Qiong Xie is now an associate professor in the Department of Medicinal Chemistry, School of Pharmacy, Fudan University. She received her B.S. and Ph.D. degrees from School of Pharmacy, Fudan University in 2002 and 2007 respectively. Since 2007, she worked in School of Pharmacy at Fudan University. From 2010 to 2011, she went to University of Arizona as a visiting scholar with Professor Victor J. Hruby. Her research interests are primarily in the chemical synthesis, design & discovery, and molecular mechanisms of small molecules in treating central nervous system (CNS) diseases and inflammatory diseases. Specific research areas include neurodegenerative diseases, neuropathic pain, inflammatory and autoimmune diseases, and cancer.
She was the recipient of the 2010 “Chen Guang” Project of Shanghai Municipal Education Commission. In 2017 she received the “Special Award” in Mini-course Teaching Contest and the “Second Prize” in Teaching Competence Competition within Young Teachers from National Colleges of Pharmacy. She was also one of the recipients of 2017 Shanghai Science and Technology Progress Award (First Prize) and 2017 National Medical Science and Technology Award (Second Prize).
Neurodegenerative diseases; Neuropathic pain; Modulators of inflammation and immunity; Cancer drug design and synthesis
Education
2002/09-2007/06 School of Pharmacy, Fudan University, Ph.D. in Medicinal Chemistry
1998/09-2002/06 School of Pharmacy, Fudan University (Former Shanghai Medical University), Bachelor’s Degree in Pharmacy
Professional Experiences
2017/12-Present School of Pharmacy, Fudan University, Associate Professor
2007/07-2017/12 School of Pharmacy, Fudan University, Lecturer
2010/11-2011/11 Department of Chemistry and Biochemistry, University of Arizona, Visiting Scholar, Hruby’s Group
Teaching Activities
Courses: Medicinal Chemistry I, Drug Design, Experimental Medicinal Chemistry, etc. for the undergraduates, and Advanced Medicinal Chemistry for graduate students
Tutoring: undergraduate student in Fudan College (2008-2010)
Book: “An Introduction of CADD” (2nd Ed.), by Wei Fu and Deyong Ye, 2017/9, Chemical Industry Press
Grants & Projects
1. Science and Technology Commission of Shanghai Municipality (14431905600), 2014/7-2017/9, Participate (in charge of sub-project)
2. “Chen Guang” Project supported by Shanghai MEC (10CG03), 2011/1-2012/12, Organize
3. NSFC (30801435), 2009/1-2011/12, Organize
4. Specialized Research Fund for the Doctoral Program of Higher Education (200802461095), 2009/1-2011/12, Organize
Awards & Honors
1. 2017 Shanghai Science and Technology Progress Award (First Prize)
2. 2017 National Medical Science and Technology Award (Second Prize)
3. 2017 National Colleges of Pharmacy Young Teachers’ Mini-course Teaching Contest (Special Award) and Teaching Competence Competition (First Prize)
4. 2017 Outstanding Undergraduate Teaching Individual in School of Pharmacy, Fudan University
5. 2015 Shanghai Medical Science and Technology Award (Second Prize)
6. 2014 Teaching Competition within Young Teachers in School of Pharmacy, Fudan University (Second Prize)
Selected Publications（latest 5 yrs，<20 papers）
1. Yafei Huang, Mingcheng Yu, Nannan Sun, Ting Tang, Fazhi Yu, Xiaoxia Song, Qiong Xie*, Wei Fu, Liming Shao, Yonghui Wang*. Discovery of carbazole carboxamides as novel RORγt inverse agonists. Eur. J. Med. Chem., 2018, 148: 465-476.
2. Dengqi Xue, Hao Chen, Yulong Xu, Haihua Yu, Linqian Yu, Wei Li, Qiong Xie*, Liming Shao*. Microwave-assisted synthesis of hydroxyl-containing isoquinolines by metal-free radical cyclization of vinyl isocyanides with alcohols. Org. Biomol. Chem., 2017, 15(47), 10044-10052.
3. Hongpeng Sun#, Li Xiao#, Wei Li, Qiong Xie*, Liming Shao*. On-water silver(I)-catalyzed cycloisomerization of acetylenic free amines/amides toward 7-azaindole/indole/isoquinolone derivatives. Synthesis, 2017, 49(21), 4845-4852.
4. Li Xiao, Yilin Zheng, Qiong Xie*, Liming Shao*. Palladium-catalyzed cascade Saegusa–Heck reaction: Synthesis of β,β-diarylacroleins from arylpropanals and aryl iodides. Eur. J. Org. Chem., 2017, 2017(40), 5880–5883.
5. Qiong Xie, Zhaoxi Zheng, Biyun Shao, Wei Fu, Zheng Xia, Wei Li, Jian Sun, Wei Zheng, Weiwei Zhang, Wei Sheng, Qihong Zhang, Hongzhuan Chen, Hao Wang*, Zhuibai Qiu*. Pharmacophore-based design and discovery of (-)-meptazinol carbamates as dual modulators of cholinesterase and amyloidogenesis. J. Enzym. Inhib. Med. Chem., 2017, 32(1): 659-671.
6. Jian Shen#, Xi-cheng Yang#, Ming-cheng Yu, Li Xiao, Xun-jie Zhang, Hui-jiao Sun, Hao Chen, Guan-xin Pan, Yu-rong Yan, Si-chen Wang, Wei Li*, Lu Zhou*, Qiong Xie, Lin-qian Yu, Yong-hui Wang, Li-ming Shao*. Discovery, synthesis, biological evaluation and structure-based optimization of novel piperidine derivatives as acetylcholine-binding protein ligands. Acta Pharmacol. Sin., 2017, 38: 146–155.
7. Yu-Long Xu#, Yi-Yi Chen#, Wei Li, Qiong Xie, Li-Ming Shao*. Microwave-assisted synthesis of phenanthridines by radical insertion/cyclization of biphenyl isocyanides. J. Org. Chem., 2016, 81(18): 8426–8435.
8. Yulong Xu, Qiong Xie, Wei Li, Hongpeng Sun, Yonghui Wang, Liming Shao*. A convenient aqueous copper-catalyzed synthesis of quinazolinones. Tetrahedron, 2015, 71(29), 4853–4858.
9. Shaobing Cheng, Wei Zheng*, Ping Gong, Qiang Zhou, Qiong Xie, Lining Yu, Peiyi Zhang, Liangkang Chen, Juan Li*, Jianxing Chen, Hailin Chen, Hongzhuan Chen. (–)-Meptazinol-melatonin hybrids as novel dual inhibitors of cholinesterases and amyloid-β aggregation with high antioxidant potency for Alzheimer’s therapy. Bioorg. Med. Chem., 2015, 23(13), 3110-3118.
Patents
1. Qiong Xie, et al. CN105622509B, 2017-12-29.
2. Zhuibai Qiu, Qiong Xie, et al. Meptazinol biligand derivatives and/or their salts, preparation method and uses thereof. EP2048134B1, 2015-9-23.
3. Zhuibai Qiu, Qiong Xie, et al. JP5118696B2, 2012-10-26.
4. Zhuibai Qiu, Qiong Xie, et al. CN101037430B, 2012-8-1.
5. Zhuibai Qiu, Qiong Xie, et al. Bivalent (-)-meptazinol compounds and/or their salts, and their preparation and futilization. US8232270B2, 2012-7-31
