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    • Faculty & Staff
    Lu Wang, Ph.D.
    2021/09/24 18:23:31
    Personal information
    Lu Wang, Ph.D.
    Youth Principle Investigator
    Email: lwangfd@fudan.edu.cn
    Address:No 826 Zhangheng Rd, Pudong, Shanghai,China 201203
    Personal website: https://www.x-mol.com/groups/luwangfd
    Dr. Lu Wang got his Bachelor degree in China Pharmaceutical University(2006-2010) and Master degree in Fudan University (2010-2013). From 2013 to 2017, Dr. Lu Wang finished his Ph. D. program in National University of Singapore under the supervision of Prof. Young-tae Chang. Later, he started hispost-doc research work with the support from Humboldt Fellowship in Max-Planck Institute for Medical Research in Heidelberg, Germany under the guidance of Prof. Kai Johnsson. Since June 2021, Dr. Lu Wang joined the School of Pharmacy,Fudan University as a youth principle investigator with the support from the Overseas Young High-Level Talent Recruitment Programs and Fudan University Research Initial Funding. His research interests mainly focus on the molecularimaging and chemical biology, especially on the design and synthesis of fluorescent probes for bioimaging and biosensing. Till now, he has published more than 20 SCI papers in top journals, including Nat. Chem., J. Am. Chem.Soc, Angew. Chem. (total citation: 1854, h-index: 19). He has developed several popular fluorescent probes for live-cell imaging, e.g. monitoring mitochondrial ATP fluctuation (probe commercialized by Merck) and wash-free muclti-color super-resolution microscopy (probe commercialized by Spirochrome).

    Keywords of research interests

      Fluorescent probe; Super-resolution imaging; protein labeling and
      engineering; Point-of-care diagnosis; peptide library

    Curriculum Vitae

      Education

      2013.09 - 2017.05, PhD, Chemistry, National University ofSingapore

      2010.09 - 2013.07, M.Sc. Pharmaceutics, Fudan University

      2006.08 - 2010.06, B.Sc. Pharmaceutics, ChinaPharmaceutical University

      Professional Experiences

      2021.05 - present  Youth PrincipleInvestigator, School of Pharmacy, Fudan University, PR China.

      2017.10 - 2021.05  Postdoctoral fellow,Max-Planck institute for medical research, Germany

      2017.02 - 2017.09  Postdoctoral fellow, Agencyfor Science, Technology and Research (A*STAR), Singapore

      Grants & Projects

            OverseasYoung High-Level Talent Recruitment Programs (2021-2024)

            FudanUniversity Research Initial Funding, 3,000,000 RMB, (2021-2024)

      Awards & Honors

          2018-2020  Humboldt Research Fellowship for Postdoctoral Researchers,Germany

          2017  Chinese Government Award for Outstanding Self-Financed StudentsAbroad, China

           2017 ResearchOpportunities Week, Technical University of Munich,Germany                                                                                                  

          2016  Student Travel Stipend Award, World Molecular Imaging Congress,USA                                    

      Invited Presentations

           1.Virtual EMBOWorkshop: Chemical Biolgoy, Sep 2020, Germany (Invited talk)

           2.InternationalChemical Biology and Molecular Imaging Conference, July 2019 Edinburgh, UK(Invited talk)

          3.Max-Planck-Institute for Medical Research, May 2019, Germany (Invited talk)

          4.Representative of students for Chinese Government Award for OutstandingSelf-Financed Students Abroad, Apr. 2017, Singapore (Invited talk)

           5.écolepolytechnique fédérale de Lausanne (EPFL), Mar. 2017, Lausanne, Switzerland.(Invited talk)

           6.InternationalChemical Biology & Molecular Imaging Conference, Feb. 2017, Singapore(Invited talk)

      Selected Publications

             1.  LuWang,* Mai Tran,Elisa D’Este, Julia Roberti, Birgit Koch, Lin Xue, Kai Johnsson*, A general strategy to developcell permeable and fluorogenic probes for multi-colour nanoscopy. Nat.Chem. 2020, 12,165–172. (Highly Cited Paper)

