Keywords of research interests

Oral drug delivery; Nanoparticles; In vivo fate; Poorly water-soluble drugs; Pharmaceutical technology

Curriculum Vitae

Education

1996.9-1999.7  School of Pharmacy, Sichuan University (formerly West China University of Medical Sciences), Chengdu, China. PhD under the supervision of Prof. Bin Lu.

1993.9-1996.6  School of Pharmacy, The Second Military Medical University, Shanghai, China. MS under the supervision of Prof. Quan Zhou.

1988.9-1992.6  School of Pharmacy, The Second Military Medical University, Shanghai, China, BS.

Professional Experiences

2007.1-present  School of Pharmacy, Fudan University, Shanghai, China. Professor.

2002.1-2006.12  School of Pharmacy, Fudan University, Shanghai, China. Associate Professor.

2000.10-2001.12  School of Pharmacy, Fudan University, Shanghai, China. Lecturer.

1999.7-2000.8  Department of Pharmacy, No. 208 Hospital, Changchun, China. Senior Pharmacist.

1992.7-1993.8  Department of Pharmacy, No. 208 Hospital, Changchun, China. Pharmacist.

Teaching Activities

Pharmaceutics I for undergraduates

Pharmaceutics II for undergraduates

Biopharmaceutics and pharmacokinetics for undergraduates

Introduction to pharmaceutics for undergraduates

Frontier in cross-discipline of pharmaceutics for postgraduates

Experimental design and optimization in pharmaceutical sciences for postgraduates

Selected topics in advanced pharmaceutics for postgraduates

Targeted drug delivery systems for postgraduates

Grants & Projects

1Co-PI, Mechanistic studies on highly efficient drug delivery systems for biomacromolecules. National Natural Science Fundation of China Key Project (81690263), 2017.01-2021.12.

2PI, Study on in vivo fate and mechanisms of action of orally delivered lipid-based nano drug delivery systems based on water-quenching infrared fluorescent probes. National Natural Science Fundation of China Regular Project (81573363), 2016.1-2019.12.

3Co-PI, Basic research on new-type molecular imaging nanoprobes for lung cancer. National Key Basic Research Program (2015CB931800), 2015.1-2019.8.

4PI, Study on highly efficient sirolimus controlled-release delivery systems based on controlling release of integral nanoparticles. Science and Technology Commission of Shanghai Municipality (14JC1490300), 2014.9-2017.8.

5PI, Studies on enhanced oral absorption of biomacromolecules by nanoparticles. New Century Excellent Techers Program of Ministry of Education (NCET-11-0114). 2012.1-2014.12.

6PI, Enhanced oral bioavailability of poorly water-soluble and poorly permeable drugs by lipid-based nanocarriers: a mechanistic study. Shanghai Commision of Education The Twilight Scholar Project (10SG05). 2011.1-2013.12.

7PI, Drug delivery systems of poorly water-soluble drugs based on natural nanomaterials (10430709200). International S & T Collaboration between Governments by Science and Technology Commission of Shanghai Municipality (University of Alberta, Canada). 2010.4-2012.3

8Co-PI, TCM Innovative Technology Platform (2009ZX09313-008). National Key Innovation Program on New Drugs. 2009.1-2010.12

9Co-PI, New Drug General Innovative Technology Platform (2009ZX09301-011). National Key Innovation Program on New Drugs. 2009.1-2010.12

10PI, Transfersomes as Potential Oral Insulin Drug Delivery Systems: Protransfersome Concept and Mechanistic Study. Novo Nordisk A/S, 2008.10-2011.9

11PI, Enhanced oral bioavailability of poorly water-soluble drugs by solidified self-nanoemulsifying drug delivery systems (0952nm03200). Science and Technology Commission of Shanghai Municipality, 2009.7-2011.9

12PI, Solid dispersion of polypeptides: enhanced formulation stability and oral bioavailability of insulin. Novo Nordisk A/S

13PI, Lymphatic absorption by the oral route: rationale design of delivery systems exemplified by self-microemulsifying and micellar drug delivery systems. F. Hoffmann-La Roche Ltd.

14Co-PI, Enhanced efficacy of water-insoluble drugs by nanotechnology. National Key Basic Research Project (2009CB930300). 2009.1-2013.12

15Co-PI, Thermosensitive gelation of liposome interior (30801440). National Natural Science Foundation of China. 2009.1-2011.12

16Co-PI, Enhanced oral absorption of water-insoluble drugs by mixed micelle precursors (0852nm04400). Science and Technology Commission of Shanghai Municipality, 2008.10-2010.9

17Co-PI, Targeted nano-carriers in therapy and diagnosis of cerebral diseases. National Key Basic Research Project (2007CB935800). 2009.1-2013.12

18Co-PI, Study on long-circulating Chanshu liposomes (0652m013), Science and Technology Commission of Shanghai Municipality, 2006.10-2009.9

19PI, Trans-membrane transport of anti-cancer drugs mediated by self-asembling cyclic peptide nanotubes and activities (30672546). National Natural Science Foundation of China, 2007.1-2009.12

20PI, Oral Colon-specific Drug Delivery System (024319114), Science and Technology Commission of Shanghai Municipality, 2002.10-2005.10

