Anti-cancer Drug; Fluorescent Dye; Photodynamic Therapy; Organic Synthesis
Education
Oct 1998-Oct 2002:Post -Doctor (Supervisor: Professor E. M. Carreira), ETH-Zürich (Swiss Federal Institute of Technology, Zürich), Lab für Organische Chemie, Switzerland.
Jul 1998-Oct 1998:Post-Doctor (Supervisor: Professor E. M. Carreira), California Institute of Technology, Department of Chemistry, USA.
Jul 1997- Jul 1998:Visiting Scholar (Supervisor: Professor P. M. Rentzepis), University of California, Irvine, Department of Chemistry, USA.
Sep 1994-Jul 1997:Organic Chemistry Ph.D. (Supervisor: Professor M. G. Fan), Institute of Photographic Chemistry, P. R. China.
Sep 1987-Ju. 1990:Organic Chemistry Master (Supervisor: Professor M. G. Fan), Institute of Photographic Chemistry, P. R. China.
Sep 1983-Jul 1987:B.S. Chemistry, Wuhan University, Department of Chemistry, P. R. China
Professional Experiences
Apr 2009 -present:School of Pharmacy, Fudan University. Professor
Nov 2005- Mar 2009:Roche R&D Center (China) Ltd, Associate Research Investigator; Research Investigator; Innovation Manager
Oct 2002-Nov 2005:ETHZ (Swiss Federal Institute of Technology, Zürich), Wissenschaftlicher Mitarbeiter
Jul 1990- Jul 1994:Henan University, P. R. China.Lecturer
Teaching Activities
Responsible for the courses of “Advanced Organic Chemistry” and “Reactions in Medicinal Chemistry”.
Selected Publications
1. Pyridinium substituted BODIPY as NIR fluorescent probe for simultaneous sensing of hydrogen sulphide/glutathione and cysteine/homocysteine
Jian Zhang, Xin Ji, Junliang Zhou, Zhongjian Chen*, Xiaochun Dong*, Weili Zhao*, Sens. Actuators B, 2018, 257, 1076–1082.
2. Meso-heteroaryl BODIPY dyes as dual-responsive fluorescent probesfor discrimination of Cys from Hcy and GSH
Jian Zhang, Xin Ji, Hang Ren, Junliang Zhou, Zhongjian Chen*, Xiaochun Dong*, Weili Zhao*, Sens. Actuators B, 2018, 260, 861-869.
3. Water-Soluble Fluorescent Probe with Dual Mitochondria/Lysosome Targetability for Selective Superoxide Detection in Live Cells and in Zebrafish Embryos
Xiuhong Lu, Zhongjian Chen*, Xiaochun Dong*, Weili Zhao*, ACS Sens., 2018, 3, 59?64.
4. A simple, water soluble flavone-based fluorescent probe for fast detection of Cys
Hang Ren, Junliang Zhou, Xiaochun Dong*, Weili Zhao*, J. Photochem. Photobio. A: Chem., 2018, 355, 72–77.
5. Overcoming the resistance mechanisms of Smoothened inhibitors
Xiaochun Dong, Chenglin Wang, Zhongjian Chen*, Weili Zhao*, Drug Discov. Today, 2018, 23, 704–710.
6. Size-Dependent Translocation of Nanoemulsions via Oral Delivery
Fei Xia, Wufa Fan, Sifan Jiang, Yuhua Ma, Yi Lu, Jianping Qi, Ejaj Ahmad, Xiaochun Dong, Weili Zhao*, Wei Wu*, ACS Appl. Mater. Interfaces, 2017, 9, 21660?21672.
7. Efficient one-pot construction of unsymmetrical disulfide bonds with TCCA
Feng Yang, Wen Wang, Kaidi Li, Weili Zhao*, Xiaochun Dong*, Tetrahedron Lett., 2017, 58, 218–222.
