Dr. Juan Xiong received her Ph. D. degree in Pharmacognosy in 2010 from University of Tokushima in Japan, under the guidance of Professor Yoshihisa Takayishi and Professor Yoshiki Kashiwada. Prior to her doctoral work, Dr. Xiong obtained her B.S. and M.S. degrees in Pharmacy from Wuhan University in 2005 and 2007, respectively. In the early 2011, she joined the Department of Natural Products Chemistry, School of Pharmacy at Fudan University. Her research interest mainly lies in the isolation, structure elucidation, and synthetic optimization of novel bioactive natural products for the treatment of the neurodegenerative disorders (e.g. Alzheimer’s disease, AD) and cardiovascular diseases from traditional Chinese medicines, medicinal plants, rare and endangered plants, and microorganisms. Dr. Xiong has published over 30 research papers and reviews, and applied for 12 invention patents
Rapid isolation and structural elucidation of novel natural products；Structural modification of natural bioactive compounds; Novel metabolites from Endangered and rare ornamental plants; Novel metabolites from endophytic microorganisms; Bioactivities (e.g., anti-neurodegeneration)
Education
Ph.D. degree
(10/2007 - 09/2010) Natural Products Chemistry, Faculty of Pharmaceutical Sciences, Tokushima University, Japan
M.Sc. degree
(09/2005 - 06/2007)Medicinal Chemistry, School of Pharmaceutical Sciences, Wuhan University, PR China
B.Sc. degree
(09/2001 - 06/2005)Pharmacy, School of Pharmaceutical Sciences,
Wuhan University, PR China
Professional Experiences
12/2016 - Present:Associate Professor, Department of Natural Products Chemistry, School of Pharmacy, Fudan University.
03/2018 – 05/2018:Research Fellow, School of Biological Sciences, Nanyang Technological University
05/ 2011- 11/ 2016:Lecturer, Department of Natural Products Chemistry, School of Pharmacy, Fudan University.
Teaching Activities
Undergraduate Courses: <Natural Medicinal Chemistry I>, <Natural Medicinal Chemistry II>, <Introduction of Natural Medicines>, and <Experimental Medicinal Chemistry I>
Master Courses: <Modern Separation Techniques> and <Natural Products Chemistry>
Grants & Projects
1.PI of project funded by National Natural Science Foundation of China (NSFC) entitled “Studies on novel terpenoids from four Chloranthus plants endemic to China and their biological activities” (NO. 21772025, Grant Period: 1/2018-12/2021)
2.PI of project funded by NSFC entitled “Reversal of P-glycoprotein-mediated multidrug resistance in cancer cells by chemical constituents from the barks of Ailanthus altissima” (NO. 81202420, Grant Period: 1/2013-12/2015)
3.PI of project funded by the Ph.D. Programs Foundation of Ministry of Education (MOE) of China entitled “Studies of novel Lycopodium alkaloids from Phlegmariurus fargesii and their neurotrophic activity” (NO. 20120071120049, Grant Period: 1/2013-12/2015)
4.Member of another nine projects mainly including three NSFC grants, one 973 Program grant, and one National Major Scientific and Technological Special Project for “Significant New Drugs Development”.
Awards & Honors
Winner of ‘Daiichi Sankyo Awards for Teachers’ of Fudan University (2017)
Selected Publications
1.Xiong Juan#, Jiang Wan#, Jie Ding, Pei-Pei Wang, Guang-Lei Ma, Li Jia, Hu Jin-Feng*, Camellianols A?G, barrigenol-like triterpenoids with PTP1B inhibitory effects from the endangered ornamental plant Camellia crapnelliana, Journal of Natural Products 2017, 80: 2874-2882. (# co-first author)
2.Xiong Juan, Hong Zhi-Lai, Gao Li-Xin, Shen Jie, Liu Shu-Ting, Yang Guo-Xun, Li Jia*, Zeng Huaqiang, Hu Jin-Feng*, Chlorabietols A-C, phloroglucinol-diterpene adducts from the Chloranthaceae Plant Chloranthus oldhamii, Journal of Organic Chemistry 2015, 80: 11080-11085.
3.Xiong Juan, Hong Zhi-Lai, Xu Peng, Zou Yike, Yu Shang-Bo, Yang Guo-Xun, Hu Jin-Feng*, ent-Abietane diterpenoids with anti-neuroinflammatory activity from the rare Chloranthaceae plant Chloranthus oldhamii, Organic & Biomolecular Chemistry 2016, 14: 4678-4689.
4.Xiong Juan, Wu Xi-Ying, Wang Pei-Pei, Lao Choiwan*, Fan Hui, Ma Guang-Lei, Tang Yu, Li Jia, Hu Jin-Feng*. Acylated iridoid diglycosides from the cultivated endangered ornamental tree Gmelina hainanensis. Phytochemistry Letters, 2018, 25: 17-21.
5.Xiong Juan, Bui Van-Binh, Liu Xin-Hua*, Hong Zhi-Lai, Yang Guo-Xun，Hu Jin-Feng*, Lignans from the stems of Clematis armandii ("Chuan-Mu-Tong") and their anti-neuroinflammatory activities，Journal of Ethnopharmacology 2014, 153: 737-743.