21PI, Splenic targeting of DNA-loaded stealth nanoparticles (03YQHB008), Supported by Shanghai Commission of Education for Excellent University Teacher Candicates, 2004.1-2005.12

22PI, Tumoral, cerebral and splenic targeting of stealth nanoparticles (0243nm067), Science and Technology Commission of Shanghai Municipality, 2002.10-2004.10

23PI, Experimental investigation on the effect of adriamycin-loaded polybutyrate microsphere on proliferative vitreoretinopathy (30100204). National Natural Science Foundation of China, 2002.1-2004.12

24PI, Optimized solubilization of Traditional Chinese Medicines. Launching support for excellent young teachers by Fudan University. 2002.1-2002.12

25PI, Fast-dissolving oral dosage forms. Shanghai Commission of Education for most valued disciplines. 2001.1-2003.12

26PI, Anti-myopic study of pirenzepine intraocular delivery system. Shanghai Commision of Science and Technology, 2002.10-2004.10

Awards & Honors

1Shanghai Excellent Ph.D. dissertation award, 2016 (as advisor).

260th Anniversary Distinguished Contributors Award by Chinese Pharmaceutical Journal, 2013

3New Century Excellent Talent, 2011

4Shanghai Suguang Scholar, 2010

5China Young Experts of Pharmaceutics Award, 2010. Awarded by Chinese Pharmaceutical Association.

6Wuyingfan Award by Fudan University, 2009

7Shanghai Excellent Young Teacher Award, 2008

8Shanghai Excellent M. S. dissertation award, 2008 (as advisor)

9Pharmaceutical experimental design and optimization. Excellent teaching course award by Fudan University, 2008

10Excellent graduate student supervisor award, 2008

11Fudan Excellent M.S. dissertation awards, 2008 (as advisor)

12Hongkong sponsors award, 2007

13Novel colon-specific drug delivery systems. Grade 3 award by Shanghai Pharmaceutical Association, 2006

14Practice of reform of the pharmaceutics course for graduate students. Grade 2 award for excellent teaching by Shanghai Municipal Committee of Education, 2005

15Fuhua Award by Fudan University, 2005

16Fostering plan for excellent young teachers by Shanghai Committee of Education (03YQHB008), 2003

17Fostering plan and award for the third “star of the century” by Fudan University, 2002

18Huachang Award by Fudan University, 2002

19Nimodipine buoyant sustained-release tablet capable of intragastric retention, Grade 3 award for progress in science and technology by the People’s Liberation Army, 2001

20Study on sustained-release nifedipine microspheres, Grade 3 award for progress in science and technology by the People’s Liberation Army, 1998

Memberships

Editorial Board Members

AAPS PharmSciTech (2015-)

Archives of Pharmacal Research (2013-)

Asian Journal of Pharmaceutical Sciences (2011-)

Central South Pharmacy (Chinese, 2003-)

Chinese Journal of Pharmaceutics (Chinese, 2008-)

International Journal of Pharmaceutics (2017-)

Journal of Basic and Clinical Pharmacy (2008-)

Journal of Chinese Pharmaceutical Sciences (2006-)

Journal of Pharmaceutical Research (Chinese, 2015-)

Nanomedicine and Nanobiology (2013-)

Progress of China Pharmaceutical Sciences (Chinese, 2009-)

World Pharmacy (Chinese, 2007-)

Acta Pharmaceutica Sinica (Chinese, 2017-)

Services and Committees

AAPS, Member

ACS, Member

CSP (Chinese Society of Particuology), Bioparticles Committee Member

CPA (Chinese Pharmaceutical Association), Pharmaceutics Committee Member

CMBA (China Medicinal Biotech Association), Nanobiotechnology Committee Member

CACM (China Association of Chinese Medicine), Chinese Patent Drugs Committee Member, Formulation Committee Member

NDRC (National Development and Reform Commission), Drug Pricing Committee Member

SFDA (State Food and Drug Administration), New Drug Evaluation Committee member

MOA (Ministry of Agriculture), New Veterinary Drug Evaluation Committee member,

WFCMS (World Federation of Chinese Medicine Societies), TCM Pharmaceutics Committee Member

Invited Presentations

1. Applications of environment-responsive probes in investigation of the in vivo fate of nanoparticles. The Second Lingnan International Conference of Pharmaceutical Sciences. Guangzhou, China. 2017.12.1-3.

2. Probing in vivo fate of nanoparticles using environment-responsive fluorophores. 2017 Asian Federation for Pharmaceutical Sciences Conference. Xiamen, China. 2017.11.21-23.

3. Probing in vivo fate of nanoparticles based on environment-responsive fluorophores. 2017 APCCOM. Kaifeng, China. 2017.08.9-10.

4. Development of novel water-quenching environment-responsive probes and applications in biological fate study of nanoparticles. 2016 Chinese Pharmaceutical Conference. Nanjing. 2016.11.18-20.

5. Utilizing oral nanoparticles to enhance drug absorption-study and application. 6th Annual Drug Delivery & Formulation Asia Summit. Shanghai 2016.10.27-28.

6. In vivo fate of lipid-based nanocarriers studied using a novel water-quenching probe. 2016 Cross-strait DDS Symposium. Hsinchu, Taiwan. 2016. 3.25-26.

