Dr. Dao-Feng Chen graduated from Shanghai Medical University in 1986 and obtained his Ph.D. degree from China Pharmaceutical University in 1991. He joined Fudan University in 1991 and became a full professor in 1997, and worked as an associate dean of School of Pharmacy from 1995 to 2005. He worked as visiting professor at the University of North Carolina at Chapel Hill (USA) in 2002 and Kyushu University (Japan) in 2006. Dr. Chen was named as Trans-Century Training Talent by the Ministry of Education of China in 1996 and outstanding young scientist by the Natural Science Foundation of China in 2009. He is the chairman of Department of Pharmacognosy at Fudan University and a member of the State Pharmacopoeia Commission of China. He is also an editorial board member of Current Traditional Medicine, Chinese Journal of Natural Medicines and Acta Pharmacologica Sinica.
Pharmacognosy, TCMs, Bioactive compounds, Quality, Plant Polysaccharides
Education
Ph. D. in Pharmacognosy, School of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing, 1986-1991.
B. S. in Pharmacy, School of Pharmacy, Shanghai Medical University, 1981-1986.
Professional Experiences
1991-1993: Assistant Professor, Shanghai Medical University, Shanghai, China.
1994-1997: Associate Professor, Shanghai Medical University, Shanghai, China.
1997-present: Professor, Fudan University, Shanghai, China;
1995-2005: Associate Dean, School of Pharmacy, Fudan University, Shanghai, China.
1990: Guest Researcher, Toyama Med. and Pharm. University, Japan.
1998: Visiting Scholar, University of Alabama at Birmingham, USA.
2002: Visiting Professor, School of Pharmacy, University of North Carolina at Chapel Hill, USA.
2006: Visiting Professor, Gruadate School of Pharmaceutical Sciences, Kyushu University, Japan.
Teaching Activities
Pharmacognosy (for B. S. students);
Selections of Advanced Pharmacognosy (for M. S. students);
A Brief Introduction to Chemotaxonomy of Medicinal Plants (for M. S. students);
A Brief Introduction to the Chinese Pharmacopoeia (for M. S. students);
Modern Pharmacognosy (for Ph. D. students);
Resource Science of Traditional Chinese Medicines (for Ph. D. students).
Research Interests
1. Biologically active compounds of the natural medicines;
2. quality control of the traditional Chinese medicines.
Grants & Projects
1. National Natural Science Foundation of China (Key Program): Effective Constituents and Action Mechanisms of Traditional Chinese Medicines for the Treatment of Respiratory Virus Infections. No. 81330089, PI, ￥2,900,000, 2014.1-2018.12.
2. National Natural Science Foundation of China (Regular Program): Anti-HIV Diterpenoids from Stellera chamaejasme and its Related Species. No. 81273486, PI, ￥850,000, 2013.01-2016.12.
3. State Key Program for Innovative Drugs from the Ministry of Science and Technology of China: The Key Approaches for Investigation of the Effective Constituents of Traditional Chinese Medicines. No. 2009ZX09502-013, PI, ￥7,350,000, 2009.1-2011.12.