6.Tang Yu#, Xiong Juan#, Zhang Jing-Jing, Wei-Wang, Zhang Hai-Yan*, Hu Jin-Feng*, Annotinolides A?C, three lycopodane-derived 8,5-lactones with polycyclic skeletons from Lycopodium annotinum. Organic Letters 2016, 18: 4376-4379. (# co-first author)
7.Hu Chang-Ling#, Xiong, Juan#, Gao Li-Xin, Li Jia, Zeng Huaqiang, Zou Yike, Hu Jin-Feng*, Diterpenoids from the shed trunk barks of the endangered plant Pinus dabeshanensis and their PTP1B inhibitory effects. RSC Advances 2016, 6: 60467–60478. (# co-first author)
8.Xiong Juan, Liu Xin-Hua, Bui Van-Binh, Hong Zhi-Lai, Wang Li-Jun, Zhao Yun, Fan Hui, Yang Guo-Xun, Hu Jin-Feng*, Phenolic constituents from the leaves of Cratoxylum formosum ssp. pruniflorum, Fitoterapia 2014, 94: 114-119.
9.Xiong Juan, Liu Shu-Ting, Tang Yu, Wang Wen-Xuan, Bui Van-Binh, Zhao Yun, Fan Hui, Yang Guo-Xun, Hu Jin-Feng*, Sesquiterpenoids from the aerial parts of Chloranthus elatior, Phytochemistry Letters 2013, 6: 586-589.
10.Xiong Juan, Huang Ya, Wu Xi-Ying, Liu Xin-Hua, Fan Hui, Wang Wei, Zhao Yun, Yang Guo-Xun, Zhang Hai-Yan, Hu Jin-Feng*, Chemical constituents from the fermented mycelia of the medicinal fungus Xylaria nigripes, Helvetica Chimica Acta 2016, 99: 83-89.
11.Xiong Juan, Huang Ya, Tang Yu, You Mei, Hu Jin-Feng*, Pentacyclic triterpenoids from the roots of Rhodomyrtus tomentosa, Chinese Journal of Organic Chemistry, 2013, 33: 1304-1308.
12.Ma Guang-Lei, Xiong Juan*, Ezzat E. A. Osman, Huang Ting, Yang Guo-Xun, Hu Jin-Feng*. LC-MS guided isolation of sinodamines A and B: Chimonanthine-type alkaloids from the endangered ornamental plant Sinocalycanthus chinensis. Phytochemistry 2018, 151: 61-68. (* corresponding author)
13.Hu Chang-Ling, Xiong Juan*, Wang Pei-Pei, Ma Guang-Lei, Tang Yu, Yang Guo-Xun, Li Jia, Hu Jin-Feng*, Diterpenoids from the needles and twigs of the cultivated endangered pine Pinus kwangtungensis and their PTP1B inhibitory effects. Phytochemistry Letters 2017, 20: 239-245. (* corresponding author)
14.Hu Chang-Ling, Xiong Juan*, Xu Peng, Cheng Ke-Jun, Yang Guo-Xun, Hu Jin-Feng*, Lignans from the shed trunk barks of the critically endangered plant Abies beshanzuensis and their antineuroinflammatory activities. Natural Product Research 2017, 31: 1358-1364. (* corresponding author)
15.Tang Yu, Xiong Juan*, Zou Yike, Zhang Hai-Yan, Hu Jin-Feng*, Palhicerines A–F, Lycopodium alkaloids from the club moss Palhinhaea cernua, Phytochemistry 2016, 131: 130-139. (* corresponding author)
16.Meng Wei-Jia, Xiong Juan*, Wang Wen-Xuan, Zhang Hai-Yan, Zeng Hua-Qiang, Hu Jin-Feng*, Phlefargesiine A, a C16N2 Lycopodium alkaloid with an unprecedented [6/7/6/6]-tetracyclic skeleton from Phlegmariurus fargesii. Tetrahedron Letters 2016, 57: 3218-3221. (* corresponding author)
17.Wu Xi-Ying, Xiong Juan*, Liu Xin-Hua, Hu Jin-Feng, Chemical constituents from the rare cliffplant Orestitrophe rupifraga and their anti-nueroinflammatory activity. Chemistry & Biodiversity 2016, 13: 1030–1037. (* corresponding author)
Patents
1.CN 103211864B, Priority date: 20/01/2012, Grant.
2.CN 103980198B, Priority date: 08/02/2013, Grant.
3.CN 105801396A, Priority date: 29/12/2014, Grant.
4.CN 105837592A, Priority date: 11/01/2015, Grant.
5.CN 105859745A, Priority date: 20/01/2015, Grant.
6.CN 106466310A, Priority date: 17/08/2015, Application.
7.CN 106957324A, Priority date: 11/01/2016, Application.
8.CN 106957225A, Priority date: 11/01/2016, Application.
9.CN 107021942A, Priority date: 01/02/2016, Application.
10.CN 107459446A, Priority date: 05/06/2016, Application.