7. In vivo fate of lipid-based nanoparticles. 2015 Symposium on Development and Internalization of Chinese Pharmaceutical Industries. Hangzhou. 2015. 13-15.

8. Recent advances on novel drug delivery systems. 2015 Annual Meeting of Fujian Pharmaceutical Association. Quanzhou. 2015.4.18.

9. Advances in enhanced oral absorption of poorly water-soluble drugs by lipid-based nanocarriers. 2014 Shanghai Symposium on Industrial Development of Nanotechnology and New Materials. Shanghai. 2014.10.20.

10. Studies on enhanced oral delivery by lipid-based nanocarriers. 2014 China Pharmaceutics Conference & The 6th Asian Arden Pharmaceutical Technology Symposium. Changsha. 2014.9.20-21.

11. Dissolution and Absorption of the Active Components of Phytomedicines. 2014 International Innovative TCM and Phytomedicine Summit. Nanchang. 2014.9.18-19

12. Application of Nanotechnology in enhanced drug bioavailability. The 1st Merck-Millipore Asian Pharmaceutical Technology Summit—Enhancing the Bioavailability of Your Formulations. Shanghai. 2014.6.10

13. Enhanced oral delivery through ligand-mediated enteric epithelial targeting. The 3rd Asian Pharmaceutics Forum. Shenyang. 2014.5.25-27

14. Ligand-mediated Targeting to Intestinal Epithelia for Enhanced Oral Delivery. WCPT7. Beijing. 2014.5.19-21.

15. Novel Delivery Systems and Pharmaceutical Technologies for TCM. 2013 International Innovative TCM and Phytomedicine Summit. Nanchang. 2013.11.7-8.

16. Nanomedicine R & D in Shanghai. 2013 Shanghai Nanomedicine Workshop. Shanghai. 2013.11.1 (Speaker and Modulator)

17. Novel Delivery System for TCM—Opportunities and Challenges. The 11th China (Shanghai) International Drug Innovation Frontier Technologies and Industrialization Summit. Shanghai. 2013.10.16-18.

18. Studies on Controlled Release of Integral Nanoparticles. The 1st Bioparticles Symposium. Urumqi. 2013.9.21-22 (Vice Chairman)

19. Targeted Drug Delivery Systems—Advances and Perspectives. 2012 Shanghai Symposium on Nanotechnology and Industrial Development. Shanghai. 2012.11.1-3 (Session Chair: Nanotechnology and Biomedicines)

20. Application of Fluid-bed Coating Technology in Solidification of Liquidic Dosage Forms. 2012 Chinese Pharmaceutics Conference. Chengdu. 2012.9.23

21. Advances in Technologies of Manufacturing Solid Dosage Forms from Liquids. Institute of Chinese Medicines, Macao University. 2012.6.18

22. Panel Discussion: Advancing Formulation Development through Winning Drug Delivery Collaboration between Academia and Industry (one of three Panelists). Drug Delivery & Formulation Asia Summit 2011. Shanghai. 2011.12.6-7.

23. Panel Discussion: Overview NDDS’s Role in the Development of Traditional Chinese Medicine (TCM) (Modulator). Drug Delivery & Formulation Asia Summit 2011. Shanghai. 2011.12.6-7.

24. Synchronous and Controlled Release Delivery Systems of Multiple Components Based on the Osmotic Release Strategy. Annual Meeting of Chinese Association of TCM Pharmaceutics Chapter. Kunming. 2011.11.4-6.

25. Enhanced oral bioavailability of poorly water-soluble drugs by lipid-based nanocarriers. Chinano 2010. Suzhou. 2010.11.13-14.

26. Preparation of solid dosage forms from liquids by fluid-bed coating technique. 2010 Symposium on manufacturing and application of biomedical particles. Shanghai. 2010.9.27

27. Strategies and pharmaceutical technologies for absorption enhancement of poorly water-soluble drugs. The 4th Guobang Symposium of Pharmaceutical Dosage Forms. Shanghai. 2010.8.2-4.

28. Sustained-release delivery systems of TCM based on synchronous release of multiple components. The Annual Meeting of Traditional Chinese Medicine. 2010.8.13-15. Shenyang, China.

29. Strategies and pharmaceutical technologies to overcome oral absorption problems of poorly water-soluble drugs. The fifth Guobang Symposium for Pharmaceutical Technology. 2010.8.2-4. Shanghai, China.

30. Enhancement of oral absorption of poorly water-soluble drugs—Dissolution or Permeation? The 2nd Arden Symposium for Pharmaceutical Technology. 2010.6.11-13. Shenyang, China.

31. Liposomes with gelated interior as novel drug delivery carriers. 2010 International Symposium for Advanced Drug Delivery. 2010.4.29-30. Hsin Chu, Taiwan.

32. Fluid-bed coating as a new technique to prepare solid dosage forms from liquids. The 1st International Symposium for Industrial Pharmacy and Clinical Pharmacy. 2009.10.9-11. Guangzhou, China.

33. Enhanced oral bioavailability of poorly water-soluble drugs by lipid-based delivery systems. The 4th International Symposium on Drug Delivery. 2009.9.24. Shanghai, China.

