Novel Opioid-like Substances and Their Potential Use in Analgesia, Drug Addiction and Major Depressive Disorder
Diversity-oriented Design and Phenotypic Screening for CNS-active Agents
PDX-based Design, Screening and Discovery for Chemotherapeutic Agents and Combinations
Education
Sept. 2002 -Jul. 2007, Ph. D. Candidate (Medicinal Chemistry), Fudan University
Sept. 1998- Jul. 2002, B.A. (Pharmacy), Fudan University (Former Shanghai Medical University)
Professional Experiences
Dec. 2016-Presnet: Associate Professor, Fudan University
Jul. 2007-Nov. 2016: Lecturer, Fudan University
Oct. 2012-Oct. 2013: Visiting Scholar, Fudan University
Teaching Activities
Graduate Courses
Drug Design Progress
Medicinal Chemistry Progress
Undergraduate Courses:
Drug Design
Medicinal Chemistry II
Experimental Medicinal Chemistry
Experimental Medicinal Chemistry II
Grants & Projects
1. CAS Key Laboratory of Receptor Research (2017-2018)
2. Strategic Priority Research Program of the Chinese Academy of Sciences (subproject, 2017-2018)
Selected Publications
1. Wei Li#, Jian-Dong Long#, Yuan-Yuan Qian#, Yu Long, Xue-Jun Xu, Yu-Jun Wang, Qing Shen, Zuo-Neng Wang, Xi-Cheng Yang, Li Xiao, Hong-Peng Sun, Yu-Long Xu, Yi-Yi Chen, Qiong Xie, Yong-Hui Wang, Li-Ming Shao, Jing-Gen Liu*, Zhui-Bai Qiu, Wei Fu*. The pharmacological heterogeneity of nepenthone analogs in conferring highly selective and potent kappa-opioid agonistic activities. ACS Chem NeuroSci, 2017, 8 (4), 766–76.
2. Jian Shen#, Xi-cheng Yang#, Ming-cheng Yu, Li Xiao, Xun-jie Zhang, Hui-jiao Sun, Hao Chen, Guan-xin Pan, Yu-rong Yan, Si-chen Wang, Wei Li*, Lu Zhou*, Qiong Xie, Lin-qian Yu, Yong-hui Wang, Li-ming Shao*. Discovery, synthesis, biological evaluation and structure-based optimization of novel piperidine derivatives as acetylcholine-binding protein ligands. Acta Pharmacol Sin, 2017, 38(1): 146-55.
3. Yulong Xu, Yi-yi Chen, Wei Li, Qiong Xie, Liming Shao*. Microwave-assisted synthesis of phenanthridines by radical insertion/cyclization of biphenyl isocyanides. J Org Chem, 2016, 81: 8426-35.
4. Wei Li#, Jian Wu#, Lili Xu#, Peng Du, Xuechu Zhen*, Wei Fu*. Functional reversal of (-)-Stepholidine analogues by replacement of benzazepine substructure using the ring-expansion strategy, Chem Biol Drug Des, 2016, 88(4), 599-607.
5. Qing Shen, Yuanyuan Qian, Xiaoqin Huang, Xuejun Xu, Wei Li*, Jinggen Liu*, and Wei Fu*. Discovery of potent and selective agonists of delta opioid receptor by revisiting the “Message-Address” concept. ACS Med Chem Lett, 2016, 7 (4), 391–6.
6. Qing Shen, Yuan-yuan Qian, Xue-jun Xu, Wei Li*, Jing-gen Liu*, Wei Fu*. Design, synthesis and biological evaluation of N-phenylalkyl-substituted tramadol derivatives as novel mu opioid receptor ligands. Acta Pharmacol Sin, 2015, 36: 887-94.
7. Yulong Xu, Qiong Xie, Wei Li, Hongpeng Sun, Yonghui Wang, Liming Shao*, A convenient aqueous copper-catalyzed synthesis of quinazolinones. Tetrahedron, 2015, 72(29):4853-8.
8. Anna W. Sromek, Shaohui Zhang, Vamsidhar Akurathi, Alan B. Packard, Wei Li, David Alagille, Thomas J. Morley, Ronald Baldwin, Gilles Tamagnan, John L. Neumeyer*. Convenient synthesis of 18F-radiolabeled R-(-)-N-n-propyl-2-(3- fluoropropanoxy-11-hydroxy noraporphine. J Labelled Compd Radiopharm, 2014, 57(14):725-9.
9. Brian A. Provencher, Anna W. Sromek, Wei Li, Shayla Russell, Elena Chartoff, Brian I. Knapp, Jean M. Bidlack, John L. Neumeyer*. Synthesis and pharmacological evaluation of aminothiazolo morphinans at the mu and kappa opioid receptors. J Med Chem, 2013, 56, 8872-8.
10. Wei Li#, Li-li Xu#, Qiong Xie, Yan Chen, Mei-yan Lu, Bo Chao, Xing-hai Wang, Yun Tang, Zhui-bai Qiu, Wei Fu* & Choiwan Lau*, Theoretical and NMR investigations on the conformations of (-)-meptazinol hydrochloride in solution, Mol Simulat, 2013, 39(13),1065-9.
