Following obtained master of pharmacy degree in Shanghai Medical University in 1999, Dr. Teng Shen remained on the school staff until now. In 2005 he won the doctor of pharmacy degree in Fudan University. He had published more than 40 research papers, obtained 4 new drug certificates or clinical approvals, and 6 authorized invention patents. His studies were funded by the National Natural Science Foundation, State Project For Essential Drug Research and Development, project of Shanghai Science and Technology Commission. His main research achievements are as follows: development of ligustrazine phosphate transdermal paste and aspirin sustained-release tablets that had been approved for clinical trial by SFDA, studies on rheological characteristic of gel patch such as cataplasma, revealing oral lymphatic absorption rules of breviscapine, paclitaxel, fenofibrate using the mesenteric lymph cannulation technique.
Transdermal drug delivery; Topical drug delivery; Dermatopharmacokinetic; Novel oral formulation; Epilepsy targeting
Education
2001-2005 Fudan Univ. Ph.D. in Pharmaceutical Science
1996-1999 Shanghai Medical Univ. M.S. in Pharmaceutical Science
1992-1996 Shanghai Medical Univ. Bachelor of Science of Pharmacy
Professional Experiences
1999-present Associate professor, Department of Pharmaceutics, School of Pharmacy, Fudan University
Teaching Activities
1. Pharmaceutics (I)-3cr
2. Biopharmaceutics -2cr
3. Biotechnology drug delivery system-2cr
Grants & Projects
1. National Natural Science Foundation of China, 81072594, Brain targeting mechanism of vitamin C derivative modified polymer micelles and its anti-stroke research, 2010/01-2013/12, completed, Hosting
2. Modernization of Traditional Chinese Medicine, Shanghai Science and Technology Commission, 07DZ19713, Pre-clinical research and development of SanjiezhiTong cataplasm, 2007/07-2010/07, completed, Hosting
3. National Science and Technology Major Project “Creation of Major New Drugs” and “Twelfth Five Year Plan” Project Establishment, 2009ZX09310-003, Subtopics - Development of Breviscapine Self-Microemulsion Capsules, 2012/02-2015/12, Completed, Hosting project
4. National Science and Technology Major Project, 2009 ZX09310-006, Subtopics - Development of Aspirin Sustained Release Tablets, 2009/01-2011/05, Completed, Participating.
Selected Publications（latest 5 yrs，<20 papers）
1. Xin Meng#, Jiansheng Liu#, Xiangrong Yu#, Jiajia Li, Xiaotong Lu, Teng Shen*, Pluronic F127 and D-α-Tocopheryl Polyethylene Glycol Succinate (TPGS) Mixed Micelles for Targeting Drug Delivery across the Blood Brain Barrier, Scientific Reports, 2017, 7(1): 2964-2975
2. Qingqing Cai, Xinxian Deng, Zhongdong Li*, Dianyun An, Teng Shen*, Mingkang Zhong, Effects of lipid vehicle and P-glycoprotein inhibition on the mesenteric lymphatic transport of paclitaxel in unconscious, lymph duct-cannulated rats, Drug Delivery, 2016, 23(1): 147-153
3. Jiansheng Liu#, Yajing He#, Jun Zhang, Jiajia Li, Xiangrong Yu, Zhonglian Cao, Fanmin Meng, Yuwu Zhao, Xunyi Wu*, Teng Shen*, Zhen Hong, Functionalized Nanocarrier Combined Seizure-Specific Vector with P-glycoprotein Modulation Property for Antiepileptic Drug Delivery, Biomaterials, 2016, 74: 64-76
4. Jiansheng Liu#, Jianhong Wang#, Jie Zhou, Xinghua Tang, Lan Xu, Teng Shen*, Xunyi Wu*, Zhen Hong, Enhanced Brain Delivery of Lamotrigine with Pluronic® P123-based Nanocarrier, International Journal of Nanomedicine, 2014, 9: 3923-3935
5. Jian Wang, Hongqin Zhang, Dianyun An, Jian Yu, Wei Li, Teng Shen*, Jianxin Wang, Rheological Characterization of Cataplasm Bases Composed of Cross-Linked Partially Neutralized Polyacrylate Hydrogel, AAPS PharmSciTech, 2014, 15(5):1149-1154
6. Teng Shen*, Huinan Xu, Weiyu Weng, Jianfeng Zhang, Development of a Reservoir-Type Transdermal Delivery System Containing Eucalyptus Oil for Tetramethylpyrazine, Drug Delivery, 2013, 20(1): 19-24
7. Teng Shen*, Huinan Xu, Weiyu Weng, Jianfeng Zhang, Single- and Multiple-dose Pharmacokinetics of a Novel Tetramethylpyrazine Reservoir-type Transdermal Patch Versus Tetramethylpyrazine Phosphate Oral Tablets in Healthy Normal Volunteers, and in Vitro/in Vivo Correlation, Biological and Pharmaceutical Bulletin, 2013, 36(6): 1-7
8. Hongrong Xu#, Guoxia Ji#, Qi Wang, Xuening Li, Yijuan Gong, Yun Zhang, Wei Li, Teng Shen*, Dose-dependent pharmacokinetics of bulleyaconitine A in rats, Pharmazie, 2013, 68: 170-172
Patents
1. Shen Teng, Weng Weiyu. “Pharmaceutical Combination preparation for oral delivery of scutellarin and method for preparing same.”App. No. 200610117176.0
2. Shen Teng, Xu Huinan, Weng Weiyu, Zhang Jianfeng. “Microemulsion composition for oral administration of heparin and method for preparing same.” Flied No. 200610023501.7
3. Shen Teng, Xu Huinan, Weng Weiyu, Zhan Jiangfang. “Trandermal patch containing tetramethylpyrazine base and process for producing thereof .” Filed No. 200310116764.9.
