Wei Zhang, an associate professor of medicinal chemistry, obtained his Ph.D. degree from Ocean University of China in 2008 and joined the faculty of School of Pharmacy, Fudan University in 2009. His research interests include organic synthesis and drug/chemical probe discovery from marine peptides.
Total synthesis of marine natural products
Design, synthesis and biological evaluation of aspartic proteinase inhibitors
Development of new synthetic methods
Education
Sep. 2005-Jun. 2008, Ph.D. (Medicinal Chemistry), School of Medicine and Pharmacy, Ocean University of China
Sep. 2002-Jul. 2005, M.S. (Medicinal Chemistry), School of Medicine and Pharmacy, Ocean University of China
Sep. 1998-Jul. 2002, B.S. (Marine Chemistry), College of Chemistry and Chemical Engineering, Ocean University of China
Professional Experiences
Dec. 2015-Present, Associate Professor, School of Pharmacy, Fudan University
Nov. 2009-Nov. 2015, Assistant Professor, School of Pharmacy, Fudan University
Jan. 2012-Jan. 2013, College of Pharmacy, University of Florida, Visiting Scholar
Jul. 2008-Oct. 2009, Assistant Professor, School of Medicine and Pharmacy, Ocean University of China
Teaching Activities
Basic Organic Chemistry, Organic Synthesis, Experimental Organic Chemistry I/II
Grants & Projects
National Natural Science Foundation of China (General Program, No. 81573340), 2016-2019, 648000 CNY, PI
National Natural Science Foundation of China (Young Scholar Program, No. 81001392), 2011-2013, 210000 CNY, PI
“Zhuo Xue” Talent Plan of Fudan University, 2015-2018, 300000 CNY, PI
National Science & Technology Major Project “Key New Drug Creation and Manufacturing Program” (No. 2009ZX09102-014), 2009-2010, 2580000 CNY, Co-PI
Awards & Honors
2014, The Teaching Award of Daiichi Sankyo Pharmaceutical
2014, Third Prize of the 4th National Young Teachers' Teaching Competition in Higher Medical Schools
2015, “Zhuo Xue” Talent Plan of Fudan University
2018, The Teaching Award of DC Investment (Tibet)
Invited Presentations
Invited Speaker, the 13th Chinese Annual Symposium on Marine Drugs & 2017 International Marine Drugs Symposium (Youth Forum), Qingdao, Nov. 2017
Selected Publications
1. Wu Ping#, Xu Senhan#, Xu Hao, Hu Haiyan, Zhang Wei*. One-pot syntheses of α,α-dibromoacetophenones from aromatic alkenes with 1,3-dibromo-5,5-dimethylhydantoin. Tetrahedron Letters, 2017, 58, 618–621.
2. Xu Hao#, Bao Keting#, Tang Shuai, Ai Jing*, Hu Haiyan*, Zhang Wei*. Cyanobacterial peptides as a prototype for the design of cathepsin D inhibitors. Journal of Peptide Science, 2017, 23, 701–706.
3. Wu Ping#, Cai Weijing#, Chen Qi-Yin, Xu Senhan, Yin Ruwen, Li Yingxia, Zhang Wei*, Luesch Hendrick*. Total synthesis and biological evaluation of apratoxin E and its C30 epimer: Configurational reassignment of the natural product. Organic Letters, 2016, 18, 5400–5403.
4. Xu Senhan#, Wu Ping#, Zhang Wei*. 1,3-Dibromo-5,5-dimethylhydantoin (DBH) mediated one-pot syntheses of α-bromo/amino ketones from alkenes in water. Organic & Biomolecular Chemistry, 2016, 14, 11389-11395.
5. Yan Qi, Wang Yujie, Zhang Wei*, Li Yingxia*. Novel azetidine-containing TZT-1027 analogues as antitumor agents. Marine Drugs, 2016, 14, 85.
6. Liu Shihui#, Chen Xiaobei#, Hu Yanwei*, Yuan Laiqi, Chen Shaohua, Wu Ping, Wang Wei, Zhang Shilei*, Zhang Wei*. An efficient method for the production of terminal alkynes from 1,1-dibromo-1-alkenes and its application in the total synthesis of natural product dihydroxerulin. Advanced Synthesis & Catalysis, 2015, 357, 553?560.
7. Liu Jian, Chen Wuyan, Xu Yechun, Ren Sumei, Zhang Wei*, Li Yingxia*. Design, synthesis and biological evaluation of tasiamide B derivatives as BACE1 inhibitors. Bioorganic & Medicinal Chemistry, 2015, 23, 1963–1974.
8. Zhang Wei, Sun Tiantian, Ma Zhenhua, Li Yingxia*. Design, synthesis and biological evaluation of tasiamide analogues as tumor inhibitors. Marine Drugs, 2014, 12, 2308?2325.
9. Zhang Wei#, Ai Jing#, Shi Dakuo, Peng Xia, Ji Yinchun, Liu Jian, Geng Meiyu*, Yingxia Li*. Discovery of novel type II c-Met inhibitors based on BMS-777607. European Journal of Medicinal Chemistry, 2014, 80, 254?266.
10. Liu Yanxia#, Zhang Wei#, Li Li#, Salvador, Lilibeth A., Chen Tiantian, Chen Wuyan, Felsenstein Kevin M., Ladd Thomas B., Price Ashleigh R., Golde Todd E., He Jianhua, Xu Yechun*, Li Yingxia*, Luesch Hendrik*. Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases. Journal of Medicinal Chemistry, 2012, 55, 10749?10765.
Patents
1. Preparation of salicylanilide compounds as antitumor agents. Li Yingxia, Zhang Wei, Ding Ning, Xiao Hualing. Faming Zhuanli Shenqing (2011), CN 102249945.
2. Method for preparation of Celastrol long-chain alcohol ester. Li Yingxia, Zhang Wei, Ding Ning. Faming Zhuanli Shenqing (2012), CN 102532238.
3. Preparation of polypeptides as cathepsin D inhibitors. Zhang Wei, Wu Ping, Li Yingxia. Faming Zhuanli Shenqing (2015), CN 105001300.
4. Method for preparing (S)-4-amino-5-mercaptopentanoic acid. Zhang Wei, Li Yingxia, Wu Ping. Faming Zhuanli Shenqing (2016), CN 106187843.
5. Screening method of small molecule inhibitor with cathepsin D as target. Zhang Wei, Li Yingxia, Gao Dingding, Bao Keting. Faming Zhuanli Shenqing (2017), CN 107346379.
6. Oxoapratoxin E and its preparation method and application. Zhang Wei, Wu Ping, Xu Senhan. Faming Zhuanli Shenqing (2017), CN 107344957.
7. Method for preparing 3,7-dihydroxy-2,5,8,8-tetramethylnonanoic acid. Zhang Wei, Wu Ping, Xu Senhan. Faming Zhuanli Shenqing (2017), CN 107344909.
8. Preparation method of alpha, alpha-bis-brominated ketone, Zhang Wei, Wu Ping, Xu Senhan. Faming Zhuanli Shenqing (2018), CN 107867987.
