李嫣，复旦大学药学院药物分析学教授，博士生导师，主要研究方向为基于纳米材料的抗体药物质量评价、复杂样品前处理、药物毒物分析、农兽药残留分析。主持国家自然科学基金面上项目3项，青年项目1项，其他省部级项目4项。在Chem. Soc. Rev.、Trends Anal. Chem.、Anal. Chem.、Anal. Chim. Acta、Talanta等杂志上发表SCI论文100余篇。任教育部高等教育教学评估中心药学教育专业认证专家组成员；上海市药学会药物分析专业委员会委员，国家药品监督管理局治疗类单抗质量控制重点实验室学术委员会委员；以及J. Pharm. Anal.、J. Anal. Testing等多个学术期刊的青年编委。
2003.09 – 2008.06 复旦大学化学系 博士
1999.09 – 2003.06 复旦大学化学系 本科
2017.12 至今 复旦大学药学院，教授
2011.07 –2017.12 复旦大学药学院，副教授
2008.07 – 2011.06 复旦大学药学院，讲师
1.国家自然科学基金面上项目，2023.01-2026.12，主持。
2.国家自然科学基金面上项目，2020.01-2023.12，主持。
3.上海市科技创新计划专项定向项目子课题，2024.12.-2027.11，主持。
4.国家及部委重点实验室开放课题，2022.07-2024.06，主持。
5.国家中长期重大专项，2018.01-2020.12，参与。
6.国家自然科学基金面上项目，2017.01-2020.12，主持。
1. 上海市药学会药物分析专业委员会副主任委员
2. 中国分析测试协会分析药学分会委员
3. 中国医药生物技术协会药物分析技术分会委员
4. 中国药学会药物分析专业委员会青年委员
5. 中国中医药信息学会中医临床药学分会常务理事
6. Journal of Pharmaceutical Analysis、Journal of Analysis and Testing、《中国药理学通报》青年编委。
1.基于纳米材料的药物分析新方法开发及应用研究
2.基于纳米材料的药物评价
3.基于微纳技术的体外诊断及治疗药物监测
本团队长期深耕基于纳米材料的药物分析新方法开发及应用研究，核心研究方向为基于纳米材料的药物评价、基于微纳技术的体外诊断及治疗药物监测等。目前已成功设计合成磁性金属有机框架材料、磁性共价有机框架材料、磁性石墨烯-介孔硅复合材料等50余种新型磁性纳米材料，应用于中药中真菌毒素检测、抗体药物质量评价、临床疾病早期诊断、食品中农兽药残留检测等多种领域。主持国家级项目4项、省部级项目4项；以第一/通讯作者在TrAC-Trend Anal. Chem.、Anal. Chem.、Sensor Actuat. B-Chem.等领域知名期刊发表SCI论文80余篇，申请发明专利10余项，获教育部自然科学奖二等奖。
1. Wu, G., Xiang Y., Liu, H., Hu, C., Li, Y.*, Feng, J.*, & Li, Y.*, Virtual Screening Combined with Phase Transition-FRET for Discovery of Small-Molecule FcRn Antagonists. Analytical Chemistry, 2025, 97:10661-10670.
2. Feng, J., Jiang, L., Cao, Y., Deng, C., & Li, Y.*, Tractable Method for Rapid Quality Assessment of Therapeutic Antibodies in Harvested Cell Culture Fluid based on FcγRIIIa Immobilized Magnetic Microspheres. Analytical Chemistry, 2022, 94:11492-11499.
3. Cao, Y., Feng, J., Zhang, Q., Deng, C.*, Yang, C.*, & Li, Y.*, Magnetic 3D macroporous MOF oriented urinary exosome metabolomics for early diagnosis of bladder cancer. Journal of Nanobiotechnology, 2024, 22:671.
4. Xiang, Y., Wu, G., Hu, C., Liu, H., & Li, Y.*, Three-in-one lateral flow aptasensor based on magnetic nanoparticles for on-site detection of ochratoxin A in Astragalus membranaceus. Sensors and Actuators B: Chemical, 2024, 408: 135545.
5. Xiang, Y., Hu, C., Wu, G., Xu, S., & Li, Y.*, Nanomaterial-based microfluidic systems for cancer biomarker detection: Recent applications and future perspectives. Trends in Analytical Chemistry, 2023, 158:116835.
6. Liu, H., Cao, H., Xiang, Y., Hu, C., Wu, G., & Li Y.*, Aptamer-functionalized magnetic covalent organic frameworks for rapid extraction and LC-MS/MS quantification of gentamicin in milk. Food Chemistry, 2025, 493:145889.
