Dr. Hai-Yan Zhu obtained her Ph.D. from Heilongjiang University of Chinese Medicine in 2002. After she accomplished her post-doctoral study in Shanghai Institute of Materia Medica, Chinese Academy of Sciences in 2004, she continued working as an associated research fellow there. . In 2006, Dr. Zhu joined the Department of Microbiological and Biochemical Pharmacy, School of Pharmacy, Fudan University, and was appointed as associate professor in 2015. Her researches mainly focused on discovering the novel active antiviral and anti-inflammation components from Chinese herbs, and exploring its antiviral mechanism. Dr Zhu researches strongly supported active compounds from Chinese herbs might play their unique roles in virus infection therapies, i.g. baicalin could modulate the autophagic behavior in host cells to inhibit influenza virus replication.
Anti-virus and immune regulation in influenza; Mucosa immune on gut- lung axis; The influenza and gut homeostasis
Education and Professional Experiences
2015.12- Associate Professor, Department of Microbiological ＆ Biochemical Pharmacy, School of Pharmacy, Fudan University
2006.11-2015.12 Lecturer, Department of Biosynthesis, School of Pharmacy, Fudan University
2004.09-2006.11 Associate research fellow, Shanghai Institute of Materia Medica,Chinese Academy of Sciences
2002.09-2004.9 Postdoctor, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
1991.09-2002.07 Bachelor, Master, Ph.D., Heilongjiang University of Chinese Medicine
Teaching Activities
Courses taught: Biopharmaceutics, Biopharmaceutical technology, Virus versus human being.
Grants & Projects
1. National Natural Science Foundation of China, No. 81673713(2017-2020) Project leader
2. National Natural Science Foundation of China, No. 81173173(2012-2015) Project leader
3. National Natural Science Foundation of China, No. 81330089 (2014-2018) Major participant
4. National Natural Science Foundation of China, No. 30500655 (2006-2008) Project leader
Selected Publications
1. Zhu HY, Lu XX, Ling LJ, Li H, Ou YY, Shi XL, Lu Y, Zhang YY, Chen DF. Houttuynia cordata polysaccharides ameliorate pneumonia severity and intestinal injury in mice with influenza virus infection. J Ethnopharmacol. 2018,23;218:90-99.
2. Zhu H, Chen M, Shi X, Shi C, Huang C.Material basis studies of anti-Influenza A active ingredients in Tanreqing Injection.Biomed Chromatogr. 2017 Sep 15. doi: 10.1002/bmc.4097.
3. Shi X1, Zhu H1, Zhang Y, Zhou M, Tang D, Zhang H.XuefuZhuyu decoction protected cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy.BMC Complement Altern Med. 2017 Jun 19;17(1):325. doi: 10.1186/s12906-017-1822-0.PMID: 28629357
4. Li YB1, Zhu HY1, Wang SF, Qian XL, Fan JJ, Wang ZY, Song P, Lu WY, Ju DW*. Interplay of oxidative stress and autophagy in PAMAM dendrimers-induced neurotoxicity. Theranostics. 2015 ,5(12):1363-77.
5. Lijuan Chen,Xin Yan, Qianlin Yan, Jiajun Fan, Hai Huang, Xunlong Shi, Lei Han, Tianxiong Han, and Haiyan Zhu*.The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in Mice. Evidence-Based Complementary and Alternative Medicine. 2015. doi: 10.1155/2015/790739.
6. Hai-yan Zhu , Lei Han , Xun-long Shi , Bao-long Wanga, Hai Huanga, Xin Wang, Dao-feng Chen ,Dian-wen Jua, Mei-qing Feng.Baicalin inhibits autophagy induced by influenza A virus H3N2. Antiviral Research. 2015,113: 62–70.
7. Hai-Yan Zhu，Hai Huang，Xun-Long Shi，Wei Zhou，Pei Zhou，Qian-Lin Yan，Hong-Guang Zhu，Dian-Wen Ju*. Chinese herb decoction QZD protects mice from influenza A pneumonia through inhibition of inflammatory cytokine storm. Chinese Journal of Integrative Medicine.2015,21(5):376-83.
8. Zhu H, Shi X, Ju D, Huang H, Wei W, Dong X. Anti-inflammatory effect of thalidomide on H1N1 influenza virus-induced pulmonary injury in mice. Inflammation. 2014 ,37(6):2091-8.
9. Lijuan Chen, Jiajun Fan, Yubin Li, Xunlong Shi, DianwenJu, Qianlin Yan, Xin Yan, Lei Han,Haiyan Zhu*.Modified Jiu Wei QiangHuo decoction improves dysfunctional metabolomics in influenza A pneumonia-infected mice. Biomedical Chromatography. 2014, 28(4):468-74. (IF=1.662)
10. Shi X, Zhou W, Huang H, Zhu H, Zhou P, Zhu H*,Ju D*，Inhibition of the inflammatory cytokine tumor necrosis factor-alpha with etanercept provides protection against lethal H1N1 influenza infection in mice. Critical Care. 2013,17(6):R301.
