1986.09 – 1991.07 第二军医大学药学院 药学本科
1991.09 – 1994.07 第二军医大学药学院 药理学硕士
1996.09 – 1999.07 第二军医大学基础部 医学免疫学博士
研究员，博士研究生导师，上海市科技启明星，上海市优秀学科带头人，中国微生物学会干扰素与细胞因子专业委员会副主任委员，中国医药生物技术协会单抗专委会委员，上海市药学会生化与生物技术药物专委会专委
生物药物学系主任
上海免疫治疗药物工程技术研究中心主任
自1994年以来历任第二军医大学助教与讲师，NIH访问学者，MediPharm研究员，复旦大学药学院研究员。关于TNT肿瘤单克隆抗体新药研究发表在国际著名杂志Journal of Clinical Oncology，关于肿瘤免疫治疗的研究成果发表在Cancer Research，Cancer Immunology Research, STTT等杂志，关于细胞自噬的研究论文发表在Autophagy等杂志；此外还在Advanced Science, Biomaterials，Journal for ImmunoTherapy of Cancer,等杂志上发表210余篇SCI论文，被引用12000 余次。研究和新药开发项目获得科技部新药重大创制、国家自然科学基金、科技部创新基金、上海市科委重大科技攻关项目等资助。负责多个单抗和细胞因子类生物技术新药的研发，申请国内发明专利50余项，获批美国发明专利1项，多次获得国家和军队科技进步奖。
1. 抗体与细胞因子等生物技术药物的研究与开发
2. 肿瘤、代谢性疾病和心血管疾病的免疫治疗与基因治疗研究
3. 生物技术药物靶向纳米递送研究
1. Bai Y, Nan Y, Wu T, Zhu A, Xie X, Sun Y, Deng Y, Dou Z, Hu X, Zhou R, Xu S, Zhang Y, Fan J*, Ju D*. Lipid Nanoparticle-Mediated Delivery of CRISPR-Cas9 Against Rubicon Ameliorates NAFLD by Modulating CD36 Along with Glycerophospholipid Metabolism. Adv Sci. 2024;11(31):e2400493
2. Nan Y, Bai Y, Hu X, Zhou K, Wu T, Zhu A, Li M, Dou Z, Cao Z, Zhang X, Xu S, Zhang Y, Lin J, Zeng X, Fan J, Zhang X*, Wang X*, Ju D*. Targeting IL-33 reprograms the tumor microenvironment and potentiates antitumor response to anti-PD-L1 immunotherapy. J Immunother Cancer. 2024;12(9):e009236
3. Hu X, Nan Y, Zhang Y, Fan J, Wang H, Bai Y, Zhang Y, Zhang X, Zhu Z, Cao Z, Ye X, Wu T, Xu S, Wu Z, Hu W*, Ju D*. Simultaneously blocking ANGPTL3 and CD47 prevents the progression of atherosclerosis through regulating lipid metabolism, macrophagic efferocytosis and lipid peroxidation. Pharmacol Res. 2024 Oct 31:107486
4. Hu X, Fan J, Ma Q, Han L, Cao Z, Xu C, Luan J, Jing G, Nan Y, Wu T, Zhang Y, Wang H, Zhang Y*, Ju D*. A novel nanobody-heavy chain antibody against Angiopoietin-like protein 3 reduces plasma lipids and relieves nonalcoholic fatty liver disease. J Nanobiotechnology. 2022 May 19;20(1):237
5. Shao T, Chen T, Chen Y, Liu X, Chen YL, Wang Q, Zhu T, Guo M, Li H, Ju D*, Wang C*. Construction of paclitaxel-based antibody-drug conjugates with a PEGylated linker to achieve superior therapeutic index. Signal Transduct Target Ther. 2020 Jul 29;5(1):132
6. Zhang X, Wang Y, Fan J, Chen W, Luan J, Mei X, Wang S, Li Y, Ye L, Li S, Tian W, Yin K*, Ju D*. Blocking CD47 efficiently potentiated therapeutic effects of anti-angiogenic therapy in non-small cell lung cancer. J Immunother Cancer 2019; 7(1):346.
7. Luan J, Chen W, Fan J, Wang S, Zhang X, Zai W, Jin X, Wang Y, Feng Z, Zhang J, Liu ML*, Ju D*. GSDMD membrane pore is critical for IL-1β release and antagonizing IL-1β by hepatocyte-specific nanobiologics is a promising therapeutics for murine alcoholic steatohepatitis. Biomaterials 2020; 227:119570.
8. Chen W, Luan J, Wei G, Zhang X, Fan J, Zai W, Wang S, Wang Y, Liang Y, Nan Y, Yin C, Li Y, Liu ML*, Ju D*. In vivo hepatocellular expression of interleukin-22 using penetratin-based hybrid nanoparticles as potential anti-hepatitis therapeutics. Biomaterials 2018; 187:66-80.
9. Zhang X, Fan J, Wang S, Li Y, Wang Y, Li S, Luan J, Wang Z, Song P, Chen Q, Tian W, Ju D*. Targeting CD47 and autophagy enhanced anti-tumor effects in non-small cell lung cancer. Cancer Immunology Research 2017; 5(5):363-375
10. Fan J, Sun Y, Wang S, Li Y, Zeng X, Cao Z, Yang P, Song P, Wang Z, Xian Z, Gao H, Chen Q, Cui D, Ju D*. Inhibition of autophagy overcomes the nanotoxicity elicited by Cadmium-based Quantum Dots. Biomaterials 2016; 78:102-114
11. Zeng X, Zhao H, Li Y, Fan J, Sun Y, Wang Z, Wang S, Song P, Ju D*. Targeting hedgehog signaling pathway and autophagy overcomes drug resistance of BCR-ABL positive chronic myeloid leukemia. Autophagy 2015; 11(2):355-372.
12. Wang S, Li Y, Fan J, Wang Z, Zeng X, Sun Y, Song P, Ju D*. The role of autophagy in the neurotoxicity of cationic PAMAM dendrimers. Biomaterials 2014; 35(26):7588-7597.
13. Liu Y, Sun Y, Cao C, Yang Y, Wu Y, Ju D*, Li F*. Long-term biodistribution in vivo and toxicity of radioactive/magnetic hydroxyapatite nanorods. Biomaterials 2014; 35(10):3348-55.
14. Chen S, Yu L, Jiang C, Zhao Y, Sun D, Li S, Liao G, Chen Y, Fu Q, Tao Q, Ye D, Hu P, Khawli LA, Taylor CR, Epstein AL, Ju D*. Pivotal study of iodine-131-labeled chimeric tumor necrosis treatment radioimmunotherapy in patients with advanced lung cancer. Journal of Clinical Oncology 2005; 23(7): 1538-1547.
15. Ju D, Yang Y, Lou GL, Tao Q, He L, Cao X*. Interleukin 18 transfection enhances anti-tumor immunity induced by dendritic cell-tumor cell conjugates. Cancer Research 2001; 61(9):3735-3740.