Awards & Honors
1. First award 1991, on advances in science and technology by the State Administration of Traditional Chinese Medicine, P. R. China
2. First award 2006, on natural sciences by the Ministry of Education, P. R. China
Memberships
1. Member of the Pharmacopoeia Commission of the People’s Republic of China (2002-)
2. Vice chairman of Specialty Committee of TCM Pharmacognosy, the World Federation of Chinese Medicine Societies（2014-）
3. Vice chairman of Specialty Committee of TCM Chemistry, the World Federation of Chinese Medicine Societies（2011-）
Invited Presentations
1. Protective Effect of Flavonoids Enriched from Scutellariae Radix on Acute Lung Injury Induced by Influenza A Virus in Mice and Their in vivo Metabolic Activation. The Second Shandong (Linyi) International Symposium on the Innovation and Development of Traditional Medicine (November 16-17, 2017, Linyi, China)
2. Discovery and Characterization of Anticomplement Agents from Traditional Chinese Medicines. The 3rd Hunan International Forum for Innovation and Development of Biomedicine and Chinese Medicine（November 2-3, 2017, Changsha, China）
3. Identification and Enrichment of Anti-HIV Diterpenoids from Stellera chamaejasme. 3rd Sino-Italian Symposium on Bioactive Natural Products & 1st International Forum for Drug Discovery Chemistry（October 13-15, 2017, Nanjing, China）
4. Discovery and Characterization of Anticomplement Agents from Traditional Chinese Medicines. The 14th Chinese-Russian Biomedcal Forum（October 10-11, 2017, Blagoveshchensk, Russia）
5. Effective Constituents and Quality Control of Traditional Chinese Medicines with Functions of Heat-clearing and Detoxification. Forum on Quality Research and Standardization on Chinese Medicines (August 24-25, 2017, Hongkong, China)
6. Immunomodulating Plant Polysaccharides and Quality Control of Traditional Chinese Medicines. The 3rd Annunal Conference of Speciality Committee of TCM Pharmacognosy of the Word Fedaration of Chinese Medicine Societies (December, 15-17, 2016, Shanghai, China)
7. Anticomplement Agents from Medicinal Plants and Their Medical Properties. The Fifth International Symposium on Edible & Medicinal Plant Resources and the Bioactive Ingredients (November 4-7, 2016, Shenzhen, China)
8. Anticomplement Agents from TCMs and Their Beneficial Effects on Acute Lung Injury. The 9th Shanghai International Conference on Traditional Chinese Medicine and Natural Medicine（October 19-21, 2016, Shanghai, China）
9. Plant Polysaccharides from Traditional Chinese Medicines as Anticomplement Agents. 2nd Eskitis/SIMM International Symposium: Development of Modern TCM through Multidisciplinary Integration (November 16-18, 2015, Brisbane, Australia)
10. Authentication and Analysis of Schisnadra chinensis and Schisandra sphenanthera in Chinese Patent Medicines. The 2nd Annunal Conference of Speciality Committee of TCM Pharmacognosy of the Word Fedaration of Chinese Medicine Societies (October 25-26, 2015, Wuhan, China)
11. Isolation, Characterization and Medical Properties of Anticomplement Agents from Traditional Chinese Medicines. Joint Meeting of the GP-TCM Research Association, the TCM Chemistry Specialty Committee and the TCM Pharmaceutical Analysis Specialty Committee of the World Federation of Chinese Medicine Societies (July 12-15, 2015, Mons, Belgium)
12. Anti-complementary Agents from TCMs and Their Medical Properties. The 10th NHP Research Conference (May 12-15, 2013, Windsor, Ontario, Canada)
Selected Publications（latest 5 yrs，<20 papers）
1. HC Zheng, Y Lu, DF Chen. Anticomplement Compounds from Polygonum chinense. Bioorganic & Medicinal Chemistry Letters, 2018, 28: 1495-1500.
2. HY Zhu, XX Lu, LJ Ling, H Li, YY Ou, XL Shi, Y Lu, YY Zhang, DF Chen. Houttuynia cordata Polysaccharides Ameliorate Pneumonia Severity and Intestinal Injury in Mice with Influenza Virus Infection. Journal of Ethnopharmacology, 2018, 218: 90-99.
3. R Zhan, L Xia, JH Shao, C Wang, DF Chen. Polysaccharide Isolated from Chinese Jujube Fruit (Zizyphus jujube cv. junzao) Exerts Anti-inflammatory Effects through MAPK Signaling. Journal of Functional Foods, 2018, 40: 461-470.
4. P Jiang, Y Lu, DF Chen. Qualitative and Quantitative Analysis of Multiple Components for Quality Control of Deng-Zhan-Sheng-Mai Capsules by Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry Coupled with Chemometrics. Journal of Separation Science, 2017, 40: 612-624.
