1986.9 - 1991.7 中国药科大学 博士（生药学）
1981.9 - 1986.7 上海医科大学 学士（药学）
2019.07 至今 复旦大学天然药物学系 系主任、教授、博导
2006.10 - 2006.11 日本九州大学药学院 访问教授
2002.01 - 2002.07 美国北卡罗莱纳大学药学院 访问教授
1999.03 - 2019.07 复旦大学生药学教研室 主任、博导
1998.02 - 1999.01 美国阿拉巴马大学伯明翰分校 访问学者
1997.07 - 2019.07 复旦大学生药学教研室 教 授
1995.03 - 2005.09 复旦大学药学院 副院长
1993.12 - 1997.06 上海医科大学生药学教研室 副教授
1991.07 - 1993.11 上海医科大学生药学教研室 讲师
国家杰出青年，教育部跨世纪人才，上海市优秀学科带头人，上海市曙光学者
1. 芩百清肺浓缩丸治疗支原体肺炎的免疫调控与整合作用，国家自然科学基金区域联合重点项目（U25A20171）
2. 清热解毒方药治疗肺部感染的免疫调控机制与药效物质，国家自然科学基金重点项目（82030113）
3. 功能多糖库的构建，科技部“重大新药创制”重大科技专项课题“中药功能多糖库的构建及其关键技术研究”子课题（2019ZX09735001-002）
4. 清热类中药的抗补体活性多糖及其构效关系，国家自然科学基金面上项目（81872977）
5. 清热解毒中药治疗呼吸系统病毒感染的药效物质与作用机制，国家自然科学基金重点项目（81330089）
6. 中药化学（清热解毒中药的药效物质基础及其作用机制），国家杰出青年科学基金项目（30925042）
7. 中药药效物质基础及物质资源库研究关键技术，科技部“重大新药创制”重大科技专项课题（2009ZX09502-013）
天然先导化合物的发现和优化，科技部“重大新药创制”重大科技专项课题“创新药物研究开发技术平台建设”子课题（2009ZX09301-011）
世界中医药学会联合会中药化学/中药分析/中药鉴定专委会 副主任委员
第八至第十二届国家药典委员会委员
上海市植物学会副理事长
教育部高等学校科学技术奖自然科学一等奖（第一完成人，2007）
国务院政府特殊津贴获得者（2001）
1. 中药抗呼吸系统感染的药效物质与作用机制
2. 中药多糖的结构解析与免疫调控机制
3. 中药质量标准与新药研究
1. XX Li, WX Ding, Y Lu, HY Zhu, WL Bao, Y Liu, JR Lyu, LS Zhou, H Li, JY Li, DF Chen. An Anti-complement Homogeneous Polysaccharide from Houttuynia cordata Ameliorates Acute Pneumonia with H1N1 and MRSA Coinfection through Rectifying Treg/Th17 Imbalance in the Gut–Lung Axis and NLRP3 Inflammasome Activation. Acta Pharmaceutica Sinica B2025, 15(6): 3073-3091
2. WL Bao, JR Lyu, GZ Feng, LF Guo, D Zhao, KY You, Y Liu, HD Li, P Du. DF Chen, XY Shen. Aloe Emodin Promotes Mucosal Healing by Modifying the Differentiation Fate of Enteroendocrine Cells via Regulating Cellular Free Fatty Acid Sensitivity.Acta Pharmaceutica Sinica B 2024, 14(9): 3964-3982
3. LF Guo, WL Bao, SY Yang, Y Liu, JR Lyu, T Wang, Y Lu, H Li, HY Zhu, DF Chen. Rhei Radix et Rhizoma in Xuanbai-Chengqi Decoction Strengthens the Intestinal Barrier Function and Promotes Lung Barrier Repair in Preventing Severe Viral Pneumonia Induced by Influenza A Virus. Journal of Ethnopharmacology2024, 319: 11723
4. LJ Ling, AQ Ren, Y Lu, YY Zhang, HY Zhu, P Tu, H Li, DF Chen. The Synergistic Effect and Mechanisms of Flavonoids and Polysaccharides from Houttuynia cordataon H1N1-induced Pneumonia in Mice. Journal of Ethnopharmacology2023, 302: 115761
5. LS Zhou, YK Jiao, JY Tang, ZZ Zhao, HY Zhu, Y Lu, DF Chen. Ultrafiltration Isolation, Structure and Effects on H1N1-induced Acute Lung Injury of a Heteropolysaccharide from Houttuynia cordata. International Journal of Biological Macromolecules 2022, 222: 2414-2425
6. J Zhang, JY Huo, ZZ Zhao, Y Lu, Z Hong, H Li, DF Chen. An Anticomplement Homogeneous Polysaccharide from Hedyotis diffusa Attenuates Lipopolysaccharide-induced Acute Lung Injury and Inhibits Neutrophil Extracellular Trap Formation. Phytomedicine 2022, 107: 154453
