教育经历

1998.10-2002.10 瑞士联邦苏黎世理工学院，博士后

1998.07-1998.10 美国加州理工学院，博士后

1997.07-1998.07 美国加州大学尔湾分校，访问学者

1994.07-1997.07 中国科学院感光化学研究所，博士

1987.07-1990-07 中国科学院感光化学研究所，硕士

1983.07-1987.07 武汉大学化学系，学士

工作经历

2009.04-   复旦大学药学院， 研究员、博导

2005.11-2009.03 罗氏研发（中国）有限公司，药物研发副主任、主任

2002.10-2005.11 瑞士联邦苏黎世理工学院“Wissenschaftlicher Mitarbeiter”

1990.07-1994.07 河南大学物理系，助教，讲师

研究方向

代表性论著

1. Discovery of an Amino Acid-Modified Near-Infrared Aza-BODIPY Photosensitizer as an Immune Initiator for Potent Photodynamic Therapy in Melanoma. Zhiliang Yu, Hong Wang, Zhongjian Chen, Xiaochun Dong, Weili Zhao*, Yuling Shi*, Quangang Zhu*. J. Med. Chem., 2022, 65, 3616−3631.

2. Development of environment-insensitive and highly emissive BODIPYs via installation of N, N’-dialkylsubstituted amide at meso position. Junping Bai, Junliang Zhou, Xin Ji, Nannan Wang, Xiaochun Dong*, Wei Wu*, Weili Zhao*. Chin. Chem. Lett., 2022, 33, 4175–4178.

3. Near-infrared fluorophores with absolute aggregation-caused quenching and negligible fluorescence re-illumination for in vivo bioimaging of nanocarriers. Yifan Cai, Xin Ji, Yunsen Zhang, Chang Liu, Zichen Zhang, Yongjiu Lv, Xiaochun Dong, Haisheng He, Jianping Qi, Yi Lu, Defang Ouyang*, Weili Zhao*, Wei Wu*. Aggregate, 2022, e277.

4. Accurate and sensitive probing of onset of micellization based on absolute aggregation-caused quenching effect. Haisheng He, Chang Liu, Jiang Ming, Yongjiu Lv, Jianping Qi, Yi Lu, Xiaochun Dong, Weili Zhao*, Wei Wu*. Aggregate, 2022, 3, e163.

5. Discovery of meso-(meta-pyridinium) BODIPY photosensitizers: In vitro and in vivo evaluations for antimicrobial photodynamic therapy. Guangyu Lin, Mei Hu, Rong Zhang, Yuanxing Zhu, Kedan Gu, Junping Bai, Jiyang Li*, Xiaochun Dong*,Weili Zhao*, J. Med. Chem., 2021, 64, 18143−18157.

6. Discovery of a Monoiodo Aza-BODIPY Near-Infrared Photosensitizer: in vitro and in vivo Evaluation for Photodynamic Therapy. Zhiliang Yu, Junliang Zhou, Xin Ji, Guangyu Lin, Shuang Xu, Xiaochun Dong*, Weili Zhao*, J. Med. Chem., 2020, 63, 9950−9964.

7. Anchoring BODIPY photosensitizers enable pan-microbial photoinactivation. Kedan Gu, Guangyu Lin, Yuanxing Zhu, Xin Ji, Jiyang Li*, Xiaochun Dong*, Weili Zhao*, Eur. J. Med. Chem.,2020, 199, 112361.

8. Azetidine-Containing Heterospirocycles Enhance the Performance of Fluorophores. Junliang Zhou, Xianfeng Lin, Xin Ji, Shuang Xu, Chang Liu, Xiaochun Dong*, Weili Zhao*, Org. Lett., 2020, 22, 4413−4417.

9. Response to Comment on “Water-Soluble Fluorescent Probe with Dual Mitochondria/Lysosome Targetability Superoxide Detection in Live Cells and in Zebrafish Embryos”. Xiuhong Lu, Guangyu Lin, Xiaochun Dong*, Weili Zhao*, Zhongjian Chen*, ACS Sensors, 2019, 4, 3084-3087.

10. Fluorescent probe for sensitive discrimination of Hcy and Cys/GSH in living cells via dual-emission. Shuang Xu, Junliang Zhou, Xiaochun Dong*, Weili Zhao*, Quangang Zhu*, Anal. Chim. Acta, 2019, 1074, 123–130.

11. Visualizing Nitric Oxide in Mitochondria and Lysosomes of Living Cells with N-Nitrosation of BODIPY-based Fluorescent Probes. Zhiliang Yu, Junliang Zhou, Xiaochun Dong*, Weili Zhao*, Zhongjian Chen*, Anal. Chim. Acta, 2019, 1067, 88–97.

12. Pyridinium substituted BODIPY as NIR fluorescent probe for simultaneous sensing of hydrogen sulphide/glutathione and cysteine/homocysteine. Jian Zhang, Xin Ji, Junliang Zhou, Zhongjian Chen*, Xiaochun Dong*, Weili Zhao*, Sens. Actuators B, 2018, 257, 1076–1082.

13. Water-Soluble Fluorescent Probe with Dual Mitochondria/Lysosome Targetability for Selective Superoxide Detection in Live Cells and in Zebrafish Embryos. Xiuhong Lu, Zhongjian Chen*, Xiaochun Dong*, Weili Zhao*, ACS Sensors, 2018, 3, 59-64.

14. Overcoming the resistance mechanisms of Smoothened inhibitors. Xiaochun Dong, Chenglin Wang, Zhongjian Chen*, Weili Zhao*, Drug Discovery Today, 2018, 23, 704–710.

15. A mitochondria-targeted turn-on fuorescent probe for the detection of glutathione in living cells. Jian Zhang, Xiaolong Bao, Junliang Zhou, Fangfang Peng, Hang Ren, Xiaochun Dong*, Weili Zhao*, Biosens. Bioelectron., 2016, 85, 164–170.

16. A multi-functional probe to discriminate Lys, Arg, His, Cys, Hcy and GSH from common amino acids. Xiuhong Lu, Wen Wang, Qian Dong, Xiaolong Bao, Xianfeng Lin, Weixing Zhang, Xiaochun Dong*, Weili Zhao*, Chem. Commun. 2015, 51, 1498-1501.