Dr. Xian-Yi Sha obtained his Ph.D. from Fudan University in 2005. Dr Sha joined School of Pharmacy, Fudan University in 2005 as a lecturer in the Department of Pharmaceutics. He completed a postdoctoral fellowship in Karmanos Cancer Institute (2007-2008). Dr. Sha was promoted to associate professor in 2009. Dr. Sha was selected Shanghai Rising Star in 2010. Dr. Sha’s research in the past few years mainly focuses on the development of multifunctional micelle drug delivery for therapy of MDR cancer and the core-shell ternary complexes system based on electrostatically adsorbed coatings strategy for gene/drug efficient delivery. Starting from 2005, Dr. Sha has published over 40 peer-reviewed papers, which have received a total citation of >1000 times.
Drug delivery; Nanoparticle; MDR; Gene delivery
Education
2002.9-2005.6: Ph.D, Department of Pharmaceutics, School of Pharmacy, Fudan University
Professional Experiences
2017.12-Present: Professor, Ph.D supervisor, Department of Pharmaceutics, School of Pharmacy, Fudan University
2015.10-2016.10: Inspector (serve temporary position), Center for Drug Certification and Evaluation, Shanghai Municipal Food and Drug Administration
2009.12-2017.11: Associate Professor, Department of Pharmaceutics, School of Pharmacy, Fudan University
2007.2-2008.8: Postdoctoral, Karmanos Cancer Institute, America
2005.7-2009.11: Lecturer, Department of Pharmaceutics, School of Pharmacy, Fudan University
Teaching Activities
Responsible for teaching the course of Polymers in Pharmaceutics for undergraduates and two professional courses of Advanced pharmaceutics and Drug delivery materials for graduates.
Grants & Projects（latest 5 yrs）
1. National Natural Science Foundation: Ambroxol Modulates Autophagy in Tumor Cells and Promotes the Effect of Alveolar Surfactant in Chemotherapy and Mechanism of Lung Cancer, 2018.1-2021.12, Principle Investigator.
2. National Natural Science Foundation: CQ induces autophagic death of Fe3O4 nanoclusters combined with hyperthermia for tumor therapy and mechanism of action, 2016.1-2019.12, Principle Investigator.
3. Shanghai Science and Technology Commission Project: Study on Nasal Inhalation Preparations of Effective constituent of Artemisia for Viral Infectious Diseases, 2015.7-2018.9, Principle Investigator.
4. National Natural Science Foundation -Xinjiang joint fund key projects: Study on Substance Basis and Mechanism of Antiretroviral Activity of Xinjiang Artemisia,2014.1-2017.12, Co-Principle Investigator.
5. National Natural Science Foundation: D-type IC-8 Peptide Modified Reducing Dendritic RHB Self-assembled Double Targeted Nucleic Acid Delivery Vector, 2013.1-2016.12, Principle Investigator.
Awards & Honors
Shanghai Young Rising-Star; Sanofi Youth Biopharmaceutical Award of Chinese Pharmaceutical Association; Merck Award for Teaching Merit.
Memberships
A member of the Committee of Chinese Medicine in Shanghai Pharmaceutical Association, the review expert of Shanghai Pudong Science and Technology Commission project.
Selected Publications（latest 5 yrs）
1. Gu Jijin, Chen Xinyi, Fang Xiaoling, Sha Xianyi*. Retro-inverso d-peptide-modified hyaluronic acid/bioreducible hyperbranched poly (amido amine)/pDNA core-shell ternary nanoparticles for the dual-targeted delivery of short hairpin RNA-encoding plasmids. Acta Biomater 2017, 57:156-169.
2. Zhang Xiulei, Chen Qinyue, Chen M, Ren Xiaoqing, Wang Xiaofei, Qian Jianghui, Sun Yajuan, Sha Xianyi*. Ambroxol enhances anti-cancer effect of microtubule-stabilizing drug to lung carcinoma through blocking autophagic flux in lysosome-dependent way. Am J Cancer Res. 2017, 7(12):2406-2421.
3. Gu Jijin, Chen Xinyi, Ren Xiaoqing, Zhang Xiulei, Fang Xiaoling, Sha Xianyi*. CD44-Targeted Hyaluronic Acid-Coated Redox-Responsive Hyperbranched Poly(amido amine)/Plasmid DNA Ternary Nanoassemblies for Efficient Gene Delivery. Bioconjugate Chemistry 2016, 27:1723?1736.
