2015.9 – 2018.7 复旦大学药学院 博士
2012.9 – 2015.7 郑州大学药学院 硕士
2008.9 – 2012.7 郑州大学药学院 本科
2020.9 – 至今 复旦大学生物药物学系 青年研究员
2018.7 – 2020.8 宾夕法尼亚大学肿瘤生物学 博士后
1.国家自然科学基金委，青年科学基金项目，2023-2025，主持
2.上海市科学技术委员会，科技创新行动计划，2021-2024，主持
3.复旦大学，复旦大学引进人才科研基金，2021-2025，主持
4.国家自然科学基金委，面上项目，2018-2021，参与
2021 上海市青年科技英才“扬帆计划”入选者
2020 上海“海外高层次人才引进计划”入选者
2018 上海市普通高等学校优秀博士毕业生
2017 ESMO Immuno Oncology Congress 2017. Poster Discussion & Travel Award
2017 宝钢教育奖学金特等奖
2017 JSMO Annual Meeting. Oral Presentation & Travel Award
2016 ESMO Asia 2016 Congress. Poster Presentation & Travel Award
2016 JSMO Annual Meeting. Oral Presentation & Travel Award
2015 河南省普通高等学校优秀毕业生
2014 研究生国家奖学金
1. 新型免疫治疗药物研发
2. 微环境与肿瘤免疫治疗机制研究
1.Xu C, Ju D*, Zhang X*. Cell Membrane-Derived Vesicle: A Novel Vehicle for Cancer Immunotherapy. Frontiers in Immunology. 2022;13:923598.
2.Wang R, Liu H, He P, An D, Guo X, Zhang X*, Feng M*. Inhibition of PCSK9 enhances the antitumor effect of PD-1 inhibitor in colorectal cancer by promoting the infiltration of CD8+ T cells and the exclusion of Treg cells. Frontiers in Immunology. 2022;13:947756.
3.Xu C, Ju D*, Zhang X*.Chimeric antigen receptor T cell therapy: challenges and opportunities in lung cancer. Antibody Therapeutics. 2022;5:73-83.
4.Feng Z, He X, Zhang X, Wu Y, Xing B, Knowles A, Shan Q, Miller S, Hojnacki T, Ma J, Katona BW, Gade TP, Schrader J, Metz DC, June CH, Hua X*. Eradication of Neuroendocrine Tumors by CDH17CAR T Cells Without Toxicity to Normal Tissue. Nature Cancer. 2022;3:581-594.
5.Zhang X, Wang Y, Fan J, Chen W, Luan J, Mei X, Wang S, Li Y, Ye L,Li S, Tian W, Yin K*, Ju D*. Blocking CD47 efficiently potentiated therapeuticeffects of anti-angiogenic therapy in non-small cell lung cancer. Journal for ImmunoTherapy of Cancer. 2019; 7:346.
6.Zhang X, Fan J, Ju D*. Insights into CD47/SIRPα axis-targetingtumor immunotherapy. Antibody Therapeutics. 2018; 1:37-42.
7.Zhang X, Chen W, Fan J, Wang S, Xian Z, Luan J, Li Y, Wang Y, NanY, Luo M, Li S, Tian W, Ju D*. Disrupting CD47-SIRPα axis alone or combinedwith autophagy depletion for the therapy of glioblastoma. Carcinogenesis. 2018;39:689-699.
8.Zhang X, Wang S, Nan Y, Fan J, Chen W, Luan J, Wang Y, Liang Y, LiS, Tian W, Ju D*. Inhibition of autophagy potentiated the anti-tumor effects ofVEGF and CD47 bispecific therapy in glioblastoma. Applied Microbiology and Biotechnology. 2018; 102:6503-6513.
9.Zhang X, Luan J, Chen W, Fan J, Nan Y, Wang Y, Liang Y, Meng G, JuD*. Mesoporous silica nanoparticles induced hepatotoxicity via NLRP3inflammasome activation and caspase-1-dependent pyroptosis. Nanoscale. 2018;10:9141-9152.
10.Zhang X, Fan J, Wang S, Li Y, Wang Y, Li S, Luan J, Wang Z, Song P,Chen Q, Tian W, Ju D*. Targeting CD47 and autophagy elicited enhancedanti-tumor effects in non-small cell lung cancer. Cancer Immunology Research. 2017; 5:363-375. (Spotlight Research)
11.Zhang X, Gu Y, Chen T, Yang D, Wang X, Jiang B, Shao K, Zhao W,Wang C, Wang J, Zhang Q, Liu H*. Synthesis, in vitro and in vivo anticanceractivities of novel 4-substituted 1,2-bis(4-chlorophenyl)-pyrazolidine-3,5-dione derivatives. MedChemComm. 2015, 6:1781-1786.