34. Enhanced or controlled oral delivery of active compounds: application of biomaterials. Sino-Canada Mutual Collaboration Symposium on nanotechnology in the field of bioscience. 2009.9.23. Shanghai, China.

35. Transport of small molecules mediated by transmembrane self-assembling cyclic peptide nanotubes. Roche Marco Polo Symposium 2009 3nd Roche Drug Delivery Symposium in Far East. 2009.9.14-7. Seoul, Korea

36. Oral fast-dissolving dosage forms and techniques. 2009.5.12. State Food and Drug Administration. Suzhou, China.

37. One-step formulation of solid dispersion by fluid-bed coating technique for BCS II drugs. Roche Marco Polo Symposium 2008 2nd Roche Drug Delivery Symposium in Far East. 2008.12.3-4. Shanghai, China

38. Novel Drug Delivery Systems for Phytomedicines. 2008.11.10. The Korean Society of Pharmaceutical Sciences and Technology 2008 International Symposium “Bio-Nano Fusion Technology for Drug Development”. Seoul, Korea.

39. Application of solid dispersion in pharmaceutical dosage forms. Shanghai Pharmaceutical Industries Society. 2008. Shanghai, China

40. Novel drug delivery systems and pharmaceutical technologies: status quo, R&D strategies. Bio-forum the 10th International Symposium on Biotechnology. Shanghai 2008.

41. Oral fast-dissolving dosage forms and new technologies. State Food and Drug Administration. Shanghai 2008.

42. R & D of novel oral colon-specific drug delivery systems. State Food and Drug Administration. Shanghai 2007.

43. “Orally disintegrating tablet”-overview and perspectives. The 12th symposium on manufacturing of tablets. Shanghai 2005.

44. A novel pH-, time- and enzyme-controlled colon-specific delivery system. The 2th International Symposium on Drug Delivery. 2005.10.26-28. Shanghai

45. Development and Evaluation of Melting-congealed Pills of Drugs of Botanical Origin. School of Pharmacy, Nagasaki University. Nagasaki, 2003.

Selected Publications

1. Haisheng He, Sifan Jiang, Yunchang Xie, Yi Lu, Jianping Qi, Xiaochun Dong, Weili Zhao, Zongning Yin, Wei Wu*. Reassessment of long circulation via monitoring of integral polymeric nanoparticles justifies a more accurate understanding. Nanoscale Horizons 2018, DOI: 10.1039/C8NH00010G

2. Yunhai Feng, Haisheng He, Fengqian Li, Yi Lu, Jianping Qi, Wei Wu*. An update on the role of nanovehicles in nose-to-brain drug delivery. Drug Discovery Today 2018, doi: 10.1016/j.drudis.2018.01.005

3. Qin Yu, Xiying Wu, Quangang Zhu, Wei Wu, Zhongjian Chen*, Ye Li*, Yi Lu*. Enhanced transdermal delivery of meloxicam by nanocrystals: Preparation, in vitro and in vivo evaluation. Asian Journal of Pharmaceutical Sciences 2017, DOI: 10.1016/j.ajps.2017.10.004

4. Jianping Qi, Jie Zhuang, Yongjiu Lv, Yi Lu, Wei Wu*. Exploiting or overcoming the dome trap for enhanced oral immunization and drug delivery. Journal of Controlled Release 2018, 275:92-106.

5. Haisheng He, Yi Lu, Jianping Qi, Weili Zhao, Xiaochun Dong, Wei Wu*. Biomimetic thiamine- and niacin-decorated liposomes for enhanced oral delivery of insulin. Acta Pharmaceutica Sinica B 2018, 8(1): 97-105.

6. Zhongjian Chen, Yongjiu Lv, Jianping Qi, Hailong Yuan, Quangang Zhu, Yi Lu*, Wei Wu. Overcoming or circumventing the stratum corneum barrier for efficient transcutaneous immunization. Drug Discovery Today 2018, 23(1): 181-186.

7. Chengying Shen, Yinqian Yang, Baode Shen, Yike Xie, Jianping Qi, Xiaochun Dong, Weili Zhao, Weifeng Zhu, Wei Wu, Hailong Yuan*, and Yi Lu*. Self-discriminating Fluorescent Hybrid Nanocrystals: Efficient and Accurate Tracking of Translocation via Oral Delivery. Nanoscale 2018, 10(1): 436-450

8. Yike Xie, Baokui Shi, Fei Xia, Jianping Qi, Xiaochun Dong, Weili Zhao, Tonglei Li?, Wei Wu?, Yi Lu???. Epithelia transmembrane transport of orally administered ultrafne drug particles evidenced by environment sensitive fluorophores in cellular and animal studies. Journal of Controlled Release 2018, 270:65-75.

9. Dong Li, Jie Zhuang, Haisheng He, Sifan Jiang, Amrita Banerjee, Yi Lu, Wei Wu, Samir Mitragotri, Li Gan*, Jianping Qi*. Influence of Particle Geometry on Gastrointestinal Transit and Absorption following Oral Administration. ACS Applied Materials & Interfaces 2017, 9(49): 42492–42502.

10. Bo Wan, Yikang Dai, Dailei Liu, Jianping Qi, Xiaochun Dong, Weili Zhao, Wei Wu*, Yi Lu*. Intraocular fate of polycaprolactone nanoparticles administered via intravitreal and various periocular routes: Bioimaging of integral nanoparticles using environment-sensitive fluorophores. Journal of Biomedical Nanotechnology 2017, 13(8): 960-972.

