1992.09 – 1996.07 上海医科大学药学院药学专业 获理学学士
1996.09 – 1999.07 上海医科大学药学院药剂学专业 获硕士学位
2001.09 – 2005.07 复旦大学药学院药剂学专业 获博士学位
1999.07 – 至今 复旦大学药学院药剂学系，助教，讲师，副教授
硕士生导师；药剂学系教学副主任
1. 国家自然科学基金面上项目, 维生素C衍生物修饰聚合物胶束的脑靶向机制及其抗脑卒中的研究（No.81072594），2010–2013，主持
2. 上海市科委中药现代化项目,散结止痛巴布剂的临床前研制(07DZ19713)，2007–2010，主持
3. 参与国家科技重大专项“重大新药创制”项目3项，其中主持子课题“阿司匹林缓释片的研制”（2009ZX09310-006）和“灯盏花素自微乳胶囊的研制”（2009ZX09310-003）
4. 参与国际合作项目1项（罗氏制药：口服淋巴吸收机理及给药系统研究，2008–2009）
5. 承担企业合作与技术服务项目10余项，涉及透皮贴剂、凝胶贴膏、乳膏等外用制剂的开发与体外透皮（IVPT）比较评价，以及可溶性微针制备工艺开发
1. 可溶性微针经皮递药系统（疫苗、蛋白/多肽及难溶性药物的经皮递送）
2. 透皮给药系统与外用制剂的开发及评价
3. 口服吸收与淋巴转运机制及新型制剂技术的研究
1. 围绕可溶性微针开展系统研究，建立冻干法制备可溶性微针贴片的技术路线，缩短成型时间、降低含水量并改善热敏性药物的稳定性；构建了负载疫苗、重组水蛭素、他克莫司纳米晶的可溶性微针及光热抗肿瘤微针等经皮递送系统，相关成果发表于ACS Applied Materials & Interfaces、International Journal of Pharmaceutics、Asian Journal of Pharmaceutical Sciences等期刊，“一种使用冷冻干燥技术制备可溶性微针贴片的方法”获授权发明专利。
2. 建立外用制剂体外释放（IVRT）、体外透皮（IVPT）、皮肤滞留及流变学评价体系，开展凝胶贴膏基质流变学研究及多项外用制剂比较评价研究；完成散结止痛凝胶贴膏临床前研究并进行中药新药注册申报，“他莫昔芬凝胶贴膏及其制备方法”获授权发明专利。
3. 采用膜控型透皮给药系统设计方案，研制贴片面积在20cm2内成功实现治疗剂量的川芎嗪经皮吸收达到有效治疗水平。人体临床药代动力学试验研究显示，与口服普通片3次/日比较，每日1次应用该贴片在24h内产生平稳持久的治疗血浓，显著降低了血药浓度波动。本品获得SFDA新药临床研究批件并转让企业。
4. 针对阿司匹林对湿、热敏感而极易水解，该药缓释片原研品实际稳定性小于1年。采用水不溶性材料-乙基纤维素作为骨架，研制品的缓释曲线与原研品一致，长期稳定性达到3年。本品获得SFDA临床试验批件并转让生产企业。
5. 创建大鼠肠系膜淋巴插管技术，研究了紫杉醇、灯盏花素的口服淋巴转运规律，用以指导难溶性药物口服新型制剂的研发。研究成果获得第六届《药学学报》优秀研究论文奖。
6. 利用胃肠道酯解原理设计口服脂质给药系统，灯盏花素口服自微乳在重大新药创制十二五制剂平台的资助下开展了临床前研究。
7. 申请专利16项，授权专利9项。
累计发表学术论文50余篇，其中以第一或通讯作者发表SCI论文16篇。代表性论文如下：
1. Tong Su#, Zequn Tang#, Jiayi Hu, Yuyu Zhu, Teng Shen*. Innovative freeze-drying technique in the fabrication of dissolving microneedle patch: Enhancing transdermal drug delivery efficiency. Drug Delivery and Translational Research. 2024, 14(11): 3112-3127.
2. Zening Men, Tong Su, Zequn Tang, Jun Liang*, Teng Shen*. Tacrolimus nanocrystals microneedle patch for plaque psoriasis. International Journal of Pharmaceutics. 2022, 627: 122207.
