Dr. Ai-Jun Hou is currently a Professor and vice Dean at School of Pharmacy, Fudan University. She obtained her Ph.D. degree from Kunming Institute of Botany, Chinese Academy of Sciences in 1999. From 1999 to 2000, she did postdoctoral studies at Toho University, Japan. Thereafter, Dr. Hou joined the faculty of School of Pharmacy, Fudan University in 2000. She was promoted to Professor and vice Dean in 2007. From 2004 to 2005, she worked as a visiting scholar at University of Konstanz, Germany. Dr. Hou’s research interests focus on drug discovery and development from traditional Chinese medicine, with anti-cancer and anti-diabetes as particular targets.She is the recipient of some important awards, including winner of excellent young scientist fund of the National Natural Science Foundation of China in 2012, Shanghai Shu Guang Scholar in 2012, and New Century Excellent Talents award of the Ministry of Education of China in 2009.
Natural products chemistry, drug discovery and development from TCM
Education
Ph.D., Kunming Institute of Botany, Chinese Academy of Sciences, 1996-1999
M.S., Henan College of Traditional Chinese Medicine, 1993-1996
B.S., Henan College of Traditional Chinese Medicine, 1989-1993
Professional Experiences
Jan. 2007-Present: Professor, Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, China
Jun. 2007-Jun. 2017: Vice Dean, School of Pharmacy, Fudan University, Shanghai, China
Sep. 2004-Aug. 2005: Visiting scholar, University of Konstanz, Germany
Nov. 2001-Dec. 2006: Associate Professor, Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, China
Nov. 2000-Oct. 2001: Lecturer, School of Pharmacy, Fudan University, Shanghai, China
Aug. 1999-Jun. 2000: Post-doctor, Faculty of Pharmaceutical Sciences, Toho University, Japan
Teaching Activities
Phytochemical analysis (for Ph.D. students)
Progress on natural products chemistry (for Ph.D. students)
Spectrum analysis (for M.S. students)
Research and development of New Drug from TCM (for B.S. students)
Grants & Projects
1. National Natural Science Foundation of China (General Program): Discovery of novel clerodane diterpenes and study on their antiviral activity. No. 21672040, PI, 2017.1-2020.12
2. National Natural Science Foundation of China (Excellent Young Scientists Fund): Natural products chemistry. No. 81222045, PI, 2013.1-2015.12
3. National Natural Science Foundation of China (NSFC-Xinjiang Joint Fund): Studies on the bioactive constituents of five Fritillaria species endemic to Xinjiang and their germplasm resource evaluation. No. U1403201, Co-PI, 2015.1-2018.12
4. The Shu Guang Project from Shanghai Municipal Education Commission and Shanghai Education Development Foundation. No. 12SG02, PI, 2013.1-2015.12
5. The Program for New Century Excellent Talents in University from Ministry of Education of China. No. NCET-09-0313, PI, 2010.1-2012.12
Awards & Honors
Excellent Young Teacher of Shanghai Higher Institution (2008)
Shanghai Shu Guang Scholar (2012)
The Second prize of Shanghai Teaching Achievements Awards (rank the first and second, 2013)
The First prize of Fudan University Teaching Achievements Award (rank the first, 2017)
Memberships
1. Member of the Editorial Advisory Board of Chemistry & Biodiversity (2017-date)