11. Yuhua Ma, Haisheng He, Fei Xia, Yingxia Li, Yan Lu, Daofeng Chen, Jianping Qi, Wei Zhang*, Yi Lu*, Wei Wu*. In vivo fate of lipid-silybin conjugate nanoparticles: implications on enhanced oral bioavailability. Nanomedicine: Nanotechnology, Biology and Medicine 2017, 13(8): 2643-2654.

12. Yuhua Ma, Haisheng He, Wufa Fan, Yingxia Li, Wei Zhang, Weili Zhao, Jianping Qi, Yi Lu*, Xiaochun Dong*, Wei Wu*. In Vivo Fate of Biomimetic Mixed Micelles as Nanocarriers for Bioavailability Enhancement of Lipid-Drug Conjugates. ACS Biomaterials Science & Engineering 2017, 3(10), 2399-2409.

13. Sifan Jiang, Haisheng He, Yi Lu, Jianping Qi, Xiaochun Dong, Weili Zhao, Zongning Yin*, Wei Wu*. Preparation and in vitro evaluation of methoxy polyethylene glycol-polycaprolactone nanoparticles loading a water-quenching fluorescent probe. Academic Journal of Second Military Medical University, 2017, 38(8): 107-113. (in Chinese)

14. Rui Su, Wufa Fan, Ye Li, Wei Wu, Yi Lu*. Investigation on Transdermal Translocation of Nanoemulsions Based on Integral Identification. Chinese Journal of Pharmaceuticals, 2017, 48(7): 1022-1029. (in Chinese)

15. Fei Xia, Wufa Fan, Sifan Jiang, Yuhua Ma, Yi Lu, Jianping Qi, Ejaj Ahmad, Xiaochun Dong, Weili Zhao*, Wei Wu*. Size-Dependent Translocation of Nanoemulsions via Oral Delivery. ACS Applied Materials & Interfaces 2017, 9(26):21660-21672.

16. Rui Su, Wufa Fan, Qin Yu, Xiaochun Dong, Jianping Qi, Quangang Zhu, Weili Zhao, Wei Wu, Zhongjian Chen*, Ye Li*, Yi Lu*. Size-dependent penetration of nanoemulsions into epidermis and hair follicles: implications for transdermal delivery and immunization. Oncotarget 2017, 8(24):38214-38226.

17. Yike Xie, Zhongjian Chen, Rui Su, Ye Li, Jianping Qi, Wei Wu, Yi Lu*. Preparation and Optimization of Amorphous Ursodeoxycholic Acid Nanosuspensions by Nanoprecipitation based on Acid-base Neutralization for Enhanced Dissolution. Current Drug Delivery 2017, 14(4): 483-491.

18. Yi Lu, Jianping Qi, Weili Zhao, Xiaochun Dong, Wei Wu*. In vivo fate of nanocrystals. Drug Discovery Today 2017, 22(4):744-750.

19. Ejaj Ahmad, Yunhai Feng, Jianping Qi, Wufa Fan, Yuhua Ma, Haisheng He, Fei Xia, Xiaochun Dong, Weili Zhao, Yi Lu*, Wei Wu*. Evidence of nose-to-brain delivery of nanoemulsions: cargoes but not vehicles. Nanoscale 2017, 9(3): 1174-1183.

20. Xiongwei Hu, Xiaochun Dong, Yi Lu, Jianping Qi, Weili Zhao, Wei Wu*. Bioimaging of nanoparticles: the crucial role of discriminating nanoparticles from  free probes. Drug Discovery Today 2017, 22(2): 382-387.

21. Jianping Qi, Jie Zhuang, Yi Lu, Weili Zhao, Xiaochun Dong, Wei Wu*. In vivo fate of lipid-based nanoparticles. Drug Discovery Today 2017, 22(1): 166-172.

22. Haisheng He, Jian Zhang, Yunchang Xie, Yi Lu, Jianping Qi, Ejaj Ahmad, Xiaochun Dong, Weili Zhao*, Wei Wu*. Bioimaging of Intravenous Polymeric Micelles Based on Discrimination of Integral Particles Using an Environment-Responsive Probe. Molecular Pharmaceutics 2016, 13(11): 4013-9.

23. Zhiqiang Tian, Qin Yu, Yunchang Xie, Li Xiang, Fengqian Li, Yi Lu, Xiaochun Dong, Weili Zhao, Jianping Qi*, Wei Wu*. Controlling release of integral lipid nanoparticles based on osmotic pump technology. Pharmaceutical Research 2016, 33(8): 1988-97.

24. Yunchang Xie, Sifan Jiang, Fei Xia, Xiongwei Hu, Haisheng He, Zongning Yin, Jianping Qi, Yi Lu, Wei Wu*. Glucan microparticles thickened with thermosensitive gels as potential carriers for oral delivery of insulin. Journal of Material Chemistry B 2016, 4, 4040-4048. (Cover)

25. Baode Shen, Na Wu, Chengying Shen, Fucheng Zhang, Yan Wu, Pinghua Xu, Lihong Zhang, Wei Wu*, Yi Lu, Jin Han, Yonggang Wang, Hailong Yuan*. Hyperoside nanocrystals for HBV treatment: process optimization, in vitro and in vivo evaluation. Drug Development and Industrial Pharmacy 2016, 42(11): 1772-81.

