Dr. Ning DING obtained his Ph.D. from Ocean University of China in 2007. After that, he held a postdoctoral position in Department of Chemistry, Purdue University (2007-2009). Dr. DING joined the faculty of School of Pharmacy, Fudan University in 2009 as a lecture and became an associate professor in 2013. Between 08/2014 and 02/2016 he was carrying out his research as a visiting professor at the Complex Carbohydrate Research Center, the University of Georgia. Dr. DING’s research interests mainly focus on the interface of carbohydrate chemistry and medicinal chemistry, which yielded over 60 peer-reviewed research publications.
Carbohydrate chemistry; Medicinal chemistry
EDUCATION
2004-2007 Ph. D. in Medicinal Chemistry, Ocean University of China
2001-2004 M.S. in Medicinal Chemistry, Ocean University of China
1997-2001 B.Sc, in Medicinal Chemistry, Ocean University of China
PROFESSIONAL EXPERIENCE
2013-present Associate Professor, Department of Medicinal Chemistry, Fudan University, P. R. China
2014-2016 Visiting Scholar, Complex Carbohydrate Research Center, the University of Georgia, USA
2009-2012 Assistant Professor, Department of Medicinal Chemistry, Fudan University, P. R. China
2007-2008 Postdoctoral fellow, Department of Chemistry, Purdue University (West Lafayette), USA
Teaching Activities
Medicinal Chemistry (Undergraduate Students)
Introduction to Chemical Biology (Undergraduate Students)
Medicinal Chemistry (Graduate Students)
Advanced Medicinal Chemistry (Graduate Student)
Awards & Honors
2018 De-Chuan Fellowship, School of Pharmacy, Fudan University
2017 Science and Technology Innovation Fellowship (17431902400), Shanghai Government
2013 Daiichi Sankyo Fellowship, Fudan University,
2013 Teaching Award for Young Teachers (Second Class), Fudan University
2012 Teaching Award for Young Teachers (First Class), School of Pharmacy, Fudan University
2012 Zhuo-Xue Fellowship, Fudan University
Grants & Projects
1. Efficient synthesis of Carbohydrate-based drugs：National Major Scientific and Technological Special Project for “Significant New Drugs Development” (2018ZX09711002-006-008)
2. Preclinical investigation of an EGFR inhibitors: Shanghai science and Technology Innovation Fund (No. 17431902400)
3. Synthesis and biological investigation of Ginsenosides (Supported by an accompany)
4. SAR studies of marine-derived glycoceramide (NSFC, Research start fund of the returnees of the Ministry of Education).
Selected Publications
1. Shiqiang Yan, Sumei Ren, Ning Ding, Yingxia Li*. Concise total synthesis of acylated phenolic glycosides vitexnegheteroin A and ovatoside D. Carbohydrate Research, 2018, 460, 41-46.
2. Dongming Yao#, Yichu Liu#, Qi Gao, Qiang Sui, Xiaoping Liu*, Ning Ding*. A comparison of benzyl and 2-naphthylmethyl ethers as permanent hydroxyl protecting groups in the synthesis of ?lpha-galactoglycosphingolipids KRN7000 and PBS-57. Journal of Carbohydrate Chemistry 2017, 36, 173-188.
3. Ning Ding, Xiuru Li, Zoeisha S. Chinoy, Geert-Jan Boons*. Synthesis of a glycosylphosphatidylinositol anchor derived from Leishmania donovani that can be functionalized by Cu-catalyzed azide-alkyne cycloadditions. Organic Letters 2017, 19, 3827?3830.
4. Dongming Yao#, Yichu Liu#, Shiqiang Yan, Yingxia Li, Chun Hu, Ning Ding*. Evidence of robust participation by an equatorial 4-O group in glycosylation on a 2-azido-2-deoxy-glucopyranosyl donor. Chemical Communications, 2017, 53, 2986-2989.
5. Yichu Liu, Xiaoyan Xu, Qi Gao, Shiqiang Yan, Yingxia Li, Ning Ding*. Rapid access to 6”-functionalized ?-galactosyl ceramides by using 2-naphthylmethyl ether as the permanent protecting group. Bioorganic & Medicinal Chemistry Letters, 2017, 27, 1795-1798.
6. Qi Yan, Ning Ding, Yingxia Li*. Synthesis and biological evaluation of novel dioxa-bicycle C-aryl glucosides as SGLT2 inhibitors. Carbohydrate Research 2016, 421, 1-8.
7. Xiaozhe Fu, Mingming Zhang, Qi Gao, Fengling Yang, Yingxia Li, Ning Ding*. Total synthesis of two diastereomers of megastigmane glycoside lauroside B. Journal of Carbohydrate Chemistry 2015, 34, 445-459.
8. Juan Wang, Yuanqiu Peng, Yuan Liu, Jun Yang, Ning Ding, Wenfu Tan*. Berberine, a natural compound, suppresses Hedgehog signaling pathway activity and cancer growth. BMC Cancer 2015, 15: 595.
9. Kun Shao, Yu Zhang, Ning Ding, Shixian Huang, Jiqin Wu, Jianfeng Li, Chunfu Yang, Qibin Leng, Liya Ye, Jinning Lou, Liping Zhu, Chen Jiang*. Functionalized nanoscale micelles with brain targeting ability and intercellular microenvironment biosensitivity for anti‐intracranial infection applications. Advanced healthcare materials 2015 Jan 28; 4(2): 291-300.
10. Kun Shao, Ning Ding, Shixian Huang, Sumei Ren, Yu Zhang, Yuyang Kuang, Yubo Guo, Haojun Ma, Sai An, Yingxia Li, Chen Jiang*. Smart nanodevice combined tumor-specific vector with cellular microenvironment-triggered property for highly effective antiglioma therapy. ACS Nano. 2014, 8, 1191-1203.
11. Yongfeng Tao, Ning Ding*, Sumei Ren, Yingxia Li*. Heck-type cross-coupling between halo-exo-glycals and endo-glycals: a practical way to achieve C-glycosidic disaccharides. Tetrahedron Letters 2013, 54, 6101-6104.
12. Lu Wang, Xiao Zhu, Cheng Xie, Ning Ding, Xiaofu Weng, Weiyue Lu, Xunbin Wei*, and Cong Li*. Imaging acidosis in tumor by a pH-activatable near-infrared fluorescence probe. Chemical Communications 2012, 48(95), 11677-11679.
13. Ning Ding, Qing Chen, Wei Zhang, Sumei Ren, Ying Guo*, Yingxia Li*. Structure-activity relationships of saponin derivatives: A series of entry inhibitors for highly pathogenic H5N1 influenza virus. European Journal of Medicinal Chemistry 2012, 53, 316-326.
14. Ning Ding, Wei Zhang, Hualing Xiao, Peng Wang, Yingxia Li*. Synthesis and biological evaluation of a series of novel salicylanilides as inhibitors of EGFR protein tyrosine kinases. Chinese Chemical Letters 2012, 23, 529-532.