7. CC Shi, LS Zhou, H Li, XL Shi, YY Zhang, Y Lu, HY Zhu, DF Chen. Intestinal Microbiota Metabolizing Houttuynia cordata Polysaccharides in H1N1-induced Pneumonia Mice Contributed to Th17/Treg Rebalance in Gut-Lung Axis. International Journal of Biological Macromolecules 2022, 221: 288-302
8. CC Shi, HY Zhu, H Li, DL Zeng, XL Shi, YY Zhang,Y Lu, LJ Ling, CY Wang, DF Chen. Regulating the Balance of Th17/Treg Cells in Gut-Lung Axis Contributed to theTherapeutic Effect of Houttuynia cordata Polysaccharides on H1N1-inducedAcute Lung Injury. International Journal of Biological Macromolecules 2020, 158: 52-66
9. LJ Ling, Y Lu, YY Zhang, HY Zhu, P Tu, H Li, DF Chen. Flavonoids from Houttuynia cordata Attenuate H1N1-induced Acute Lung Injury in Mice via Inhibition of Influenza Virus and Toll-like Receptor Signalling. Phytomedicine 2020, 67: 153150
10. HD Zhao, Y Lu, M Yan, CH Chen, Susan Morris-Natschke, KH Lee, DF Chen. Rapid Recognition and Targeted Isolation of Anti-HIV Daphnane Diterpenes from Daphne genkwaGuided by UPLC-MSn. J Nat Prod2020, 83:134-141
11. HJ Zhi, X Jin, HY Zhu, H Li, YY Zhang, Y Lu, DF Chen. Exploring the Effective Materials of Flavonoids-enriched Extract from Scutellaria baicalensis Roots based on the Metabolic Activation in Influenza Virus A Induced Acute Lung Injury. J Pharm Biomed Anal2020, 112876
12. YS Huang, Y Lu, CH Chen, KH Lee, DF Chen. Potent Anti-HIV Ingenane Diterpenoids from Euphorbia ebracteolata. J Nat Prod2019, 82(6): 1587-1592
13. HJ Zhi, HY Zhu, YY Zhang, Y Lu, H Li, DF Chen. In vivoEffect of Quantified Flavonoids-enriched Extract of Scutellaria baicalensisRoot on Acute Lung Injury Induced by Influenza A Virus. Phytomedicine2019,57: 105-116
14. HY Zhu, XX Lu, LJ Ling, H Li, YY Ou, XL Shi, Y Lu, YY Zhang, DF Chen. Houttuynia cordata Polysaccharides Ameliorate Pneumonia Severity and Intestinal Injury in Mice with Influenza Virus Infection. Journal of Ethnopharmacology2018, 218: 90-99
15. Y Lu, Y Jiang, LJ Ling, YY Zhang, H Li, DF Chen. Beneficial Effects of Houttuynia cordata Polysaccharides on ‘Two-hit’ Acute Lung Injury and Endotoxic Fever in Rats Associated with Anti-complementary Activities. Acta Pharmaceutica Sinica B 2018, 8(2): 218-227
16. M Yan,Y Lu,CH Chen,Y Zhao, KH Lee,DF Chen.Stelleralides D–J and Anti-HIV Daphnane Diterpenes from Stellera chamaejasme. J Nat Prod2015, 78(11): 2712-2718
17. JY Xie, H Li, HY Di, XQ Cheng, YY Zhang, DF Chen. Bupleurum chinenseDC Polysaccharides Attenuates Lipopolysaccharide-induced Acute Lung Injury in Mice.Phytomedicine2012, 19(2): 130-137
18. Y Lu, DF Chen. Analysis of Schisandra chinensis and Schisandra sphenanthera. Journal of Chromatography A2009, 1216(11): 1980-1990
19. H Xu, YY Zhang, JW Zhang, DF Chen.Isolation and Characterization of an Anti-complementary Polysaccharide D3-S1 from the Roots of Bupleurum smithii. International Immunopharmacology 2007, 7(2):175-182
20. YQ Yu, PL Ding, DF Chen. Determination of Quinolizidine Alkaloids in Sophora Medicinal Plants by Capillary Electrophoresis.Analytica Chimica Acta2004, 523(1): 15-20
