Dr. Jun Chen obtained his Ph.D. from Fudan University in 2005. He is now a professor and Ph. D. supervisor in Department of Pharmaceutics, School of Pharmacy, Fudan University. His research interests focused on the brain and tumor targeting delivery system. He has worked as the principal investigator of 3 projects from National Nature Science Foundation of China and 2 projects from Science and Technology Commission of Shanghai Municipality. He served as a reviewer for the pharmaceutical science journals including ACS Nano, Biomaterials, Molecular Pharmaceutics, Pharmaceutical Research and International Journal of Pharmaceutics. He has now published over 80 research articles including more than 30 first/corresponding author ones, some of which in the first-class journals in the field of pharmaceutical science. He is co-editor of an academic book, and owns two licensed patents. In 2012, he won Program for New Century Excellent Talents in University and Chinese Pharmaceutical Association-Shijiazhuang Yong Pharmaceutics Scientist Awards.
Targeting drug delivery system; Tumor targeting; Cancer immunotherapy; Bio-inspired drug delivery system; Pharmacokinetics
Education
1993-1997, B.S. in Pharmacy, Shanghai Medical University, Shanghai, P.R. China
1999-2005, Ph.D. in Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, P.R. China.
Professional Experiences
1997.7-2001.12, Research Assistant, Department of Pharmaceutical analysis, School of Pharmacy, Fudan University, Shanghai, P.R. China.
2002.1-2008.11, Lecturer, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, P.R. China.
2008.12-2014.12, Associate Professor, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, P.R. China.
2015.1-presnt, Professor, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, P.R. China.
Teaching Activities
Pharmacokinetics, Biopharmaceutics and Pharmacokinetics
Grants & Projects
1. Neutrophile membrane-functionalized biomimetic nanoparticles for circulating tumor cells and pre-metastatic niche targeting therapy, National Natural Science Foundation of China (81673019, 2017.1-2020.12)
2. Porphyrin-poly-(ε-caprolactone) nanoparticles as photodynamic and chemotherapeutic drug delivery systems for targeting multi-modal cancer therapy, National Natural Science Foundation of China (81373353, 2014.01-2017.12 )
3. The microfluidic chips based platform for brain targeting delivery, National Natural Science Foundation of China (81072592, 2011.01-2013.12 )
4. Aptamer-functionalized PEG-PLGA cubosome for tumor targeting, National Natural Science Foundation of China (30801439, 2009.01-2011.12 )
Awards & Honors
1. The basic and clinical study of new targeting drugs and early diagnosis/intervention strategy for Alzheimer's disease. Shanghai Science and Technology Progress Award. (First prize, rank 8/15, 2017/11/16).
2. Study on brain tumor targeting drug delivery system. Natural Science Award of Ministry of Education. (Second prize, rank 4/7, 2017/02/22).
3. Study on brain tumor targeting drug delivery system. Shanghai Science and Technology Progress Award. (Second prize, rank 4/6, 2016/11/25).
4. Mentor of Shanghai Graduate Outstanding Achievements (Thesis, Master graduate student: Hu Quanyin, 2016/06).
5. Mentor of Shanghai Graduate Outstanding Achievements (Thesis, Master graduate student: Gu Guangzhi, 2015/05).
6. Mentor of Shanghai Graduate Outstanding Achievements (Thesis, Master graduate student: Xia Huimin, 2014/04).
7. Program for New Century Excellent Talents in University (2012/12/26).
8. Chinese Pharmaceutical Association–Shijiazhuang Pharmaceutical Group Yong Pharmaceutics Scientist Awards (2012/12).
9. Lectin-conjugated nanoparticles for drug delivery into brain following intranasal administration. Science and Technology Progress Award. (Second prize, rank 5/8, 2010/08/01).
