Dr. Jin-Feng Hu obtained his Ph.D. in 1996 in Natural Organic Chemistry at Lanzhou University. He was a Postdoctoral Fellow (1996-1998) in Institute of Materia Medica (CAMS & PUMC). Then, he joined the Hans-Knoell-Institute for Natural Products Research as a German BMBF Fellow (1998-2000). He moved to the United States as a Postdoctoral Fellow with the University of Mississippi (2000-2001), and at the Genomics Institute of the Novartis Research Foundation/The Scripps Research Institute (2001-2002). He left his position as a Principal Scientist in Natural Products Chemistry from Sequoia Sciences, Inc. (USA), where he worked from 2002 to 2006, and since then has been a Full Professor at East China Normal University (2006-2011) and Fudan University (2011-present). He has published over 140 scientific papers, reviews, and book chapters. His group is now actively involved in the isolation, structure elucidation, and synthetic optimization of bioactive natural products and related chemical biology studies.
High-throughput Natural Products Chemistry; Miniaturization of Structure Elucidation; Bioactive Natural Products; Rare/Endangered Plants; Natural Products for Chemical Biology Studies
Education
Natural Organic Chemistry (Ph. D., 1996.7), Organic Chemistry (MSc., 1993.7), Applied Chemistry (B.S., 1990.7), Lanzhou University, P.R. China
Phytochemistry (Postdoctoral Associate, 1996.8-1998.8), Institute of Materia Medica (Chinese Academy of Medical Sciences and Peking Union Medical College, CAMS & PUMC)
Natural Products Chemistry (German BMBF Fellow, 1998.9-2000.2), Hans-Knoell-Institute (HKI) for Natural Products Research (Germany)
Natural Products Chemistry (Postdoctoral Associate, 2000.2-2001.8), Department of Pharmcognosy, School of Pharmacy, The University of Mississippi (USA)
Natural Products Chemistry & Chemical Biology (Postdoctoral Fellow, 2001.8-2002.3), Genomics Institute of the Novartis Research Foundation (GNF)/The Scripps Research Institute (TSRI, Schultz Lab) (USA)
Professional Experiences
03/2011 - Present: Professor and Chair, Department of Natural Products Chemistry, School of Pharmacy, Fudan University (Shanghai, China)
03/2006 – 02/2011: Professor and Deputy Director of Key Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University (Shanghai, China)
03/ 2002- 03/ 2006: Principal Scientist, Natural Products Chemistry; Sequoia Sciences, Inc. (San Diego, California, USA).
Teaching Activities
Undergraduate Courses: <Natural Medicinal Chemistry I>, <Natural Medicinal Chemistry II>, and <Introduction of Natural Medicines>
Master Courses: <Modern Separation Techniques>, <Natural Products Chemistry>, <Recent Progress on Pharmaceutical Research>
Ph.D. Courses: <Recent Progress on Pharmaceutical Research> and <Chemical Biology： An Introduction>
Grants & Projects
Selected Major Ongoing Research Supports
Studies on Novel Terpenoids from Six Endangered Pinaceae Plants Endemic to China and Their Bioactivities against Type 2 Diabetes Mellitus (No. 81773599), Grant Type: National Natural Science Foundation of China (NSFC), Grant Period: 01/01/2018-12/31/2021.
Studies on Novel Alkaloids from Four Lycopodiaceae Plants and Their Bioactivities against Alzheimer’s Disease (No. 21472021), Grant Type: National Natural Science Foundation of China (NSFC), Grant Period: 01/01/2015-12/31/2018.
Ministry of Science and Technology (MOST, grant No. 2017ZX09305008-005, 2017/07-2020/06), Shanghai Municipal Science and Technology Commission (SMSTC, grant No. 17430742200, 2017/12-2019/09).
Selected Past Research Supports
NSFC (grant Nos. 81273401, 90713040, 30640068), MOST (973 project No. 2013CB530704, 2011ZX09307-002-01), Ministry of Education (MOE, grant Nos. 20120071110049, NCET-06-0422), SMSTC (grant Nos. 11DZ1921203, 07DZ22006, 06DZ19002, 06PJ14033).
