教育经历

1998.9-2002.7  复旦大学药学院药学专业本科

2002.9–2004.7 复旦大学药学院药物化学教研室硕士研究生

2004.9-2007.7  复旦大学药学院药物化学教研室博士研究生

工作经历

2016.12 – 至今        复旦大学药学院药物化学系，副教授

2012.10– 2013.10   Medicinal Chemistry Laboratory, Alcohol and Drug Abuse Research Center, McLean Hospital | Psychiatric affiliate of Harvard Medical School，访问学者

2007.7 – 2016.11    复旦大学药学院药物化学教研室，讲师

研究方向

代表性论著

1. Jiangwen Gui, Jiawen Luo, Denggao Zhang, Zhiwen Wang, Chao Zhang, Meng Sun, Jiaqi Tan, Siyuan Tang, Shaoliang Duan, Yuliang Lin, Min Liu, Lijin Feng, Liming Shao, Jing-gen Liu, Panwen Liu, Wei Li, Yujun Wang. Pharmacological Characterization of SLL-022CCP, A Selective Kappa Opioid Receptor Agonist with Potent Antinociceptive Effects and Low Central Side Effects. ACS Omega. 2026, 11, 36322–36336 https://doi.org/10.1021/acsomega.6c04362

2. Shaoliang Duan, Shuyang Hu, Yun Fang, Min Liu, Yuliang Lin, Jiangwen Gui, Siyuan Tang, Chao Zhang, Denggao Zhang, Xiaobo Mai, Songyu Yao, Jinggen Liu, Liming Shao, Wei Fu, Yujun Wang, Wei Li. Discovery of a Highly Selective and Potent Kappa Opioid Receptor Agonist from N-cyclopropylmethyl-7α-piperazinyl-6,14-endoethano-tetrahydronorthebaines.Eur J Med Chem, 2026, 315, October 5, 118964. https://doi.org/10.1016/j.ejmech.2026.118964

3. Yi-Quan Shen, Pan-Wen Liu, Denggao Zhang, Min Liu, Jia-Wen Luo, Yuliang Lin, Jiang-Wen Gui, Li-Jin Feng, Jing-Gen Liu, Wei Li, YuJun Wang. SLL-023ACP, a KOR/MOR Dual Agonist, Produces Potent Antinociception with Fewer Side Effects. Biochem Biophys Res Commun, 2026, 806, March 26, 153411. https://doi.org/10.1016/j.bbrc.2026.153411

4. Siyuan Tang, Jiangwen Gui, Yingjie Lan,Panwen Liu, Yuliang Lin, Meng Sun, Shaoliang Duan, Chao Zhang, Denggao Zhang, Min Liu, Xiaobo Mai,Jiaqi Tan, Zhiwen Wang, Jinggen Liu, Liming Shao, Wei Fu, Yujun Wang, Wei Li.Structure-Activity Relationship of N-cyclopropylmethyl-7α-(m-methylaminophenyl)-6,14-endoethano-northebaine Derivatives as G-Protein-Biased KOR-Selective Agonists. Eur J Med Chem, 2026, 306, March 16, 118591 https://doi.org/10.1016/j.ejmech.2026.118591

5. Xiaodi Xu, Haoran Zhu, Qingbo Shao, Baiyu Chen, Jing Lin, Yang Gao, Zhenzhou He, Wei Fu, Wei Li. Discovery, SAR, and Molecular Basis of (R)-1-((3R,4S)-3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-3-(3-fluorophenyl)-2-methylpropan-1-one as a Novel Potent Analgesic. Bioorg Med Chem, 2026, 132, Jan 1, 118474. https://doi.org/10.1016/j.bmc.2025.11847

6. Denggao Zhang, Jiangwen Gui, Linghui Kong, Chuyuan Hu, Xinmeng Kou, Biying Wang, Shaoliang Duan,Min Liu, Zixiang Li, Jiawen Luo, Siyuan Tang, Hui Xiao, Zeyi Du, Qiong Xie, Jinggen Liu, Liming Shao, Wei Fu, Yujun Wang, Wei Li. Design, Synthesis, and Biological Activity of Novel Para-substituted Phenylamino and Phenyl Derivatives of Northebaine as Selective Delta Opioid Receptor Agonists. Bioorg Med Chem, 2025, 130, Aug 28, 118373. https://doi.org/10.1016/j.bmc.2025.118373

