Dr. Yingxia Li obtained her B.S. and Ph.D. degree from Ocean University of China in1989 and 1999. She finished her Ph.D. dissertation at the University of Osaka (Japan) from 1995 to 1998 supported by Japan–China join doctoral promotion program.
She accepted an assistant professorship position at Ocean University of China in 1989 and was promoted to associate professor and professor in 1998 and 2001.She joined the faculty of the School of Pharmacy, Fudan University in 2009. Dr. Li’s research interests focus on the synthesis and structural optimization of active marine natural products and target-based drug design, synthesis and structural optimization.
Anticancer drug discovery; Structure-based drug discovery; Structural optimization and synthesis of natural products; Carbohydtrate-based drugs
Education
1993-1998 PhD. in Marine drug, Ocean University of China, Supervisor: Prof. Huashi Guan
1995-1998 Research student in Medicinal Chemistry, Osaka University, Japan, Supervisor: Prof. Iwata Chuzo
1986-1989 M.S. in chemistry, Ocean University of China, Supervisor: Prof. Jingxian Yang
1997-2001 B.Sc, in chemistry, Ocean University of China
Professional Experiences
2009-present Professor, Department of Medicinal Chemistry, School of Pharmacy, Fudan University
2001-2009 Professor, Department of Medicinal Chemistry, Ocean University of China
1999-2001 Associate professor, Department of Medicinal Chemistry, Ocean University of China
1994-1999 Assistant professor, Institute of Marine Drug and Food, Ocean University of China
1989-1994 Lecturer, Institute of Marine Drug and Food, Ocean University of China
Teaching Activities
Medicinal chemistry, undergraduate, 12 Hrs;
Advanced medicinal chemistry, graduate, 9 Hrs;
Advanced organic chemistry, graduate, 6 Hrs;
Carbohydrate chemistry, graduate, 36 Hrs.
Grants & Projects
1. Discover new-generation tubulin inhibitors derived from marine polyketide PM060184, National Natural Science Foundation of China, 480,000 RMB, 2018-2021
2. Structural optimization and biological evaluation of novel small molecule inhibitors of STAT3, National Natural Science Foundation of China, 1100,000 RMB, 2015-2018
3. Preclinical study of a new taxinol derivative TM2, Science and technology support project in the field of biological medicine in Shanghai, 500,000 RMB, 2014-2017
4. Structural modification and chemical total syntheses of marine drug candidates , National Major Science and Technology Project, 10,600,000 RMB
Awards & Honors
1. 2011 Outstanding academic leaders in Shanghai, Shanghai Municipal Science and Technology Commission
Memberships
2. Committee member, Department of Medicinal Chemistry, Chinese Pharmaceutical Association
3. Vice chairman, Department of Marine Drugs, Shanghai Pharmaceutical Association
4. Editorial board member, Chinese Journal Medicinal chemistry
5. Editorial board member, Frontiers
Selected Publications
1. Dingding Gao, Yingxia Li，Identification and preliminary structure–activity relationships of 1-Indanone derivatives as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors， Bioorganic & Medicinal Chemistry, 2017, 25(14), 3780-3791
2. Jing Cui，Xia Peng，Dingding Gao，Yang Dai，Jing Ai，YingxiaLi ，Optimization of 1H -indazol-3-amine derivatives as potent fibroblast growth factor receptor inhibitors，Bioorganic & Medicinal Chemistry letter，2017, 27, 3782–3786.
3. Ruwen Yin, Guoyun Liu, Ping Wu， Wei Zhang， Yingxia Li，Synthesis, conformational analysis and biological evaluation of the lactam analogue of the cyclodepsipeptide apratoxin A Tetrahedron, 2016, 72(27-28), 3823-3831.
4. Hong Cui, Lian Liu, Yingxi Li, Design, synthesis and biological evaluation of c-Met kinase inhibitors bearing 2-oxo-1,2-dihydroquinoline scaffold Bioorganic & Medicinal Chemistry Letters, 2016 , 26(18), 4483-4486.
5. Dingding Gao, Mingming Zhang, Yingxia Li, Design, synthesis and biological evaluation of benzyloxyphenyl-methylaminophenol derivatives as STAT3 signaling pathway inhibitors Bioorganic & Medicinal Chemistry 2016 , 72(27-28), 3823-3831.
6. Qiang Xiao, Rong Qu, Dingding Gao, Qi Yan, Linjiang Tong, Wei Zhang, Jian Ding, Hua Xie, Yingxia Li , Discovery of 5-(methylthio)pyrimidine derivatives as L858R/T790M mutant selective epidermal growth factor receptor (EGFR) inhibitors, Bioorganic & Medicinal Chemistry, 2016, 24(12), 2673-2680
7. Jian Liu, Wuyan Chen, Yechun Xu, Sumei Ren, Wei Zhang, Yingxia Li. Design, synthesis and biological evaluation of tasiamide B derivatives as BACE1 inhibitors. Bioorganic & Medicinal Chemistry, 2015, 23, 1963-1974
8. Jian Liu, Xia Peng, Yang Dai, Wei Zhang, Sumei Ren, Jing Ai, Meiyu Geng, Yingxia Li. Design, synthesis and biological evaluation of novel FGFR inhibitors bearing an indazole scaffold. Organic & Biomolecular Chemistry, 2015, 13, 7643-7654
9. Haiyan Cai, Qiufeng Liu, Dingding Gao, Ting Wang, Tiantian Chen, Guirui Yan, Kaixian Chen, Yechun Xu, Heyao Wang, Yingxia Li, Weiliang Zhu, Novel fatty acid binding protein 4 (FABP4) inhibitors: Virtual screening, synthesis and crystal structure determination, European Journal of Medicinal Chemistry, 2015, 90, 241-250.
10. Zhang Wei, Ai Jing, Shi Dakuo, Peng Xia, Ji Yinchun, Liu Jian, Geng Meiyu, Li Yingxia. Discovery of novel type II c-Met inhibitors based on BMS-777607. European Journal of Medicinal Chemistry, 2014, 80, 254-266.
11. Mingming Zhang, Weiliang Zhu, Ning Ding, Wei Zhang, Yingxia Li. Identification and characterization of small molecule inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening. Bioorganic & Medicinal Chemistry Letters, 2013, 23, 2225-2229.
12. Junlong Xiong, Ning Ding, Yingxia Li. Synthesis of the pentasaccharide moiety of Thornasterside A. European Journal of Organic Chemistry, 2013, 6158–6166
13. Yongfeng Tao, Ning Ding, Sumei Ren, Yingxia Li. Heck-type cross-coupling between halo-exo-glycals and endo-glycals: a practical way to achieve C-glycosidic disaccharides. Tetrahedron Letters, 2013, 54, 6101-6104.
14. Mingming Zhang, Weiliang Zhu, Yingxia Li. Discovery of novel inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening. European Journal of Medicinal Chemistry, 2013, 62, 301-310.
15. Qingchao Liu, Hongchun Liu, Lei Zhang, Tiantian Guo, Peng Wang, Meiyu Geng, Yingxia Li. Synthesis and antitumor activities of naturally occurring oleanolic acid triterpenoid saponins and their derivatives. European Journal of Medicinal Chemistry, 2013, 64, 1-15
