Dr. Xiaochun Dong got his bachelor degree from East China Normal University in 1997 and joined Fudan University as teacher assistant and then Lecturer. He obtained his Ph.D. degree in medicinal chemistry from Fudan University in 2007. From 2008-2009, he did postdoctoral training in University of Minnesota (U.S.A.). Since 2013, he became an associate professor at School of Pharmacy, Fudan University. His research expertise concerns medicinal chemistry and chemical biology, focusing on the design and synthesis of small molecule targeting of specific oncogenic signal transduction pathways such as Hedgehog signaling pathway. He has published 16 research papers on academic journals including Org Lett, Chem Comm, Bioorg Med Chem Lett, etc. He also filed more than 20 patent applications and 13 of them were granted.
Small molecule drugs R & D; New methodologies for synthetic drugs
Education
2007 Ph.D., School of Pharmacy, Fudan University, China
2003 M.S., School of Pharmacy, Fudan University, China
1997 B.A., Department of Chemistry, East China Normal University, China
Professional Experiences
2013-present Associate Professor, School of Pharmacy, Fudan University, China
2008-2009 PostDoc, College of Pharmacy, University of Minnesota, US
Teaching Activities
For undergraduate students:
Medicinal Chemistry I,
Organic reactions for drug synthesis
For graduate students:
Advanced organic chemistry,
Progress in medicinal chemistry
Grants & Projects
1. National Nature Science Foundation of China (21572037), Studies on design, synthesis and SAR of Hedgehog pathway inhibitors with novel structure. Project Leader, 2016.1-2019.12
2. Shanghai Municipal Natural Science Foundation (12ZR1403300), Design, synthesis and antitumor evaluation of Hedgehog pathway inhibitors containing four-membered heterocycles. Project Leader, 2012.7-2015.6
Selected Publications（latest 5 yrs，<20 papers）
1. Xiuhong Lu, Zhongjian Chen*, Xiaochun Dong*, Weili Zhao*. Water-soluble fluorescent probe with dual mitochondria/lysosome targetability for selective superoxide detection in live cells and in zebrafish embryos. ACS Sensors, 2018, 3, 59-64
2. Xiaochun Dong, Chenglin Wang, Zhongjian Chen*, Weili Zhao*. Overcoming the Resistance mechanisms of Smoothened inhibitors, Drug Discovery Today, 2018, 23, 704-710
3. Xiuhong Lu, Yuanqiu Peng, Chenglin Wang, Jun Yang, Xiaolong Bao, Qian Dong, Weili Zhao*, Wenfu Tan*, Xiaochun Dong*. Design, synthesis, and biological evaluation of optimized phthalazine derivatives as hedgehog signaling pathway inhibitors. European Journal of Medicinal Chemistry, 2017, 138, 384-395.
4. Feng Yang, Wen Wang, Kaidi Li, Weili Zhao*, Xiaochun Dong*. Efficient one-pot construction of unsymmetrical disulfide bonds with TCCA. Tetrahedron Letters, 2017, 58, 218-222.
5. Xiaolong Bao, Yuanqiu Peng, Xiuhong Lu, Jun Yang, Weili Zhao*, Wenfu Tan*, Xiaochun Dong*. Synthesis and evaluation of novel benzylphthalazine derivatives as hedgehog signaling pathway inhibitors. Bioorganic & Medicinal Chemistry Letters, 2016, 26, 3048-3051.
6. Xiuhong Lu, Wen Wang, Qian Dong, Xiaolong Bao, Xianfeng Lin, Weixing Zhang, Xiaochun Dong*, Weili Zhao*. A multi-functional probe to discriminate Lys, Arg, His, Cys, Hcy and GSH from common amino acids. Chemical Communications, 2015, 51(8): 1498-1501
7. Jian Zhang, Jiamin Wang, Weili Zhao, and Xiaochun Dong*. A BODIPY-based NIR Probe for Detecting Mercury(II) in Solution and in Living Cells. Chemistry letters, 2015, 44 (7): 952-954
8. Qian Dong, Xia Peng, Wen Wang, Yang Dai, Weili Zhao, Jing Ai*, Xiaochun Dong*. Design and Synthesis of 5-aminopyrazole and 5-aminotriazole Derivatives as FGFR Inhibitors. Chinese journal of Organic Chemistry, 2015, 35, 1939-1947
9. Feng Zhao, Zhaohu Lin, Feng Wang, Weili Zhao, Xiaochun Dong*. Four- membered heterocycles-containing 4-anilino-quinazoline derivatives as epidermal growth factor receptor (EGFR) kinase inhibitors. Bioorganic & Medicinal Chemistry Letters, 2013, 23(19): 5385-5388
10. Yichao Zhao, Wen Wang, Jian Li,Feng Wang, Xiufang Zheng, Hongying Yun, Weili Zhao, Xiaochun Dong*. FeCl3/Pyridine: Dual-activation in Opening of Epoxide with Carboxylic Acid under Solvent Free Condition Tetrahedron Letters, 2013, 54 (44): 5849-5852
Patents
1. N-(2-Chloro-6-methylbenzyl)-2[(2-methylpytimidin-4-yl)amino]thiazole-5-formamide derivatives and their application. Chinese Patent: ZL201310179739.9, 20160907
2. o-Amino benzamide derivatives and their application. Chinese Patent: ZL 201410175341.2, 20171229