26. Yunchang Xie, Xiongwei Hu, Haisheng He, Fei Xia, Yuhua Ma, Jianping Qi, Xiaochun Dong, Weili Zhao, Yi Lu*, Wei Wu*. Tracking Translocation of Glucan Microparticles Targeting M Cells: Implications for Oral Drug Delivery. Journal of Material Chemistry B 2016, 4: 2864-2873. (Cover) 2016 Journal of Materials Chemistry B Hot Papers

27. Qin Yu, Xiongwei Hu, Yuhua Ma, Yunchang Xie, Yi Lu, Jianping Qi, Li Xiang, Fengqian Li*, Wei Wu*. Lipids-based nanostructured lipid carriers (NLCs) for improved oral bioavailability of sirolimus. Drug Delivery 2016, 23(4): 1469-1475.

28. Peipei Guan, Yi Lu, Jianping Qi, Wei Wu*. Readily Restoring Freeze-dried Probilosomes as potential Nanocarriers for Enhancing Oral Delivery of Cyclosporine A. Colloids and Surfaces B: Biointerfaces 2016, 144: 143-151.

29. Jian Chen, Fei Xia, Sifan Jiang, Yunchang Xie, Zhang Bei, Yi Lu, Wei Wu*. Transmembrane Delivery of Anticancer Drugs through Self-assembly of Cyclic Peptide Nanotubes. Nanoscale 2016, 8: 7127-7136.

30. Xiongwei Hu, Wufa Fan, Zhou Yu, Yi Lu, Jianping Qi, Jian Zhang, Xiaochun Dong, Weili Zhao*, Wei Wu*. Evidence does not support intact absorption of solid lipid nanoparticles via oral delivery. Nanoscale 2016, 8: 7024-7035. (Cover)

31. Yi Lu, Ye Li, Wei Wu*. Injected Nanocrystals for Targeted Drug Delivery. Acta Pharmaceutica Sinica B 2016, 6(2): 106-113.

32. Yunchang Xie, Yueneng Yi, Xiongwei Hu, Mingzhu Shangguan, Lijuan Wang, Yi Lu, Jianping Qi, Wei Wu*. Synchronous microencapsulation of multiple components in silymarin into PLGA nanoparticles by an emulsification/solvent evaporation method. Pharmaceutical Development and Technology 2016, 21(6): 672-679.

33. Wei Wu*, Yi Lu, Jianping Qi. Editorial: Oral delivery of liposomes. Therapeutic Delivery 2015, 6(11), 1239–1241.

34. Lijuan Wang, Xiongwei Hu, Baode Shen, Yunchang Xie, Chengying Shen, Yi Lu, Jianping Qi, Hailong Yuan*, Wei Wu*. Enhanced stability of liposomes against solidification stress during freeze-drying and spray-drying by coating with calcium alginate. Journal of Drug Delivery Science and Technology 2015, 30 (Part A): 163-170.

35. Xiongwei Hu, Jian Zhang, Zhou Yu, Yunchang Xie, Haisheng He, Jianping Qi, Weili Zhao*, Wei Wu*. Environment-responsive Aza-BODIPY Dyes Quenching in Water as Potential Probes to Visualize the in Vivo Fate of Lipid-based Nanocarriers. Nanomedicine: Nanotechnology, Biology and Medicine 2015, 11(8): 1939-1948.

36. Yi Lu, Yan Chen, Richard A. Gemeinhart, Wei Wu, Tonglei Li*. Developing Nanocrystals for Cancer Treatment. Nanomedicine (Lond) 2015, 10(16): 2537-2552.

37. Yueneng Yi, Liangxing Tu, Kaili Hu, Wei Wu ?, Jianfang Feng*. The construction of puerarin nanocrystals and its pharmacokinetic and in vivo–in vitro correlation (IVIVC) studies on beagle dog. Colloids and Surfaces B: Biointerfaces 2015,133: 164-170.

38. Xuezhi Yin, Linda Sharon Daintree, Sheng Ding, Daniel Mark Ledger, Bing Wang, Wenwen Zhao, Jianping Qi, Wei Wu*, Jiansheng Han*. Itraconazole solid dispersion prepared by a supercritical fluid technique: preparation, in vitro characterization and bioavailability in beagle dogs. Drug Design, Development and Therapy 2015,9: 2801-2810.

39. Xiuli Wei, Yi Lu*, Jianping Qi, Baojian Wu, Jian Chen, Huinan Xu, Wei Wu. An in situ crosslinked compression coat comprised of pectin and calcium chloride for colon-specific delivery of indomethacin. Drug Delivery 2015, 22(3): 298-305.

40. Mingzhu Shangguan, Jianping Qi, Yi Lu, Wei Wu*. Comparison of the oral bioavailability of silymarin-loaded lipid nanoparticles with their artificial lipolysate counterparts: implications on the contribution of integral structure. International Journal of Pharmaceutics 2015, 489(1-2):195-202.

