长期从事基于疾病表型特征的抗糖尿病及并发症的药物靶点探索及机制研究，以损伤因素为出发点，通过器官保护预防并缓解糖尿病及其并发症的发生发展。目前已建立抗糖尿病药物体内、体外研究平台，构建了药物筛选、药效评估和机制探索的工作体系。基于中医药在治疗慢性疾病中独特的优势，结合中医学理论，聚焦于从天然化合物中寻找新型的抗糖尿病药物。
2004-2008，复旦大学，药学院药理教研室，药理学博士
1994-1997，沈阳药科大学，药学系药理教研室，药理学硕士
1990-1994，沈阳药科大学，药学系药剂教研室，药物制剂学学士
2016-至今，复旦大学药学院药理学系，副教授
2009-2011， 美国马里兰大学医学院，博士后
2000-2015，复旦大学药学院药理教研室，讲师
1997-2000，上海医科大学药学院药理教研室，助教
1994-1997，沈阳药科大学药理教研室，硕士生
1. 国家自然科学基金面上项目（82574656），基于肠道菌-3-oxoLCA轴探讨柴胡多糖调控肠-肾间Th17细胞串扰改善CKD肾脏炎症的机制。
2. 国家自然科学基金面上项目（82073859），SNX10调控RANKL/RANK/OPG信号轴在内皮细胞介导的糖尿病血管钙化中的作用及机制研究。
3. 国家自然科学基金上项目（81673658），基于解毒通络探讨柴胡多糖阻断HMGB1-TLR2/4信号通路防治糖尿病肾病。
4. 国家自然科学基金面上项目（81673690），多基源藏药圆柏的清热药效物质基础与品质评价。
5. 国家自然科学基金新疆联合基金（U1403201），五种新疆特有贝母的药效物质基础研究与资源评价。
6. 国家自然科学基金面上项目（81274165），补体抑制剂柴胡多糖对狼疮小鼠的防治作用的机制研究。
7. 上海市科学技术委员会专项项目（09dZ1973202），鞘蕊苏平喘有效部位及其制剂的研究。
1. 糖尿病及其并发症治疗新靶标与新药物的研究；
2. 代谢性疾病调控网络中功能分子的发现，天然治疗药物的筛选和研究
3. 干细胞及其外泌体等先进治疗药物的药效学评价与药理机制研究。
1. Ruotong Yin, Yalin Wang, Peng Zhang, Mengyao Sun, Zijie Jin, Shihao Ma, Qingyu Huang*, Hongbo Weng*. Promoting ubiquitin-dependent Drp1 degradation contributes to the protective effect of Astragalin against diabetic renal fibrosis. Biochemical Pharmacology, 2025,241:117158.
2. Zijie Jin, Ruotong Yin, Yan Yuan, Chen Zheng, Peng Zhang, Yalin Wang, Hongbo Weng*. Dapagliflozin ameliorates hepatic steatosis via suppressing LXRα-mediated synthesis of lipids and bile acids. Biochemical Pharmacology, 2024,223:116167.
3. Rongrong Zhu, Yan Yuan, Rourou Qi, Jianying Liang*, Yan Shi*, Hongbo Weng*. Quantitative profiling of carboxylic compounds by gas chromatography-mass spectrometry for revealing biomarkers of diabetic kidney disease. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2023,1231:123930.
4. Zijie Jin, Yan Yuan, Chen Zheng, Shijian Liu, Hongbo Weng*. Effects of sodium-glucose co-transporter 2 inhibitors on liver fibrosis in non-alcoholic fatty liver disease patients with type 2 diabetes mellitus: An updated meta-analysis of randomized controlled trials. J Diabetes Complications. 2023;37(8):108558.
5. Meng-yao Sun, Hui-jing Ye, Chen Zheng, Zi-jie Jin, Yan Yuan and Hong-bo Weng*. Astragalin ameliorates renal injury in diabetic mice by modulating mitochondrial quality control via AMPK dependent PGC1α pathway, Acta Pharmacologica Sinica, 2023, 0:1-11.
6. Hui-jing Ye, Meng-yao Sun, Zi-jie Jin, Yan Yuan, Hong-bo Weng*. FTY-720 alleviates diabetes-induced liver injury by inhibiting oxidative stress and inflammation. Fundam Clin Pharmacol. 2023,37(5):960-970.
7. Yan Yuan#, Mengyao Sun#, Zijie Jin, Chen Zheng, Huijing Ye, Hongbo Weng*. Dapagliflozin ameliorates diabetic renal injury through suppressing the self-perpetuating cycle of inflammation mediated by HMGB1 feedback signaling in the kidney. European journal of pharmacology, 2023, 943:175560.
8. Wenbo Mao, Yujuan Fan, Xu Wang, Guize Feng, Yan You, Haidong Li, Yongyan Chen, Jialin Yang, Hongbo Weng*, Xiaoyan Shen*, Phloretin ameliorates diabetes-induced endothelial injury through AMPK-dependent anti-EndMT pathway. Pharmacological Research, 2022, 179:106205.
9. Yan Yuan#, Yuanxia Liu#, Mengyao Sun, Huijing Ye, Yuchen Feng, Zhenzhen Liu, Lingyu Pan, Hongbo Weng*. Aggravated renal fibrosis is positively associated with the activation of HMGB1-TLR2/4 signaling in STZ-induced diabetic mice. Open Life Sciences, 2022, 17(1):1451-1461.
10. Xin-Yue Cao, Jia-Hui Ni, Xu Wang, Gui-Ze Feng, Hai-Dong Li, Wei-Lian Bao, Yi-Rui, Wang Ke, Yuan You, Hong-Bo Weng*, Xiao-Yan Shen*, Total glucosides of Paeony restores intestinal barrier function through inhibiting Lyn/Snail signaling pathway in colitis mice. Phytomedicine, 2021, 87:153590.
11. Liu Zhen-Zhen#, Weng Hong-Bo#, Zhang Li-Jie, Pan Ling-Yu, Sun Wei, Chen Hai-Xia, Chen Mei-Yu, Zeng Tao, Zhang Yun-Yi, Chen Dao-Feng*, LI Hong*. Bupleurum polysaccharides ameliorated renal injury in diabetic mice associated with suppression of HMGB1-TLR4 signaling, Chinese Journal of Natural Medicines, 2019; 17(9): 641-649.
12. Yuchen Feng#, Hongbo Weng#, Lijun Ling, Tao Zeng, Yunyi Zhang, Daofeng Chen*, Hong Li*. Modulating the gut microbiota and inflammation is involved in the effect of Bupleurum polysaccharides against diabetic nephropathy in mice, International Journal of Biological Macromolecules, 2019, 132:1001-1011.
13. Weng, H. B#; Han, W. K#; Xiong, Y. W; Jin, Z. H; Lan, Z; Liu, C; Zhang, X. M*; Peng, W. *, Taxus chinensis ameliorates diabetic nephropathy through down-regulating TGF-beta1/Smad pathway, Chin J Nat Med, 2018, 16(2): 90-96.
14. Hong-Bo Weng, Hai-Xia Chen, Ming-Wei Wang*. Innovation in neglected tropical disease drug discovery and development. Infectious Diseases of Poverty, 2018, 7: 67.
