Dr. Qi-zhi Zhang obtained her Ph.D. in Pharmaceutics from Fudan University in 2003. She has been a professor at the Department of Pharmaceutics, Fudan University since 2012. She is also an editorial board member of Chinese Pharmaceutical journal, Committee member of Shanghai Pharmaceutical Association. Research interests include increasing the therapeutic effects of drugs to Alzheimer's disease and brain metastasis by using mutli-functioned nanoparticles through systemic administration, industrialization of nano preparation, and development of new preparations via nasal route. Dr. Zhang has composed 8 books and published 53 papers in Sci. She has applied 10 invention patents, 2 of which were certificated. She has been awarded the Natural Science Award of Ministry of Education and Shanghai.
CNS drug delivery; Intranasal drug delivery; Alzheimer’s disease; Metastatic encephaloma; Albumin nano-injection
Education
1988.9-1992.7 School of Pharmacy, West China University of Medical Science
Specialty: Medicinal Chemistry. Degree: BS
1994.9-1997.7 School of Pharmacy, West China University of Medical Science
Specialty: Pharmaceutics. Degree: Master
1999.9-2003.7 School of Pharmacy, Fudan University
Specialty: Pharmaceutics. Degree: Ph.D
Professional Experiences
1992.7-1994.8 Assistant Engineer, The sixth pharmaceutical factory, Chongqing
2008.7-2009.7 Scientist, Hong Kong Comprehensive Drug Enterprises Ltd
1997.7-2005.5 Lecturer, School of Pharmacy, Fudan University
2005.5-2012.12 Associate professor, School of Pharmacy, Fudan University
2013.1-present Professor, School of Pharmacy, Fudan University
Teaching Activities
《Pharmaceutics I》(undergraduate class, Excellent courses in Shanghai)
《Industrial pharmacy》 (postgraduate course)
《Progress in pharmacokinetics》(postgraduate course)
《Frontiers of pharmaceutical development》(postgraduate course)
Grants & Projects
1. National Natural Science Foundation, Brain neuron-targeted nano delivery system for the combination therapy of Alzheimer’s disease targeting both ?-amyloid and tau protein (No. 81473150), 2015.1-2018.12, PI
2. National Natural Science Foundation, Dual functional ligands conjugated drug delivery system for the treatment of Alzheimer’s disease (No. 81273461), 2013.1-2016.12, PI
3. National Natural Science Foundation, Wheat germ agglutinin-decorated nanoparticles for peptide/protein delivery into brain following intranasal administration (No. 30772657), 2008.1-2010.12, PI
4. Special Project for Nano-technology from Shanghai, Design of albumin nanoparticle delivery system for antitumor drugs of tinib type and its key preparation technology (No.12nm0501500), 2012.10-2015.6, PI
Awards & Honors
1. 2017.11, “Basic and clinical research for new drugs targeting Alzheimer's disease and its early intervention strategies” was awarded “First Prize for Science & technology Development/ Achievement of Shanghai” (ranked fourteenth)
2. 2016.12, Project “Study of brain tumor targeting drug delivery” was awarded “Second Prize of Natural Science of the Ministry of Education” (ranked fifth)
3. 2016.12, Project “Study of brain tumor targeting drug delivery” was awarded “Second Prize of Natural Science of Shanghai” (ranked fifth)
4. 2011.1, Project “Investigations on novel targeting drug delivery systems for brain major diseases” was awarded “First Prize of Natural Science of the Ministry of Education” (ranked third)
5. 2010.11, Project “Investigations on novel targeting drug delivery systems for brain major diseases” was awarded “Second Prize of Natural Science of Shanghai” (ranked third)
Invited Presentations
1. Dual-functional nanoparticles as a biomacromolecule delivery system for Alzheimer's disease therapy, The 11th Chinese Pharmaceutical Conference 2017
2. Dual-targeted delivery system for the treatment of Alzheimer's disease, Yangtze River Delta Pharmaceutical Development Forum 2014
Selected Publications
1. Wang P, Zheng X, Guo Q, Yang P, Pang X, Qian K, Lu W, Zhang QZ*, Jiang X. Systemic delivery of BACE1 siRNA through neuron-targeted nanocomplexes for treatment of Alzheimer's disease. J Control Release, 2018, 279: 220-233
2. Zheng X, Zhang C, Guo Q, Wan X, Shao X, Liu Q, Zhang QZ*. Dual-functional nanoparticles for precise drug delivery to Alzheimer's disease lesions: Targeting mechanisms, pharmacodynamics and safety. Int J Pharm, 2017, 525: 237-248.
3. Zheng XY, Pang XY, Yang P, Wan X, Wei Y, Guo Q, Zhang QZ*, Jiang XG. A hybrid siRNA delivery complex for enhanced brain penetration and precise amyloid plaque targeting in Alzheimer's disease mice. Acta Biomaterialia, 2017, 49: 388-401.
