Keywords of research interests

Immunopharmacology; Autoimmune disease; Inflammation; Traditional Chinese herb

Curriculum Vitae

Education

2006  Ph.D. in Pharmacology, Fudan University

1995  M.S. in Pharmacology, Shanghai medical University

1989  B.S. in Pharmacology , Shanghai medical University

Professional Experiences

1989-1992     Xiamen Zhongsun hospital, Pharmacist

1995-present    Fudan University, Associate professor

Teaching Activities

1. Courses taught: Pharmacology, Immunopharmacology, Basic medicine, Imunology, Experimental pharmacology

2. Licensed pharmacist training

2000-2001     Section for Medical Inflammation, University of Lund, Sweden, Visiting Scholar

Grants & Projects

In charge:

2013-2016: Supported by the National Natural Science Foundation of China 700,000

Mechanisms underlying the activity of Bupleurum polysaccharides as a complement inhibitor attenuates lupus in mice

2013-2015:  Supported by Science and Technology Commission of Shanghai Municipality 400,000

Bupleurum polysaccharides as a complement inhibitor attenuates lupus in mice

2009-2010: Supported by the State Key Program for New Drugs from the Ministry of Science and Technology, China 700,000

Key technology for effective material basic of traditional Chinese medicine and for material resource: Evaluation techniques for pharmacological function of agents in lupus and arthritis

2001-2003:  Supported by the National Natural Science Foundation of China 150,000

Establishment and evaluation of animal models for lupus

Participant:

1. 2014-2018  Key project of National Natural Science Foundation of China (No.81330089)，100,000

Therapeutic effect of Chinese herb with heat-clearing and detoxicating activities on virus infection on respiratory system, the material basis for efficacy and mechanism of action

2. 2010~2013 The national science foundation for outstanding youth : chemistry of Chinese materia medica（No.30925042） 100,000

The material basis for efficacy and mechanism of action

3. 2012-2015  Mega project of science research from the Ministry of Science and Technology, China.20.000

  Key technology for the preparation and quality control of polysaccharides drugs.

4. 2009~2010  State Key Program for New Drugs from the Ministry of Science and Technology, China (2009ZX09301-011) 100,000

Platform construction for research and development of original new drugs : discovering and optimizing of nature leading compounds.

5. 2009~2011 Research Fund for the Doctoral Program of Higher Education（No. 200802460055）20,000

Agents from Arnebiae with anti-complement activities removing pathogenic heat from blood.

6. 2008~2011  Science and Technology Commission of Shanghai Municipality（No.08DZ1971202）20,000

Medical value of drugs with anti-complement activities extrated from Houttuynia cordata and Lithospermum  purpurocaeruleum.

7. 2006~2008  National Natural Science Foundation of China (No. 30572315) 20,000

Anti-complement agents from Bupleurum and Eucommia and their pharmacological functions on acute respiratory distress syndrome.

8. 2005~2007 Science and Technology Commission of Shanghai Municipality（No.034319233） 10,000

Establishment new screening system for complement inhibitors  

In charge: Preclinical study for new drugs (pharmaceutical factory)

1. Anti-inflammatory and analgesic effects of esflurbiprofen gel (25,000)

2. Anti-inflammatory and analgesic effects of thalidomide (200,000)

3. Anti-inflammatory and analgesic effects of transdermal penetration of bulleyaconitine A (240,000)

4. Effect of oligonucleotides （TLREXIN）on lupus syndromes Induced by Campylobacter Jejuni in Mice (200,000)

In charge of international cooperation: Wakan Shoyaku Botany Institute, Tokyo, Japan

Immunomodulatory effects of Ganoderma lucidum (240,000)

Awards & Honors

2006  Excellent doctoral thesis Award, Fudan University

Memberships

Member, Chinese Pharmacological Society

Member, Chinese Pharmaceutical Association

Selected Publications（latest 5 yrs，<20 papers）

*Corresponding author

1. Ying-ye Ou, Yun Jiang, Hong Li*,Yun-yi Zhang, Yan Lu, and Dao-feng Chen. Polysaccharides from Arnebia euchroma ameliorated Endotoxic Fever and Acute Lung Injury in Rats Through Inhibiting Complement System. Inflammation,40(1), February 2017; IF=2.995

2. Wu ML, Li Hong*, Zhang YY, Chen DF. Development of a C3c-based ELISA method for the determination of anti-complementary potency of Bupleurum polysaccharides. Acta Pharmaceutica Sinica B 2015;5(4):316–322 IF=0.2