7. Cao, Y., Li, J., Feng, J., Xiang, Y., Zhu, J., Li, Y., Yu, Y.*, & Li, Y.*, Core-shell structured magnetic covalent-organic frameworks for rapid extraction and preconcentration of okadaic acid in seawater and shellfish followed with LC-MS/MS quantification. Food Chemistry, 2022, 374:131778.
8. Hu, C., Zhou, L., Yuan, S., Hou, J., Zhang, Y., Xiang, P.*, & Li, Y.*, Lateral flow assays for rapid detection of drugs of abuse: A review focusing on nanomaterial labels and intelligent analysis. Talanta, 2026, 309:130023.
9. Cao, Y., Liao, S., Deng, C., Qin H., & Li, Y.*, A pH-responsive phase-transition bi-affinity nanopolymer-assisted exosome metabolomics for early screening of osteoarthritis. Talanta, 2025, 283:127144.
10. Cao, Y., Qin, Y., Cheng, Q., Zhong, J., Han, B., & Li, Y.*, Bifunctional nanomaterial enabled high-specific isolation of urinary exosomes for cervical cancer metabolomics analysis and biomarker discovery. Talanta, 2025, 285:127280.
11. Cao, H., Li, Y., Feng, J., Cao, Y., Xiang Y., & Li, Y.*, Boronic acid-functionalized magnetic covalent organic frameworks based solid-phase extraction coupled with hydrophilic interaction chromatography-tandem mass spectrometry for the determination of trace gentamicin residues in milk. Talanta, 2024, 279: 126678.
12. Feng, J., Cao, H., Xiang, Y., Deng, C., & Li, Y.*, An integrated methodology for quality assessment of therapeutic antibodies with potential long circulation half-life in harvested cell culture fluid using FcRn immobilized hydrophilic magnetic graphene. Talanta, 2024, 272:125781.
13. Hu, C., Feng, J., Cao, Y., Chen, L., & Li, Y.*, Deep eutectic solvents in sample preparation and determination methods of pesticides: Recent advances and future prospects. Talanta, 2024, 266:125092.
14. Liu, H., Li, Y., Xiang, Y., Cao, H., & Li, Y.*, Simultaneous Determination of Trace Matrine and Oxymatrine Pesticide Residues in Tea by Magnetic Solid-Phase Extraction Coupled with Liquid Chromatography-Tandem Mass Spectrometry. Journal of Analysis and Testing, 2024, 8: 245-250.
15. Zhu, R., Hu, C., Yan, H., Cui, J., Zhang, X., Yuan, S., Li, Y.*,& Xiang, P.*, Magnetic graphene-imine-linked covalent organic polymer composites for fast extraction and UPLC-MS/MS quantification of 14 trace drugs of abuse and their metabolites in wastewater. Journal of Chromatography A, 2026, 1781:467086.
16. Yuan, S., Xiang, Y., Chen, L., Xiang, P.*, & Li, Y.*, Magnetic solid-phase extraction based on polydopamine-coated magnetic nanoparticles for rapid and sensitive analysis of eleven illicit drugs and metabolites in wastewater with the aid of UHPLC-MS/MS. Journal of Chromatography A, 2024, 1718:464703.
17. Xiang, Y., Liu, H., Feng, J., Li, H., Li, G., & Li, Y.*, A portable integrated magnetic solid-phase extraction device combined with an enzyme-catalyzed colorimetric lateral flow aptasensor for on-site detection of ochratoxin A. Analytical and Bioanalytical Chemistry, 2026, https://doi.org/10.1007/s00216-026-06593-0.
18. Feng, J., Cao, Y., Xiang, Y., Deng, C., & Li, Y.*, FcRn-immobilized magnetic macroporous ZIF-8: A novel size-exclusion adsorbent for the extraction of therapeutic antibodies. Separation and Purification Technology, 2025, 364:132421.
19. Hou, J., Hu, C., Li, H., Liu, H., Xiang, Y., Wu, G., & Li, Y.*, Nanomaterial-based magnetic solid-phase extraction in pharmaceutical and biomedical analysis. Journal of Pharmaceutical and Biomedical Analysis, 2025, 253:116543.
20. Cao, Y., Zhu, J., Li, Y., Qin, Y., Huang, T., & Li, Y.*, Magnetic covalent-organic frameworks-based extraction followed by UHPLC-MS/MS for determination and pharmacokinetic study of trace angoroside C in rat plasma after oral administration of Xuanbo Shuangsheng Granule. Journal of Separation Science,2022, https://doi.org/10.1002/jssc.202100941.
授权发明专利
1. 一种磁固相萃取结合快速原位衍生化的体内药物分析方法，2024.5.17，CN114594170B.
2. 一种同时检测血浆中格列美脲及二甲双胍的快速前处理方法，2023.4.14，CN111693636B.
