2001.9–2006.7, 北京大学化学与分子工程学院, 博士
1997.9–2001.7, 北京大学化学与分子工程学院，学士
2019.12- 至今 复旦大学药学院, 教授
2013.12-2019.11 复旦大学药学院, 副教授
2010.09-2012.07 芝加哥大学化学系, 访问学者
2008.07-2013.11 复旦大学药学院, 讲师
2006.07-2008.07 北京大学化学与分子工程学院， 博士后
2024 – 现在 中国药学会药物化学专业委员会委员
2024 – 现在 上海市药学会药物化学专业委员会副主任委员
2022年 中国药学会科技二等奖（第一完成人）
2022年 上海市药学科技一等奖（第一完成人）
2021年 上海市优秀学术带头人
2019年 国家级青年人才
2015年 上海市青年科技启明星
1、国家自然科学基金委员会, 联合基金重点项目, U24A20524, 2025.1-2028.12，主持。
2、科技部重点研发计划子课题, 2023YFC3603303, 2023.12-2026.11，主持。
3、上海市科委, 基础研究特区计划, 21TQ016, 2021.8-2026.8，主持。
4、上海市科委, 优秀学术带头人, 21XD1420600, 2021.9-2024.8，主持。
5、国家自然科学基金委员会, 面上项目, 22077019, 2021.1-2024.12，主持。
1. 靶向糖脂代谢酶（SMS、PGAM1等）的原创新药研究
2. 基于表型筛选的药靶发现与确证
3. 基于ABPP-CoDEL技术的共价配体筛选体系建立与新型共价弹头开发
专注于原创靶标的小分子药物研究，特别是靶向糖脂代谢相关酶的原创新药开发，用于抗肿瘤、糖尿病及干眼症的治疗。以通讯作者身份（含共同）在Cell Metab.、Nat. Struct. Mol. Biol、PNAS、JACS、Angew Chem、JMC、APSB等杂志上发表多篇研究论文，申请10多项专利包括3项PCT专利，完成2项新药项目成果转化，获得中国药学会科技二等奖、上海药学科技一等奖（均排名第一）
1. Li H, Xu Y*, Zheng Y, Xue Z, Li Q, Jia Fan, Jia X, Weng L, Jiang L, Ruan X, Zhang R, Yin Y, Zhou L, Li F, Huang H, Li J, Tan M, Fan J, Cai J*, Chen GQ, Zhou L*. CBX4 acetoacetylation as an Inhibitory Mechanism of HIF-1α activity. Cell Chem Biol. in press.
2. Ruan X, Zhang L, Dong L, Wang Y, Zeng L, Yang M, Bi H*, Feng M*, Zhang L*, Zhou L*. Discovery of 1,3,4-Thiadiazole Sulfonamide-Based Potent Inhibitors against the Unsaturated Fatty Acid Synthase FabX of Helicobacter pylori. J Med Chem. 2025; 68(16): 17175-17188.
3. Zhang R, Sun M, Xiao X, Li H, Jiang L, Chen J, Yang M, Yao X, Shan C*, Zhou L*. Discovery of N-(1,3,4-Thiadiazol-2-yl)amide Derivatives as Uncompetitive Inhibitors of 6-Phosphogluconate Dehydrogenase. J Med Chem. 2025;68(15):15403-15421.
4. Wu X, Li S, Liang T, Yu Q, Zhang Y, Liu J, Li K, Liu Z, Cui M, Zhao Y, Han X, Jin R, Tan M, Chen XH, Zhao Y, Zheng M, Sun Y*, Zhou L*, Lu X*. Proteome-Wide Data Guides the Discovery of Lysine-Targeting Covalent Inhibitors Using DNA-Encoded Chemical Libraries. Angew Chem Int Ed Engl. 2025;64(25):e202505581.
5. Zhang L, Ruan X, Hang X, Heng D, Cai C, Zeng L, Zhang G, Zhou L*, Bi H*, Zhang L*. Antagonist Targeting the Species-Specific Fatty Acid Dehydrogenase/Isomerase FabX for Anti-H. pylori Infection. Adv Sci (Weinh). 2025;12(18):e2414844.
6. Yang J, Lu Y, Hu K, Zhang X, Wang W, Ye D, Mo M, Xiao X, Wan X, Wu Y, Zhang S, Huang H, Qu Z, Hu Y, Cao Y*, Hong J*, Zhou L*. Discovery of a novel thiophene carboxamide analogue as a highly potent and selective sphingomyelin synthase 2 inhibitor for dry eye disease therapy. Acta Pharm Sin B. 2025;15(1):392-408.
7. Wang C, Zhang M, Li S, Gong M, Luo MY, Zhang MC, Zou JH, Shen N, Xu L, Lei HM, Bi L, Zhu L, Wang Z, Chen HZ*, Zhou L*, Shen Y*. A phosphoglycerate mutase 1 allosteric inhibitor restrains TAM-mediated colon cancer progression. Acta Pharm Sin B. 2024; 14(11):4819-4831.