41. Meng Cui, Wei Wu, Lars Hovgaard, Yi Lu, Dawei Chen*, Jianping Qi*. Liposomes containing cholesterol analogues of botanical origin as drug delivery systems to enhance the oral absorption of insulin. International Journal of Pharmaceutics 2015, 489(1-2):277-284.

42. Jianping Qi, Yi Lu, Wei Wu*. Manufacturing solid dosage forms from bulk liquids using the fluid-bed drying technology. Current Pharmaceutical Desig 2015, 21(19): 2668-2676.

43. Yi Lu, Yiting Qiu, Jianping Qi, Meiqing Feng, Dianwen Ju, Wei Wu*. Biomimetic reassembled chylomicrons as novel association model for the prediction of lymphatic transportation of highly lipophilic drugs via the oral route. International Journal of Pharmaceutics 2015, 483: 69-76.

44. Peipei Guan, Yi Lu, Jianping Qi, Mengmeng Niu, Ruyue Lian, Wei Wu*. Solidification of liposomes by freeze-drying: The importance of incorporating gelatin as interior support on enhanced physical stability. International Journal of Pharmaceutics 2015, 478: 655-64.

45. Kai Wang, Jianping Qi*, Tengfei Weng, Zhiqiang Tian, Yi Lu, Kaili Hu, Zongning Yin*, Wei Wu. Enhancement of oral bioavailability of cyclosporine A: comparison of various nanoscale drug delivery systems. International Journal of Nanomedicine 2014, 9: 4991-4999

46. Tengfei Weng, Jianping Qi*, Yi Lu, Kai Wang, Zhiqiang Tian, Kaili Hu, Zongning Yin, Wei Wu. The role of lipid-based nano delivery systems on oral bioavailability enhancement of fenofibrate, a BCS II drug: comparison with fast-release formulations. Journal of Nanobiotechnology 2014,12: 39

47. Wei He, Yi Lu, Jianping Qi, Lingyun Chen, Lifang Yin, Wei Wu*. Shell cross-linked nanoemulsions as drug delivery systems: converting into dry formulations by fluid-bed coating. Nanomedicine and Nanobiology 2014,1: 35-42.

48. Xingwang Zhang, Jianping Qi*, Yi Lu, Xiongwei Hu, Wei He, Wei Wu. Enhanced hypoglycemic effect of biotin-modified liposomes loading insulin: effect of formulation variables, intracellular trafficking and cytotoxicity. Nanoscale Research Letters 2014, 9(1): 185

49. Xingwang Zhang, Wei Wu*. Ligand-mediated active targeting for enhanced oral absorption. Drug Discovery Today  2014, 19(7): 898-904.

50. Yi Lu, Ning Tang, Ruyue Lian, Jianping Qi, Wei Wu*. Understanding the relationship between wettability and dissolution of solid dispersion. International Journal of Pharmaceutics 2014, 465(1-2): 25-31.

51. Shi-ying Jin, Jin Han, Shi-xiao Jin, Qing-yuan Lv, Jin-xia Bai, Hong-ge Chen, Rui-sheng Li, Wei Wu*, Hai-long Yuan*. Characterization and evaluation in vivo of baicalin-nanocrystals prepared by an ultrasonic-homogenization-fluid bed drying method. Chinese Journal of Natural Medicine, 2014, 12(1): 71-80

52. Mingzhu Shangguan, Yi Lu, Jianping Qi, Jin Han, Zhiqiang Tian, Yunchang Xie, Fuqiang Hu, Hailong Yuan, Wei Wu*. Binary lipids-based nanostructured lipid carriers for improved oral bioavailability of silymarin. Journal of Biomaterials Applications 2014, 28(6): 887-896.

53. Mengmeng Niu, Ya’nan Tan, Peipei Guan, Lars Hovgaard, Yi Lu, Jianping Qi, Ruyue Lian, Xiaoyang Li, Wei Wu*. Enhanced oral absorption of insulin-loaded liposomes containing bile salts: a mechanistic study. International Journal of Pharmaceutics 2014, 460: 119-130.

54. Xingwang Zhang, Jianping Qi, Yi Lu, Xiaoyang Li, Wei He, Wei Wu*. Biotinylated liposomes as potential carriers for oral delivery of insulin. Nanomedicine: Nanotechnology, Biology and Medicine 2014, 10: 167-176.

55. Liangxing Tu, Yueneng Yi, Wei Wu, Fuqiang Hu, Kaili Hu, Jianfang Feng. Effects of particle size on the pharmacokinetics of puerarin nanocrystals and microcrystals after oral administration to rat. International Journal of Pharmaceutics, 2013, 458(1): 135-140.

56. Bei Zhang, Jian Chen, Yi Lu, Jianping Qi, Wei Wu*. Liposomes interiorly thickened with thermosensitive nanogel as novel drug delivery systems. International Journal of Pharmaceutics 2013, 455: 276-284.

57. Wei He, Yi Lu, Jianping Qi, Lingyun Chen, Lifang Yin, Wei Wu*. Formulating food protein-stabilized indomethacin nanosuspensions into pellets by fluid-bed coating technology: Physical characterization, redispersibility and dissolution. International Journal of Nanomedicine 2013, 8: 3119-3128.

