1997.09 – 2002.09 沈阳药科大学药剂学专业
1992.09 – 1996.07 天津医科大学药学专业
2016.12 – 复旦大学药学院，教授
2008.02 – 2009.03 美国马里兰大学，人类病毒学研究所，访问学者
2007.09 – 2016.11 复旦大学药学院，副教授
2004.10 – 2007.08 复旦大学药学院，讲师
2002.10 – 2004.09 复旦大学药学院，博士后
2026-2028治疗眼底疾病的蛋白药物滴眼液的转化研究，上海市卫生健康委员会医学新技术研究与转化种子计划重点项目
2025-2028穿膜肽药物递送，上海长三角技术创新研究院重点项目
2025-2029治疗脑肿瘤的有机大分子纳米药物工艺优化及放大研究，国家重点研发计划“纳米前沿”重点专项（参加）
2023-2026调控分子间结合促进穿膜肽介导蛋白药物无创眼内递送的机理研究，国家自然科学基金
2021-2024蛋白药物创新剂型的临床前研究，上海市“科技创新行动计划”生物医药科技支撑专项项目
2021-2024无创给药保眼治疗视网膜母细胞瘤的探索与实践，上海市“科技创新行动计划”自然科学基金项目
2017- 2021生物大分子药物高效递释系统的递送机制，自然科学基金重大项目课题（参加）
2016-2019柔性多价装订肽构建的自组装寡核苷酸递送系统用于治疗老年黄斑变性，国家自然科学基金
2012-2015双重促渗机制介导协同拮抗TGF-β共载药系统眼前段递药研究，国家自然科学基金
2012-2015外用避孕新剂型的研究，国家科技支撑计划
2026 上海医学科技奖三等奖，上海市医学会
2025妇幼健康科学技术自然科学三等奖，中国妇幼健康研究会
2023Acta Biomaterialia Reviewer Award
2021复旦大学研究生教学成果二等奖
2018 中国药物制剂大会优秀青年药剂工作者报告特等奖
2018复旦大学药学院珀金埃尔默奖
2017药学学报优秀审稿人
2016首届健康与纳米技术产学研医成果大赛二等奖
2016中国药物制剂大会青年药剂学奖
2016药学学报优秀审稿人
2014长三角药物制剂发展论坛优秀论文二等奖
2014中国药学会-中恒青年药剂学奖
主要从事黏膜和局部给药的基础与应用研究，以及生物大分子的修饰与递送研究。致力于克服药物递送屏障的载体设计与发现，发展通过无创给药途径递送生物大分子的新策略，并推动黏膜和局部给药新剂型向临床应用转化。
1.无创给药策略促进眼部药物吸收：从临床需求出发，致力于设计新颖实用、兼有良好顺应性与高生物利用度的眼科制剂，通过多种策略满足不同类型药物的递送需求，改善生物大分子穿透眼部吸收屏障的能力。与国内外企业合作开发眼科新制剂，推动基础研究成果向临床应用转化。
2. 多肽蛋白质类药物的修饰与递送：借助固相合成与计算机辅助设计手段探索多肽结构与功能的相关性。通过结构改造，增强多肽穿透生理屏障能力与靶向递送能力，并利用其构建携载蛋白质或核酸类药物的功能化黏膜给药系统和靶向给药系统。
3. 环境敏感凝胶用于智能药物递送：基于用药部位的生理/病理特点，设计具有不同触发相变机理并满足不同临床需求的环境敏感型原位凝胶，并探索其在黏膜给药和局部注射给药等途径的应用。为企业开发的原位凝胶产品已获批准进入中美临床试验。
1.Chenghao Liu, Feiyang Geng, Yuhan Liu, Haiyan Zhu, Xunlong Shi, Weiyue Lu, Gang Wei*, Intranasal delivery of engineered macrophage-membrane-coated nanoparticles with enhanced Dectin-1 expression for targeted therapy of cryptococcal meningitis, Biomaterials, 2027, 337, 124559.
2.Sanjiang Du, Hanlin Wang, Feiyang Geng, Zongxu Zhang, Chenghao Liu, Weiyue Lu, Gang Wei*, Skin-penetrating peptides derived from computational simulation improve transdermal absorption and facilitate topical treatment of melanoma, Acta Pharmaceutica Sinica B, 2026,16(2):1140-1154.