Awards & Honors
1. New Century Excellent Talent Award of Ministry of Education, China (2006);
2. Pu-Jiang Scientific Talent Award of Shanghai Municipal Science and Technology Commission, China (2006).
3. Elsevier’s Most Cited Chinese Researchers (2014 through 2017).
Selected Peer-reviewed Publications (latest 5 yrs, 20 of 140 papers in total)
1) G.-L. Ma, J. Xiong, E. E. A. Osman, T. Huang, G.-X. Yang, J.-F. Hu*. LC-MS guided isolation of sinodamines A and B: new chimonanthine-type alkaloids from the endangered ornamental plant Sinocalycanthus chinensis. Phytochemistry 151: 61–68 (2018).
2) L.-L. Pan, P. Xu, X.-L. Luo, L.-J. Wang, S.-Y. Liu, Y.-Z. Zhu, J.-F. Hu*, X.-H. Liu*. Shizukaol B, an active sesquiterpene from Chloranthus henryi, attenuates LPS-induced inflammatory responses in BV2 microglial cells. Biomedicine & Pharmacotherapy 88: 878–884 (2017).
3) Y. Tang, J. Xing, Y. Zou, W. Wang, C. Huang, H.-Y. Zhang, J.-F. Hu*. Annotinolide F and Lycoannotines A–I, further Lycopodium alkaloids from Lycopodium annotinum. Phytochemistry 143: 1–11 (2017).
4) Y. Tang, J. Xiong, J.-J. Zhang, W. Wang, H.-Y. Zhang, J.-F. Hu*. Annotinolides A-C, Three Lycopodane-derived 8,5-Lactones with Polycyclic Skeletons from Lycopodium annotinum. Organic Letters 18: 4376-4379 (2016).
5) G.-L. Ma, J. Xiong, G.-X. Yang, L.-L. Pan, C.-L. Hu, W. Wang, H. Fan, Q.-H. Zhao, H.-Y. Zhang, J.-F. Hu*. Biginkgosides A–I, Unexpected Minor Dimeric Flavonol Diglycosidic Truxinate and Truxillate Esters from Ginkgo biloba Leaves and Their Anti-neuroinflammatory and Neuroprotective Activities. Journal of Natural Products 79: 1354-1364 (2016).
6) Y. Tang, J. Xiong, Y. Zou, H.-Y. Zhang, J.-F. Hu*. Palhicerines A–F, Lycopodium alkaloids from the club moss Palhinhaea cernua. Phytochemistry 131: 130–139 (2016).
7) J. Xiong, Z.-L. Hong, P. Xu, Y. Zou, S.-B. Yu, G.-X. Yang, J.-F. Hu*.ent-Abietane diterpenoids with anti-neuroinflammatory activity from the rare Chloranthaceae plant Chloranthus oldhamii. Organic & Biomolecular Chemistry 14: 4678-4689 (2016).
8) W.-J. Meng, J. Xiong, W.-X. Wang, H.-Y. Zhang, H.-Q. Zeng, J.-F. Hu*. Phlefargesiine A, a C16N2 Lycopodium alkaloid with an unprecedented [6/7/6/6]-tetracyclic skeleton from Phlegmariurus fargesii. Tetrahedron Letters 57: 3218–3221 (2016).
9) C.-L. Hu, J. Xiong, J.-Y. Li, L.-X. Gao, W.-X. Wang, K.-J. Cheng, G.-X. Yang, J. Li, J.-F. Hu*. Rare Sesquiterpenoids from the Shed Trunk Barks of the Critically Endangered Plant Abies beshanzuensis and Their Bioactivities. European Journal of Organic Chemistry 1832-1835 (2016).
10) C.-L. Hu, J. Xiong, L.-X. Gao, J. Li, H.-Q. Zeng, J.-F. Hu*. Diterpenoids from the shed trunk barks of the endangered plant Pinus dabeshanensis and their PTP1B inhibitory effects. RSC Advances 6:60467–60478 (2016).
11) X.-L. Luo, S.-Y. Liu, L.-J. Wang, Q.-Y. Zhang, P. Xu, L.-L. Pan*, J.-F. Hu*. A tetramethoxychalcone from Chloranthus henryi suppresses lipopolysaccharide-induced inflammatory responses in BV2 microglia. European Journal of Pharmacology 774: 135-143 (2016).
