Dr. Gang Wei obtained his Ph.D. from Shenyang Pharmaceutical University in 2002. In the same year, he joined School of Pharmacy, Fudan University as a postdoc fellow, and two years later he worked there as a faculty member. Dr. Wei was promoted to associate professor in 2007, and now is the vice director of Pharmaceutics Department. He is also an editorial board member of Chinese Journal of Pharmaceutics and young editor of Acta Pharmacologica Sinica.
Mucous Membrane Drug Delivery, Modification and Delivery of Biomacromolecules
Education
1997 – 2002 Ph.D. in Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, P.R. China
1992 – 1996 B.S. in Pharmacy, Tianjin Medical University, Tianjin, P.R. China
Professional Experiences
2016-present Professor of Pharmaceutics, Department of Pharmaceutics, School of Pharmacy, Fudan University
2013-present Deputy Director, Department of Pharmaceutics, School of Pharmacy, Fudan University
2008-2009 Visiting Scholar, Institute of Human Virology, School of Medicine, University of Maryland, USA
2007-2016 Associate Professor of Pharmaceutics, Department of Pharmaceutics, School of Pharmacy, Fudan University
2004-2007 Lecturer of Pharmaceutics, Department of Pharmaceutics, School of Pharmacy, Fudan University
2002-2004 Postdoctoral Fellow, Department of Pharmaceutics, School of Pharmacy, Fudan University
Teaching Activities
Introduction to Pharmaceutics for undergraduates
Biopharmaceutics and Pharmacokinetics for undergraduates
Modification and Delivery of Peptides and Proteins for postgraduates
Targeted Drug Delivery Systems for postgraduates
Physical Pharmacy for undergraduates and postgraduates
Polymers in Pharmaceutics for undergraduates
Grants & Projects
1. Self-assembled oligonucleotide delivery system constructed by flexible multivalent stapled peptide for the treatment of age-related macular degeneration. National Natural Science Foundation of China, No. 81573358, 2015-2019. Role: PI
2. Synergetic antagonists of TGF-β co-delivery targeting to anterior segment of eye mediated by dual-penetrating enhancement mechanisms. National Natural Science Foundation of China, No. 81172994, 2012-2015. Role: PI
3. Studies on novel dosage forms of topical contraception. Sub-project of National Science and Technology Support Program, No. 2012BAI31B04, 2012-2015. Role: PI
4. Studies on the druggability of novel NF-κB inhibitory peptide for oncotherapy. Key Project from Shanghai Committee of Science and Technology, No. 11431921200, 2011-2014. Role: Co-PI
Awards & Honors
2014 “Excellent Young Scientist” by Chinese Pharmaceutical Association
Selected Publications
1. Kuan Jiang, Xin Gao, Qing Shen, Changyou Zhan, Yanyu Zhang, Cao Xie, Gang Wei*, Weiyue Lu. Discerning the composition of penetratin for safe penetration from cornea to retina. Acta Biomater., 2017, 63: 123-134
2. Lingyu Tai, Chang Liu, Kuan Jiang, Xishan Chen, Linglin Feng, Weisan Pan*, Gang Wei*, Weiyue Lu. A novel penetratin-modified complex for noninvasive intraocular delivery of antisense oligonucleotides. Int J Pharmaceut., 2017, 529: 347–356
3. Lingyu Tai, Chang Liu, Kuan Jiang, Xishan Chen, Gang Wei*, Weiyue Lu, Weisan Pan*. Noninvasive delivery of oligonucleotide by penetratin- modified polyplexes to inhibit protein expression of intraocular tumor. Nanomedicine: NBM., 2017, 13: 2091-2100
4. Yu Liu#, Fujin Yang#, Linglin Feng, Long Yang, Lingyun Chen, Gang Wei*, Weiyue Lu. In vivo retention of poloxamer-based in situ hydrogels for vaginal application in mouse and rat models. Acta Pharmaceutica Sinica B, 2017, 7(4): 502–509
5. Chang Liu#, Kuan Jiang#, Lingyu Tai, Yu Liu, Gang Wei*, Weiyue Lu, and Weisan Pan. Facile Noninvasive Retina Gene Delivery Enabled by Penetratin. ACS Appl. Mater. Interfaces, 2016, 8 (30): 19256–19267
6. Li Zhang, Yanyu Zhang, Lingyu Tai, Kuan Jiang, Cao Xie, Zhuoquan Li, Yao-Zhong Lin, Gang Wei*, Weiyue Lu, Weisan Pan. Functionalized cell nucleus-penetrating peptide combined with doxorubicin for synergistic treatment of glioma. Acta Biomater., 2016, 42: 90-101
7. Li Zhang#, Wenjia Shen#, Jiabin Luan, Dongxiao Yang, Gang Wei*, Lin Yu*, Weiyue Lu, Jiandong Ding. Sustained intravitreal delivery of dexamethasone using an injectable and biodegradable thermogel. Acta Biomater., 2015, 23: 271-281
8. Liu C, Tai LY, Zhang WJ, Wei G*, Pan WS, Lu WY. Penetratin, a potentially powerful absorption enhancer for noninvasive intraocular drug delivery. Mol Pharm., 2014, 11(4): 1218-1227.
9. Zhang WJ, Wang Y, Lee BTK, Liu C, Wei G*, Lu WY. A novel nanoscale-dispersed eye ointment for the treatment of dry eye disease. Nanotechnology, 2014, 25: 125101.
10. Liu XL, Liu C, Zhang WJ, Xie C, Wei G*, Lu WY. Oligoarginine- modified biodegradable nanoparticles improve the intestinal absorption of insulin. Int J Pharmaceut., 2013, 448(1), 159-167.
Patents
1. Wei G, Liu XL, Zhang WJ, Liu C, Lu WY. Cell penetrating peptide-modified nanoparticle and its preparation method. ZL201110268168.7
2. Liu Y, Lu WY, Wei G. Thermosensitive bioadhesive in situ forming gel for vaginal application. ZL200810200716.0
3. Wei G, Lu WY, Li C, Xie C. Bioadhesive ophthalmic liposome and its preparation method. ZL200810042942.0
4. Lu WY, Wei G, Jin L. Long-lasting thymopentin implant and its preparation method. ZL200710043570.9
5. Wei G, Jiang K, Lu WY, Gao X. Delivery system for Biomacromolecules based on multivalence cell-penetrating peptides. 2017107868803 (Pending)
6. Wei G, Jiang K, Lu WY, Liu C, Tai LY. Lipophilic derivatives based on wild type penetratin. 2017104143347 (Pending)
7. Bo Liang, Wei G. Pharmaceutical formulations that form gel in situ. PCT/US2016/058722 (Pending)
8. Wei G, Yang FJ, Lu WY, Feng LL, Liu Y, Yang L, Chen L. A nonoxinol- loaded thermosensitive hydrogel and its preparation method. 201410572393.3 (Pending)
9. Wei G, Benjamin TK Lee, Zhang WJ, Lu WY, Johnson YN Lau, Shun CD Lam. Ophthalmic composition, method for preparing the same, and use of the same. PCT/CN2013/073259 (Pending)
