Dr. Yang WANG received her Ph.D from School of Pharmacy, Fudan University in 2005 and worked as a full professor in 2010, majoring in medicinal chemistry. She has been in charge of the Experimental Teaching Center of Pharmaceutical Sciences since 2006. She is one of the members of Medicinal Chemistry Committee, Shanghai Pharmaceutical Society. She published more than 40 research papers and obtained 5 patent licenses. She participated in publishing 3 academic books and published 1 teaching material as editor-in-chief. She was awarded Baogang Prize of Excellent Teachers in 2015 and the 2nd Shanghai Teaching Achievement Prize (the 2nd completer) in 2013.
synthesis; structure-activity relationship; drug design; anti-tumor; natural product.
Education
1. 1985.09-1989.06 Department of Chemistry, Zhengzhou University, Bachelor in Chemistry.
2. 1989.09-1992.06 Department of Chemistry, Zhengzhou University, Master in Organic Chemistry.
3. 2001.09-2005.06 School of Pharmacy, Fudan University, Ph.D in Medicinal Chemistry.
Professional Experiences
1. 1992.07-1999.03 Department of Chemistry, Zhengzhou University, Teaching Assistant & Lecturer (since 1995).
2. 1993.09-1994.09 Ryukoku University, Japan, Visiting Scholar.
3. 1999.04-present Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Associate Professor (since 2000) & Professor (since 2010).
4. 2006.01-present Experimental Teaching Center of Pharmaceutical Sciences, School of Pharmacy, Fudan University, Director.
Teaching Activities
Organic Chemistry & Medicinal Chemistry
Grants & Projects
The design, synthesis and bioactivities of new type of coumarin derivatives with anti-HIV activity (NSFC)
The design, asymmetric synthesis and anti-myocardial ischemic activity of novel Danshensu derivatives (NSFC)
The synthesis and structural modifications of natural isoprenylated flavonoids and their bioactivities against metabolic diseases (NSFC)
The design, synthesis and anti-tumor activities of novel diaryl β-lactam derivatives as potential tubulin polymerization inhibitors (NSFC)
Awards & Honors
2015 Baosteel Excellent Teacher Award
2013 Shanghai Teaching Achievement Award, Second Prize, 2nd accomplisher
Memberships
2011.10-present Member of Committee of Medicinal Chemistry in Shanghai Pharmaceutical Association
Selected Publications
1. Zhou, P.; Liang, Y.; Zhang, H.; Jiang, H.; Feng, K.; Xu, P.; Wang, J.; Wang, X.; Ding, K.*; Luo, C.*; Liu, M.*; Wang, Y.* Design, Synthesis, Biological Evaluation and Cocrystal Structures with Tubulin of Chiral β-Lactam Bridged Combretastatin A-4 Analogues as Potent Antitumor Agents, Eur. J. Med. Chem. 2018, 144, 817-842.
2. Zhang M.; Liang, Y.-R.; Li, H.; Liu, M.-M.*; Wang, Y.* Design, Synthesis, and Biological Evaluation of Hydantoin Bridged Analogues of Combretastatin A-4 as Potential Anticancer Agents, Bioorg. Med. Chem. 2017, 25, 6623-6634.
3. Sheng, X.; Jia, X.-Y.; Tang, F.; Wang, Y.*; Hou, A.-J.* The Total Synthesis of (±)-Sanggenol F, Tetrahedron 2017, 73, 3485-3491.
4. Zhou, P.; Liu, Y.; Zhou, L.; Zhu, K.; Feng, K.; Zhang, H.; Liang, Y.; Jiang, H.; Luo, C.*; Liu, M.*; Wang, Y.* Potent Anti-tumor Activities and Structure Basis of the Chiral β-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin, J. Med. Chem. 2016, 59, 10329-10334.
5. Wu, J. F.; Liu, M. M.; Huang, S. X.*; Wang, Y.* Design and Synthesis of Novel Substituted Naphthyridines as Potential c-Met Kinase Inhibitors Based on MK-2461, Bioorg. Med. Chem. Lett. 2015, 25, 3251-3255.
6. Tang, F.; Wang, Y.*; Hou, A. J.* Total Syntheses of Nigrasin I and Kuwanon C, Tetrahedron 2014, 70, 3963-3970.
7. Zhang, W. J.; Wu, J. F.; Zhou, P. F.; Wang, Y.*; Hou, A. J.* Total Syntheses of Norartocarpin and Artocarpin, Tetrahedron 2013, 69, 5850-5858.
8. Jia, Y. L.; Dong, X. Y.; Zhou, P. F.; Liu, X. H.; Pan, L. L.; Xin, H.; Zhu, Y. Z.*; Wang, Y.* The Synthesis and Biological Evaluation of Novel Danshensu-cysteine Analog Conjugates as Cardiovascular-protective Agents, Eur. J. Med. Chem. 2012, 55, 176-187.
9. Wang, J.; Zhou, P. F.; Wang, Y.* Selective sp3 C-H Bond Activation Based on Carbocation Relay: Friedel-Crafts Reaction with Alkane as the Alkylating Component, Eur. J. Org. Chem. 2011, 264-270.
10. Zhang, J. L.; Wang, J.; Qiu, Z. B.*; Wang, Y.* Highly Regio- and Diastereoselective Halohydroxylation of Olefins: A Facile Synthesis of Vicinal Halohydrins, Tetrahedron 2011, 67, 6859-6867.