3. Mengfang Wu, Tian Xia, Yaran Li, Tianfa Wang, Shijia Yang, Jinchao Yu, Qiaoyan Liang, Teng Shen*, Min Yu*, Bing Zhao*. Design and fabrication of r-hirudin loaded dissolving microneedle patch for minimally invasive and long-term treatment of thromboembolic disease. Asian Journal of Pharmaceutical Sciences. 2022, 17(2): 284-297.
4. Zening Men#, Xiaotong Lu#, Ting He, Mengfang Wu, Tong Su, Teng Shen*. Microneedle patch-assisted transdermal administration of recombinant hirudin for the treatment of thrombotic diseases. International Journal of Pharmaceutics. 2022, 612: 121332.
5. Ting He#, Yu Luo#*, Qin Zhang#, Zening Men, Tong Su, Linpeng Fan, Hangrong Chen*, Teng Shen*. Hyalase-mediated cascade degradation of a matrix barrier and immune cell penetration by a photothermal microneedle for efficient anticancer therapy. ACS Applied Materials & Interfaces. 2021, 13(23): 26790-26799.
6. Xiangying Meng#, Jiajia Li#, Junhong Ni#, Xiaotong Lu, Ting He, Zening Men, Jiansheng Liu*, Teng Shen*. Electro-responsive brain-targeting mixed micelles based on Pluronic F127 and d-α-tocopherol polyethylene glycol succinate–ferrocene. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2020, 601: 124986.
7. Xin Meng#, Jiansheng Liu#, Xiangrong Yu#, Jiajia Li, Xiaotong Lu, Teng Shen*. Pluronic F127 and D-α-tocopheryl polyethylene glycol succinate (TPGS) mixed micelles for targeting drug delivery across the blood brain barrier. Scientific Reports. 2017, 7: 2964.
8. Jiansheng Liu#, Yajing He#, Jun Zhang, Jiajia Li, Xiangrong Yu, Zhonglian Cao, Fanmin Meng, Yuwu Zhao, Xunyi Wu*, Teng Shen*, Zhen Hong. Functionalized nanocarrier combined seizure-specific vector with P-glycoprotein modulation property for antiepileptic drug delivery. Biomaterials. 2016, 74: 64-76.
9. Jiansheng Liu#, Jianhong Wang#, Jie Zhou, Xinghua Tang, Lan Xu, Teng Shen*, Xunyi Wu*, Zhen Hong. Enhanced brain delivery of lamotrigine with Pluronic® P123-based nanocarrier. International Journal of Nanomedicine. 2014, 9: 3923-3935.
10. Jian Wang, Hongqin Zhang, Dianyun An, Jian Yu, Wei Li, Teng Shen*, Jianxin Wang. Rheological Characterization of Cataplasm Bases Composed of Cross-Linked Partially Neutralized Polyacrylate Hydrogel. AAPS PharmSciTech. 2014, 15(5):1149-54.
11. Qingqing Cai, Xinxian Deng, Zhongdong Li*, Dianyun An, Teng Shen*, Mingkang Zhong. Effects of lipid vehicle and P-glycoprotein inhibition on the mesenteric lymphatic transport of paclitaxel in unconscious, lymph duct-cannulated rats. Drug Delivery. 2016, 23(1): 147-153.
12. Teng Shen*, Huinan Xu, Weiyu Weng, Jianfeng Zhang. Development of a Reservoir-Type Transdermal Delivery System Containing Eucalyptus Oil for Tetramethylpyrazine. Drug Delivery. 2013, 20(1): 19-24.
13. Teng Shen*, Huinan Xu, etc. Single- and Multiple-dose Pharmacokinetics of a Novel Tetramethylpyrazine Reservoir-type Transdermal Patch Versus Tetramethylpyrazine Phosphate Oral Tablets in Healthy Normal Volunteers, and In Vitro/In Vivo Correlation. Biological and Pharmaceutical Bulletin. 2013, 36(6): 931-937.
14. Hongrong Xu#, Guoxia Ji#, Qi Wang, Xuening Li, Yijuan Gong, Yun Zhang, Wei Li, Teng Shen*. Dose-dependent Pharmacokinetics of Bulleyaconitine A in Rats. Die Pharmazie. 2013, 68:170-172.
15. Qi Wang#, Bo Tan#, Yijuan Gong, Guoxia Ji, Yun Zhang, Ping Yang, Wei Li, Teng Shen*. Determination of bulleyaconitine A in plasma by a sensitive LC–MS/MS method and its application to an oral pharmacokinetic study in rats. Journal of Pharmaceutical and Biomedical Analysis. 2012, 71: 202–206.
