王聪博士现为复旦大学药学院青年研究员，博士生导师。博士毕业于复旦大学药学院，后于复旦大学工研院从事博士后研究。王聪博士聚焦于脑疾病诊治重大需求，针对临床广泛使用的结构成像存在灵敏度不足、特异性不佳、时效性不强等瓶颈，在构建高灵敏、高特异性可视化神经系统探针方面做出了系统的工作。在国际权威期刊发表论文20余篇，包括Nat Biomed Eng、EBioMedicine、Adv Mater等，获得中国授权专利2项。作为课题负责人承担国家级项目3项，上海市项目3项；入选博士后创新人才支持计划、上海脑科学与类脑研究中心“求索杰出青年”计划、上海市“启明星”人才项目等，曾获得2023世界分子影像大会的Young Investigator Award、2020百特中国青年研究者奖等荣誉。
1. 上海市科学技术委员会启明星项目， 2023.04-2026.03，主持
2. 国家自然科学基金委员会青年科学基金项目，2023.01-2025.12，主持
3. 中国博士后科学基金会创新人才支持计划，2020.06-2023.05，主持
4. 上海市人力资源和社会保障局超级博士后激励计划，2020.06-2022.05，主持
5. 上海脑科学与类脑研究中心“求索杰出青年”计划，2020.07-2023.06，主持
6. 中国博士后科学基金会面上项目， 2021.01-2023.05，主持
7. 复旦大学引进人才科研基金， 2023.07-2026.06，主持
1. 2023世界分子影像大会Young Investigator Award（全球仅3人）
2. 百特中国青年研究者一等奖 (2020)
3. 中国医药生物技术协会生物医学成像技术分会，委员
4. 中国化学会会员
5. 上海市医学会会员
1. 跨血脑屏障功能分子影像探针开发
2. 放射性诊疗药物研制
3. 基于神经环路的脑疾病调控新策略
本团队瞄准难治性癫痫诊治重大需求，针对临床广泛使用的结构成像存在灵敏度不足、特异性不佳、时效性不强等瓶颈，在构建高灵敏、高特异性可视化神经系统探针方面做出了系统的工作，提出了受体“梯次双靶”成像策略，开发了可视化神经元异常放电定位致癫灶的影像技术，实现了致痫灶从“结构看不见”到“功能看得见”的跨越，对扩大临床难治性癫痫手术适用人群具有重要意义。
1. Cong Wang#, Wanbing Sun#, Jun Zhang#, Jianping Zhang, Qinghua Guo, Xingyu Zhou, Dandan Fan, Haoran Liu, Ming Qi, Xihui Gao, Haiyan Xu, Zhaobing Gao, Mei Tian, Hong Zhang, Jianhong Wang, Zixuan Wei, Nicholas J. Long, Ying Mao* and Cong Li*. An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy. Nature Biomedical Engineering. 2021, 5: 278-289.
2. Cong Wang#, Jianping Zhang#, Shaoli Song, Zhi Li, Shujie Yin, Wenjia Duan, Zixuan Wei, Ming Qi, Wanbing Sun, Lu Zhang, Luo Chen, Xihui Gao, Ying Mao, Hao Wang*, Liang Chen*, Cong Li*. Imaging epileptic foci in mouse models via a low-density lipoprotein receptor-related protein-1 targeting strategy. EBioMedicine, 2021, 63: 103156.
3. Cong Wang, Qiaomei Jin, Shengwei Yang, Dongjian Zhang, Qin Wang, Jindian Li, Shaoli Song, Ziping Sun, Yicheng Ni, Jian Zhang*, Zhiqi Yin*. Synthesis and Evaluation of 131I‑Skyrin as a Necrosis Avid Agent for Potential Targeted Radionuclide Therapy of Solid Tumors. Molecular Pharmaceutics, 2016, 13, 180-189.
4. Jing Zhao#, Cong Wang#, Wanbing Sun, Cong Li*. Tailoring Materials for Epilepsy Imaging: From Biomarkers to Imaging Probes. Advanced Materials, 2022, 34, 2203667.
5. Zhi Li#, Wanbing Sun#, Wenjia Duan#, Yiqing Jiang, Ming Chen, Guorong Lin, Qinyue Wang, Zhen Fan, Yusheng Tong, Luo Chen, Jianing Li, Guangli Cheng, Cong Wang*, Cong Li*, and Liang Chen*. Guiding Epilepsy Surgery with an LRP1-Targeted SPECT/SERRS Dual-Mode Imaging Probe. ACS Applied Materials Interfaces, 2023, 15, 14-25.
6. Wenjia Duan#, Cong Wang#, Yiqing Jiang, An Sui, Zhi Li, Lu Wang, Zuhai Lei, Silvio Aime, Jinhua Yu* and Cong Li*. A ratiometric SERS probe for imaging the macrophage phenotypes in live mice with epilepsy and brain tumor. Advanced Healthcare Materials, 2023, 12(27): 2301000.
