Keywords of research interests

Biopharmaceutics, Pharmacokinetics and Clinical Pharmacy:

1. Drug ADME/Tox and its regulation

2. Transporters and metabolic enzymes-mediated drug-drug interaction

3. Pharmacometabolomics

4. Herb-induced and drug-induced liver injury (HILI and DILI)

Curriculum Vitae

Education

Sep 2004-Jun 2007  West China School of Pharmacy, Sichuan University , Ph.D. in Pharmaceutics

Sep 2001-Jun 2004  Sichuan Industrial Institute of Antibiotics, SFDA, M.S. in Pharmaceutics

Sep 1992-Jun 1996  School of Pharmacy, Shandong Medical University, Pharmaceutical Sciences

Professional Experiences

Aug 2007-present  Lecturer and Associate Professor, School of Pharmacy, Fudan University

Dec 2010-Dec 2011 Visiting scholar, College of Pharmacy, University of Houston

Jul 1996-Aug 2001  Pharmacist, Department of pharmacy, Xiazhang Hospital, Taian City, Shandong Province  

Teaching Activities

Teaching courses

1. Clinical pharmacokinetics (major speaker)

2. Clinical pharmacy skills and practice (major speaker)

3. Hospital pharmacy (major speaker)

4. Pharmaceutical service and health (major speaker)

5. Introduction to clinical pharmacy

6. Clinical Pharmacotherapeutics I

7. Clinical Pharmacotherapeutics II

8. Clinical Pharmacotherapeutics

9. Clinical evaluation of drugs

Teaching Projects

1. Pharmacy education reform research in 2008---Research and practice on training mode of clinical pharmacy talents in China. (Program director, No.2008017, supported by Pharmacy Education Research Association, China Association of High Education)

2. Pharmacy education reform research in 2010- Research on professional courses and teaching system of clinical pharmacy (Program director, No. 201016, supported by Pharmacy Education Research Association, China Association of High Education)

3. Pharmacy education reform research in 2012- Research and practice of the new education mode ("2+2+2") of clinical pharmacy" (Program director, No. 201237, supported by Pharmacy Education Research Association, China Association of High Education)

4. Regular higher education "13th Five-Year"planning textbooks and digitization project--- introduction to clinical pharmacy. (China Science Publishing & Media Ltd. (CSPM), 2016)

5. Improving the undergraduate education quality of Fudan University---clinical pharmacy (Fudan University, 2013)

Textbooks & monographs

1. Introduction to clinical pharmacy (editor-in-chief, Science Press, ISBN 978-7-03-053001-1, July 2017)

2. Introduction to pharmaceutical services (deputy editor, People's Medical Publishing House, ISBN9787117221870, February 2016)

3. Pharmaceutical care practice (deputy editor, China Medical Science Press, ISBN 9787506778886，January 10, 2016, )

4. Theory and practice of clinical pharmacy (editorial board member, People's medical publishing house, ISBN 9787117150859，March, 2012)

5. Pandect of clinical pharmacotherapeutics (editorial board member, People's medical publishing house, ISBN 9787117227469，January 1, 2017)

6. Pharmacology (editorial board member, Fudan University Press, ISBN: 9787309117271, June 1, 2016)

7. Evidence-based pharmacy (editorial board member, Higher Education Press, 2018)

Grants & Projects

1. Influence of Polygonum multiflorum Thunb on metabolism and transport of bilirubin and its hepatotoxicity mechanism based on OATPs/UGT1A1/MRPs regulation (project principal, Supported by General Program of National Natural Science Funds of China, NO. 81374051，2014 -2017)

2. Jaundice-relieving mechanism and pharmacodynamic material basis of Capillary Wormwood Herb based on regulation of transporters and metabolic enzymes-mediated transport and metabolism of bilirubin and bile acids  (project principal, Supported by Science and Research Fund of Shanghai Municipal Commission of Health and Family Planning, No. 201740094,  2018-2020)

3. Research on influence of traditional Chinese medicine (Polygonum multiflorum Thunb) on metabolism and transport of bilirubin and its hepatotoxicity mechanism based on OATP1/UGT1A1/MRP2 regulation (project principal, Supported by young teacher’s ability improvement project of the Fundamental Research Funds for the Central Universities, NO. 20520133531，2013 -2016)

4. Molecular mechanism and material basis of Yinzhihuang in removing jaundice based on regulation of transporters and enzymes-mediated transport and metabolism of bilirubin (Supported by MHHFDU-SPFDU Joint Research Fund, No. RO-MY201707, 2018-2019)

5. Laxative Effect and Safety Assessment of New Ultrasonic Water (Enterprise project, CXF0080111, Supported by Supported by Wuxi Tianxia ultrasonic equipment Co. Ltd, 2014-2015)

