1998/9 - 2001/6，同济医科大学，临床医学，博士
1995/9 - 1998/6，衡阳医学院，临床医学，硕士
1990/9 - 1995/6，湖南中医学院，中医临床学，学士
2017/12-至今，复旦大学，研究员
2009/7 - 2017/12，复旦大学，副研究员
2008/4 - 2009/4，中国科学院上海生化细胞所，副研究员
2003/10 - 2008/4，美国国家卫生研究院，NIDCR，访问学者
2001/10-2003/10，中国科学院上海药物研究所，博士后
研究员；博士生导师；硕士生导师
1、中国药理学会肿瘤药理专业委员会委员
2、中国抗癌协会抗癌药物专业委员会委员
3、中国生化药物杂志编委
1、抗肿瘤药物体外、体内活性评价
2、分子靶向抗肿瘤药物的研发
1. Liu G#, Huang W#, Wang J#, Liu X, Yang J, Zhang Y, Geng Y, Tan W*, Zhang A*. Discovery of Novel Macrocyclic Hedgehog Pathway Inhibitors Acting by Suppressing the Gli-Mediated Transcription. J Med Chem. 2017 Oct 12;60(19):8218-8245. (highlighted by BioCentury).
2. Zhang X, Zhao F, Wu Y, Yang J, Han GW, Zhao S, Ishchenko A, Ye L, Lin X, Ding K, Dharmarajan V, Griffin PR, Gati C, Nelson G, Hunter MS, Hanson MA, Cherezov V, Stevens RC, Tan W*, Tao H*, Xu F*. Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand. Nat Commun. 2017 May 17;8:15383.
3. Liu G#, Xue D#, Yang J#, Wang J#, Liu X, Huang W, Li J, Long YQ*, Tan W*, Zhang A*.Design, Synthesis, and Pharmacological Evaluation of 2-(2,5-Dimethyl-5,6,7,8-tetrahydroquinolin-8-yl)-N-aryl Propanamides as Novel Smoothened (Smo) Antagonists. J Med Chem. 2016 Dec 22;59(24):11050-11068.
4. Kong Y#, Peng Y#, Liu Y#, Xin H, Zhan X, Tan W*. Twist1 and Snail link Hedgehog signaling to tumor-initiating cell-like properties and acquired chemoresistance independently of ABC transporters. Stem Cells. 2015 Apr;33(4):1063-74.
5. Zhan X, Wang J, Liu Y, Peng Y, Tan W*. GPCR-like signaling mediated by smoothened contributes to acquired chemoresistance through activating Gli. Mol Cancer. 2014 Jan 7;13:4.