4. Ren Xiaoqing, Zheng Rui, Fang Xiaoling, Yang Wuli*, Sha Xianyi*. Red blood cell membrane camouflaged magnetic nanoclusters for imaging-guided photothermal therapy. Biomaterials 2016,92:13-24.
5. Liang Huihui, Ren Xiaoqing, Qian Jianghui, Zhang Xiulei, Meng Lin, Wang Xiaofei, Li Lei, Fang Xiaoling, Sha Xianyi*. Size-Shifting Micelle Nanoclusters Based on a Cross-Linked and pH-Sensitive Framework for Enhanced Tumor Targeting and Deep Penetration Features. ACS Appl Mater Interfaces 2016, 8(16):10136-46.
6. Gu Jijin, Hao Junguo, Fang Xiaoling, Sha Xianyi*. Factors influencing the transfection efficiency and cellular uptake mechanisms of Pluronic P123-modified polypropyleneimine/pDNA polyplexes in multidrug resistant breast cancer cells. Colloids Surf B Biointerfaces 2016, 140(1):83-93.
7. Zhang Xiaoyan, Wang Xiaofei, Zhong Weitong, Ren Xiaoqing, Sha Xianyi*, Fang Xiaoling*. Matrix metalloproteinases-2/9-sensitive peptide-conjugated polymer micelles for site-specific release of drugs and enhancing tumor accumulation: preparation and in vitro and in vivo evaluation. Int J Nanomedicine 2016, 11:1643-61.
8. Fan Zhuoyang, Chen Cheng, Pang Xiaoying, Yu Zhou, Qi Yan, Chen Xinyi, Liang Huihui, Sha Xianyi*. Adding Vitamin E-TPGS to the Formulation of Genexol-PM: Specially Mixed Micelles Improve Drug-Loading Ability and Cytotoxicity against Multidrug-Resistant Tumors Significantly. PLoS One 2015, 10(4):e0120129.
9. Gu Jijin, Hao Junguo, Fang Xiaoling, Sha Xianyi*. Reversal of P-glycoprotein-mediated multidrug resistance by CD44 antibody-targeted nanocomplexes for short hairpin RNA-encoding plasmid DNA delivery. Biomaterials, 2015 45: 99-114.
10. Gu Jijin, Chen Xinyi, Xin Hongliang, Fang Xiaoling, Sha Xianyi*. Serum-resistant complex nanoparticles functionalized with imidazole-rich polypeptide for gene delivery to pulmonary metastatic melanoma. Int J Pharm 2014, 461(1-2):559-69.
11. Chen Xinyi, Fan Zhuoyang, Chen Yanzuo, Fang Xiaoling, Sha Xianyi*. Retro-inverso carbohydrate mimetic peptides with annexin1-binding selectivity, are stable in vivo, and target tumor vasculature. PLoS One 2013, 8(12):e80390.
12. Chen Yanzuo, Yang Wuli, Chang Baisong, Hu Hangting, Fang Xiaoling, Sha Xianyi*. In vivo distribution and antitumor activity of doxorubicin-loaded N-isopropylacrylamide-co-methacrylic acid coated mesoporous silica nanoparticles and safety evaluation. Eur J Pharm Biopharm 2013, 85(3):406-12.
13. Chen Yanzuo, Zhang Wei, Gu Jijin, Ren Qinyue, Fan Zhuoyang, Zhong Weitong, Fang Xiaoling, Sha Xianyi*. Enhanced antitumor efficacy by methotrexate conjugated Pluronic mixed micelles against KBv multidrug resistant cancer. Int J Pharm 2013, 452(1-2):421-33.
14. Gu Zhengyi, He Jinhua, Yang Xi, Sha Xianyi*. Quantitative determination of rupestonic acid in rat plasma by high-performance liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study. Biomed Chromatogr 2013, 27(5):563-7.
15. Fan Zhuoyang, Wu Juan,Fang Xiaoling, Sha Xianyi*. A new function of Vitamin E-TPGS in the intestinal lymphatic transport of lipophilic drugs: Enhancing the secretion of chylomicrons. Int J Pharm 2013, 445(1-2):141-7.
Patents
1. Sha Xianyi, Fang Xiaoling, Chen Yanzuo. Preparation of a drug-loading micelle targeting at the receptor of intergin, ZL201210445957.8.
2. Sha Xianyi, Li Yajuan, Fang Xiaolin. The pharmaceutical usage of total phenolic acid in Arnebia euchroma, ZL200810042330.1.
3. Fang Xiaoling, Jiang Xinyi, Sha Xianyi. Preparation of a PTX-loading biodegradable Nanocomposite, ZL201110174751.1.