12) L.-L. Pan, Q.-Y. Zhang, X.-L. Luo, J. Xiong, P. Xu, S.-Y. Liu, J.-F. Hu*, X.-H. Liu*. (7R,8S)-9-Acetyl-dehydrodiconiferyl alcohol inhibits inflammation and migration in lipopolysaccharide-stimulated macrophages. Phytomedicine 23: 541–549 (2016).
13) L.-L. Pan, X.-L. Wang, Q.-Y. Zhang, X.-L. Luo, P. Xu, S.-Y. Liu, J.-F. Hu*, Xin-Hua Liu*. Boehmenan, a lignan from the Chinese medicinal plant Clematis armandii, induces apoptosis in lung cancer cells through modulation of EGF-dependent pathways. Phytomedicine 23: 468–476 (2016).
14) S.-Y. Liu, P. Xu, X.-L. Luo, J.-F. Hu*, Xin-Hua Liu*. (7R,8S)-Dehydrodiconiferyl alcohol suppresses lipopolysaccharide-induced inflammatory responses in BV2 microglia by inhibiting MAPK signaling. Neurochemical Research 41: 1570–1577 (2016).
15) J. Xiong, Z.-L. Hong, L.-X. Gao, J. Shen, S.-T. Liu, G.-X. Yang, J. Li, H.-Q. Zeng, J.-F. Hu*. Chlorabietols A–C, Phloroglucinol-Diterpene Adducts from the Rare Chloranthaceae Plant Chloranthus oldhamii. The Journal of Organic Chemistry 80: 11080-11085 (2015).
16) L.-J. Wang, J. Xiong, S.-T. Liu, L.-L. Pan, G.-X. Yang, J.-F. Hu*. ent-Abietane-type and Related Seco-/Nor-diterpenoids from the Rare Chloranthaceae Plant Chloranthus sessilifolius and Their Anti-neuroinflammatory Activities. Journal of Natural Products 78: 1635-1646 (2015).
17) L. Ming, J. Xiong, Y. Huang, B.-G. Wei, H. Fan, Y. Zhao, W.-Z. Zhai, J.-F. Hu*. Xylapyrrosides A and B, Two Rare Sugar-Morpholine Spiroketal Pyrrole-Derived Alkaloids from Xylaria nigripes: Isolation, Complete Structure Elucidation, and Total Syntheses. Tetrahedron 71: 5285-5295 (2015).
18) M. Ye, J. Xiong, J.-J. Zhu, J.-L. Hong, Y. Zhao, H. Fan, G.-X. Yang, G. Xia, J.-F. Hu*. Leonurusoleanolides E-J, minor spirocyclic triterpenoids from Leonurus japonicus fruits. Journal of Natural Products 77: 178–182 (2014).
19) J. Xiong, V.-B. Bui, X.-H. Liu, Z.-L. Hong, G.-X. Yang, J.-F. Hu*. Lignans from the stems of Clematis armandii (“Chuan-Mu-Tong”) and their anti-neuroinflammatory activities. Journal of Ethnopharmacology 153: 737–743 (2014).
20) Y. Tang, Y. Fu, J. Xiong, M. Li, G.-L. Ma, G.-X. Yang, B.-G. Wei, Y. Zhao, H.-Y. Zhang, J.-F. Hu*. Casuarinines A–J, lycodine-type alkaloids from Lycopodiastrum casuarinoides. Journal of Natural Products 76: 1475–1484 (2013).
Patents
(1) CN 103211864B, Priority date: 20/01/2012, Granted.
(2) CN 103980198B, Priority date: 08/02/2013, Granted.
(3) CN 105801396A, Priority date: 29/12/2014, Granted.
(4) CN 105837592A, Priority date: 11/01/2015, Granted.
(5) CN 105859745A, Priority date: 20/01/2015, Granted.
(6) CN 106466310A, Priority date: 17/08/2015, Application.
(7) CN 106957324A, Priority date: 11/01/2016, Application.
(8) CN 106957225A, Priority date: 11/01/2016, Application.
(9) CN 107021942A, Priority date: 01/02/2016, Application.
(10) CN 107459446A, Priority date: 05/06/2016, Application.