3.Chong Chen#, Min Zhu#, Xingyan Fan#, Kangjia Lv#, Kuan Jiang#, Yuchen Zhang, Haoliang Zhang, Xinming Qi, Benjamin TK Lee*, Yakun Wan*, Gang Wei*, Kun Liu*, Xun Xu*, Continuous Suppression of Pathological Retinal and Choroidal Neovascularization in Cynomolgus Monkeys via Noninvasive Ophthalmic Delivery of a Novel Anti‐VEGFA Nanobody and Proprietary Penetratin Analog Formulation, Adv Sci. 2026,13(1): e04660.
4.Fan X, Jiang K, Zhao Y, Lee BT, Geng F, Brelen ME, Lu W, Wei G*. Peptide-Bound Aflibercept Eye Drops for Treatment of Neovascular Age-Related Macular Degeneration in Nonhuman Primates. Adv Sci. 2025, 12(11): e2410744.
5.Chenghao Liu, Qing Chang, Xingyan Fan, Nana Meng, Jiasheng Lu, Qinfeng Shu, Yijun Xie, Christian Celia*, Gang Wei*, Xiaoyong Deng*. Rational construction of CQDs-based targeted multifunctional nanoplatform for synergistic chemo-photothermal tumor therapy. Journal of Colloid and Interface Science. 2025, 677 (Part B): 79-90.
6.Feiyang Geng, Xingyan Fan, Yu Liu, Weiyue Lu, Gang Wei*. Recent advances in nanocrystal-based technologies applied for ocular drug delivery. Expert Opin Drug Deliv. 2024, 21(2):211-227.
7.Wang HL, Li JN, Kan WJ, Xu GY, Luo GH, Song N, Wu WB, Feng B, Fu JF, Tu YT, Liu MM, Xu R, Zhou YB*, Wei G*, Li J*. Chloroquine enhances the efficacy of chemotherapy drugs against acute myeloid leukemia by inactivating the autophagy pathway. Acta Pharmacol Sin. 2023, 44(11):2296-2306.
8.Wang H, Wu Z, Cao Y, Gao L, Shao J, Zhao Y, Zhang J, Zhou Y, Wei G*, Li J*, Zhu H*. Exploration of novel four-membered-heterocycle constructed peptidyl proteasome inhibitors with improved metabolic stability for cancer treatment. Bioorg Chem. 2023, 138:106626.
9.Fan X#, Jiang K#, Geng F, Lu W, Wei G*. Ocular therapies with biomacromolecules: From local injection to eyedrop and emerging noninvasive delivery strategies. Adv Drug Deliv Rev. 2023, 197:114864.
10.Gao, X.#; Fan, X.#; Jiang, K.; Hu, Y.; Liu, Y.; Lu, W.; Wei, G*. Intraocular siRNA Delivery Mediated by Penetratin Derivative to Silence Orthotopic Retinoblastoma Gene. Pharmaceutics 2023, 15, 745.
11.Tiantian Yang, Aohua Wang, Di Nie, Weiwei Fan, Xiaohe Jiang, Miaorong Yu, Shiyan Guo, Chunliu Zhu, Gang Wei*, Yong Gan*. Ligand-switchable nanoparticles resembling viral surface for sequential drug delivery and improved oral insulin therapy. Nat Commun 2022, 13: 6649.