2. Vice secretary general of Ministry of Education’s Steering Committee for Pharmacy Education (2013-date)
3. Committee member of Pharmacy Education Division, Chinese Pharmaceutical Association (2015-date)
4. Committee member of Youth Working Division, Chinese Pharmaceutical Association (2017-date)
5. Committee member of Plant Chemistry & Resources Section, Botanical Society of China (2013-date)
Selected Publications（latest 5 yrs，<20 papers）
1. Hai-Bing Liao#, Guang-Hui Huang#, Mei-Hua Yu, Chun Lei, Ai-Jun Hou*. Five Pairs of Meroterpenoid Enantiomers from Rhododendron capitatum. The Journal of Organic Chemistry, 2017, 82(3): 1632-1637
2. Xiao Sheng, Xin-Yu Jia, Fei Tang, Yang Wang*, Ai-Jun Hou*. The Total Synthesis of (+/-)-Sanggenol F. Tetrahedron, 2017, 73(25): 3485-3491
3. Qing-Hua Huang, Chun Lei, Pei-Pei Wang, Jing-Ya Li, Jia Li, Ai-Jun Hou*. Isoprenylated Phenolic Compounds with PTP1B Inhibition from Morus alba. Fitoterapia, 2017, 122: 138-143
4. Lai-Bin Zhang#, Hai-Bing Liao#, Hai-Yan Zhu, Mei-Hua Yu, Chun Lei, Ai-Jun Hou*. Antiviral Clerodane Diterpenoids from Dodonaea viscosa. Tetrahedron, 2016, 72(49): 8036-8041
5. Chun Lei, Lai-Bin Zhang, Jing Yang, Li-Xin Gao, Jing-Ya Li, Jia Li, Ai-Jun Hou*. Macdentichalcone, a Unique Polycyclic Dimeric Chalcone from Macaranga denticulata. Tetrahedron Letters, 2016, 57(49): 5475-5478
6. Hai-Bing Liao, Chun Lei, Li-Xin Gao, Jing-Ya Li, Jia Li, Ai-Jun Hou*. Two Enantiomeric Pairs of Meroterpenoids from Rhododendron capitatum. Organic Letters, 2015, 17(20): 5040-5043
7. Meng Wang, Li-Xin Gao, Jue Wang, Jing-Ya Li, Mei-Hua Yu, Jia Li, Ai-Jun Hou*. Diels-Alder Adducts with PTP1B Inhibition from Morus notabilis. Phytochemistry, 2015, 109: 140-146
8. Chang-Chang Liu, Chun Lei, Yang Zhong, Li-Xin Gao, Jing-Ya Li, Mei-Hua Yu, Jia Li, Ai-Jun Hou*. Novel Grayanane Diterpenoids from Rhododendron principis. Tetrahedron, 2014, 70(29): 4317-4322
9. Fei Tang, Yang Wang*, Ai-Jun Hou*. Total Syntheses of Nigrasin I and Kuwanon C. Tetrahedron, 2014, 70(26): 3963-3970。
10. Wen-Jing Zhang, Jing-Fang Wu, Peng-Fei Zhou, Yang Wang*, Ai-Jun Hou*. Total Syntheses of Norartocarpin and Artocarpin. Tetrahedron, 2013, 69(29): 5850-5858
Patents
1. Ai-Jun Hou, He-Yao Wang, Jun Ji, Jin-Wei Wu, Xiao Hu, Yang Wang. Application of flavonoid to drug for treating metabolic diseases. Chinese Invention Patent, No. ZL201310168616.5
2. Ai-Jun Hou, Yang Wang, Chun Lei, Wen-Jing Zhang, Mei-Hua Yu. Method for synthesis of natural products having lipase inhibitory activity and application. Chinese Invention Patent, No. ZL201210378621.4
3. Ai-Jun Hou, He-Yao Wang, Chun Lei, Ting Zhao, Gui-Rui Yan, Mei-Hua Yu. Method for preparation of prenylated flavonoid and its application in preparation of pancreatic lipase inhibitor. Chinese Invention Patent, No. ZL201110137006.X
4. Ai-Jun Hou, He-Yao Wang, Jun Ji, Jin-Wei Wu, Xiao Hu, Yang Wang. Application of flavonoid to drug for treating metabolic diseases. Chinese Invention Patent, No. ZL201110001869.4
5. Ai-Jun Hou, He-Yao Wang, Jian-Ming Huang, Ting Zhao, Gui-Rui Yan. Extract of Artocarpus nitidus and its application as pancreatic lipase inhibitor and anti-obesity agent. Chinese Invention Patent, No. ZL200910047607.4