8. Design, synthesis, and biological evaluation of optimized phthalazine derivatives as hedgehog signaling pathway inhibitors
Xiuhong Lu, Yuanqiu Peng, Chenglin Wang, Jun Yang, Xiaolong Bao, Qian Dong, Weili Zhao*, Wenfu Tan *, Xiaochun Dong*, Eur. J. Med. Chem., 2017, 138, 384–395.
9. Bioimaging of Intravenous Polymeric Micelles Based on Discrimination of Integral Particles Using an Environment-Responsive Probe
Haisheng He, Jian Zhang, Yunchang Xie, Yi Lu, Jianping Qi, Ejaj Ahmad, Xiaochun Dong, Weili Zhao*, Wei Wu*, Mol. Pharmaceutics, 2016, 13, 4013?4019.
10. A mitochondria-targeted turn-on ?uorescent probe for the detection of glutathione in living cells
Jian Zhang, Xiaolong Bao, Junliang Zhou, Fangfang Peng, Hang Ren, Xiaochun Dong*, Weili Zhao*, Biosens. Bioelectron., 2016, 85, 164–170.
11. A near-infrared BODIPY-based ?uorescent probe for the detection of hydrogen sul?de in fetal bovine serum and living cells
Jian Zhang, Junliang Zhou, Xiaochun Dong*, Xing Zheng*, Weili Zhao*, RSC Adv., 2016, 6, 51304–51309.
12. Evidence does not support absorption of intact solid lipid nanoparticles via oral delivery
Xiongwei Hu, Wufa Fan, Zhou Yu, Yi Lu, Jianping Qi, Jian Zhang, Xiaochun Dong, Weili Zhao*, Wei Wu*, Nanoscale, 2016, 8, 7024–7035.
13. Synthesis and evaluation of novel benzylphthalazine derivatives as hedgehog signaling pathway inhibitors
Xiaolong Bao, Yuanqiu Pen, Xiuhong Lu, Jun Yang, Weili Zhao,* Wenfu Tan,* Xiaochun Dong*, Bioorg. Med. Chem. Lett., 2016, 26, 3048–3057.
14. Synthesis and sequential photochromism of thiophene-linked bis-pyrans
Xiuhong Lu, Qian Dong, Xiaochun Dong, Weili Zhao*, Tetrahedron, 2015, 71, 4061–4069.
15. Environment-responsive aza-BODIPY dyes quenching in water as potential probes to visualize the in vivo fate of lipid-based nanocarriers
Xiongwei Hu, Jian Zhang, Zhou Yu, Yunchang Xie, Haisheng He, Jianping Qi, Xiaochun Dong, Yi Lu, Weili Zhao,* Wei Wu*, Nanomed-Nanotechnol., 2015, 11, 1939–1948.
16. Dual emission channels for sensitive discrimination of Cys/Hcy and GSH in plasma and cells
Yuanlin Zhang, Xiangmin Shao, Yue Wang, Fuchao Pan, Ruixue Kang, Fangfang Peng, Zhentao Huang, Weijuan Zhang,* Weili Zhao*, Chem. Commun. 2015, 51, 4245–4248.
17. A multi-functional probe to discriminate Lys, Arg, His, Cys, Hcy and GSH from common amino acids
Xiuhong Lu, Wen Wang, Qian Dong, Xiaolong Bao, Xianfeng Lin, Weixing Zhang, Xiaochun Dong*, Weili Zhao*, Chem. Commun. 2015, 51, 1498–1501.
18. Highly Selective and Sensitive 1?Amino BODIPY-Based Red Fluorescent Probe for Thiophenols with High Off-to-On Contrast Ratio
Xiangmin Shao, Ruixue Kang, Yuanlin Zhang, Zhentao Huang, Fangfang Peng, Jian Zhang,Yue Wang, Fuchao Pan, Weijuan Zhang,* Weili Zhao*, Anal. Chem. 2015, 87, 399?405.