           2.  Lu Wang*,1, Julien Hiblot1,Christoph Popp, Lin Xue, Kai Johnsson*, Environmentally SensitiveColor-Shifting Fluorophores for Bioimaging. Angew. Chem. Int. Ed. 2020, 2020,59, 21880 (VIP paper) (1Equally contributing authors)

           3.  Wei Li1, Lu Wang1, Shulu Yin,Huanhua Lai, Lin Yuan,* Xiaobing Zhang, Engineering a Highly Selective Probefor Ratiometric Imaging H2Sn and Revealing its Signaling Pathway in Fatty LiverDisease, Chem. Sci., 2020, 11, 7991-7999.  (1Equallycontributing authors)

           4.   Lu Wang, Michelle S. Frei, Aleksandar Salim, KaiJohnsson, Small-Molecule Fluorescent Probes for Live-Cell Super-ResolutionMicroscopy. J. Am. Chem. Soc. 2019,141, 7, 2770. (Highly Cited Paper)

            5.   Lu Wang,1 Dongdong Su,1 Stuart Berry,Jung Yeol Lee, Young-Tae Chang, A New Approach for Turn-on FluorescenceSensing of L-DOPA. Chem. Comm. 2017, 53, 12465-12468. (IF=6.164, Citation: 7) (1Equallycontributing authors)

      6.  Lu Wang, JingyeZhang, Beomsue Kim, et al, Boronic Acid: A Bio-Inspired Strategy to Increasethe Sensitivity and Selectivity of Fluorescent NADH Probe. J. Am. Chem.Soc. 2016, 138, 10394.

             7.  Lu Wang, Lin Yuan, Xian Zeng, et al,Multisite-binding switchable fluorescent probe for monitoring mitochondrial ATPlevel fluctuation in live cells, Angew. Chem. Int. Ed. 2016,55, 1773–1776.

               8.  LinYuan1, Lu Wang1, Bikram Keshari Agrawalla, etal, Development of targetable two-photon fluorescent probes to imagehypochlorous acid in mitochondria and lysosome in live cell and inflamed mousemodel. J. Am. Chem.Soc., 2015, 137, 5930–5938. (1Equallycontributing authors) (Highly Cited Paper)

            9.   Lu Wang1, Zhichao Fan1, JingyeZhang, et al. Evaluatingtumor metastatic potential by imaging intratumoral acidosis via ph-activatablenear-infrared fluorescent probe. Int. J. Cancer, 2015, 136, E107-E116. (1Equallycontributing authors)

           10.  Lu Wang, Xiao Zhu, Cheng Xie, et al, Imaging intratumoralacidosis by using a pH-activatable near-infrared fluorescence probe. Chem. Comm. 2012,48, 11677-11679.

           11.  Lu Wang, Jiefu Jin, et al. A cyanine based fluorophore emitting both single photonnear-infrared fluorescence and two-photon deep red fluorescence in aqueoussolution. Org. Biomol. Chem., 2012, 10, 5366-5370.

           12.  LuWang and Cong Li. pH responsive fluorescence nanoprobe imaging oftumors by sensing the acidic microenvironment. J. Mater. Chem., 2011, 21, 15862–15871.

           13.  LuWang, Cong Li.Fluorescence nanoprobe imaging tumor by sensing the acidic microenvironment.Chapter 9. Nanomedicine and Cancer. 2011, Science Publishers: 978-1-57808-727.

      Patents

            1.  Title: cell permeable fluorogenic probe, Applicants: Kai Johnsson,* Lu Wang,* (*Equal contribution) EP Prio PatentAppilication 18210676.5, Filing data: 06.12.2018, patent PCT pending

            2.  Title: pH sensitive Near-Infrared fluorophores for sensing tumoracidic environment. Applicants: Cong Li, Jingye Zhang, Zi Wang, Ziyao Xu,Lu Wang, CN106281306B, Authorization date: 09.08.2019



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