7. Linghui Kong, Songyu Yao, Denggao Zhang, Jiangwen Gui, Baiyu Chen, Min Liu, Siyuan Tang, Chuyuan Hu, Shaoliang Duan, Biying Wang, Zixiang Li, Yiquan Shen, Yingjie Lan, Xiaoning Liu, Zeyi Du, Zihan Liu, Qiong Xie, Anan Liu, Jingrui Chai, Jinggen Liu, Liming Shao, Wei Fu, Yujun Wang, Wei Li. Structure−Activity Relationship of N-cyclopropylmethyl-7α-[para-(arylcarboxamido)phenyl]-6,14-endoethanotetrahydronorthebaines as Potent and Selective Kappa Opioid Receptor Agonists. J Med Chem, 2025, 68(15), 15889–15909. https://doi.org/10.1021/acs.jmedchem.5c00882

8. Siyuan Tang, Shuyang Hu, Lijing Feng, Linghui Kong, Jiangwen Gui, Ying Zhang, Zi-Han Liu, Denggao Zhang, An-An Liu, Xiao Liu, Chuyuan Hu, Yingjie Lan, Xiaoning Liu, Zixiang Li, Panwen Liu, Shaoliang Duan, Zeyi Du, Min Liu, Qiong Xie, Jinggen Liu, Liming Shao, Wei Fu, Yujun Wang, Wei Li.Structure–Activity Relationship Analysis of Meta-Substituted N-Cyclopropylmethyl-nornepenthones with Mixed KOR/MOR Activities.Eur J Med Chem, 2025, May 5:289:117449. https://doi.org/10.1016/j.ejmech.2025.117449

9. Zixiang Li, Rufeng Ye, Qian He, Jiashuo Lu, Yanting Sun, Xiujian Sun, Siyuan Tang, Shuyang Hu, Jingrui Chai, Linghui Kong, Xiaoning Liu, Jing Chen, Yun Fang, Yingjie Lan, Qiong Xie, Jinggen Liu, Liming Shao, Wei Fu, Yujun Wang, Wei Li. Discovery of an Ortho-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethano-tetrahydronorthebaine Derivative as a Selective and Potent Kappa Opioid Receptor Agonist with Subsided Sedative Effect. J Med Chem, 2024, 67(9), 7112-7129. https://doi.org/10.1021/acs.jmedchem.3c02439

10. Linghui Kong, Kuan Ning, Xiao Liu, Jiashuo Lu, Baiyu Chen, Rongrong Ye, Zixiang Li, Shuang Jiang, Siyuan Tang, Jingrui Chai, Yun Fang, Yingjie Lan, Xiaobo Mai, Qiong Xie, Jinggen Liu, Liming Shao, Wei Fu, Yujun Wang, Wei Li. Reversal of Subtype-Selectivity and Function by the Introduction of a Para-Benzamidyl Substituent to N-cyclopropylmethylnornepenthone. Eur J Med Chem, 2023, Oct 5;258:115589. https://doi.org/10.1016/j.ejmech.2023.115589

11. Linghui Kong, Xuelian Shu, Siyuan Tang, Rongrong Ye, Huijiao Sun, Shuang Jiang, Zixiang Li, Jingrui Chai, Yun Fang, Yinjie Lan, Linqian Yu, Qiong Xie, Wei Fu, Yujun Wang, Wei Li, Zhuibai Qiu, Jinggen Liu, and Liming Shao. SLL-627 is a Highly Selective and Potent Κ Opioid Receptor (KOR) Agonist with an Unexpected Non-Reduction in Locomotor Activity. J Med Chem, 2022, 65(15), 10377-10392. https://doi.org/10.1021/acs.jmedchem.2c00014

12. Yuanyuan Wei, Yan Ma, Songyu Yao, Linghui Kong, Xiao Liu, Jingrui Chai, Jing Chen, Wei Li, Yujun Wang, Liming Shao, Jinggen Liu. Novel Selective κ Agonists SLL-039 And SLL-1206 Produce Potent Antinociception with Fewer Sedation and Aversion.Acta Pharmacol Sin, 2022, 43(6):1372-1382. doi: 10.1038/s41401-021-00761-x

