姓 名 | 李付琸 | 性 别 | 男 |
职 称 | 青年研究员 | 学 历 | 博士 |
电 话 | 传 真 | ||
电子邮件 | lifuzhuo@fudan.edu.cn | 个人主页 | |
通讯地址 | 上海浦东新区张衡路826号，化学北楼413室 | ||
2012-2017 北京大学化学生物学与生物技术学院理学博士（导师：杨震教授，龚建贤副教授）
2008-2012 兰州大学化学化工学院理学学士（导师：李瀛教授）
2022至今 复旦大学药学院青年研究员
2017-2022 Scripps研究所博士后（导师：Prof. Hans Renata）
2022 – 2027 复旦大学引进人才科研基金
2017 – 2019 深圳市“个人创客”项目，GRCK20170424144259727，抗癌先导药物牛樟芝素的合成工艺研究
化学酶法策略在活性天然产物和手性药物合成中的应用
活性天然产物的构效关系与作用机制研究
1.Li, F.#; Deng, H.#; Renata, H.* Remote B-Ring Oxidation of Sclareol with an Engineered P450 Facilitates Divergent Access to Complex Terpenoids. J. Am. Chem. Soc.2022,144, 7616−7621.
2.Li, F.; Renata, H.* A Chiral-Pool-Based Strategy to Access Trans-Syn-Fused Drimane Meroterpenoids: Chemoenzymatic Total Syntheses of Polysin, N-Acetyl-Polyveoline and the Chrodrimanins. J. Am. Chem. Soc. 2021, 143, 18280.
3.Li, F.#; Yang, L.-C.#; Zhang, J.; Chen. J. S.; Renata, H.* Stereoselective Synthesis of β-Branched α-Amino Acids via a Biocatalytic Dynamic Kinetic Resolution. Angew. Chem. Int. Ed.2021, 60, 17680.
4.Li, J.#; Li, F.#; King-Smith, E.#; Renata, H.* “Merging Chemoenzymatic and Radical-Based Retrosynthetic Logic for Rapid and Modular Synthesis of Oxidized Meroterpenoids.” Nat. Chem.2020, 12, 173.
5.Li, F.#; Zhang, X.#; Renata, H.* “Enzymatic C–H Functionalizations for Natural Product Synthesis.” Curr. Opin. Chem. Biol.2019, 49, 25.
6.Li, F.; Tu, Q.; Chen. S.; Zhu, L.; Lan, Y.*; Gong, J.*; Yang, Z.* “Bioinspired Asymmetric Synthesis of Hispidanin A” Angew. Chem. Int. Ed.2017, 56, 5844.
7.Li, F.; Li, S.; Zhang, P.; Huang, Z.; Zhang, W.*; Gong, J.-X.*; Yang Z.* “A Chiral Pool Approach for Asymmetric Syntheses of (-)-Antrocin, (+)-Asperolide C and (-)-trans-Ozic acid.” Chem. Commun.2016, 52, 12426.
8.Li, S.; Li, F.; Gong, J.*; Yang. Z.* “Palladium-Catalyzed Carbonylative Cyclization of Aryl Alkenes/Alkenols: A New Reaction Mode for the Synthesis of Electron-Rich Chromanes.” Org. Lett.2015, 17, 1240.
9.Zhang, W.; Shao, W.; Li, F.; Gong, J.*; Yang. Z.* “Asymmetric Total Synthesis of (-)-Maoecrystal V.” Chem. Asian J.2015, 10, 1874.
10.Han, J.; Li, F.; Li, C.-C.* “Collective Synthesis of Humulanolides Using a Metathesis Cascade Reaction.” J. Am. Chem. Soc. 2014, 136, 13610.
11.李付琸; 张伟滨; 张鹏鹏; 黄智辉; 龚建贤; 曾耀铭; 杨震；牛樟芝素的制备方法, 2017-9-29, 中国, 专利号：201610550546.3
# equal contribution.