Awards & Honors

1. The First Presentation Award in the 2014 Shanghai Forum of DMPK（08/30/2014 , Title：Inhibition of Human UGT1A1-Mediated Bilirubin Glucuronidation by Danshen (Salvia Miltiorrhiza) injection, Compound Danshen injection and their constituents；Division of Drug Metabolism, Chinese Pharmacological Society）

2. The Excellence Award in the 8th ISDNP（10/10/2014, Title：Inhibition of Human UGT1A1-Mediated Bilirubin Glucuronidation by Danshen (Salvia Miltiorrhiza) injection, Compound Danshen injection and their constituents；Committee of ISDNP）

3. The First Paper Award in 2016 Sino-American Forum of Clinical Pharmacy, Shanghai, May 27-29, 2016.Inhibition of Human UGT1A1-Mediated BilirubinGlucuronidation by Salvianolic Acid A, Salvianolic Acid B and Polyphenolic Acid-rich Danshen (Salvia miltiorrhiza) Injections.

4. The Second Prize of 2012 Fudan University Excellent Teaching Results for Graduate---Construction of the high quality curriculum and textbook for clinical pharmacotherapeutics (Graduate School of Fudan University, 2013)

5. The Third Prize of “Excellent papers on medical education and medical education management in 2013" (Title: Pharm .D. Education in America and its Inspiration to Clinical Pharmacy Education in China; Society of Medical Education of Chinese Medical Association (CMA) and Medical Education Specialty Committee of China Association of High Education, Nov 2014, Ranking 1 )

6. The Second prize of Shanghai higher education teaching achievement Award in 2017 -- Exploration and innovation in the Training mode of clinical Pharmacy talents (Ranking 3, March, 2018)

7. The First prize of Fudan University teaching achievement Award in 2017 -- Exploration and innovation in the Training mode of clinical Pharmacy talents (Ranking 3, Jan, 2018)

8. The Second Prize in Fudan University graduate teaching achievement Award -- Construction of high quality curriculum and its textbook of Clinical Pharmacotherapeutics” (Ranking 5, Nov, 2012)

Memberships

Editorial Board Member of Journals

1. Editorial board member of EC Pharmacology and Toxicology (ECPT)

2. Editorial board member of Madridge Journal of Pharmaceutical Research（MJPR）

3. Editorial board member of Pharmaceutical research

Members of the academic organizations

1. Committee member of the Evidence-based Pharmacy Committee of China Pharmaceutical Association (CPA)

2. Director of the Popular Science Branch of China Medical Association of Minorities (CMAM)

3. Committee member of Professional Committee of Drug Metabolism, Shanghai Pharmacological Society

4. Member of ACS、ISSX、Chinese Society of Toxicology and Shanghai Pharmaceutical Association

Invited Presentations

1. Simultaneous determination of bilirubin and its glucuronides in different biological incubation systems by HPLC method and its application to bilirubin glucuronidation and its inhibition by herbs. BIT’s 14th Annual Congress of International Drug Discovery Science & Technology - 2016 (IDDST-2016), Nanjing, November 16-19, 2016

2. Inhibition of Human UGT1A1-Mediated Bilirubin Glucuronidation by Danshen (Salvia Miltiorrhiza) injection, Compound Danshen injection and their constituents. Shanghai Forum of DMPK, Shanghai, 2014,

3. Inhibition of Human UGT1A1-Mediated Bilirubin Glucuronidation by Danshen (Salvia Miltiorrhiza) injection, Compound Danshen injection and their constituents. Sino Academic Symposium on the development of national medicine, Chengdu, Sep.26-28, 2014

4. Mutual Regioselective Inhibition of Human UGT1A1-Mediated Glucuronidation of Four Flavonoids. The 11th National Youth Pharmacist' Forum on the latest research achievements. Hangzhou, June 21, 2012.

5. Inhibition of UGT1A1-Mediated Bilirubin Glucuronidation by Traditional Chinese Medicine (TCM) Injections，school of Pharmaceutical Science,  Taishan Medical University,Taian, July 3, 2014.

6. Inhibition of Human UGT1A1-Mediated Bilirubin Glucuronidation by Salvianolic Acid A, Salvianolic Acid B and Polyphenolic Acid-rich Salvia miltiorrhiza (Danshen) Injections. The founding conference of the science popularization branch of China Medical Association of Minorities，Beijing, September,20-22,2017

7. Inhibition of Human UGT1A1-Mediated Bilirubin Glucuronidation by Polyphenolic Acids Impact Safety of Popular Salvianolic Acid A/B-Containing Chinese medicinal herbs. The 3rd young scientists Forum on pharmacokinetics, Nanjing, Nov 3-5，2017