5. Q Wen, Z Cao, Y Lu, DF Chen. Anticomplement Triterpenoids from the Roots of Ilex asprella. Bioorganic & Medicinal Chemistry Letters, 2017, 27: 880-886.
6. YY Ou, Y Jiang, H Li, YY Zhang, Y Lu, DF Chen. Polysaccharides from Arnebia euchroma Ameliorated Endotoxic Fever and Acute Lung Injury in Rats through Inhibiting Complement System. Inflammation, 2017, 40(1): 275-284.
7. RY Tian, Y Lu, DF Chen. Four New Diterpenoids from the Roots of Euphorbia pekinensis. Chemistry & Biodiversity, 2016, 13(10): 1404-1409.
8. P Jiang, Y Lu, DF Chen. Authentication of Schisandra chinensis and Schisandra sphenanthera in Chinese Patent Medicines. J Pharm Biomed Anal, 2016, 131: 263-271.
9. DS Du, ZH Cheng, DF Chen. Structure Characterization of Two Novel Polysaccharides Isolated from the Spikes of Prunella vulgaris and Their Anticomplement Activities. Journal of Ethnopharmacology, 2016, 193: 345-353.
10. M Yan, Y Lu, CH Chen, Y Zhao, KH Lee, DF Chen. Stelleralides D–J and Anti-HIV Daphnane Diterpenes from Stellera chamaejasme. J Nat Prod, 2015, 78(11): 2712-2718.
11. LY Pan, HB Weng, H Li, ZZ Liu, YY Xu, CJ Zhou, XX Lu, XY Su, YY Zhang, DF Chen. Therapeutic Effects of Bupleurum Polysaccharides in Streptozotocin Induced Diabetic Mice. PLOS ONE, 2015, 10(7): e0133212.
12. YY Xu, YY Zhang, YY Ou, XX Lu, LY Pan, H Li, Y Lu, DF Chen. Houttuynia cordata Thunb. Polysaccharides Ameliorates Lipopolysaccharide-induced Acute Lung Injury in Mice. Journal of Ethnopharmacology, 2015, 173: 81-90.
13. WH Song, ZH Cheng, DF Chen. Anticomplement Monoterpenoid Glucosides from the Root Bark of Paeonia suffruticosa. J Nat Prod, 2014, 77(1): 42-48.
14. J Wu, YY Zhang, L Guo, H Li, DF Chen. Bupleurum Polysaccharides Attenuates Lipopolysaccharide-induced Inflammation via Modulating Toll-Like Receptor 4 Signaling. PLOS ONE, 2013, 8(10): e78051
15. Q Wang, HT Chen, KF Bastow, SL Morris-Natscheke, KH Lee, DF Chen. Songaricalarins A-E, Cytotoxic Oplopane Sesquiterpenes from Ligularia songarica. J Nat Prod, 2013, 76(3): 305-310
Patents
1. Daofeng Chen, Han Xu, Yunyi Zhang, Jie Zhou, Jianwen Zhang. The application of Bupleurum polysaccharides on the treatment of ARDS. Chinese Invention Patent, No. ZL200610146024.3.
2. Daofeng Chen, Hongwei Zhu, Hong Li, Zheng Wang, Yunyi Zhang. The application of Eucommia ulmoides polysaccharides on the treatment of SLE. Chinese Invention Patent, No. ZL200710043452.8.
3. Daofeng Chen, Yun Jiang, Yan Lu, Yunyi Zhang. The preparation and medicinal application of Houttuynia cordata polysaccharides. Chinese Invention Patent, No. ZL201010022880.4.
4. Daofeng Chen, Yun Jiang, Yunyi Zhang. The application of Arnebia euchroma polysaccharides on the treatment of ALI and ARDS. Chinese Invention Patent, No. ZL201110284642.5.
5. Daofeng Chen, Min Yan, Yan Lu, Kuo-Hsiung Lee. Daphnane diterpenoids and their application on preparing anti-HIV drugs. Chinese Invention Patent, No. ZL201410308774.0.
