Fuzhuo Li, PhD
Associate Professor
Email: lifuzhuo(at)fudan.edu.cn
Address: 826 Zhangheng Road, Pudong, Shanghai, China
Personal website: www.x-mol.com/groups/li_fuzhuo?lang=en
Dr. Fuzhuo Li obtained his B.A. degree from Lanzhou University in 2012. In 2017, he earned his Ph.D. from Peking University under the supervision of Professor Zhen Yang. After conducting postdoctoral research with Professor Hans Renata at Scripps Research, he embarked on his independent career at the School of Pharmacy, Fudan University. His research is centered around the development of biocatalytic methodologies and the chemoenzymatic synthesis of natural products.
Natural product synthesis, Biocatalysis, Chemoenzymatic synthesis
Education
2012 to 2017 Peking University Shenzhen Graduate School, Guangdong, China
Ph.D. in Organic Chemistry with Professor Zhen Yang
2008 to 2012 Lanzhou University, Lanzhou, Gansu, China
B.S. in Chemistry, Undergraduate research with Professor Ying Li
Professional Experiences
2022 to present Fudan University, School of Pharmacy, Shanghai, China
Associate Professor
2017 to 2022 Scripps Research, Jupiter, FL, USA
Postdoctoral Associate with Professor Hans Renata
Teaching Activities
Nutrition Constituents of Food, Food Chemistry, Experimental Medicinal Chemistry, etc.
Grants & Projects
National Natural Science Foundation of China Grants, Excellent Young Scientists Fund Program (Oversea) (2024/01-2027/12)
National Natural Science Foundation of China Grants, Youth Program (2023/01-2026/12)
Natural Science Foundation of Shanghai Municipality, Regular Program (2023/04-2026/03)
Awards & Honors
Mingzhu Talent of Pudong, 2024
Outstanding Thesis Award of Peking University, 2017
Distinguished Graduate in Beijing, 2017
National Scholarship of Ph.D. Students, 2016
Selected Publications
1. Du, W.; Cheng, Z.; Pan, X.; Liu, C.; Yue, M.; Li, T.; Xiao, Z.; Li, L.-L.; Zeng, X.; Lin, X.; Li, F.*; Dong, L.-B.* Microbe Engineering to Provide Drimane-Type Building Blocks for Chiral Pool Synthesis of Meroterpenoids. Angew. Chem. Int. Ed.2024, e202419463.
2. Li, F.; Deng, H.; Renata, H.* Chemoenzymatic Approaches for Exploring Structure–Activity Relationship Studies of Bioactive Natural Products. Nat. Synth.2023, 2, 708.
3. Li, F.#; Deng, H.#; Renata, H.* Remote B-Ring Oxidation of Sclareol with an Engineered P450 Facilitates Divergent Access to Complex Terpenoids. J. Am. Chem. Soc.2022, 144, 7616.
4. Li, F.; Renata, H.* A Chiral-Pool-Based Strategy to Access Trans-Syn-Fused Drimane Meroterpenoids: Chemoenzymatic Total Syntheses of Polysin, N-Acetyl-Polyveoline and the Chrodrimanins. J. Am. Chem. Soc.2021, 143, 18280.
5. Li, F.#; Yang, L.-C.#; Zhang, J.; Chen. J. S.; Renata, H.* Stereoselective Synthesis of β-Branched α-Amino Acids via a Biocatalytic Dynamic Kinetic Resolution. Angew. Chem. Int. Ed.2021, 60, 17680.
6. Li, J.#; Li, F.#; King-Smith, E.#; Renata, H.* Merging Chemoenzymatic and Radical-Based Retrosynthetic Logic for Rapid and Modular Synthesis of Oxidized Meroterpenoids. Nat. Chem.2020, 12, 173.
7. Li, F.#; Zhang, X.#; Renata, H.* Enzymatic C–H Functionalizations for Natural Product Synthesis. Curr. Opin. Chem. Biol.2019, 49, 25.
8. Li, F.; Tu, Q.; Chen. S.; Zhu, L.; Lan, Y.*; Gong, J.*; Yang, Z.* Bioinspired Asymmetric Synthesis of Hispidanin A. Angew. Chem. Int. Ed.2017, 56, 5844.
