Dr. Guo’s Research Interests include: 1. Gasotransmitters in cardiovascular system. a, The interaction hydrogen sulfide (H2S) on the vascular contraction and ion channel modulations; b, Regulation of the endogenous generation of gasotransmitters from blood vessels with physiological or pharmacological interventions; c, The specific molecular targets of gasotransmitter on their target proteins; d, The altered gasotransmitter metabolism and cardiovascular functions in diabetes or hypertension. 2. Molecular basis and structure-function relationship of voltage-gated channels in vascular smooth muscle cells (SMCs). 3. Health applications of novel nutraceutical and herb products. Prairie natural resources and Chinese herbs for their specific nutritional and therapeutic values for cardiovascular health, anti-oxidant protection, anti-ischemia injury therapy, and impotence improvement. Extraction and purification of active components from herbs, insects, and other natural resources will be performed.
Cardiovascular functions; Patch-clamp; Gasotransmitters; Hypertension; Diabetes.
Research
1. 2013.1-2015.12 The Research Fund for the Doctoral Program of Higher Education (No. 20120071120048). Title: The Role and Mechanism of Endogenous Hydrogen Sulfide in Microvascular Complications of Diabetic Rat Heart. 40,000 yuan Principal
2. 2011.1-2012.12 Foundation for University Key Teacher by Ministry of Education (No. 10FX072). Title: Effect of ZYZ802 on Oxidative Stress Pathway in Diabetic Vascular Complications. 50,000 yuan Principal
3. 2007.1-2009.12 Foundation of Shanghai Science and Technology Commission(KLF301008). Title: Mechanism of Hydrogen Sulfide related Signal Transduction in Myocardial Cells in Acute Myocardial Infarction. 20,000 yuan Principal
4. 2009.1-2014.8 National Key Basic Research Program(20090619061812500). Tiltle: Interaction of endogenous H2S with protein target molecules that mediate cardiac physiology and pathology and its mechanism. 29 million yuan Participant and Project secretary
Major Academic Part-time
2015.5-2020.5 The Fifth Clinical Pharmacology Committee of Shanghai Pharmacological Society Member, secretary
Publications
1. Novel rhynchophylline analogues as microvascular relaxation agents for the treatment of microvascular dysfunction caused by diabetes. Guo W*, Zhu H, Wang Z, Chen JA, Wu J, Zhu Y, Gu X. Eur J Med Chem. 2017 Oct 20;139:657-664. Epub 2017 Aug 10. (IF=4.519)
2. Atherosclerosis and the Hydrogen Sulfide Signaling Pathway - Therapeutic Approaches to Disease Prevention. Wang ZJ, Wu J, Guo W*, Zhu YZ. Cell Physiol Biochem. 2017;42(3):859-875. doi: 10.1159/000478628. Epub 2017 Jun 23. Review. (*Co-Corresponding author) (IF=5.104)
3. Shen Y, Shen Z, Miao L, Xin X, Lin S, Zhu Y, Guo W*, Zhu YZ*. miRNA-30 family inhibition protects against cardiac ischemic injury by regulating cystathionine-?-lyase expression. Antioxid Redox Signal. 2015 Jan 20;22(3):224-40. (*Co-Corresponding author) (IF=7.093)
4. Shen Y, Shen Z, Luo S, Guo W*, Zhu YZ*. The Cardioprotective Effects of Hydrogen Sulfide in Heart Diseases: From Molecular Mechanisms to Therapeutic Potential. Oxid Med Cell Longev. 2015; 2015: 925167. (*Co-Corresponding author) (IF=4.492)
5. Kan J$, Guo W$, Huang C, Bao G, Zhu Y, Zhu YZ. S-propargyl-cysteine, a novel water-soluble modulator of endogenous hydrogen sulfide, promotes angiogenesis through activation of signal transducer and activator of transcription 3. Antioxid Redox Signal. 2014 May 20;20(15):2303-16. ($Co-first author). (IF=7.407)
6. Liang YH, Shen YQ, Guo W*, Zhu YZ*. SPRC protects hypoxia and re-oxygenation injury by improving rat cardiac contractile function and intracellular calcium handling. Nitric Oxide. 2014 Sep 15; 41: 113-9. (*Co-Corresponding author) (IF=3.521)