3. Pan L, Weng H, Li H*, Liu Z, Xu Y, Zhou C, Lu X, Su X, Zhang YY, Chen D. (2015) Therapeutic Effects of Bupleurum Polysaccharides in Streptozotocin Induced Diabetic Mice. PLoS ONE 10(7): e0133212. doi:10.1371/journal.pone.0133212； IF=3.234

4. Jiang Y-W, Li H*, Zhang Y-Y, Li W, Jiang Y-F, Ou Y-Y, Chen DF*. Beneficial Effect of Bupleurum Polysaccharides on Autoimmune-Prone MRL-lpr Mice. Clinical & developmental immunology 2012,2012:842928. doi:10.1155/2012/842928 SCI, IF=3.064  

5. Li Wen, Xie JY, Li H*, Zhang YY, Cao J, Cheng ZH, Chen DF. Viola yedoensis liposoluble fraction ameliorates lipopolysaccharide-induced acute lung injury in mice. The American Journal of Chinese Medicine. 2012. Vol. 40, No. 5, 1007–1018 SCI, IF=2.281

4.  Xie JY, Di HY, Li H* Cheng XQ, Zhang YY, Chen DF*. Bupleurum chinense DC polysaccharides attenuates lipopolysaccharide-induced acute lung injury in mice. Phytomedicine 2012,19,130-137. SCI, IF=2.972

5.  Cheng XQ, Song LJ, Li H*, Di HY, Xie JY, Zhang YY, Chen DF*.Beneficial effect of the polysaccharides from Bupleurum smithii var. parvifolium on “Two-Hit” acute lung injury in rats. Inflammation  2012, 35（5）；1715-1722（DOI: 10.1007/s10753-012-9489-7）IF=2.457

6. Jiang L, Wang Z, Zhu HW, Di HY, Li H*, Zhang YY, Chen DF. Beneficial effect of Eucommia polysaccharides on Systemic  lupus erythematosus - like syndrome induced by Campylobacter jejuni in BALB/cmice. Inflammation 2011, 402-411，DOI:10.1007/s 10753-010 -9247-7. SCI, IF=1.747

7. Cheng XQ, Li H*, Yue XL, Xie JY, Zhang YY, Di HY, Chen DF.  Macrophage immunomodulatory activity of the polysaccharides from the roots of Bupleurum smithii var. parvifolium. Journal of Ethnopharmacology 2010,130: 363-368. SCI,IF=2.466  

8. Huang H, Li H#, Zhou P, Ju DW. Protective effects of recombinant human granulocyte macrophage colony stimulating factor on H1N1 influenza virus-induced pneumonia in mice. Cytokine 2010, 51: 151-157.共同第一 SCI, IF=3.537

9. Wang Z, Li H*, Xu H, Yue XL, Cheng XQ, Hou WJ, Zhang YY , Chen DF*. Beneficial effect of Bupleurum polysaccahrides on autoimmune disease induced by Campylobacter jejuni in BALB/c mice, Ethnopharmacology，2009；124:481-487. SCI, IF=2.322  

10. Li H; Zhang YY, HuangXY, SunYN, JiaYF, Li D. Beneficial effect of tripterine on systemic lupus erythematosus induced by active chromatin in BALB/c mice. 2005；Eur  J Pharmacol,512（11）：231-237   SCI, IF=2.477.

11. Li H; Zhang YY; Tan HW; Jia YF; Li D. Therapeutic effect of tripterine on adjuvant arthritis in rats. Journal of Ethnopharmacology,2008, 118，479-484. SCI,IF=2.26  

12. Li H, Zhang YY, Sun YN, Huang XY, Jia YF, Li D. Induction of systemic lupus erythematosus (SLE) syndrome  in BALB/c mice by immunization with active chromatin. Acta Pharmacologica Sinica. 2004；25（6）：807－811. SCI,IF=1.125

13. Li H, Jia YF et al. Li Hong, Jia Yongfeng,et al. Effect of Ganoderma lucidum on collagen induced arthritis in rats. 2000，9（1）：46-49

14. Li H, Jia YF et al. Delivery of folic acid conjugated liposomes into cultured Hela cells.   Chinese Pharmaceutical Sciences.  2000，9（2）：96-99  

15. Jia YF, LI H et al The therapeutic effect of Multiglycosides of Triterygium wilfordii Hook f. On autoimmune syndrome induced by Campylobacter Jejuni in mice . Chinese Pharmaceutical Sciences ,2000;9(3)155-157

16. LI Hong, JIA Yong-Feng, PAN Yan et al。 Effect of tripterine on collagen-induced arthritis in rats. Acta Pharmacologica Sinica 1997；18（3）：270-273