Education
2015.9 – 2018.7 Fudan University School of Pharmacy Ph.D.
2012.9 – 2015.7 Zhengzhou University School of Pharmacy Master
2008.9 – 2012.7 Zhengzhou University School of Pharmacy Bachelor
Professional Experiences
2020.09 – Present Youth Principle Investigator Fudan University, China
2018.7 – 2020.8 Postdoctoral Fellow University of Pennsylvania, USA
Teaching Activities
Structure and Function ofBiomacromolecules (Graduate course, Sep 2020- Jan 2021)
Grants & Projects
Fudan University ResearchInitial Funding, 1,000,000 RMB, 2020.09-2023.09
Awards & Honors
2018 Excellent Graduate ofShanghai City. Shanghai Municipal Education Commission
2017 Baosteel Scholarship forOutstanding Students. Baosteel Education Foundation, China
2015 Excellent Graduate ofHenan Province. The Education Department of Henan Province
2014 National scholarshipfor Postgraduates. Ministry of Education of China
Memberships
2020.03 ~ present ReviewerEditor, Section of Cancer Immunotherapy, Frontiers in Immunology
2020.03 ~ present ReviewerEditor, Section of Cancer Immunotherapy, Frontiers in Oncology
Invited Presentations
European Society for MedicalOncology (ESMO) Immuno Oncology Congress 2017. Poster Discussion
2017 Japanese Society ofMedical Oncology (JSMO) Annual Meeting. Oral Presentation
European Society for MedicalOncology (ESMO) Asia 2016 Congress. Poster Presentation
2016 Japanese Society ofMedical Oncology (JSMO) Annual Meeting. Oral Presentation
Selected Publications（latest 5 yrs，<20 papers）
1. Zhang X, Wang Y, Fan J, Chen W, Luan J, Mei X, Wang S, Li Y, Ye L,Li S, Tian W, Yin K*, Ju D*. Blocking CD47 efficiently potentiated therapeuticeffects of anti-angiogenic therapy in non-small cell lung cancer. Journal forImmunoTherapy of Cancer. 2019; 7:346.
2. Zhang X, Fan J, Ju D*. Insights into CD47/SIRPα axis-targetingtumor immunotherapy. Antibody Therapeutics. 2018; 1:37-42.
3. Zhang X, Chen W, Fan J, Wang S, Xian Z, Luan J, Li Y, Wang Y, NanY, Luo M, Li S, Tian W, Ju D*. Disrupting CD47-SIRPα axis alone or combinedwith autophagy depletion for the therapy of glioblastoma. Carcinogenesis. 2018;39:689-699.
4. Zhang X, Wang S, Nan Y, Fan J, Chen W, Luan J, Wang Y, Liang Y, LiS, Tian W, Ju D*. Inhibition of autophagy potentiated the anti-tumor effects ofVEGF and CD47 bispecific therapy in glioblastoma. Applied Microbiology and Biotechnology.2018; 102:6503-6513.
5. Zhang X, Luan J, Chen W, Fan J, Nan Y, Wang Y, Liang Y, Meng G, JuD*. Mesoporous silica nanoparticles induced hepatotoxicity via NLRP3inflammasome activation and caspase-1-dependent pyroptosis. Nanoscale. 2018;10:9141-9152.
6. Zhang X, Fan J, Wang S, Li Y, Wang Y, Li S, Luan J, Wang Z, Song P,Chen Q, Tian W, Ju D*. Targeting CD47 and autophagy elicited enhancedanti-tumor effects in non-small cell lung cancer. Cancer Immunology Research.2017; 5:363-375. (Spotlight Research)
7. Zhang X, Gu Y, Chen T, Yang D, Wang X, Jiang B, Shao K, Zhao W,Wang C, Wang J, Zhang Q, Liu H*. Synthesis, in vitro and in vivo anticanceractivities of novel 4-substituted 1,2-bis(4-chlorophenyl)-pyrazolidine-3,5-dione derivatives. MedChemComm. 2015; 6:1781-1786.
8. Fan J, Zhang X, Wang S, Chen W, Li Y, Zeng X,Wang Y, Luan J, Li L, Wang Z, Sun X, Shen B, Ju D*. Regulating autophagyfacilitated therapeutic efficacy of the sonic Hedgehog pathway inhibition onlung adenocarcinoma through GLI2 suppression and ROS production. Cell Death& Disease. 2019; 10:626.
9. Luan J, Zhang X, Wang S, Li Y, Fan J, Chen W,Zai W, Wang S, Wang Y, Chen M, Meng G, Ju D*. NOD-Like Receptor Protein 3Inflammasome-Dependent IL-1β Accelerated ConA-Induced Hepatitis. Frontiers inImmunology. 2018; 9:758.
10. Wang Y, Zhang X, Fan J, Chen W, Luan J, Nan Y,Wang S, Chen Q, Zhang Y, Wu Y, Ju D*. Activating Autophagy Enhanced theAntitumor Effect of Antibody Drug Conjugates Rituximab-Monomethyl Auristatin E.Frontiers in Immunology. 2018; 9:1799.
11. Fan J, Wang S, Zhang X, Chen W, Li Y, Yang P, Cao Z,Wang Y, Lu W, Ju D*. Quantum Dots Elicit Hepatotoxicity throughLysosome-Dependent Autophagy Activation and Reactive Oxygen Species Production.ACS Biomaterials Science & Engineering. 2018; 4:1418-1427.
12. Chen W, Zhang X, Fan J, Zai W, Luan J, Li Y,Wang S, Chen Q, Wang Y, Liang Y, Ju D*. Tethering interleukin-22 toapolipoprotein A-I ameliorates mice from acetaminophen-induced liver injury.Theranostics. 2017; 7:4135-4148.
13. Song P, Wang Z, Zhang X, Fan J, Li Y, Chen Q, Wang S,Liu P, Luan J, Ye L, Ju D*. The role of autophagy in asparaginase-inducedimmune suppression of macrophages. Cell Death & Disease. 2017; 8:e2721.
14. Shen W, Zhang X, Fu X, Fan J, Luan J, Cao Z,Yang P, Xu Z, Ju D*. A novel and promising therapeutic approach for NSCLC:recombinant human arginase alone or combined with autophagy inhibitor. CellDeath & Disease. 2017; 8:e2720.
15. Ren J, Zhang X, Yu B, Wang X, Shao K, Zhu X,Liu H*. Discovery of novel AHLs as potent antiproliferative agents. EuropeanJournal of Medicinal Chemistry. 2015; 93:321-329.
