Dr. JiBin Dong received her doctor degree from Fudan University in 2008. She joined School of Pharmacy, Fudan University in Year 1997, after obtained her bachelor and master degree from China Pharmaceutical University. Her major is metabolism of phospholipids and metabolic diseases, especially focus on sphingomyelin and atherosclerosis.
lipid metabolism, atherosclerosis, macrophage, tumor microenvironment, sphingomyelin
Education
2008 Ph.D. Biochemistry and molecular Biology, Fudan University
1997 M.S. Biochemical Pharmacy, China Pharmaceutical University
1992 B.S. Biopharmaceutical, China Pharmaceutical University
Professional Experiences
1997- Present, Department of Pharmacology & Biochemistry,School of Pharmacy, Fudan University
1992-1994 Assistant Engineer, North China Pharmaceutical Group Co., Ltd.
Teaching Activities
undergraduate courses: Biochemistry , Molecular Biology
Graduate courses: Advanced Biochemistry in Pharmaceutical studies.
Selected Publications（latest 5 yrs，<20 papers）
1. Wan, Q., Deng, Y., Huang, Y., Yu, Z., Wang, C., Wang, K., Dong, J., Chen, Y. Synthesis and Antitumor Evaluation of Novel Hybrids of Phenylsulfonylfuroxan and Estradiol Derivatives. ChemistryOpen, 2019;9(2), 176–182.
2. Chen Y, Dong J, Zhang X, Chen X, Wang L, Chen H, Ge J, Jiang XC. Evacetrapib reduces preβ-1 HDL in patients with atherosclerotic cardiovascular disease or diabetes. Atherosclerosis. 2019 Jun; 285:147-152.
3. Yang K, Nong K, Gu Q, Dong J, Wang J. Discovery of N-hydroxy-3-alkoxybenzamides as direct acid sphingomyelinase inhibitors using a ligand-based pharmacophore model. Eur J Med Chem. 2018 Mar 27; 151: 389-400.
4. Yang K, Gao B, Ming X, Huang Z, Wang M, Dong J*, Wang J*. Synthesis and evaluation of xanthone derivatives as acid sphingomyelinase inhibitors: potential treatment for UV-induced skin damage. Future Med Chem. 2017 Oct;9(16):1887-1898.
5. Chen Y#, Dong J#, Chen X, Jiang H, Bakillah A, Zhang X, Li Z, Yin J, Liang D, Zou Y, Hussain M, Cuchel M, Rader D, Chen H, Ge J, Jiang XC. Human serum preβ1-high density lipoprotein levels are independently and negatively associated with coronary artery diseases. Nutr Metab (Lond). 2016 May 17;13:36.
6. Xue Y, Dong J*, Liang J*. Chinese hamster ovary-sphingomyelin synthase2 biospecific extraction and liquid chromatography with tandem mass spectrometry analysis for the prediction of bioactive components of Rhizoma Polygoni Cuspidati. J Sep Sci. 2016 Mar;39(6):1067-72.