7. Feng Zeng, Yahong Shi, Chunni Wu, Jianming Liang, Qixin Zhong, Karen Briley, Bin Xu, Yongzhuo Huang, Manmei Long, Cong Wang, Jian Chen, Yonghua Tang, Xinying Li, Mengda Jiang, Luting Wang, Qin Xu, Liu Yang, Peng Chen, Shengzhong Duan, Jingyuan Xie*, Cong Li*, Yingwei Wu*. A drug-free nanozyme for mitigating oxidative stress and inflammatory bowel disease. Journal of Nanobiotechnology. 2022, 20(1), 107.
8. Mengling Wang, Feng Zeng, Fengling Ning, Yinhang Wang, Shilin Zhou, Jiaqi He, Cong Li, Cong Wang, Xiaolin Sun, Dongliang Zhang, Jisheng Xiao, Ping Hu, Svetlana Reilly, Hong Xin*, Xudong Xu*, Xuemei Zhang*. Ceria nanoparticles ameliorate renal fibrosis by modulating the balance between oxidative phosphorylation and aerobic glycolysis. Journal of Nanobiotechnology 2022, 20 (1), 3.
9. Dandan Fan, Qi Yue, Jian Chen, Cong Wang, Ruilin Yu, Ziyi Jin, Shujie Yin, Qinyue Wang, Luo Chen, Xueling Liao, Chengyuan Peng, Jianpin Zhang, Zhonglian Cao, Ying Mao, Ruimin Huang, Liang Chen & Cong Li. Reprogramming the immunosuppressive microenvironment of IDH1 wild-type glioblastoma by blocking Wnt signaling between microglia and cancer cells. OncoImmunology,2021, 10(1): 1932061.
10. Yicheng Wang, Zuhai Lei, Cong Wang, Chong Cao, Jiayi Hu, Ling Du, Limei Han and Cong Li. Unsymmetrical pentamethine cyanines for visualizing physiological acidities from the whole animal to the cellular scale with pH-responsive deep-red fluorescence. RSC Advances, 2021,11(29): 17871.
11. Wenjia Duan#, Qi Yue#, Ying Liu#, Yunfei Zhang, Qinghua Guo, Cong Wang, Shujie Yin, Dandan Fan, Wenjing Xu, Jiexian Zhuang, Jiachao Gong, Xinwei Li, Ruimin Huang, Liang Chen, Silvio Aime, Zhongliang Wang, Jianfeng Feng, Ying Mao, XiaoYong Zhang and Cong Li. A pH ratiometrically responsive surface enhanced resonance Raman scattering probe for tumor acidic margin delineation and image-guided surgery. Chemical Science, 2020, 11(17): 4397.
12. Limei Han#, Wenjia Duan#, Xinwei Li#, Cong Wang, Ziyi Jin, Yuting Zhai, Chong Cao, Luo Chen, Wenjing Xu, Ying Liu, YongYan Bi, Jianfeng Feng, Mao Ying, Qi Yue*, Xiao-Yong Zhang*, and Cong Li*. Surface-Enhanced Resonance Raman Scattering-Guided Brain Tumor Surgery Showing Prognostic Benefit in Rat Models. ACS Applied Materials & Interfaces, 2019, 11, 15241-15250.
13. Pengpeng Sun#, Yunfei Zhang#, Kaicheng Li#, Cong Wang, Feng Zeng, Jinyu Zhu, Yingwei Wu*, Xiaofeng Tao*. Image-guided surgery of head and neck carcinoma in rabbit models by intra-operatively defining tumour-infiltrated margins and metastatic lymph nodes. EBioMedicine, 2019, 50, 93-102.
14. Qin Wang#, Shengwei Yang, Cuihua Jiang, Jindian Li, Cong Wang, Linwei Chen#, Qiaomei Jin, Shaoli Song, Yuanbo Feng, Yicheng Ni, Jian Zhang*, Zhiqi Yin*. Discovery of Radioiodinated Monomeric Anthraquinones as a Novel Class of Necrosis Avid Agents for Early Imaging of Necrotic Myocardium. Scientific Reports, 2016, 6, 21341.
15. Jindian Li#, Jian Zhang#, Shengwei Yang, Cuihua Jiang, DongJian Zhang, Qiaomei Jin, Qin Wang, Cong Wang, Yicheng Ni, Zhiqi Yin*, Shaoli Song*. Synthesis and Preclinical Evaluation of Radioiodinated Hypericin Dicarboxylic Acid as a Necrosis Avid Agent in Rat Models of Induced Hepatic, Muscular, and Myocardial Necroses. Molecular Pharmaceutics, 2016, 13, 232-240.
16. Ling Li, Dongjian Zhang, Shengwei Yang, Shaoli Song, Jindian Li, Qin Wang, Cong Wang, Yuanbo Feng, Yicheng Ni, Jian Zhang*, Wei Liu*, Zhiqi Yin*. Effects of Glycosylation on Biodistribution and Imaging Quality of Necrotic Myocardium of Iodine-131 Labeled Sennidins. Molecular Imaging and Biology, 2016, 18: 877-886.
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