Chen Ying graduated from Shanghai medical university in Medicinal Chemistry in July 1994. Then, she joined the department of organic chemistry as a teaching assistant at School Pharmacy in the same University. In 2000, Dr. Chen obtained her Ph.D. in Medicinal Chemistry from Fudan University. Thereafter, she joined the department of medicinal chemistry and served as an associate professor in 2002 and a professor in 2015, respectively, at School Pharmacy of Fudan University. Meanwhile, as a visiting scholar, she worked at School Pharmacy in University of North Carolina form 2008 to 2009. Her research work mainly focuses on the study of structure modification and optimization of nature product with anti-cancer, and the utility of steroidol as a new resource.
The study of structure modification and optimization of nature product with anti-cancer or anti-HIV
The utility of natural steroidol as a new resource
Education
Sept.1995 - Dec. 2000, Ph.D. (Medicinal Chemistry) School of Pharmacy, Fudan University
Sept.1990-Jul.1994, B.S. (Medicinal Chemistry) School of Pharmacy, Shanghai Medical University
Professional Experiences
Jul.1994-Dec.2000, Assistant Professor, Lecturer, Department of Organic Chemistry, School of Pharmacy, Shanghai Medical University
Jan.2001-Present, Associate professor, Professor, Department of Medicinal Chemistry, School of Pharmacy, Fudan University
Sept.2008-Aug.2009, Visiting Scholar, Department of Natural Product, School of Pharmacy, University of North Carolina, Chapel Hill
Teaching Activities
Four courses of Organic Synthesis, Medicinal Chemistry, Clinical medicinal chemistry and Introduction to Medicinal Chemistry for undergraduate students;
And one course of Advanced Medicinal Chemistry for graduate students
Grants & Projects
1. The study on development of a candidate new drug from hybrides of coumarin and furoxan with against MDR-cancer by target lysosomes using P-gp, Funding from "Major New Drugs Innovation and Development" of National Science and Technology Major Projects (2018ZX09711002-007-005, 2018-2020)
2. The study on structural optimization of novel hybrides of benzopyrone with furoxan and bioactivity evaluation of anti-cancer via muti-target synergism, Awarded from Natural Science Foundation of Shanghai (14ZR1401900, 2014-2017)
3. The study on design, synthesis and anti-HIV evaluation of Seco-thia-DCK & DCPs, Awarded from Natural Science Foundation of China (30873164, 2009 -2011)
4. The research on synthesis and bioactivity of new anti-HBV agents, Awarded from Natural Science Foundation of China for Youth (30200348, 2003- 2005)
Awards & Honors
2013-2014, "March 8" Hongqi Shou Honor of Fudan University
2012, Advanced Person in Teaching, Awarded from School Pharmacy of Fudan University
2004, Youth Teacher Award of Fudan University
2000, First Grade Award from National Ministry of Education
Selected Publications
1. Yaoqing Huang, Mingming Liu, Lanfang Meng, Pan Feng, Yalan Guo, Minghua Ying, Xiuyan Zhu, Ying Chen* Synthesis and antitumor evaluation of novel hybrids of phenylsulfonylfuroxan and epiandrosterone/dehydroepiandrosterone Derivatives Steroids 2015, 101,7-14 ( SCI, IF=2.693)
2. Ming-Ming Liu, Xiao-Yu Chen, Yao-Qing Huang, Pan Feng, Ya-Lan Guo, Gong Yang*, Ying Chen*; Hybrids of Phenylsulfonylfuroxan and Coumarin as Potent Antitumor Agents Journal of Medicinal Chemistry 2014,57,9343-9356 ( SCI, IF=5.447)
3. Chunli Wang, Xiaoyu Chen, Yaoqing Huang, Jesse Yang , Ying Chen* The regio- and stereo-selective reduction of steroidal 4-en-3-ones using Na2S2O4/NaHCO3 and CuCl/NaBH4 Steroids 2013,78,1339-1346 (SCI,IF=2.716)
4. Ying Chen, Hong-Rui Liu, Hong-Shan Liu, Ming Cheng, Peng Xia, Keduo Qian, Pei-Chi Wu, Chin-Yu Lai, Yi Xia, Zheng-Yu Yang, Susan L. Morris- Natschke, and Kuo-Hsiung Lee* Antitumor Agents 292. Design, Synthesis and Pharmacological Study of S- and O-Substituted 7-Mercapo or Hydroxy- Coumarins and Chromones as Potent Cytotoxic Agents European Journal of Medicinal Chemistry; 2012,49,74-85(SCI,IF=3.499)
5. Ge Jun，Qiu Ya，Wang Chunliu，Jesse Yang， Chenying*；Clarification on the Structure of Cyclization Product of S-2-Acetylphenyl Dimethylthiocarbamate Chin. J. Org. Chem. 2012, 32, 2148-2153 (SCI,IF=0.741)
6. Hong-Shan Liu, Shi-Qing Xu, Ming Cheng, Ying Chen,* Peng Xia,* Ke-Duo Qian, Yi Xia, Zheng-Yu Yang, Chin-Ho Chen, Susan L. Morris-Natschke, and Kuo-Hsiung Lee* Anti-AIDS agents 87. New bio-isosteric dicamphanoyl-dihydropyranochromone (DCP) and dicamphanoyl-khellactone (DCK) analogues with potent anti-HIV activity Bioorganic Medicinal Chemistry Letters 2011,21,5831-5834 (SCI,IF=2.554)
7. Ying Chen, Ming Cheng, Fa-Qiang Liu, Peng Xia*, Ke-Duo Qian, Dong-Lei Yu, Yi Xia, Zheng-Yu Yang, Chin-Ho Chen, Susan L. Morris-Natschke, Kuo-Hsiung Lee *; Anti-AIDS agents 86. Synthesis and anti-HIV evaluation of 2’,3’-seco-3’-nor DCP and DCK analogues European Journal of Medicinal Chemistry; 2011, 46,4924-4936(SCI,IF=3.499)
Patents
1. Ying Chen, Xiaoyu Chen, MIngming Liu and Gong Yang, Hybrides of coumarin core with furoxan and their anti-cancer potency, ZL201410242359.X
2. Ying Chen, Peng Xia and Chunli Wang, A method on the regio-and stereo-selective reduction of steroidal 4-en-3-ones to form 3?-hydroxy-5?-H cis-A/B moiety through one-pot reaction, ZL201310089135.5
3. Ying Chen, Peng Xia and Hongrui Liu, 7-oxa, thia or aza coumarin derivatives and their application, ZL201210165359.5
4. Peng Xia and Ying Chen, A method on synthesis of 6?-bromo- androst- 4-en-3,17-diones, ZL200810108396.6