13. Qian He,Yuanyuan Wei,Xiao Liu,Rongrong Ye, Linghui Kong, Zixiang Li, Shuang Jiang, Linqian Yu, Jingrui Chai, Qiong Xie, Wei Fu, Yujun Wang, Wei Li, Zhuibai Qiu, Jinggen Liu, Liming Shao. Discovery of an M‑Substituted N‑Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active κ‑Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile. J Med Chem, 2021, 64(16), 12414–12433. https://doi.org/10.1021/acs.jmedchem.1c01082

14. Huoming Huang, Xueping Li, Peng Xie, Xinwei Li, XueJun Xu, Yuanyuan Qian, Congmin Yuan, Xiangguo Meng, JingRui Chai, Jing Chen, Jing Liu, Wenli Wang, Wei Li, YuJun Wang, Wei Fu, Jinggen Liu. Discovery, Structure–Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic. J Med Chem, 2021, 64(13), 9458–9483. https://doi.org/10.1021/acs.jmedchem.1c00722

15. Xiao Liu, Rongrong Ye, Linghui Kong, Shuang Jiang, Li Xiao, Xuejun Xu, Qian He, Yuanyuan Wei, Zixiang Li, Huijiao Sun, Qiong Xie, Xu Xu, Yan Lu, Yujun Wang, Wei Li, Wei Fu, Zhuibai Qiu, Jinggen Liu, Liming Shao. An Exploration of the SAR Connection Between Morphinan and Arylacetamide-based κ Opioid Receptor (κOR) Agonists Using the Strategy of Bridging. ACS Chem NeuroSci, 2021, 12(6), 1018-1030. https://doi.org/10.1021/acschemneuro.1c00034

16. Huoming Huang, Wenli Wang, Xuejun Xu, Chen Zhu, Yujun Wang, Jinggen Liu, Wei Li, Wei Fu. Discovery of 3-((Dimethylamino)Methyl)-4-Hydroxy-4-(3-Methoxyphenyl)-N-Phenylpiperidine-1-Carboxamide As Novel Potent Analgesic. Eur J Med Chem, 2020, 189: 112070-112084. doi: 10.1016/j.ejmech.2020.112070

17. Li Xiao, Yujun Wang, Mumei Zhang,Weiwei Wu, Linghui Kong, Yan Ma, Xuejun Xu, Xiao Liu, Qian He, Yuanyuan Qian, Huijiao Sun, Haihao Wu, Cheng Lin, Huoming Huang, Rongrong Ye, Shuang Jiang, Rufeng Ye, Congmin Yuan, Shengyang Fang, Dengqi Xue, Xicheng Yang, Hao Chen, Yilin Zheng, Linqian Yu, Qiong Xie, Lan Zheng, Wei Fu, Wei Li, Zhuibai Qiu, Jinggen Liu , Liming Shao. Discovery of a Highly Selective and Potent Kappa Opioid Receptor Agonist from N-Cyclopropylmethyl-7α-phenyl-6,14-endoethano-tetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by The Message-Address Concept. J Med Chem 2019, 62(24): 11054-11070.https://doi.org/10.1021/acs.jmedchem.9b00857

18. Huijiao Sun, Yuhua Wang, Congmin Yuan, Linghui Kong, Xuejun Xu, Yujun Wang, Haihao Wu, Cheng Lin, Yuanyuan Qian, Huoming Huang, Li Xiao, Xiao Liu, Qian He, Shengyang Fang, Dengqi Xue, Xicheng Yanga, Hao Chen, Yilin Zheng, Lan Zheng, Linqian Yu, Qiong Xie, Wei Fu, Wei Li, Jinggen Liu, Zhuibai Qiu, Liming Shao. 7β-methyl Substituent Is a Structural Locus Associated with Activity Cliff For Nepenthone Analogues. Bioorg Med Chem, 2018, 26 (14), 4254-4263. https://doi.org/10.1016/j.bmc.2018.07.020