Dr. Yuan Gao is currently an associate professor in the Department of Pharmacy and Pharmaceutical Management, School of Pharmacy, Fudan University. She obtained her MS from Shenyang Pharmaceutical University in 1998 and PhD from Second Military Medical University in 2009. Before joining Fudan University, Dr Gao worked for Shanghai-Pharma and Shanghai Changhai Hospital. There she was engaged in R&D research and served as a senior scientist. Dr. Gao received training at the Center for Drug Evaluation of China FDA. She has authored 15 publications and 9 patents. Her research is focused on regulatory science, formulations development as well as cancer targeted therapy.
Regulatory Science; Drug Development; Biopharmaceutics; Drug Delivery; Quality Control
Education
Postdoc, University of Alberta, Pharmaceutics
Postdoc, Shanghai Institute of Materia Medica, CAS, Nanomedicine
PhD, Second Military Medical University, Pharmaceutics
MS & BS, Shenyang Pharmaceutical University, Pharmaceutics
Professional Experiences
Associate Professor, Department of Pharmacy, Fudan University
Pharmacist, Changhai Hospital, Second Military Medical University
Senior Scientist, Shanghai Pharmaceutical Group
Teaching Activities
Regulatory Science, Clinical Research, GMP and GSP guidelines
Grants & Projects
CG3 aptamer-mediated tumor environment responsive micelles for targeted delivery miR-26a/enzalutamide to castrate-resistant prostate cancer，National Natural Science Foundation of China (81672545)
Selected Publications (latest 5 yrs)
1. Xia Q, Gu F, Gong C, Hu C, Gu F, Yao C, Zhang L, Qiang L, Gao S*, Gao Y*. Functionalized multi-walled carbon nanotubes for the delivery of immunostimulatory CpG oligonucleotides against prostate cancer. J Biomed Nanotechnology. (Accepted)
2. Gong C, Hu C, Gu F, Xia Q, Yao C, Zhang L, Qiang L, Gao S*, Gao Y*. Co-delivery of autophagy inhibitor ATG7 siRNA and docetaxel for breast cancer treatment. J Control Release 266, 272-286 (2017)
3. Gu F, Hu C, Tai Z, Yao C, Tian J, Zhang L, Xia Qing, Gong C, Gao Y*, Gao S* Tumour microenvironment-responsive lipoic acid nanoparticles for targeted delivery of docetaxel to lung cancer. Scientific Reports. 6: 36281 (2016)
4. Hu C, Gu F, Tai Z, Yao C, Gong C, Xia Q, Gao Y*, Gao S*. Synergistic effect of reduced polypeptide micelle for co-delivery of doxorubicin and TRAIL against drug-resistance in breast cancer. Oncotarget. 7(38):61832-44 (2016)
5. Liu Y, Wu X, Gao Y#, Zhang J, Zhang D, Gu S, Zhu G, Liu G, Li X*. Aptamer-functionalized peptide H3CR5C as a novel nanovehicle for codelivery of fasudil and miRNA-195 targeting hepatocellular carcinoma. Int J Nanomedicine. 11, 3891–905 (2016)
6. Gao Y, Sarfraz M, Roa W, Clas S-D, L?benberg R*. Hyaluronic acid–tocopheryl succinate micelles containing rifampicin for active targeting to macrophages. J. Biomed. Nanotechnology. 11: 1-18 (2015)
7. Yao C, Tai Z, Wang X, Liu J, Quan G, Wu X, Zhang L, Zhang W, Gao Y*, Gao S*. Reduction-responsive cross-linked stearyl peptide for effective delivery of plasmid DNA. Int J Nanomedicine. 10: 3403–3416 (2015)
8. Gao Y, Zuo J, Bou-Chacra N, Pinto T, Clas S, Walker, R, L?benberg, R*. In vitro release kinetics of anti- tuberculosis drugs from nanoparticles assessed using a modified dissolution apparatus. Biomed. Res. Inter. 7:527-531 (2013)