7. Yang ZY, Kan JT, Cheng ZY, Wang XL, Zhu YZ, Guo W*. Daphnoretin-induced apoptosis in HeLa cells: a possible mitochondria-dependent pathway. Cytotechnology. 2014 Jan;66(1):51-61. (*Corresponding author) (IF=1.752)
8. Guo W, Cheng ZY, Zhu YZ. Hydrogen sulfide and translational medicine. Acta Pharmacol Sin. 2013 Oct;34(10):1284-91. (IF=2.496)
9. Shen Y$, Guo W$, Wang Z, Zhang Y, Zhong L, Zhu Y. Protective effects of hydrogen sulfide in hypoxic human umbilical vein endothelial cells: a possible mitochondria-dependent pathway. Int J Mol Sci. 2013 Jun 25;14(7):13093-108. ($Co-first author). (IF=2.339)
10. Guo W, Kan JT, Cheng ZY, Chen JF, Shen YQ, Xu J, Wu D, Zhu YZ. Hydrogen sulfide as an endogenous modulator in mitochondria and mitochondria dysfunction. Oxid Med Cell Longev. 2012; 2012: 878052. (IF=3.393)
11. Yanfei Zhang$, Wei Guo$, Yadan Wen, Qinghui Xiong, Hongrui Liu, Jian Wu, Yunzeng Zou, Yizhun Zhu. SCM-198 attenuates early atherosclerotic lesion in hypercholesterolemic rabbits via modulation of inflammation and oxidative stress pathways. Atherosclerosis. 2012, 224:43-50. ($Co-first author). (IF=3.706)
12. Jian Wu, Wei Guo, Shi-Zhou Lin, Zhi-Jun Wang, Jun-Tao Kan, Si-Yao Chen, and Yi-Zhun Zhu*. Gp130-mediated STAT3 activation by S-Propargyl-Cysteine, an endogenous hydrogen sulfide initiator, prevents doxorubicin-induced cardiotoxicity. Cell Death and Disease. 2016 Aug 18;7(8):e2339.
13. Liu C, Guo W, Maerz S, Gu X, Zhu Y. 3,5-Dimethoxy-4-(3-(2-carbonyl-ethyldisulfanyl)-propionyl)-benzoic acid 4-guanidino-butyl ester: a novel twin drug that prevents primary cardiac myocytes from hypoxia-induced apoptosis. Eur J Pharmacol. 2013 Jan 30;700(1-3):118-26.
14. Liu C, Guo W, Shi X, Kaium MA, Gu X, Zhu YZ. Leonurine-cysteine analog conjugates as a new class of multifunctional anti-myocardial ischemia agent. Eur J Med Chem. 2011 Sep;46(9):3996-4009.
15. Shizhou Lin, Jian Wu, Wei Guo, Yizhun Zhu. Effects of leonurine on intracerebral haemorrhage by attenuation of peri- hematomal edema and neuroinflammation via the JNK pathway. Pharmazie. 2016, 71:644-650.
16. MAERZ Stefanie, LIU Chun-Hua, GUO Wei, ZHU Yi-Zhun. Anti-ischemic effects of bilobalide on neonatal rat cardiomyocytes and the involvement of the platelet-activating factor receptor. Bioscience Reports. 2011 Oct;31(5):439-47.
17. Xianli Wang, Qian Wang, Wei Guo, Yi-Zhun Zhu. Hydrogen sulfide attenuates cardiac dysfunction in a rat model of heart failure: a mechanism through cardiac mitochondrial protection." Bioscience Reports. 2010,31(2): 87-98.
18. Wei Guo, Yizhun Zhu. Voltage-gated calcium channels play an essential role in H2S preconditioning-induced cardioprotection in rats. Acta Physiologica Sinica. 2008, Oct. Suppl. 1:99.
Invention Patent Award
ZL 201110008036.0 A Use of Leonurine-cysteine conjugate in the manufacture of a medicament for the treatment of ischemic cardiomyopathy. Approval in 2014. Ranking 4th
Important Academic Seminars of Attendance, or Academic Reports Delivered upon Invitation
1. Oral presentation in the 22nd Cardiovascular Summit TCTAP 2017 in Seoul, Korea.
2. Oral presentation in the Second International Conference on Hydrogen Sulfide in the U.K. in 2013.
3. Outstanding Poster Awards, Title: Antioxidant and heart-protective effect of endogenous hydrogen sulfide on rats with streptozotocin-induced diabetes, the Second International Conference on Hydrogen Sulfide Biology and Medicine. Atlanta, United States. September 2012.
4. Outstanding Poster Awards, Mechanism of Hydrogen Sulfide in hypoxic human Umbilical vein endothelial cells, the Seventh Conference of United States Institute of Medicine (AAPS) Asia, Singapore. June 2012.
