Professor Chen Jiang graduated from School of Pharmacy, Shanghai Medicine University in 1993, and obtained her Ph.D. degree in Pharmaceutical Science from Kyushu University in 2003. She joined the faculty of Fudan University thereafter and promoted to professor in 2010. She became Director of Department of Pharmaceutics, School of Pharmacy, Fudan University and Deputy Director of Key Laboratory of Smart Drug Delivery, Ministry of Education in 2011. She has published over 50 papers with over 20 appearing at Adv. Mater., J. Am. Chem. Soc. ACS Nano and Biomaterials. She has applied for 5 national patents. Prof. Jiang has received Distinguished Young Scientist Fund from National Natural Science Foundation of China in 2014. Prof. Jiang's research interests mainly cover functional materials and targeting molecules for drug delivery system targeting to brain and tumors.
Brain-targeting drug delivery system; Neurodegenerative disease; Tumor-targeting drug delivery system; Microenvironment sensitive drug delivery
Education
Ph. D. in Pharmaceutics
Apr 2000-Mar 2003 Kyushu University, Fukuoka, Japan
M. S. in Pharmaceutics
Oct 1997-Mar 2000 Kyushu University, Fukuoka, Japan
B. S. in Pharmacy
Sep 1989-Jul 1993 Shanghai Medical University, Shanghai, P.R. China
Professional Experiences
Deputy Director of Key Laboratory of Smart Drug Delivery, Ministry of Education
Jan 2012-present
Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, China
Director of Department of Pharmaceutics
Jan 2011-present
Department of Pharmaceutics, School of Pharmacy, Fudan University, China
Professor of Pharmaceutics
May 2010-present
Department of Pharmaceutics, School of Pharmacy, Fudan University, China
Associate Professor of Pharmaceutics
May 2005-May 2010
Department of Pharmaceutics, School of Pharmacy, Fudan University, China
Lecturer of Pharmaceutics
Jul 2003-May 2005
Department of Pharmaceutics, School of Pharmacy, Fudan University, China
Teaching Activities
Biopharmaceutics
Grants & Projects
Program of Shanghai Academic Research Leader
Selected Publications
1. Zhang Y, Cai K, Li C, Guo Q, Chen Q, He X, Liu L, Zhang Y, Lu Y, Chen X, Sun T, Huang Y, Cheng J, Jiang C. Macrophage-Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy. Nano Lett. 2018 Feb 23;18 (3):1908–1915.
2. He X, Chen X, Liu L, Zhang Y, Lu Y, Zhang Y, Chen Q, Ruan C, Guo Q, Li C, Sun T, Jiang C. Sequentially Triggered Nanoparticles with Tumor Penetration and Intelligent Drug Release for Pancreatic Cancer Therapy. Advanced Science 2018 Feb 26. doi: 10.1002/advs.201701070. [Epub ahead of print]
3. Sun T; Jiang XT; Wang QB; Chen QJ; Lu, YF; Liu, LS; Zhang, Y; He, X; Ruan, CH; Zhang, YJ; Guo, Q; Liu, YH; Jiang, C, Substance P mediated DGLs complexing with DACHPt for targeting therapy of glioma. ACS Appl Mater Interfaces.2017 Oct 11;9(40):34603-34617.
4. Liu L, Bi Y, Zhou M, Chen X, He X, Zhang Y, Sun T, Ruan C, Chen Q, Wang H, Jiang C. Biomimetic Human Serum Albumin Nanoparticle for Efficiently Targeting Therapy to Metastatic Breast Cancers. ACS Appl Mater Interfaces. 2017 Mar 1;9(8):7424-7435.
5. Zhang Y, Lu Y, Wang F, An S, Zhang Y, Sun T, Zhu J, Jiang C. ATP/pH Dual Responsive Nanoparticle with d-[des-Arg10 ]Kallidin Mediated Efficient In Vivo Targeting Drug Delivery. Small. 2017 Jan;13(3). doi: 10.1002/smll.201602494.
6. An S, Lu X, Zhao W, Sun T, Zhang Y, Lu Y, Jiang C.Amino Acid Metabolism Abnormity and Microenvironment Variation Mediated Targeting and Controlled Glioma Chemotherapy. Small. 2016 Oct;12(40):5633-5645.
7. Liu Y, An S, Li J, Kuang Y, He X, Guo Y, Ma H, Zhang Y, Ji B, Jiang C*. Brain-targeted co-delivery of therapeutic gene and peptide by multifunctional nanoparticles in Alzheimer's disease mice. Biomaterials. 2016 Feb;80:33-45.
8. An S, He DS, Wagner E,*and Jiang C,* Peptide-like polymers exerting effective glioma-targeted siRNA delivery and release for therapeutic application. Small, 2015 Oct;11(38):5142-50.
9. Cai K, He X, Song Z, Yin Q, Zhang Y, Uckun FM, Jiang C*, Cheng J*. Dimeric drug polymeric nanoparticles with exceptionally high drug loading and quantitative loading efficiency. J Am Chem Soc. 2015 Mar 18;137(10):3458-61.
10. An S, Jiang XT, Shi J, He X, Li JF, Guo Y, Zhang Y, Ma HJ, Lu YF, Jiang C*, Single-component self-assembled RNAi nanoparticles functionalized with tumor-targeting iNGR delivering abundant siRNA for efficient glioma therapy. Biomaterials, 2015 June, 53: 330–340.
11. Shao K, Ding N, Huang S, Ren S, Zhang Y, Kuang Y, Guo Y, Ma H, An S, Li Y,Jiang C*. Smart Nanodevice Combined Tumor-Specific Vector with Cellular Microenvironment-Triggered Property for Highly Effective Antiglioma Therapy. ACS Nano. 2014 Feb 25;8(2):1191-203.
12. Han L; Liu MM; Ye DY; Zhang N; Lim Ed; Lu J; Jiang C*, Tumor cell membrane-targeting pH-dependent electron donor-acceptor fluorescence systems with low background signals. Biomaterials. 2014 Mar;35(9):2952-60.
13. Li JF, Guo YB, Kuang YY, An S, Ma HJ, Jiang C*, Choline-derivate modified co-delivery system for Glioma therapy. Biomaterials. 2013 Dec;34(36):9142-8
14. An S; Kuang YY; Li JF; Ma HJ; Guo YB; He X; Jiang C*; Brain-targeting delivery for RNAi neuroprotection against cerebral ischemia reperfusion injury. Biomaterials. 2013 34(35):8949-59.
15. Han L, Guo Y, Ma H, He X, Kuang Y, Zhang N, Lim Ed, Zhou WJ, Jiang C*. Acid Active Receptor-Specific Peptide Ligand for In Vivo Tumor-Targeted Delivery, Small, 2013 Nov 11;9(21):3647-58.
16. Huang SX, Shao K, Liu Y, Kuang YY, Li JF, An S, Guo Y, Ma HJ, Jiang C*, Tumor Targeting and Microenvironment Responsive Smart Nanoparticles for Combination Therapy of Anti-Angiogenesis and Apoptosis. ACS Nano. 2013 Mar 26;7(3):2860-71.