58. Zhiqiang Tian, Yueneng Yi, Hailong Yuan, Jin Han, Xi Zhang, Yunchang Xie, Fuqiang Hu, Yi Lu, Jianping Qi*, Wei Wu*. Solidification of nanostructured lipid carriers (NLCs) onto pellets by fluid-bed coating: preparation, in vitro characterization and bioavailability in dogs. Powder Technology 2013, 247: 120-7.

59. Xi Zhang, Yueneng Yi, Jianping Qi, Yi Lu, Zhiqiang Tian, Yunchang Xie, Fuqiang Hu, Hailong Yuan, Wei Wu*. Controlled release of self-nanoemulsifying systems from osmotic pump tablets: near zero-order release in vitro and pharmacokinetics in dogs. International Journal of Pharmaceutics 2013, 452:233-240.

60. Yikang Dai, Rui Zhou, Lin Liu, Yi Lu, Jianping Qi*, Wei Wu. Liposomes containing bile salts as novel ocular delivery systems tacrolimus (FK506): in vitro characterization and improved corneal permeation. International Journal of Nanomedicine 2013, 8: 1921-1933.

61. Mette Thing, Yi Lu*, Li Ag?rdh, Claus Larsen, Jesper ?stergaard, Wei He, Wei Wu, Frank Larsen, Susan Weng Larsen*. Prolonged naproxen joint residence time after intra-articular injection of lipophilic solutions comprising a naproxen glycolamide ester prodrug in the rat. International Journal of Pharmaceutics 2013, 451(1-2):34-40.

62. Fuxia Dong, Yi Lu*, Yunchang Xie, Jianping Qi, Fuqiang Hu, Sanming Li*, Wei Wu. Bile salts/phospholipids mixed micelle pellets precursor prepared by fluid-bed coating. International Journal of Nanomedicine 2013,8:1653-1663.

63. Wei He, Yi Lu, Jianping Qi, Lingyun Chen, Fuqiang Hu, Wei Wu*. Nanoemulsion-templated shell-crosslinked nanocapsules as drug delivery systems. International Journal of Pharmaceutics 2013, 445: 69-78.

64. Yunchang Xie, Yi Lu, Jianping Qi, Xiaoyang Li, Xi Zhang, Jin Han, Shixiao Jin, Hailong Yuan*, Wei Wu*. Synchronized and controlled release of multiple components in silymarin achieved by the osmotic release strategy. International Journal of Pharmaceutics 2013,441: 111-120.

65. Yanan Tan, Jianping Qi*, Yi Lu, Fuqiang Hu, Zongning Yin, Wei Wu. Lecithin in mixed micelles attenuates the cytotoxicity of bile salts in Caco-2 cells. Toxicology In Vitro 2013,27: 714-720.

66. Wei He, Yi Lu, Jianping Qi, Lingyun Chen, Fuqiang Hu, Wei Wu*.  Food proteins as novel nanosuspension stabilizers for poorly water-soluble drugs. International Journal of Pharmaceutics 2013,441: 269-278.

67. Shunwen Hu, Mengmeng Niu, Fuqiang Hu, Yi Lu, Jianping Qi, Zongning Yin*, Wei Wu*. Integrity and stability of oral liposomes containing bile salts studied in simulated and ex vivo gastrointestinal media. International Journal of Pharmaceutics 2013,441: 693-700.

68. Xiaoyang Li, Jianping Qi*, Yunchang Xie, Xi Zhang, Shunwen Hu, Ying Xu, Yi Lu, Wei Wu*. Nanoemulsions coated with alginate/chitosan as oral insulin delivery systems: Preparation, characterization and hypoglycemic effect in rats. International Journal of Nanomedicine 2013,8: 23-32.

69. Zhongjian Chen, Yi Lu*, Jianping Qi, Wei Wu. Enhanced dissolution, stability and physicochemical characterization of ATRA/2-hydroxypropyl-β- cyclodextrin inclusion complex pellets prepared by fluid-bed coating technique. Pharmaceutical Development and Technology 2013, 18(1): 130-136.

Patents

1. Jianping Qi, Wei Wu, Xiaoyang Li, Yi Lu. Multiple nanoemulsions exteriorly coated for oral delivery of insulin. ZL 2012101296367

2. Wei Wu, Yang Lei, Yi Lu, Jianping Qi. Solid dosage forms containing poorly water-soluble drugs and preparation methods. ZL 201110085318.0

3. Yi Lu, Wei Wu, Fuxia Dong, Jianping Qi. Solid dispersions of poorly water-soluble drugs containing phospholipids and bile salts, and the preparation methods of. ZL 201010293523.1

4. Wei Wu, Li Que, Bangxin Yao, Tao Hu. Fast disintegrating and dissolving tablet containing puerarin. ZL 2004 1 0071712.9

5. Wei Wu, Hong Xia. A dripping pill containing silymarin. ZL 2003 1 0108790.7

6. Wei Wu, Jun Li, Jining Tao, Huiping Zhao, Li Que. A preparation of 5-levolunic acid hydrochloride and its preparing method. ZL 2004 1 0025169.9

7. Wei Wu, Dizheng Du, Hulin Chen, Bofeng Wu. Fast disintegrating preparation containingg paroxetine. ZL 200510025445.6