Dr. Zhi-Hong Cheng obtained his Ph.D. from China Pharmaceutical University in 2003. He successively worked as a postdoc fellow in Shanghai Institute of Organic Chemistry (SIOC) and University of Maryland at College Park. Dr. Cheng joined the faculty of School of Pharmacy, Fudan University as an Associate Professor of Pharmacognosy in 2009. He has co-authored over 70 peer-reviewed papers, hold 5 China patents, and co-written 4 books. He is also an editorial board member of Chinese Journal of Biochemical Pharmaceutics, and Current Analytical Chemistry. He is a committee member of Division of Pharmacognosy, Shanghai Pharmaceutical Association.
Phytochemistry, Pharmacognosy, TCM, microbial transformation, quality control
Education
Ph.D. in Pharmacognosy, China Pharmaceutical University, 1998-2003;
B.S. in Analysis of Traditional Chinese Medicines, China Pharmaceutical University, 1994-1998.
Professional Experiences
Feb. 2009-date: Associate Professor, Department of Pharmacognosy, Fudan University, Shanghai, China;
Oct. 2005-Aug. 2008: Faculty Research Assistant, Department of Nutrition & Food Science, University of Maryland, College Park, MD, USA;
Jul. 2003-Oct. 2005: Postdoctoral Fellow, Shanghai Mass Spectrometry Center, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Teaching Activities
Modern methodology of TCM research (for Ph.D. students);
Component analysis of crude drugs (for M.S. students);
Brief introduction to Chinese traditional and herbal medicines (for B.S. students).
Research Interests
1. Bio-active substances of heat-clearing TCMs;
2. Microbial biotransformation of biological diterpenoids;
3. Establishing quality control methods for TCMs.
Grants & Projects
1. National Natural Science Foundation of China (General Program): Effective substances of Viola tischanica and Artemisia rupestris on actions of severe influenza. No. 81473421, PI, ￥760,000, 2015.1-2018.12;
2. National Natural Science Foundation of China (General Program): Effective substances of Viola yedoensis and Prunella vulgaris based on the complement inhibition. No. 81073025, PI, ￥330,000, 2011.1-2013.12;
3. National Natural Science Foundation of China (General Program): Development of a rapid a combined method of TLC bioautography and ambient ionization mass spectrometry for screening and estimation of lipid-lowering components of TCMs. No. 81573582, Co-PI, ￥85,500, 2016.1-2019.12.
Awards & Honors
The second prize of Science Technology Improvement Award of Science Research Famous Achievement Award in Higher Institution (rank the third, 2010).
Memberships
1. Editorial member of Current Analytical Chemistry (2015.12-date);
2. Editorial member of Chinese Journal of Biochemical Pharmaceutics (2014.6-date);
3. Member of American Chemistry Society (2015.7-date);
4. Committee member and secretary of Division of Pharmacognosy, Shanghai Pharmaceutical Association (2011.10-date).
Selected Publications（latest 5 yrs，<20 papers）
1. Xin Liu, Chengle Yin, Yue Cao, Jinge Zhou, Tao Wu, Zhihong Cheng*. Chemical constituents from Gueldenstaedtia verna and their anti-inflammatory activity. Natural Product Research, 2018, 32(10): 1145-1149;
2. Yan Qin, Boyan Gao, Haiming Shi, Jie Cao, Chengle Yin, Weiying Lu, Liangli Yu, Zhihong Cheng*. Characterization of flavonol mono-, di-, tri- and tetra-O-glycosides by ultra-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry and its application for identification of flavonol glycosides in Viola tianschanica. Journal of Pharmaceutical and Biomedical Analysis, 2017, 142: 113-124;
3. Lei Zhang, Jiyao Shi, Jihe Tang, Zhihong Cheng*, Xiaohui Lu, Yao Kong, Tao Wu*. Direct coupling of thin-layer chromatography-bioautography with electrostatic field induced spray ionization-mass spectrometry for separation and identification of lipase inhibitors in lotus leaves. Analytica Chimica Acta, 2017, 967: 52-58;
4. Yiqing Wu, Chengle Yin, Yue Cao, Xin Liu, Jinxiang Yu, Jian Zhang, Boyang Yu, Zhihong Cheng*. Regioselective hydroxylation of lathyrane diterpenoids biocatalyzed by microorganisms and its application in integrated synthesis. Journal of Molecular Catalysis B: Enzymatic, 2016, 133: S352-S359;
5. Yiqing Wu, Yue Cao, Xin Liu, Zhihong Cheng*. Regio- and stereoselective hydroxylations of ingenane diterpenoids by Mortierella ramanniana and Gibberella fujikuroi. Chinese Journal of Natural Medicines, 2016, 14(12): 939-945;
6. Dongsheng Du, Yan Lu, Zhihong Cheng*, Daofeng Chen*. Structure characterization of two novel polysaccharides isolated from the spikes of Prunella vulgaris and their anticomplement activities. Journal of Ethnopharmacology, 2016, 193: 345-353;
7. Yan Qin, Yingming Pang, Zhihong Cheng*. Needle trap device as a new sampling and preconcentration approach for volatile organic compounds of herbal medicines and its application to the analysis of volatile components in Viola tianschanica. Phytochemical Analysis, 2016, 27(6): 364-374;
8. Chengle Yin, Jinge Zhou, Yiqing Wu, Yue Cao, Tao Wu, Shoude Zhang, Honglin Li, Zhihong Cheng*. Pterocarpans and triterpenoids from Gueldenstaedtia verna. Fitoterapia, 2015, 106: 46-54;
9. Dongsheng Du, Zhihong Cheng*, Daofeng Chen*. Anti-complement sesquiterpenes from Viola yedoensis. Fitoterapia, 2015, 101: 73-79;
10. Jie Cao, Chengle Yin, Yan Qin, Zhihong Cheng*, Daofeng Chen. Approach to the study of flavone di-C-glycosides by high performance liquid chromatography-tandem ion trap mass spectrometry and its application to characterization of flavonoid composition in Viola yedoensis. Journal of Mass Spectrometry, 2014, 49: 1010-1024.
Patents
1. Zhihong Cheng, Daofeng Chen, Dongsheng Du, Jiahong Jin. Triterpenoid compounds from Prunella vulgaris and application in preparing anti-complement drugs. Chinese Invention Patent, No. ZL201010609516.8;
2. Zhihong Cheng, Daofeng Chen, Dongsheng Du. Alkaloid compounds and application in manufacturing of anticomplement agent. Chinese Invention Patent, No. ZL201210211820.6.
