2000.09 – 2004.01复旦大学药学院,获理学博士学位
1996.09 – 1999.07上海医科大学药学院,获理学硕士学位
1989.09 – 1993.07沈阳药科大学,获理学学士
2015.02 - 2016.03美国堪萨斯大学药学院,访问学者
2008.05 – 2009.02奥地利维也纳大学,访问学者
1999.07 – 至今复旦大学药学院,讲师/副教授
1993.07 – 1996.09广东省汕头市沱滨药业有限公司,助理研究员
1)上海市卫健委面上项目, DNA甲基化转移酶1(DNMT1)抑制剂对宫颈癌前病变的逆转和干预(202340236);
2) 国家自然科学基金委员会面上项目,靶向DNMT1穿膜小分子荧光探针的设计、合成及其在监测宫颈癌前病变演进过程中的应用(82173659);
3)上海市科委医药生物支撑项目, 以肝癌高表达基因FAK为靶点设计、合成肝癌新型抑制剂及其在肝癌治疗中的可行性研究 (15431902900)
4)上海市科委医药生物支撑项目, 6-甲氧基-4’,7-二羟基异黄酮4-位羰基含氮衍生物RY-2f用于卵巢癌治疗的成药性研究 (14431900600)
5)国家自然科学基金青年科学基金项目, 新结构类型新生血管抑制剂的设计、合成及对子宫内膜作用的研究 (30500631)
分子靶标抗肿瘤药物/肿瘤诊断剂研究
近五年科研论文
1. Jiawei Zhang, Jingyi Liu, Kaimin Kong, Xingzhou Li*, Qian Zhang*. Structure–activity relationship studies of 5-(Pyridin-3-yl)-1H-indole-4,7-diones as indoleamine 2,3-dioxygenase 1 inhibitors. Results in chemistry, 2024, 7, 101285.
2. Xiaoqian Hong, Qunxian Cheng, Minli Ruan , Baohua Yang , Jingyi Liu , Ling Xu*, Qian Zhang*. Determination of DNA Methyltransferase 1 in Cells Using a RG108-Fluorescein Conjugate to Monitor the Fluorescent Ratio with a Microplate Reader. Analytical Letters, 2023, 56(10), 1660-1674.
3. Hanyi Tan, Yue Liu, Chaochao Gong, Jiawei Zhang, Jian Huang*, Qian Zhang*. Synthesis and evaluation of FAK inhibitors with a 5-fluoro-7H-pyrrolo [2,3-d]pyrimidine scaffold as anti-hepatocellular carcinoma agents. European Journal of Medicinal Chemistry, 2021, 223, 113670.
4. Lei Xu, Lei Zhao, Jinjing Che, Qian Zhang*, Ruiyuan Cao*, Xingzhou Li* Identification of novel influenza polymerase PB2 inhibitors using virtual screening approach and molecular dynamics simulation analysis of active compounds. Bioorganic & Medicinal Chemistry, 2021, 52, 116515.
5. Keli Zong, Lei Xu, Yuxin Hou, Qian Zhang*, Jinjing Che, Lei Zhao, Xingzhou Li,* Virtual Screening and Molecular Dynamics Simulation Study of Influenza Polymerase PB2 Inhibitors, Molecules, 2021, 26, 6944.
6. Jiawei Zhang, Kaimin Kong, Xiangjun Li, Qian Zhang*. Kemp-type elimination of 1-arylsulfonyl-3-iodo1H-indazoles. Synthetic Communications, 2021, 51(15), 2365–2376.
7. Minli Ruan, Qunxian Cheng, Chaochao Gong, Zhonglian Cao, Ling Xu*, Qian Zhang*. Development of a kind of RG108-Fluorescein conjugates for detection of DNA methyltransferase 1 (DNMT1) in living cells. Analytical Biochemistry, 2020, 607, 113823.
8. Kaimin Kong, Jiawei Zhang, Binzhi Liu, Guangrong Meng, Qian Zhang*. Discovery of 5-(pyridin-3-yl)-1H-indole-4,7-diones as indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. Bioorganic & Medicinal Chemistry Letters, 2020, 30, 126901.
近五年获授权专利:
1. 张倩,黄健,谈寒一,龚超超,吡咯并[2,3-d]嘧啶类化合物及其盐,及制备方法和药用用途,专利号:ZL 201610801094.1,授权时间:2020/5/8;
2. 黄健,张倩,刘星,谈寒一,喹唑啉类化合物及其制备方法和用途,专利号:ZL 201610953646.0,授权时间:2019/8/16;
3. 张倩,孔凯敏,刘炳志,孟光荣,一类吲哚醌类吲哚胺-2,3-双加氧酶抑制剂及其药用用途,专利号:201810791681.6,授权日:2022/06/10;
4. 张倩,唐坚,银杏内酯B氮杂衍生物及其盐的制备及药用用途,专利号:201810373734.2,授权日:2022/10/14;
5. 张倩,徐灵,阮敏丽,程群仙,龚超超,一类 DNA 甲基转移酶 1 荧光探针及其用途,专利号:201910750081.X,授权日:2023/07/06;
6. 张倩,唐坚,银杏内酯B衍生物及其盐,及其制备方法和用途,专利号:2019 10338234.X,授权日:2023/06/28。