Selected Publications

1. Guo Ma, Ying Zhang, Wenyan Chen, Zhifang Tang, XiaomingXin, Ping Yang, Xiaoqin Liu, WeiminCai, Ming Hu. Inhibition of Human UGT1A1-Mediated Bilirubin Glucuronidation by Polyphenolic Acids Impact Safety of Popular Salvianolic Acid A/B-Containing Drugs and Herbal Products, Mol Pharm, 2017, 14(9):2952-2966

2. Guo Ma, Baojian Wu, Song Gao, Zhen Yang, Yong Ma, Ming Hu. Mutual regioselective inhibition of human UGT1A1-mediated glucuronidation of four flavonoids. Mol Pharm, 2013, 10(8):2891-2903

3. Guo Ma, Jiayuan Lin, Weimin Cai, Bo Tan, Xiaoqiang Xiang,Ying Zhang, Peng Zhang.Simultaneous determination of bilirubin and its glucuronides in liver microsomes and recombinant UGT1A1 enzyme incubation systems by HPLC method and its application to bilirubin glucuronidation studies. J Pharm Biomed Anal, 2014, 92:149-159

4.Guo Ma, Lin Zhang, Peng Zhang, Xingfei Bao, Ning Zhou, Qingling Shi, Yuanting Zheng, Hongrui Liu, Fengjiao Bu, Ying Zhang, Wenjie Huang, Fen Wang, Yizhun Zhu*, WeiminCai*. Physicochemical characteristics and gastrointestinal absorption behaviors of S-propargyl-cysteine, a potential new drug candidate for cardiovascular protection and antitumor treatment. Xenobiotica，2015, 45(4): 322-334

5. Dengfeng Tang1, Guo Ma (Co-first author), Luyan Zhang, Gang Chen. Graphene-epoxy composite electrode fabricated by in situ polycondensation for enhanced amperometric detection in capillary electrophoresis. J Chromatogr A, 2013, 1316: 127-134

6. Bo Tan, Weimin Cai, Jinlian Zhang, Ning Zhou, Guo Ma, Ping Yang, Qing Zhu, Yizhun Zhu. Identification of UDP-glucuronosyltransferase isoforms responsible for leonurine glucuronidation in human liver and intestinal microsomes. Xenobiotica, 2014, 44(9):775-784

7. Zhang H, Bu F, Li L, Jiao Z, Ma G, Cai W, Zhuang X, Lin HS, Shin JG, Xiang X. Prediction of Drug-Drug Interaction between Tacrolimus and Principal Ingredients of Wuzhi Capsule in Chinese Healthy Volunteers Using Physiologically-Based Pharmacokinetic Modelling. Basic Clin Pharmacol Toxicol. 2018; 122(3):331-340  

8. Ma Guo, Xiang Xiao-Qiang, Cai Wei-min, Hou Ai-jun. Development of clinical pharmacy in the United States and China [Article in Chinese]. International academic developments. 2017, 2:49-50

9. Chen Wen-yan, Cai Wei-min, Ma Guo*. Investigation of cognition and demand of patients and their families on clinical pharmacists and pharmaceutical services [Article in Chinese]. China Journal of Hospital Pharmacy. 2017, 37(24):25-30

10. Wang Fen, Cai Wei-min, Ma Guo*. Cognition of the medical staffs from the secondary and tertiary hospital in Shanghai on clinical pharmacy practice and clinical pharmacists. [Article in Chinese]. China Journal of Hospital Pharmacy, 2016, 36(2):122-125

11. Liu Bei, Ma Guo *. Research progress in antibacterial drug induced liver injury. [Article in Chinese]. China Journal of Hospital Pharmacy, 2016, 36（9）:778-784

12. Liu Bei, Ma Guo*.Progress in study on therapeutic drugs against neonatal jaundice. [Article in Chinese]. China Journal of Hospital Pharmacy, 2015, 35（16）：1515-1519

13. Huang Wen-jie, Cai Wei-min, Ma Guo*.Investigation on Cognition of the Clinical Pharmacists on the Clinical Pharmacy Practice and Their Profession in the Medical and Health Institutions in Shanghai [Article in Chinese].China Pharmacy, 2015, 26(36): 5048-5051

14. Jiayuan Lin, Ma Guo*. Research process in bilirubin metabolism and its regulations [Article in Chinese]. Fudan University Journal of Medical Sciences, 2014, 41 (3): 405-411

15. Ma Guo, Peng Zhang,Yuzheng Wang, Jiayuan Lin, Haian Zheng, Weimin Cai. Pharm.D. Education in America and its Inspiration to Clinical Pharmacy Education in China [Article in Chinese]. Chinese Journal of clinical pharmacy. 2013，22 (6):321-326

16. Tang Zhifang, Ma Guo*, Mei Quan Xi *.Research progress on the hepatotoxicity of Polygonummultiflorum[Article in Chinese]. Lishizhen Medicine and Materia Medica Research, 2017, 28(7):1722-1725