Mei-Qing Feng graduated from Shanghai Medical University in 1990, worked for Hebei Institute of Material Medica and Hebei Universitu of Science and Technology from 1990 to 2004, and obtained her Ph.D from Fudan University in 2004. She served as a professor in Department Microbiology and Biochemical Pharmacy, School of Pharmacy, Fudan University from 2004 to now. Research in the Biotechnology aims at development and application of novel drug candidates. Another line of work aims at biotransformation of small molecular chemicals.
Recombinant therapeutic biologics; Antibacterial agent; Evaluation and mechanism; Cancer therapeutic
Education
Dr. Meiqing Feng received a Ph.D. degree in Chemical Medicine in 2004, in Fudan University, a Master’s degree in Chemical process in 1999 in University of Petroleum and a Bachelor’s degree in Pharmacy in 1990 in Shanghai Medical University.
Professional Experiences
1990.7-1994.6 Hebei Institute of Material Medica, China.
1994.7-2004.11 Hebei Universitu of Science and Technology
2004.12-present School of Pharmacy, Fudan University.
Teaching Activities
Bio-synthetic Medicinal Chemistry,
BioPharmaceutical Technology,
Biopharmacy
Award, Honors & Memberships
2005 The third award of technology improvement, Shanghai China
Grants & Projects
1. 973 project: The basic research of novel nanopartical—based molecular imaging probes for molecular classification of lung cancer in vivo (2015-2019) (2015CB931800 )
2. NSFC: The Biotransformation pathways and mechanism of ginsenoside Rb1 to compound K and its regulation. (2008-2010)（30772676）
3. NSFC: The liver targeting of recombinant high-density lipoprotein drug complex and its mechanism. (2009-2012) (30973684)
4. NSFC: The mechanism of siRNA targeting to liver by apolipoprotein A-I and its anti- HBV activity. (2014-2015)（81341083）
5. STCSM: The nanoparticles of recombinant high-density lipoprotein targeting to liver mediated by apolipoprotein A-I .(2009-2011)（0952nm03500)
6. STCSM: The anti -atherosclerosis of apolipoprotein A-I expressed by pichia pasteoris. (2012-2015(12431900202)
Selected Publications（latest 5 yrs，<20 papers）
1. H. Zhu, L. Han, X. Shi, B. Wang, H. Huang, X. Wang, D. Chen, D. Ju, and M. Feng*. Baicalin inhibits autophagy induced by influenza A virus H3N2. Antiviral research. 113:62-70 (2015).
2. B. Wang, D. Feng, L. Han, J. Fan, X. Zhang, X. Wang, L. Ye, X. Shi, and M. Feng*. Combination of Apolipoprotein A1‐Modi Liposome–Doxorubicin with Autophagy Inhibitors Overcame Drug Resistance In Vitro. Journal of pharmaceutical sciences. 103:3994-4004 (2014).
3. Y. Li, S. Wang, Z. Wang, X. Qian, J. Fan, X. Zeng, Y. Sun, P. Song, M. Feng*, and D. Ju*. Cationic poly (amidoamine) dendrimers induced cyto-protective autophagy in hepatocellular carcinoma cells. Nanotechnology. 25:365101 (2014).
4. M. Feng, Z. Liao, L. Han, J. Li, and L. Ye. Enhancement of microbial hydroxylation of 13-ethyl-gon-4-ene-3, 17-dione by Metarhizium anisopliae using nano-liposome technique. Journal of industrial microbiology & biotechnology. 41:619-627 (2014).
5. L. Ye, J. Fan, X. Shi, Q. Tao, D. Ye, Z. Xian, X. Zeng, Y. Li, M. Feng*, and D. Ju*. Tumor necrosis therapy antibody interleukin-2 fusion protein elicits prolonged and targeted antitumor effects in vivo. Applied microbiology and biotechnology. 98:4053-4061 (2014).
6. B. Wang, Y. Yuan, L. Han, L. Ye, X. Shi, and M. Feng*. Recombinant lipoproteins reinforce cytotoxicity of doxorubicin to hepatocellular carcinoma. Journal of drug targeting. 22:76-85 (2014).
7. J. Fan, X. Zeng, Y. Li, S. Wang, Z. Wang, Y. Sun, H. Gao, G. Zhang, M. Feng*, and D. Ju*. Autophagy plays a critical role in ChLym-1-induced cytotoxicity of non-hodgkin's lymphoma cells. PloS one. 8:e72478 (2013).
8. Y. Yuan, W. Wang, B. Wang, H. Zhu, B. Zhang, and M. Feng*. Delivery of hydrophilic drug doxorubicin hydrochloride-targeted liver using apoAI as carrier. Journal of drug targeting. 21:367-374 (2013).
9. Weina Wang, Xunlong Shi, Yuan Yuan, Haiyan Zhu, Wei Zhou, Hai Huang, and
10. Meiqing Feng*. Inhibitory effect of apolipoprotein A-I on matrix etalloproteinase-2 expression in vivo and in vitro Acta Biochim Biophys Sin. 45: 194–202, 2013
11. Weina Wang, Wei Zhou, Baolong Wang, Haiyan Zhu, Meiqing Feng*. Antioxidant effect of apolipoprotein A-I on high-fat diet-induced non-alcoholic fatty liver disease in rabbits Acta Biochimica et Biophysica Sinica（DOI：10.1093/abbs/gms100.）. 2013 45: 95–103
12. Baolong Wang . Xin Wang . Chris Wayne . Xiangxiang Wang .Lei Han . Li Ye . Qun Zhao . Guixiang Jiang . Meiqing Feng. Production of a therapeutic protein by fusing it with two fragments of the carboxyl-terminal peptide of human chorionic gonadotropin b-subunit in Pichia pastoris. Biotechnol Lett 2016 DOI 10.1007/s10529-016-2038-y
13. Xiangxiang Hu, Si Shi, Huan Wang , XiaochenYu, Qian Wang, Shanshan Jiang, Dianwen Ju, LiYe & Meiqing FengBlocking autophagy improves the anti-tumor activity of afatinib in lung adenocarcinoma with activating EGFR mutations in vitro and in vivo. Scientific Reports | 7: 4559 | 2017 DOI:10.1038/s41598-017-04258-8
14. Xuan-xuan li si shi lan rong Mei-qing Feng liang Zhong The impact of liposomal linolenic acid on gastrointestinal microbiota in mice。 International Journal of Nanomedicine 2018:13 1399–1409
