliminating aging or abnormal cells in the living system. Dysregulation of apoptosis is critical for various malignant tumor diseases and drug resistance in anti-tumor therapies. Bcl-2 family proteins are key regulators of the mitochondrial apoptotic pathway. St...

25% of colorectal cancer patients will experience peritoneal metastases (CCPM) due to its natural of serosa infiltration, with a 5-year survival rate less than 10% in clinic. CCPM, which is multiple and scattered, is the terminal stage of colorectal cancer, and the therapy is extremely difficult. CCPM ...

​Glioblastoma (GBM) is the most common primary malignant glioma. As a molecular marker, isocitrate dehydrogenase 1 (IDH1) plays a key role in predicting the prognosis of GBM. The vast majority (>90%) of GBM patients belong to the IDH1 wild type (IDH1WT) group, and their median survival (about 13 mon...

Glycogen synthase kinase 3β (GSK-3β) is a highly conserved serine/threonine kinase and named for its ability to phosphorylate and inactivate glycogen synthase. GSK-3β is critical in the regulation of transcription factors and signaling pathways that modulate gene transcription, cell growth, diffe...

Metastasis is the foremost cause of cancer-related death. Current clinical treatments, including tumor resection, chemotherapy and radiation therapy, can effectively remove the primary tumor but still fail to inhibit and might even induce tumor metastasis.Therefore, exploring an effective metastasis...

Recently, Professor Chen Jiang from School of Pharmacy, Fudan University, has developed a biomimetic dendrimer-peptide nanoconjugate, which had the function of regulating the pro-inflammatory microenvironment of brain lesions and was used for early multi-target treatment of Alzheimer’s disease (AD)...

The "New Trends in Virtual Screening" special issue edited by Professor Renxiao Wang from the Department of Medicinal Chemistry, School of Pharmacy, is just published in the Journal of Chemical Information and Modeling (American Chemical Society) as the September issue (https://pubs.acs .org/toc/jci...