王聪博士现为复旦大学药学院青年研究员，博士生导师。博士毕业于复旦大学药学院，后于复旦大学工研院从事博士后研究。王聪博士聚焦于脑疾病诊治重大需求，针对临床广泛使用的结构成像存在灵敏度不足、特异性不佳、时效性不强等瓶颈，在构建高灵敏、高特异性可视化神经系统探针方面做出了系统的工作。在国际权威期刊发表论文20余篇，包括Nat Biomed Eng、EBioMedicine、Adv Mater等，获得中国授权专利2项。作为课题负责人承担国家级项目4项，上海市项目3项；入选博士后创新人才支持计划、上海市“启明星”人才项目、上海市东方英才计划青年项目等，曾获得2023世界分子影像大会的Young Investigator Award、2020百特中国青年研究者奖等荣誉。
1. 国家自然科学基金委员会面上项目，2025.01-2028.12，主持
2. 上海市人才工作局东方英才计划青年项目，2025.01-2027.12，主持
3. 上海市科学技术委员会启明星项目， 2023.04-2026.03，主持
4. 国家自然科学基金委员会青年科学基金项目，2023.01-2025.12，主持
5. 复旦大学引进人才科研基金， 2023.07-2026.06，主持
1. 2023世界分子影像大会Young Investigator Award（全球仅3人）
2. 百特中国青年研究者一等奖 (2020)
3. 中国医药生物技术协会生物医学成像技术分会，委员
4. The Innovation，青年编委，2024
5. Exploration，青年编委，2024
1. 跨血脑屏障功能分子影像探针开发
2. 放射性诊疗药物研制
3. 脑疾病调控新策略及新技术
本团队瞄准难治性癫痫诊治重大需求，针对临床广泛使用的结构成像存在灵敏度不足、特异性不佳、时效性不强等瓶颈，在构建高灵敏、高特异性可视化神经系统探针方面做出了系统的工作，提出了受体“梯次双靶”成像策略，开发了可视化神经元异常放电定位致癫灶的影像技术，实现了致痫灶从“结构看不见”到“功能看得见”的跨越，对扩大临床难治性癫痫手术适用人群具有重要意义。
1. Jing Zhao†, Yuncan Chen†, Yurui Tang†, Bohan Li, Qinyue Wang, Junfeng Wang, Xihui Gao, Yunle Zhang, Jing Wang*, Zuhai Lei*, Cong Li*, Cong Wang*. Tandem Dual-Ratiometric SERS Probe Enables Raman Imaging of Neurological pH Fluctuations in Epilepsy. Angewandte Chemie International Edition, 2025, 64(25):e202504822.
2. Cong Wang†*, Zhi Li†, Xiao Zhu, Wanbing Sun, Yue Ding, Wenjia Duan, Difei Wang, Yiqing Jiang, Ming Chen, Yuncan Chen, Jiayi Hu, Zheping Cai, Jing Zhao, Junfeng Wang, Zhen Fan, Faming Zheng, Xingyu Zhou, Fang Xie, Jianping Zhang, Yihui Guan, Kui Yan, Zuhai Lei, Qinyue Wang, Luting Wang, Xiao Xiao*, Hairong Zheng*, Liang Chen*, Cong Li* and Ying Mao*. Ultrabright Ratiometric Raman-guided Epilepsy Surgery by Intraoperatively Visualizing Proinflammatory Microglia. Cell Reports Medicine, 2025, 6(6), 102155.
3. Xin Wang†, Yanlong Cheng†, Zhengzhuo Qi, Jing Zhao, Cong Wang*. Bio-Nano Innovations for Precision Epilepsy Treatment. Advanced Healthcare Materials, 2025, 14(14), e2404857.
4. Bolin Yao†, Yanyan Kong†, Jianing Li†, Fulin Xu†, Yan Deng, Yuncan Chen, Yixiu Chen, Jian Chen, Minhua Xu, Xiao Zhu, Liang Chen, Fang Xie, Xin Zhang*, Cong Wang*, Cong Li*. Synthesis, Preclinical Evaluation and Pilot Clinical Study of a P2Y12 Receptor Targeting Radiotracer [18F]QTFT for Imaging Brain Disorders by Visualizing Anti-Inflammatory Microglia. Acta Pharmaceutica Sinica B, 2025, 15(2):1056-1069.
5. Hang Yin†, Xin Zhang†, Zheng Zhao†, Chong Cao†, Minhua Xu, Suhongrui Zhou, Tian Xuan, Ziyi Jin, Limei Han, Yang Fan, Cong Wang*, Xiao Zhu*, Ying Mao*, Jinhua Yu*, Cong Li*. AI-Enhanced Metabolite Profiling for Intraoperative IDH1 Genotyping in Glioma Using an Orthogonal Responsive SERS Probe. Advanced Science, 2025, 12(26):e2503360.
6. Shumao Xu*; Minyan Ge; Shugeng Chen; Yuchun Wang; Yurui Tang; Jinling Wang; Xinyi Cui; Chenchen Sun; Hairong Zeng; Nianhong Wang; Cong Wang*; Jing Wang*. Leveraging Laser-Patterned Copper Electrodes for Personal Healthcare. Small Methods, 2025, doi: 10.1002/smtd.202500056.
7. Yang Fan#, Hang Yin#, Jing Zhao#, Bolin Yao#, Guangli Cheng, Yaqi Yang, Minghao Yang, Luo Chen, Jian Chen, Ji Zhou, Ren Li, Botao Zhao, Xiao-Yong Zhang, Cong Wang*, Xihui Gao* and Cong Li*. Adoptive Macrophages Suppress Glioblastoma Growth by Reversing Immunosuppressive Microenvironment through Programmed Phenotype Repolarization. Cell Reports, 2025, Accepted.
8. Zhi Li#, Wanbing Sun#, Wenjia Duan#, Yiqing Jiang, Ming Chen, Guorong Lin, Qinyue Wang, Zhen Fan, Yusheng Tong, Luo Chen, Jianing Li, Guangli Cheng, Cong Wang*, Cong Li*, and Liang Chen*. Guiding Epilepsy Surgery with an LRP1-Targeted SPECT/SERRS Dual-Mode Imaging Probe. ACS Applied Materials Interfaces, 2023, 15, 14-25.
9. Cong Wang#, Wanbing Sun#, Jun Zhang#, Jianping Zhang, Qinghua Guo, Xingyu Zhou, Dandan Fan, Haoran Liu, Ming Qi, Xihui Gao, Haiyan Xu, Zhaobing Gao, Mei Tian, Hong Zhang, Jianhong Wang, Zixuan Wei, Nicholas J. Long, Ying Mao* and Cong Li*. An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy. Nature Biomedical Engineering. 2021, 5: 278-289.
10. Cong Wang#, Jianping Zhang#, Shaoli Song, Zhi Li, Shujie Yin, Wenjia Duan, Zixuan Wei, Ming Qi, Wanbing Sun, Lu Zhang, Luo Chen, Xihui Gao, Ying Mao, Hao Wang*, Liang Chen*, Cong Li*. Imaging epileptic foci in mouse models via a low-density lipoprotein receptor-related protein-1 targeting strategy. EBioMedicine, 2021, 63: 103156.
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