Chang-Mei Si, Ph.D., graduated from Northwest A&F University and joined School of Pharmacy,Fudan University in 2019. Mainly engaged in asymmetric synthesis, structuralmodifications of active compounds from traditional Chinese medicine. More than20 papers have been published as the first author or co-corresponding author.
Asymmetric synthesis
Modification ofpharmacologically active natural products
Asymmetric synthesis ofcomplex chiral fragments
2011.9-2016.6 Ph.D. (Chemical Biology); Northwest A&F University;
2007.9-2011.6 B.S. (Applied Chemistry); Northwest A&F University
Professional Experiences
2016.7-2018.12 Postdoctoral research at the School of Pharmacy, Fudan University (Medicinal Chemistry)
Grants & Projects
1. The National Natural Science Foundation of China (21702032)
2. The China Postdoctoral Science Foundation (2016M600287)
3. The Open Research Fund Program of Beijing Key Lab of Plant Resource Research and Development, BTBU (PRRD-2019-YB2)
Selected Publications（latest 5 yrs，<20 papers）
1. Zhao-Dan Chen, Zhuo Chen, Qiao-E. Wang, Chang-Mei Si*, Bang-Guo Wei, Stereoselective Approach to Access 3-Tert-Butyl-Dimethylsiloxy-2,6-Substituted Piperidines through Nucleophilic Addition of N,O-Acetals with Organozinc Reagents. Tetrahedron Lett. 2020, 61, 152051.
2. Xiao-Di Nie, Zhuo-Ya Mao, Wen Zhou, Chang-Mei Si*, Bang-Guo Wei*, Guo-Qiang Lin, A Diastereoselective Approach to Amino Alcohols and Application for Divergent Synthesis of Dolastatin 10. Org. Chem. Front. 2020, 7, 76-103.
3. Chen Wang, Zhuo-Ya Mao, Yi-Wen Liu, Qiao- E. Wang, Chang-Mei Si* and Bang-Guo Wei* Stereoselective Intermolecular [4+2] Process of N,O-Acetals with Terminal Alkynes for Construction of Functional Cis-Pyrido and Pyrrolo[1,2-C][1,3]Oxazin-1-Ones. Adv. Synth. Catal. 2020, 362, 822-831.
4. Xue-Mei Wang, Yi-Wen Liu, Rui-Jun Ma, Chang-Mei Si* and Bang-Guo Wei* Synthesis of 1,4- and 1,5-Amino Alcohols via Nucleophilic Addition of Semicyclic N,O-Acetal with Organozinc Reagents. J. Org. Chem. 2019, 84, 11261-11267;
5. Xue-Mei Wang, Yi-Wen Liu, Qiao-E Wang, Zhu Zhou, Chang-Mei Si* and Bang-Guo Wei* A divergent method to key unit of tubulysin V through one-pot diastereoselective Mannich process of N,O-acetal with ketone. Tetrahedron 2019, 75, 260-268;
6. Wen Zhou, Yan-Xue Zhang, Xiao-Di Nie, Chang-Mei Si,* Xun Sun and Bang-Guo Wei* Approach to Chiral 1 Substituted Isoquinolone and 3 Substituted Isoindolin-1-one by Addition?Cyclization Process J. Org. Chem. 2018, 83, 9879?9889;
7. Zhuo-Ya Mao, Yi-Wen Liu, Pan Han, Han-Qing Dong, Chang-Mei Si,* Bang-Guo Wei,* and Guo-Qiang Lin Regio- and Stereoselective Cascades via Aldol Condensation and 1,3-Dipolar Cycloaddition for Construction of Functional Pyrrolizidine Derivatives Org. Lett. 2018, 20, 1090?1093;
8. Pan Han, Zhu Zhou, Chang-Mei Si,* Xian-Yi Sha, Zheng-Yi Gu,* Bang-Guo Wei,* and Guo-Qiang Lin Asymmetric Synthesis of Rupestonic Acid and Pechueloic Acid Org. Lett. 2017, 19，6732?6735;
9. Wen Zhou, Xiao-Di Nie, Yu Zhang, Chang-Mei Si*, Zhu Zhou, Xun Sun, Bang-Guo Wei* A practical approach to asymmetric synthesis of dolastatin 10. Org. Biomol. Chem., 2017, 15, 6119-6131.
10. Yi-Wen Liu, Pan Han, Wen Zhou, Zhuo-Ya Mao, Chang-Mei Si*, Bang-Guo Wei* Asymmetric syntheses of epohelmins A and B by In-mediated allylation. Org. Biomol. Chem., 2016, 14, 10714-10722.
11. Chang-Mei Si, Lu-Ping Shao, Zhuo-Ya Mao, Wen Zhou, Bang-Guo Wei* An efficient approach to trans-4-hydroxy-5-substituted 2-pyrrolidinones through a stereoselective tandem Barbier process: divergent syntheses of (3R,4S)-statines, (+)-preussin and (-)-hapalosin. Org. Biomol. Chem., 2017, 15, 649-661.
12. Lu-Ping Shao#, Chang-Mei Si#, Zhuo-Ya Mao, Wen Zhou, Tadeusz F. Molinski,* Bang-Guo Wei* and Guo-Qiang Lin Synthesis and structure revision of symplocin A Org. Chem. Front., 2017, 4, 995–1004. (# co-first author)