Selected Publications
1. Kang Ting, Huang Yukun, Zhu Qianqian, Cheng Hao, Pei Yuanyuan, Feng Jingxian, Xu Minjun, Jiang Gan, Song Qingxiang, Jiang Tianze, Chen Hongzhuan, Gao Xiaoling*, Chen Jun*，Necroptotic Cancer Cells-Mimicry Nanovaccine Boosts Anti-tumor Immunity with Tailored Immune-stimulatory Modality[J]. Biomaterials. DOI: 10.1016/j.biomaterials.2018.02.033 (IF:8.402)
2. Kang Ting, Zhu Qianqian, Wei Dan, Feng Jingxian, Yao Jianhui, Jiang Tianze, Song Qingxiang, Wei Xunbin, Chen Hongzhuan, Gao Xiaoling *, Chen Jun *，Nanoparticles Coated with Neutrophil Membranes Can Effectively Treat Cancer Metastasis[J]. ACS Nano. 2017, 11, 1397-1411 (IF: 13.94)
3. Yao Jianhui, Feng Jingxian, Gao Xiaoling, Wei Dan, Kang Ting, Zhu Qianqian, Jiang Tianze, Wei Xunbin, Chen Jun*，Neovasculature and circulating tumor cells dual-targeting nanoparticles for the treatment of the highly-invasive breast cancer[J]. Biomaterials. 2017, 113:1-17 (IF:8.402)
4. Jiang Di , Gao Xiaoling, Kang Ting, Feng Xingye, YaoJianhui, Yang Mengshi, Jing Yixian, ZhuQianqian, Feng Jingxian, Chen Jun*, Actively targeting D-α-tocopheryl polyethylene glycol 1000 succinatepoly(lactic acid) nanoparticles as vesicles for chemo-photodynamic combination therapy of doxorubicin-resistant breast cancer[J]. Nanoscale. 2016, 8:3100-3118. (IF: 7.53)
5. Feng Xingye, Yao Jianhui, Gao Xiaoling, Jing Yixian, Kang Ting, Jiang Di, Jiang Tianze, Feng Jingxian, Zhu Qianqian, Jiang Xinguo, Chen Jun *, Multitargeting Peptide-Functionalized Nanoparticles Recognized Vasculogenic Mimicry, Tumor Neovasculature, and Glioma Cells for Enhanced Anti-glioma Therapy[J]. ACS Applied Materials ＆ Interfaces. 2015, 7:27885-27899 (IF:7.145)
6. Kang Ting, Zhu Qianqian, Jiang Di, Feng Xingye, Feng Jingxian, Jiang Tianze, Yao Jianhui, Jing Yixian, Song Qingxiang, Jiang Xinguo，Gao Xiaoling*, Chen Jun*，Synergistic targeting Tenascin C and neuropilin-1 for specific penetration of nanoparticles for anti-glioblastoma treatment[J]. Biomaterials. 2016, 101:60-75 (IF:8.387)
7. Feng Xingye, Jiang Di, Ting Kang, Yao Jianhui, Jing Yixian, Jiang Tianze, Feng Jingxian, Zhu Qianqian, Song Qingxiang, Dong Nan, Gao Xiaoling,* Chen Jun *，Tumor-Homing and Penetrating Peptide-Functionalized Photosensitizer-Conjugated PEG-PLA Nanoparticles for Chemo-Photodynamic Combination Therapy of Drug-Resistant Cancer. ACS Applied Materials ＆ Interfaces. 2016, 8: 17817?17832 (IF:7.145)
8. Hu Quanyin, Kang Ting, Feng Jingxian, Zhu Qianqian, Jiang Tianze, Yao Jianhui, Jiang Xinguo, Chen Jun*. Tumor Microenvironment and Angiogenic Blood Vessels Dual-Targeting for Enhanced Anti-Glioma Therapy. ACS Applied Materials ＆ Interfaces. 2016, 8: 23568?23579 (IF:7.145)
9. Feng Xingye, Gao Xiaoling, Kang Ting, Jiang Di, Yao Jianhui, Jing Yixian, Song Qingxiang, Jiang Xinguo, Liang Jianying*, Chen Jun*, Mammary-Derived Growth Inhibitor Targeting Peptide-Modified PEG-PLA Nanoparticles for Enhanced Targeted Glioblastoma Therapy[J]. Bioconjugate Chem. 2015, 26:1850-1861 (IF:4.513)
10. Kang Ting, Jiang Mengyin, Jiang Di, Feng Xingye, Yao Jianhui, Song Qingxiang, Chen Hongzhuan, Gao Xiaoling*, Chen Jun*, Enhancing Glioblastoma-Specific Penetration by Functionalization of Nanoparticles with an Iron-Mimic Peptide Targeting Transferrin/Transferrin Receptor Complex[J]. Molecular Pharmaceutics. 2015, 12:2947-2961 (IF:4.384)