4. Wan X, Zheng X, Pang X, Pang Z, Zhao J, Zhang Z, Jiang T, Xu W, Zhang QZ*, Jiang X. Lapatinib-loaded human serum albumin nanoparticles for the prevention and treatment of triple-negative breast cancer metastasis to the brain. Oncotarget, 2016, 7: 34038-34051
5. Zhang C, Liu QF, Shao XY, Qian Y, Zhang QZ*. Phage-displayed peptide-conjugated biodegradable nanoparticles enhanced brain drug delivery. Materials letters, 2016,167, 213-217
6. Wan X, Zheng XY, Pang XY, Zhang ZM, Zhang QZ*. Incorporation of lapatinib into human serum albumin nanoparticles with enhanced anti-tumor effects in HER2-positive breast cancer. Colloids Surf B Biointerfaces, 2015, 136: 817-827
7. Zheng XY, Shao XY, Zhang C, Tan YZ, Liu QF, Wan X, Zhang QZ*, Xu SM, Jiang XG. Intranasal H102 peptide-loaded liposomes for brain delivery to treat Alzheimer's Disease. Pharm Res, 2015, 32: 3837-3849
8. Liu QF, Zheng XY, Zhang C, Shao XY, Zhang X, Zhang QZ*, Jiang XG. Conjugating influenza a (H1N1) antigen to n-trimethylaminoethylmethacrylate chitosan nanoparticles improves the immunogenicity of the antigen after nasal administration. J Med Virol, 2015, 87: 1807-1815
9. Wan X, Zheng X, Pang X, Zhang Z, Jing T, Xu W, Zhang QZ*. The potential use of lapatinib-loaded human serum albumin nanoparticles in the treatment of triple-negative breast cancer. Int J Pharm, 2015, 484:16-28.
10. Liu QF, Zheng XY, Zhang C, Shao XY, Zhang X, Zhang QZ*, Jiang XG. Antigen-conjugated N-trimethylaminoethylmethacrylate chitosan nanoparticles induce strong immune responses after nasal administration. Pharm Res, 2015, 32(1): 22-36
11. Zhang C, Zheng XY, Wan X, Shao XY, Liu QF, Zhang ZM, Zhang QZ*. The potential use of H102 peptide-loaded dual-functional nanoparticles in the treatment of Alzheimer's disease. J Control Release, 2014, 192: 317-324
12. Zhang C, Wan X, Zheng XY, Shao XY, Liu QF, Zhang QZ*, Qian Y. Dual-functional nanoparticles targeting amyloid plaques in the brains of Alzheimer's disease mice. Biomaterials, 2014, 35: 456-465
13. Zhang C, Chen J, Feng CC, Shao XY, Liu QF, Zhang QZ*, Pang ZQ, Jiang XG. Intranasal nanoparticles of basic fibroblast growth factor for brain delivery to treat Alzheimer's disease. Int J Pharm, 2014, 461: 192-202
14. Liu QF, Zhang C, Zheng XY, Shao XY, Zhang X, Zhang QZ*, Jiang XG. Preparation and evaluation of antigen/N-trimethylaminoethylmethacrylate chitosan conjugates for nasal immunization. Vaccine, 2014, 32: 2582-2590
15. Shao XY, Liu QF, Zhang C, Zheng XY, Chen J, Zha Y, Qian Y, Zhang X, Zhang QZ*, Jiang XG. Concanavalin A-conjugated poly(ethylene glycol)-poly(lactic acid) nanoparticles for intranasal drug delivery to the cervical lymph nodes. J Microencapsul, 2013, 30: 780-786
16. Li JW, Zhang C, Li J, Fan L, Jiang XG, Chen J, Pang ZQ, Zhang QZ*. Brain Delivery of NAP with PEG-PLGA Nanoparticles Modified with Phage Display Peptides. Pharm Res, 2013, 30: 1813-1823
17. Qian Y, Zha Y, Feng B, Pang ZQ, Zhang B, Sun XY, Ren JF, Zhang C, Shao XY, Zhang QZ*, Jiang XG. PEGylated poly(2-(dimethylamino) ethyl methacrylate)/DNA polyplex micelles decorated with phage-displayed TGN peptide for brain-targeted gene delivery. Biomaterials, 2013, 34: 2117~2129
18. Gao HL, Qian J, Yang Z, Pang ZQ, Xi ZJ, Cao SL, Wang YC, Pan SQ, Zhang S, Wang W, Jiang XG, Zhang QZ*. Whole-cell SELEX aptamer-functionalised poly(ethyleneglycol)-poly(ε-caprolactone) nanoparticles for enhanced targeted glioblastoma therapy. Biomaterials, 2012, 33: 6264-6272.
19. Gao HL, Qian J, Cao SL, Yang Z, Pang ZQ, Pan SQ, Fan L, Xi ZJ, Jiang XG, Zhang QZ*. Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles. Biomaterials, 2012, 33: 5115-5123
Patents
1. Zhang QZ, Liu QF, Zheng XY, Shao XY, Jiang XG. Nasal immune vector based on antigen covalently conjugate to chitosan nanoparticles. ZL 201310278891.2
2. Zhang QZ, Qian Y, Jiang XG. Brain-targeted gene delivery system based on polymethacrylate. ZL 201210306885.9
3. Zhang QZ, Jiang XG. Nimodipine gel for intranasal administration. ZL200510023273.9