12.Kuan Jiang, Xingyan Fan, Yang Hu, Shengyu Yao, Yu Liu, Changyou Zhan*, Weiyue Lu, Gang Wei*. Topical instillation of cell-penetrating peptide-conjugated melphalan blocks metastases of retinoblastoma. Biomaterials. 2022, 284: 121493
13.Yang Hu, Kuan Jiang, Dongli Wang, Shengyu Yao, Linwei Lu, Huan Wang, Jie Song, Jianfen Zhou, Xingyan Fan, Yong Wang, Weiyue Lu, Jian Wang*, Gang Wei*. Core-shell lipoplexes inducing active macropinocytosis promote intranasal delivery of c-Myc siRNA for treatment of glioblastoma. Acta Biomaterialia. 2022, 138: 478-490
14.Yang Hu#, Yanyu Zhang#, Xiaoyi Wang, Kuan Jiang, Huan Wang, Shengyu Yao, Yu Liu, Yao-Zhong Lin, Gang Wei*, and Weiyue Lu. Treatment of Lung Cancer by Peptide-Modified Liposomal Irinotecan Endowed with Tumor Penetration and NF-κB Inhibitory Activities. Molecular Pharmaceutics. 2020, 17(10): 3685–3695
15.Kuan Jiang#, Junyi Chen#, Lingyu Tai#, Chang Liu, Xishan Chen, Gang Wei*, Weiyue Lu, Weisan Pan. Inhibition of post-trabeculectomy fibrosis via topically instilled antisense oligonucleotide complexes co-loaded with fluorouracil. Acta Pharmaceutica Sinica B. 2020, 10(9): 1754-1768
16.Chong Li, Jiancheng Wang*, Yiguang Wang, Huile Gao, Gang Wei, Yongzhuo Huang, Haijun Yu, Yong Gan, Yongjun Wang, Lin Mei, Huabing Chen, Haiyan Hu, Zhiping Zhang, Yiguang Jin. Recent progress in drug delivery. Acta Pharmaceutica Sinica B. 2019, 9, 6: 1145-1162. (Co-first author)
17.Kuan Jiang, Yang Hu, Xin Gao, Changyou Zhan, Yanyu Zhang, Shengyu Yao, Cao Xie, Gang Wei*, Weiyue Lu. Octopus-like Flexible Vector for Noninvasive Intraocular Delivery of Short Interfering Nucleic Acids. Nano Lett. 2019, 19(9): 6410-6417.
18.Yanyu Zhang, Li Zhang, Yang Hu, Kuan Jiang, Zhuoquan Li, Yao-Zhong Lin, Gang Wei*, Weiyue Lu. Cell-permeable NF-κB inhibitor-conjugated liposomes for treatment of glioma. J. Control. Release 2018, 289 (10) 102-113.
19.Kuan Jiang, Xin Gao, Qing Shen, Changyou Zhan, Yanyu Zhang, Cao Xie, Gang Wei*, Weiyue Lu. Discerning the composition of penetratin for safe penetration from cornea to retina. Acta Biomater. 2017, 63: 123-134 (IF=6.319, Cited=1)
20.Lingyu Tai, Chang Liu, Kuan Jiang, Xishan Chen, Linglin Feng, Weisan Pan*, Gang Wei*, Weiyue Lu. A novel penetratin-modified complex for noninvasive intraocular delivery of antisense oligonucleotides. Int J Pharmaceut. 2017, 529(1-2): 347–356
21.Lingyu Tai, Chang Liu, Kuan Jiang, Xishan Chen, Gang Wei*, Weiyue Lu, Weisan Pan*. Noninvasive delivery of oligonucleotide by penetratin-modified polyplexes to inhibit protein expression of intraocular tumor. Nanomedicine. 2017, 13(6): 2091-2100
22.Yu Liu#, Fujin Yang#, Linglin Feng, Long Yang, Lingyun Chen, Gang Wei*, Weiyue Lu. In vivo retention of poloxamer-based in situ hydrogels for vaginal application in mouse and rat models. Acta Pharmaceutica Sinica B. 2017, 7(4): 502–509
24.Chang Liu#, Kuan Jiang#, Lingyu Tai, Yu Liu, Gang Wei*, Weiyue Lu, and Weisan Pan. Facile Noninvasive Retina Gene Delivery Enabled by Penetratin. ACS Appl. Mater. Interfaces, 2016, 8 (30): 19256–19267
25.Li Zhang#, Yanyu Zhang, Lingyu Tai, Kuan Jiang, Cao Xie, Zhuoquan Li, Yao-Zhong Lin, Gang Wei*, Weiyue Lu, Weisan Pan. Functionalized cell nucleus-penetrating peptide combined with doxorubicin for synergistic treatment of glioma. Acta Biomaterialia. 2016, 42(15): 90-101