8. Han S, Ye X, Yang J, Peng X, Jiang X, Li J, Zheng X, Zhang X, Zhang Y, Zhang L, Wang W, Li J, Xin W, Zhang X, Xiao G, Peng K, Zhang L, Du X, Zhou L*, Liu W*, Li H*. Host specific sphingomyelin is critical for replication of diverse RNA viruses. Cell Chem Biol. 2024;31(12):2052-2068.
9. Lu Y, Yue CX, Zhang L, Yao D, Xia Y, Zhang Q, Zhang X, Li S, Shen Y, Cao M, Guo CR, Qin A, Zhao J, Zhou L, Yu Y, Cao Y. Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1. Science. 2024;386(6723):eadp3252.
10. Hu K, Zhang Q, Chen Y, Yang J, Xia Y, Rao B, Li S, Shen Y, Cao M, Lu H, Qin A, Jiang XC, Yao D*, Zhao J*, Zhou L*, Cao Y*. Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis. Nat Struct Mol Biol. 2024 Jun;31(6):884-895.
11. Xiang H, Zhou M, Li Y*, Zhou L*, Wang R*. Drug discovery by targeting the protein-protein interactions involved in autophagy. Acta Pharm Sin B. 2023;13(11):4373-4390.
12. Jiang L, Liu S, Jia X, Gong Q, Wen X, Lu W, Yang J, Wu X, Wang X, Suo Y, Li Y, Uesugi M, Qu ZB, Tan M*, Lu X*, Zhou L*. ABPP-CoDEL: Activity-Based Proteome Profiling-Guided Discovery of Tyrosine-Targeting Covalent Inhibitors from DNA-Encoded Libraries. J Am Chem Soc. 2023;145(46):25283-25292.
13. Zheng Y, Wang Y, Lu Z, Wan J, Jiang L, Song D, Wei C, Gao C, Shi G, Zhou J, Fan J, Ke A*, Zhou L*, Cai J*. PGAM1 Inhibition Promotes HCC Ferroptosis and Synergizes with Anti-PD-1 Immunotherapy. Adv Sci (Weinh). 2023;10(29):e2301928.
14. Li H, Liu Y, Xue Z, Zhang L, Ruan X, Yang J, Fan Z, Zhao H, Cao Y, Chen G, Xu Y*, Zhou L*. Adamantaniline Derivatives Target ATP5B to Inhibit Translation of Hypoxia Inducible Factor-1α. Adv Sci (Weinh). 2023;10(25):e2301071.
15. Liang Q, Gong M, Zou JH, Luo MY, Jiang LL, Wang C, Shen NX, Zhang MC, Xu L, Lei HM, Zhang KR, Zhang R, Zhuang G, Zhu L, Chen HZ*, Zhou L*, Shen Y*. A phosphoglycerate mutase 1 allosteric inhibitor overcomes drug resistance to EGFR-targeted therapy via disrupting IL-6/JAK2/STAT3 signaling pathway in lung adenocarcinoma. Drug Resist Updat. 2023;68:100957.
16. Wen CL, Huang K, Jiang LL, Lu XX, Dai YT, Shi MM, Tang XM, Wang QB, Zhang XD, Wang PH, Li HT, Ruan XX, Wang LW, Wang XJ, Wang Q, Lu W, Xiang XQ, Sun X, Xu YH, Lai LH, Zhan Q, Li HW, Peng CH, Chen J, Huang JY, Ye DY, Chen SJ, Chen Z*, Li M*, Fang Y*, Shen BY*, Zhou L*. An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma. Proc Natl Acad Sci U S A. 2019 ;116(46):23264-23273.
17. Huang K, Liang Q, Zhou Y, Jiang LL, Gu WM, Luo MY, Tang YB, Wang Y, Lu W, Huang M, Zhang SZ, Zhuang GL, Dai Q, Shen QC, Zhang J, Lei HM, Zhu L, Ye DY, Chen HZ*, Zhou L*, Shen Y*. A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer. Cell Metab. 2019. 30(6):1107-1119.
18. Zhou L#, Bosscher M#, Zhang C#, Ozçubukçu S, Zhang L, Zhang W, Li CJ, Liu J, Jensen MP, Lai L*, He C*. A protein engineered to bind uranyl selectively and with femtomolar affinity. Nat Chem. 2014;6(3):236-41.
19. Hitosugi T#, Zhou L#, Fan J, Elf S, Zhang L, Xie J, Wang Y, Gu TL, Ale?kovi? M, LeRoy G, Kang Y, Kang HB, Seo JH, Shan C, Jin P, Gong W, Lonial S, Arellano ML, Khoury HJ, Chen GZ, Shin DM, Khuri FR, Boggon TJ, Kang S, He C*, Chen J*. Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation. Nat Commun. 2013;4:1790. (#contribute equally)
20. Hitosugi T#, Zhou L#, Elf S, Fan J, Kang HB, Seo JH, Shan C, Dai Q, Zhang L, Xie J, Gu TL, Jin P, Ale?kovi? M, LeRoy G, Kang Y, Sudderth JA, DeBerardinis RJ, Luan CH, Chen GZ, Muller S, Shin DM, Owonikoko TK, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Ye K, Boggon TJ, Kang S, He C*, Chen J*. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012; 22(5):585-600. (#contribute equally)
