Bioanalytical techniques; Chemiluminescence; Fluorescence; Drug Quality Control; Pharmaceutical Kinetics
Education & Training
1998-2002 Fudan University, P.R. China B. S. Pharmacy
2002-2007 Fudan University, P.R. China Ph. D. Pharmaceutical Analysis & Biosensing techniques
2015-2016 Florida University, U.S.A Visiting Scholar Analytical Chemistry
Professional Experiences
2015.1-Present Assistant Professor School of Pharmacy, Fudan University, China
Fluorescent nanoclusters for the development of biosensors for the detection of DNA nucleases, amino acids and biomarkers related to diseases.
Inorganic materials for the detection of protein and small molecules
2007.7-2014.12 Lecturer School of Pharmacy, Fudan University, China
Simultaneous chemiluminescent (CL) and fluorescent methods for the detection of multi-biomarkers based on carrier and/or substrate-resolved early-stage diagnosis of diseases
Aptameric senors for the detection of protein and small molecular
Novel fluorescent nanomaterials (copper and silver nanoparticles)-based biosensors
Study on pharmacokinetic analysis of three protein and polypeptide drugs based on ELISA method, including trichosanthin, growth honmone and Interferon
Extensive research and laboratory management
Academic advisor of undergraduates
2002.9-2007.7 Ph.D. Candidate, Department of Pharmaceutical Analysis, School of Pharmacy, Fudan University, China
Development of novel CL system, especially the label-free CL protocols for rapid and highly sensitive DNA detection
Teaching Activities
Major lecturer of the courses of Pharmaceutical Analysis I and Pharmaceutical Analysis II
Participate in the courses of Chemical Analysis and Instrumental Analysis
Grants & Projects
Holding
1. National Natural Science Foundation of China (No. 21505023, 1/2016-12/2018): Design and study of hairpin DNA template-based fluorescent copper nanoparticles and its application.
2. Shanghai Natural Science Foundation of China (No. 12ZR1401800,
9/2012-8/2015): Novel DNA scaffold-based fluorescent nanoclusters and its application in biomolecular assay
3. the Research Fund for the Doctoral Program of Higher Education (No.200802461096, 1/2009-12/2011): Highly sensitive and instantaneous chemiluminescent techique for the detection of telomerase level
4. Youth Foundation of Fudan University (No.08FQ30, 1/2009-12/2010):
Simultaneous detection of multiplex biomarkers glioma for the early-stage diagnosis of disease
5. The Open Project Program of Key Lab of Smart Drug Delivery (School of Pharmacy, Fudan University), Ministry of Education, China (SDD2014-01, 9/2014-8/2016): Polyethylene glycol (PEG) and peptide cascade modified, long-circulating anti-tumor drug
Participating
1. National Natural Science Foundation of China (21375025, 1/2014-12/2017): Label-free aptametic technology for the chemiluminescent detection of biomolecular based on comformational switches
2. National Natural Science Foundation of China (21175027, 1/2012-12/2015): Novel biosensors based on template-dependent identification
3. National Natural Science Foundation of China (81302741, 1/2014-12/2016): Study on the chemiluminescent screening technique for natural protection drugs
4. Ministry of National Science and Technology 863 Program (2007AA03Z357，12/2007-11/2010): Simultaneous detection of triplex biomarkers based on quantum dots for the early-stage diagnosis of lung cance
5. “the Twelfth Five-Year Plan”, the National Drug Innovation Program
(2013ZX09J13101-05B，400 000，1/2012-12/2015): Pre-clinical study on the drug of carboxylmethyl aminomethyl catechol with Uranium to promote the release
6. Projects supported by Anhui Anke Biotechnology (Group) Co. Ltd.
(2009.10-2010.3, 2010.2-2010.8): Study on pharmacokinetics of recombinant human albumin interferon and PEGylated recombinant human interferon in rats and monkey
Selected Publications
1. Zhang L., Wan S., Jiang Y., Wang Y., Fu T., Liu Q., Cao Z., Qiu L., Tan W.* Molecular elucidation of disease biomarkers at the interface of chemistry and biology. J. Am. Chem. Soc. 2017, 139, 2532?2540.
2. Wang Y., Cui H., Cao Z., Lau C., Lu J. Additive and enhanced fluorescence effects of hairpin DNA template-based copper nanoparticles and their application for the detection of NAD+. Talanta, 2016, 154, 574–580.
3. Qiu, X.; Wang, P.; Cao, Z.* Hybridization chain reaction modulated DNA-hosted silver nanoclusters for fluorescent identification of single nucleotide polymorphisms in the let-7 miRNA family. Biosens. Bioelectron. 2014, 60, 351-357. (IF=6.451)
4. Cao, Z.; Wang, P.; Qiu, X.; Lau, C.; Lu, J*. Ligation-triggered fluorescent silver nanoclusters system for the detection of nicotinamide adenine dinucleotide. Anal. Bioanal. Chem., 2014, 406, 1895-1902. (IF=3.578)
5. Cai, S.; Cao, Z.; Lau, C.; Lu, J.* Label-free technology for the amplified detection of microRNA based on the allosteric hairpin DNA switch and hybridization chain reaction. Analyst, 2014, 139, 6022-6027. (IF=4.23)
6. Huang, T.*; Chen, N.; Wang, D.; Lai, Y.; Cao, Z.# A validated stability-indicating HPLC method for the simultaneous determination of pheniramine maleate and naphazoline hydrochloride in pharmaceutical formulations. Chem. Cent. J., 2014, 8(1), 1-7. (IF=1.663)
7. Song, W.; Zhu, K.; Cao, Z.#; Lau, C.; Lu, J#. Hybridization chain reaction-based aptameric system for the highly selective and sensitive detection of protein, Analyst, 2012, 137 (6), 1396-1401. (IF=3.969)
8. Cao Z.; Li H.; Lau C.; Zhang Y. Cross-talk-free simultaneous fluoroimmunoassay of two biomarkers based on dual-color quantum dots. Anal. Chim. Acta, 2011, 698 (1-2), 44-50. (IF=4.555)
9. Cao Z., Miao J., Zhu K., Lau C.* Instantaneous derivatization technology for the simultaneous and homogeneous detection of multiple double-stranded PCR amplicons. Analyst, 2011, 136 (19), 3981–3987. (IF=4.230)
10. Yan X.; Cao, Z. #; Lau, C.; Lu, J#. DNA Aptamer folding on magnetic beads for sequential detection of adenosine and cocaine by substrate-resolved chemiluminescence technology. Analyst, 2010, 135 (9), 2400–2407. (IF=3.913)
*:Corresponding author #: Co-corresponding author
Patents
Li, H.; Cao, Z.; Liu, C.; Lu, J. A homogenous fluorescent and chemilumenescent method for the simultenous detection of multi-biomarkers and its application.
Chinese Patent. Application No. 200910194425.X (Authorized).
Li, H.; Cao, Z.; Liu, C.; Lu, J. A homogenous fluorescent method for the multi-biomarker assay. Chinese Patent. Application No. 201010250060.0.
Sun, Y.; Zhu, K.; Cao, Z.; Liang, J.; Liu, C.; Lu, J. The preparation of PEGylated celastrol and its application. Chinese Patent. Application No. 201110138814.8
