
2000.09 – 2004.01 复旦大学药学院,获理学博士学位
1996.09 – 1999.07 上海医科大学药学院,获理学硕士学位
1989.09 – 1993.07 沈阳药科大学,获理学学士
1999.07 – 至今 复旦大学药学院,讲师/副教授
2015.02 – 2016.03 美国堪萨斯大学药学院,访问学者
2008.05 – 2009.02 奥地利维也纳大学,访问学者
1993.07 – 1996.09 广东省汕头市沱滨药业有限公司,助理研究员
1. 靶向UHRF1-DNMT1轴的DNMT1降解剂的设计、合成与生物活性研究,国家自然科学基金委员会,面上项目,No.82674817,2027.01-2030.12,主持,在研;
2. DNA甲基化转移酶1(DNMT1)抑制剂对宫颈癌前病变的逆转和干预,上海市卫健委,面上项目,No.202340236,2023.07-2026.06,主持,结题;
3. 靶向DNMT1穿膜小分子荧光探针的设计、合成及其在监测宫颈癌前病变演进过程中的应用,国家自然科学基金委员会,面上项目,No.82173659,2022.01-2025.12,主持,结题;
4. 6-甲氧基-4’,7-二羟基异黄酮4-位羰基含氮衍生物RY-2f用于卵巢癌治疗的成药性研究,上海市科委,医药生物支撑项目, No.14431900600,2014.07-2018.06,主持,结题;
5. 新结构类型新生血管抑制剂的设计、合成及对子宫内膜作用的研究,国家自然科学基金委员会,青年科学基金项目, No.30500631,2006.01-2008.12,主持,结题。
分子靶标抗肿瘤药物/肿瘤诊断剂研究
银杏内酯B衍生物及其盐,及其制备方法和用途,专利转让,2020年10月。
1. Peijia Jin,Qunxian Cheng,Xiaoqian Hong, Qingmiao Jia, Jingyi Liu, Ling Xu,Qian Zhang. Development of Covalent Small-Molecule Fluorescent Probes for DNA Methyltransferase 1 Detection in Cancer Cells and Cervical Exfoliated Cells. J. Med. Chem.,2026, 69, 8130−8147.https://doi.org/10.1021/acs.jmedchem.5c03529
2. Dongping Zhang, Ziyang Qiu, Hao Lei, Yue Liu, Lijun Zhang, Qian Zhang. Structural Optimization and Biological Evaluation of 5-Fluoro-7H-pyrrolo[2,3-d] pyrimidine Derivatives as Potent FAK Inhibitors for the Treatment of Triple Negative Breast Cancers (TNBC).Eur. J. Med. Chem., 2025, 275, 118370. https://doi.org/10.1016/j.ejmech.2025.118370
3. Guolin Wang, Jiawei Zhang, Xinhui Su, Qianhe Xu, Donghe Chen, Qian Zhang, Zhenfeng Liu. Synthesis and evaluation of 1‑methyl‑D‑Trp‑[18F]BF3: a novel tryptophan derivative radiotracer for PET imaging. J. Radioanal. Nucl. Chem.,2025, 334, 3111-3118. https://doi.org/10.1007/s10967-025-10107-0
4. Jingyi Liu, Minli Ruan, Yueqin Liu, Xiaoqian Hong, Lijun Zhang, Qian Zhang. Identification of 3-(9H-carbazol-9-yl)-2-(1,3-dioxoisoindolin-2-yl) propanoic acids as promising DNMT1 Inhibitors. Eur. J. Med. Chem.,2024, 274, 116538. https://doi.org/10.1016/j.ejmech.2024.116538
5. Jiawei Zhang, Jingyi Liu, Kaimin Kong, Xingzhou Li, Qian Zhang. Structure–activity relationship studies of 5-(Pyridin-3-yl)-1H-indole-4,7-diones as indoleamine 2,3-dioxygenase 1 inhibitors. Results chem., 2024, 7, 101285.https://doi.org/10.1016/j.rechem.2023.101285
6. Xiaoqian Hong, Qunxian Cheng, Minli Ruan, Baohua Yang, Jingyi Liu, Ling Xu, Qian Zhang. Determination of DNA Methyltransferase 1 in Cells Using a RG108-Fluorescein Conjugate to Monitor the Fluorescent Ratio with a Microplate Reader.Anal. Lett., 2023, 56(10), 1660-1674. https://doi.org/10.1080/00032719.2022.2139836
近五年获授权专利:
1. 张倩,黄健,谈寒一,龚超超,吡咯并[2,3-d]嘧啶类化合物及其盐,及制备方法和药用用途,专利号:ZL 201610801094.1,授权时间:2020/5/8;
2. 黄健,张倩,刘星,谈寒一,喹唑啉类化合物及其制备方法和用途,专利号:ZL 201610953646.0,授权时间:2019/8/16;
3. 张倩,孔凯敏,刘炳志,孟光荣,一类吲哚醌类吲哚胺-2,3-双加氧酶抑制剂及其药用用途,专利号:201810791681.6,授权日:2022/06/10;
4. 张倩,唐坚,银杏内酯B氮杂衍生物及其盐的制备及药用用途,专利号:201810373734.2,授权日:2022/10/14;
5. 张倩,徐灵,阮敏丽,程群仙,龚超超,一类 DNA 甲基转移酶 1 荧光探针及其用途,专利号:201910750081.X,授权日:2023/07/06;
6. 张倩,唐坚,银杏内酯B衍生物及其盐,及其制备方法和用途,专利号:2019 10338234.X,授权日:2023/06/28。