11. Kang Ting, Gao Xiaoling, Hu Quanyin, Jiang Di, Feng Xingye, Zhang Xue, Song Qingxiang, Yao Lei, Huang Meng, Jiang Xinguo, Pang Zhiqing, Chen Hongzhuan, Chen Jun*, iNGR-modified PEG-PLGA nanoparticles that recognize tumor vasculature and penetrate gliomas[J]. Biomaterials. 2014, 35:4319-4332 (IF:8.312)
12. Miao Deyu, Jiang Mengyin, Liu Zhongyang, Gu Guangzhi, Hu Quanyin, Kang Ting, Song Qingxiang, Yao Lei, Li Wei, Gao Xiaoling,* Sun Mingjiang, Chen Jun *, Co-administration of Dual-Targeting Nanoparticles with Penetration Enhancement Peptide for Antiglioblastoma Therapy[J]. Mol. Pharmaceutics. 2014, 11:90?101. (IF: 4.787)
13. Guangzhi Gu, Quanyin Hu, Xingye Feng, Xiaoling Gao, Jiang Menglin, Ting Kang , Di Jiang, Qingxiang Song, Hongzhuan Chen, Jun Chen *, PEG-PLA nanoparticles modified with APTEDB peptide for enhanced anti-angiogenic and anti-glioma therapy[J]. Biomaterials. 2014, 35:8215-8226. (IF:8.312)
14. Gu Guangzhi, Gao Xiaoling, Hu Quanyin, Kang Ting, Liu Zhongyang, Jiang Mengyin, Miao Deyu, Song Qingxiang, Yao Lei, Tu Yifan, Pang Zhiqing, Chen Hongzhuan, Jiang Xinguo, Chen Jun *, The influence of the penetrating peptide iRGD on the effect of paclitaxel-loaded MT1-AF7p-conjugated nanoparticles on glioma cells[J]. Biomaterials. 2013, 34:5138-5148 (IF:7.604)
15. Hu Quanyin, Gao Xiaoling, Gu Guangzhi, Kang Ting, Tu Yifan, Liu Zhongyang, Song Qingxiang, Yao Lei, Pang Zhiqing, Jiang Xinguo, Chen Hongzhuan , Chen Jun*, Glioma therapy using tumor homing and penetrating peptide functionalized PEG-PLA nanoparticles loaded with paclitaxel[J]. Biomaterials. 2013, 34(22):5640-5650 (IF:7.604)
16. Hu Quanyin, Gao Xiaoling, Kang Ting, Feng Xingye, Jiang Di, Tu Yifan, Song Qingxiang, Yao Lei, Jiang Xinguo, Chen Hongzhuan, Chen Jun*, CGKRK-modified nanoparticles for dual-targeting drug delivery to tumor cells and angiogenic blood vessels. Biomaterials, 2013, 34: 9496-9508 (IF:7.604)
17. Gu Guangzhi, Xia Huimin, Hu Quanyin, Liu Zhongyang, Jiang Mengyin, Kang Ting, Miao Deyu, Tu Yifan, Pang Zhiqing, Song Qingxiang, Yao Lei, Chen Hongzhuan, Gao Xiaoling*, Chen Jun*, PEG-co-PCL nanoparticles modified with MMP-2/9 activatable low molecular weight protamine for enhanced targeted glioblastoma therapy[J]. Biomaterials. 2013,34(1): 196-208. (IF:7.604)
18. Hu Quanyin, Gu Guangzhi, Liu Zhongyang, Jiang Mengyin, Kang Ting, Miao Deyu, Tu Yifan, Pang Zhiqing, Song Qingxiang, Yao Lei, Xia Huimin, Chen Hongzhuan, Jiang Xinguo, Gao Xiaoling*, Chen Jun*, F3 peptide-functionalized PEG-PLA nanoparticles co-administrated with tLyp-1 peptide for anti-glioma drug delivery[J]. Biomaterials. 2013,34(4): 1135-1145. (IF:7.604)
19. Liu Zhongyang, Jiang Mengyin, Kang Ting, Miao Deyu, Gu Guangzhi, Song Qingxiang, Yao Lei, Hu Quanyin, Tu Yifan, Pang Zhiqing, Chen Hongzhuan, Jiang Xinguo, Gao Xiaoling*, Chen Jun*, Lactoferrin-modified PEG-co-PCL nanoparticles for enhanced brain delivery of NAP peptide following intranasal administration[J]. Biomaterials. 2013,34(15): 3870-3881. (IF:7.604)
20. Liu Zhongyang, Gao Xiaoling, Kang Ting, Jiang Mengyin, Miao Deyu, Gu Guangzhi, Hu Quanyin, Song Qingxiang, Yao Lei, Tu Yifan, Chen Hongzhuan, Jiang Xinguo, , Chen Jun*, B6 peptide-modified PEG-PLA nanoparticles for enhanced brain delivery of neuroprotective peptide[J]. Bioconjug Chem, 2013;24(6):997-1007. (IF:4.58)
